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Genomes and GenesSpecies | Caroline OspeltSummaryAffiliation: University Hospital Country: Switzerland Publications
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Publications
Toll-like receptors in rheumatoid arthritis joint destruction mediated by two distinct pathwaysC Ospelt
WHO Collaborating Center for Molecular Biology and Novel Therapeutic Strategies for Rheumatic Diseases, Clinic for Rheumatology, University Hospital, Gloriastrasse 25, CH-8091 Zurich, Switzerland
Ann Rheum Dis 63:ii90-ii91. 2004- The role of resident synovial cells in destructive arthritisCaroline Ospelt
Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology, Gloriastrasse 23, CH 8091 Zurich, Switzerland
Best Pract Res Clin Rheumatol 22:239-52. 2008..Most importantly, by producing matrix-degrading molecules they contribute strongly to the destructive mechanisms operative in RA... - Epigenetics in rheumatoid arthritisMichelle Trenkmann
Center of Experimental Rheumatology and Zurich Center for Integrative Human Physiology ZIHP, University of Zurich, Zurich, Switzerland
Clin Rev Allergy Immunol 39:10-9. 2010..To gain a better understanding of this disease, researchers have become interested in studying epigenetic changes in rheumatoid arthritis. Here, we want to review the current knowledge on epigenetics in rheumatoid arthritis... - Inflammatory memories: is epigenetics the missing link to persistent stromal cell activation in rheumatoid arthritis?Caroline Ospelt
Center of Experimental Rheumatology, University Hospital Zurich, Switzerland
Autoimmun Rev 10:519-24. 2011.... - Safety concerns on the development of novel therapeutic drugsCaroline Ospelt
Center of Experimental Rheumatology, Zurich, Switzerland
Arthritis Res Ther 8:112. 2006.... - Antirheumatic drugs and gene signaturesCaroline Ospelt
University Hospital Zurich, Center of Experimental Rheumatology, Gloriastrasse 23, Zurich, CH 8091, Switzerland
Curr Opin Investig Drugs 8:385-9. 2007..This review discusses the strengths and weaknesses of microarray technology and gives an overview of gene expression studies currently performed in the field of antiheumatic therapies... - The dual inhibitor of lipoxygenase and cyclooxygenase ML3000 decreases the expression of CXCR3 ligandsC Ospelt
Center of Experimental Rheumatology, University Hospital Zurich, Switzerland
Ann Rheum Dis 67:524-9. 2008..To find previously unknown properties of ML3000, a competitive inhibitor of the cyclooxygenase and the lipoxygenase (LO) pathway... - Somatic mutations in mitochondria: the chicken or the egg?Caroline Ospelt
Center of Experimental Rheumatology, Zurich, Switzerland
Arthritis Res Ther 7:179-80. 2005..Further studies will show whether these mutations are actually able to trigger autoimmune inflammation in rheumatoid arthritis or whether they must be considered epiphenomena of cellular damage in chronic inflammation... - Gene analysis for exploring the effects of drugs in rheumatoid arthritisCaroline Ospelt
University Hospital, Zurich, Switzerland
Arthritis Rheum 52:2248-56. 2005 - TLRs and chronic inflammationCaroline Ospelt
Center of Experimental Rheumatology and Zurich Center of Integrative Human Physiology ZIHP, University Hospital Zurich, Gloriastr 23, CH 8091, Zurich, Switzerland
Int J Biochem Cell Biol 42:495-505. 2010..In this review, an overview of the currently known TLRs and their signaling pathways is given and reports about their expression and activation in chronic inflammatory diseases are recapitulated... - Synovial activation in rheumatoid arthritisCaroline Ospelt
Center of Experimental Rheumatology, University Hospital, Gloriastrasse 25, CH 8091 Zurich, Switzerland
Front Biosci 9:2323-34. 2004..Thanks to new techniques in basic research, novel insights into the cellular and molecular mechanisms of the pathogenesis of RA were gained and led to the development of new, specific therapeutic strategies... - Overexpression of toll-like receptors 3 and 4 in synovial tissue from patients with early rheumatoid arthritis: toll-like receptor expression in early and longstanding arthritisCaroline Ospelt
Center of Experimental Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
Arthritis Rheum 58:3684-92. 2008.... - Epigenetics and rheumatoid arthritis: the role of SENP1 in the regulation of MMP-1 expressionHanna Maciejewska-Rodrigues
Center of Experimental Rheumatology, University Hospital Zurich, Gloriastrasse 23 25, Zurich 8091, Switzerland
J Autoimmun 35:15-22. 2010..This is the first study linking the SUMOylation pathway and the production of MMP-1 to an epigenetic control mechanism mediated through histone acetylation which has a functional consequence for the invasiveness of RASF... - Effect of the oral application of a highly selective MMP-13 inhibitor in three different animal models of rheumatoid arthritisAstrid Jungel
Centre of Experimental Rheumatology, University Hospital Zurich, Gloriastrasse 25, CH 8091 Zurich, Switzerland
Ann Rheum Dis 69:898-902. 2010..To evaluate the decrease of cartilage destruction by a novel orally active and specific matrix metalloproteinase 13 (MMP-13) inhibitor in three different animal models of rheumatoid arthritis (RA)... - Altered expression of microRNA-203 in rheumatoid arthritis synovial fibroblasts and its role in fibroblast activationJoanna Stanczyk
Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology, Zurich, Switzerland
Arthritis Rheum 63:373-81. 2011..The present study was undertaken to examine alterations in expression of miR-203 in RASFs and analyze its role in fibroblast activation... - Expression, regulation, and signaling of the pattern-recognition receptor nucleotide-binding oligomerization domain 2 in rheumatoid arthritis synovial fibroblastsCaroline Ospelt
Center of Experimental Rheumatology, University Hospital Zurich, and Zurich Center of Integrative Human Physiology, University of Zurich, Zurich, Switzerland
Arthritis Rheum 60:355-63. 2009.... - Inhibition of fibroblast activation protein and dipeptidylpeptidase 4 increases cartilage invasion by rheumatoid arthritis synovial fibroblastsCaroline Ospelt
University Hospital, Zurich, Switzerland
Arthritis Rheum 62:1224-35. 2010.... - Pre-B cell colony