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Genomes and Genes | Peter SanderSummaryAffiliation: University of Zurich Country: Switzerland Publications
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Publications
Fitness cost of chromosomal drug resistance-conferring mutationsPeter Sander
Institut fur Medizinische Mikrobiologie, Universitat Zurich, CH 8028 Zurich, Switzerland
Antimicrob Agents Chemother 46:1204-11. 2002..These results argue against expectations that link decreased levels of antibiotic consumption with the decline in the level of resistance...- A recA deletion mutant of Mycobacterium bovis BCG confers protection equivalent to that of wild-type BCG but shows increased genetic stabilityPeter Sander
Institut fur Medizinische Mikrobiologie, Universitat Zurich, Gloriastrasse 30 32, CH 8028, Zurich, Switzerland
Vaccine 21:4124-7. 2003..The availability of a genetically stable, fully immunogenic BCG is important for the future development of BCG as a live vaccine... - Lipoprotein processing is required for virulence of Mycobacterium tuberculosisP Sander
Institut fur Medizinische Mikrobiologie, Universitat Zurich, Gloriastrasse 30 32, CH 8028 Zurich, Schweiz
Mol Microbiol 52:1543-52. 2004..In addition, these results hint at a promising new target for therapeutic intervention, as a highly specific inhibitor of bacterial lipoprotein signal peptidases is available... - LspA inactivation in Mycobacterium tuberculosis results in attenuation without affecting phagosome maturation arrestSilvana K Rampini
Institut fur Medizinische Mikrobiologie, Universitat Zurich, Gloriastrasse 32, CH 8006 Zurich, Switzerland
Microbiology 154:2991-3001. 2008..These observations demonstrate severe attenuation even in the presence of arrested phagosome maturation, and point to a role for the early phagosome in growth restriction of the M. tuberculosis lspA mutant... - A mycobacterial smc null mutant is proficient in DNA repair and long-term survivalCarolin Güthlein
Institut fur Medizinische Mikrobiologie, Universitat Zurich, Gloriastrasse 30 32, 8006 Zurich, Switzerland
J Bacteriol 190:452-6. 2008..Surprisingly, inactivation of smc did not result in recognizable phenotypes in hallmark assays characteristic for the function of these genes. This is in contrast to data for smc null mutants in other species... - Relief from Zmp1-mediated arrest of phagosome maturation is associated with facilitated presentation and enhanced immunogenicity of mycobacterial antigensPål Johansen
Department of Dermatology, University Hospital Zurich, Zurich, Switzerland
Clin Vaccine Immunol 18:907-13. 2011..In conclusion, our results suggest that phagosome maturation and lysosomal delivery of BCG facilitate mycobacterial antigen presentation and enhance immunogenicity... - Characterization of the mycobacterial NER system reveals novel functions of the uvrD1 helicaseCarolin Güthlein
Institut fur Medizinische Mikrobiologie, University of Zurich, Gloriastrasse 30 32, CH 8006, Zurich, Switzerland
J Bacteriol 191:555-62. 2009..This implies that in mycobacteria (which lack the postreplicative mismatch repair system) NER, and particularly the UvrD1 helicase, is involved in the processing of a subset of recombination-associated mismatches... - Engineering the rRNA decoding site of eukaryotic cytosolic ribosomes in bacteriaSven N Hobbie
Institut fur Medizinische Mikrobiologie, Universität Zürich and Laboratorium für Organische Chemie, ETH Zurich, Switzerland
Nucleic Acids Res 35:6086-93. 2007..The activities of the hybrid ribosomes indicate that helix 44 of the rRNA decoding site behaves as an autonomous domain, which can be exchanged between ribosomes of different phylogenetic domains for study of function... - Tuberculosis vaccine strain Mycobacterium bovis BCG Russia is a natural recA mutantPeter M Keller
Institut fur Medizinische Mikrobiologie, Universitat Zurich, Gloriastrasse 30 32, CH 8006 Zurich, Switzerland
BMC Microbiol 8:120. 2008..All vaccine substrains in use stem from one source, strain Bacille Calmette-Guérin. However, they differ in regions of genomic deletions, antigen expression levels, immunogenicity, and protective efficacy... - Deletion of dop in Mycobacterium smegmatis abolishes pupylation of protein substrates in vivoFrank Imkamp
ETH Zurich, Institute of Molecular Biology and Biophysics, Zurich, Switzerland
Mol Microbiol 75:744-54. 2010..Furthermore, we demonstrate that a putative N-terminal ATP-binding motif is crucial for catalysis, as a single point mutation (E10A) in this motif abolishes Dop activity both in vivo and in vitro... - Identification of apolipoprotein N-acyltransferase (Lnt) in mycobacteriaAndreas Tschumi
Institut fur Medizinische Mikrobiologie, Universitat Zurich, Gloriastrasse 30 32, CH 8006 Zurich, Switzerland
J Biol Chem 284:27146-56. 2009..In M. smegmatis and M. tuberculosis the open reading frames are annotated as MSMEG_3860 and M. tuberculosis ppm1, respectively... - Phenylethyl butyrate enhances the potency of second-line drugs against clinical isolates of Mycobacterium tuberculosisThomas Grau
Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland
Antimicrob Agents Chemother 56:1142-5. 2012.... - Lipoprotein synthesis in mycobacteriaMandana Rezwan
Institut fur Medizinische Mikrobiologie, Universitat Zurich, Gloriastrasse 32, CH 8006 Zurich, Switzerland
Microbiology 153:652-8. 2007..M. tuberculosis, the causative agent of tuberculosis, is one of the most devastating pathogens in the world. This article reviews recent findings on the synthesis, localization and function of lipoproteins in mycobacteria... - A ?-Lactamase Based Reporter System for ESX Dependent Protein Translocation in MycobacteriaTobias Rosenberger
Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland
PLoS ONE 7:e35453. 2012..Thus we have developed a powerful tool to dissect the molecular mechanisms of ESX dependent protein translocation and to screen for novel components of the ESX systems on a large scale... - Binding of neomycin-class aminoglycoside antibiotics to mutant ribosomes with alterations in the A site of 16S rRNASven N Hobbie
Institut fur Medizinische Mikrobiologie, Universitat Zurich, Gloriastr 30 32, CH 8006 Zurich, Switzerland
Antimicrob Agents Chemother 50:1489-96. 2006..U1495 wobble base pair to the Watson-Crick interaction pair 1406C-1495G yields ribosomal drug susceptibilities to 4,5-aminoglycosides comparable to those seen with the wild-type A site... - Breaking down the wall: fractionation of mycobacteriaMandana Rezwan
Institut fur Medizinische Mikrobiologie, Gloriastrasse 32, Universität Zürich CH 8006 Zürich, Switzerland
J Microbiol Methods 68:32-9. 2007..The protocol of subcellular fractionation was then validated for pathogenic species by applying the method to Mycobacterium bovis BCG cells, an attenuated strain of the M. tuberculosis complex... - Characterization of a Mycobacterium tuberculosis mutant deficient in pH-sensing adenylate cyclase Rv1264Dorothea Dittrich
Institut fur Medizinische Mikrobiologie, Universitat Zurich, Gloriastrasse 30 32, CH 8006 Zurich, Switzerland
Int J Med Microbiol 296:563-6. 2006..Consequently Rv1264 has been suggested to sense the phagosomal milieu resulting in adaption of M. tuberculosis to its intracellular niche. A targeted knock-out mutant deficient in Rv1264, however, exhibits wild-type virulence... - Involvement of CD252 (CD134L) and IL-2 in the expression of cytotoxic proteins in bacterial- or viral-activated human T cellsMichael Walch
Division of Cell Biology, Institute of Anatomy, University of Zurich, Zurich, Switzerland
J Immunol 182:7569-79. 2009..These data indicate a distinct CTL effector function in response to intracellular pathogens triggered via differing endogenous IL-2 production upon costimulation through CD252... - DNA damage induction of recA in Mycobacterium tuberculosis independently of RecA and LexAElaine O Davis
Division of Mycobacterial Research, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
Mol Microbiol 46:791-800. 2002..These observations demonstrate convincingly for the first time that there is a novel mechanism of DNA damage induction in M. tuberculosis that is independent of LexA and RecA... - The majority of inducible DNA repair genes in Mycobacterium tuberculosis are induced independently of RecALucinda Rand
National Institute for Biomedical Research, London, UK
Mol Microbiol 50:1031-42. 2003..Amongst these are genes involved in nucleotide excision repair, base excision repair, damage reversal and recombination. Thus, it appears that this novel mechanism of gene regulation is important for DNA repair in M. tuberculosis... - The functions of OmpATb, a pore-forming protein of Mycobacterium tuberculosisCatherine Raynaud
The Division of Mycobacterial Research, The National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
Mol Microbiol 46:191-201. 2002..The involvement with pH is likely to contribute to the ability of M. tuberculosis to overcome host defence mechanisms and grow in a mammalian host... - A synthetic mammalian gene circuit reveals antituberculosis compoundsWilfried Weber
Department of Biosystems Science and Engineering, Eidgenossische Technische Hochschule Zurich, Mattenstrasse 26, CH 4058 Basel, Switzerland
Proc Natl Acad Sci U S A 105:9994-8. 2008..The discovery of antituberculosis compounds by using synthetic mammalian gene circuits may establish a new line of defense against multidrug-resistant M. tuberculosis... - Mycobacterium tuberculosis prevents inflammasome activationSharon S Master
Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
Cell Host Microbe 3:224-32. 2008..Thus, we uncovered a previously masked role for IL-1beta in the control of Mtb and a mycobacterial system that prevents inflammasome and, therefore, IL-1beta activation... - Interaction of Rv1625c, a mycobacterial class IIIa adenylyl cyclase, with a mammalian congenerYing Lan Guo
Abt Pharmazeutische Biochemie, Pharmazeutisches Institut, Universitat Tubingen, Morgenstelle 8, D 72076 Tubingen, Germany
Mol Microbiol 57:667-77. 2005..In vitro growth characteristics and in vivo organ infection and mortality were unaltered in the knockout strain indicating that AC Rv1625c alone is not a virulence factor... - Lack of mismatch correction facilitates genome evolution in mycobacteriaBurkhard Springer
, , Gloriastrasse 30/32, , Switzerland
Mol Microbiol 53:1601-9. 2004..Together, the lack of mismatch correction and a high stringency of initiation of homologous recombination provide an adequate strategy for mycobacterial genome evolution, which occurs by gene duplication and divergent evolution...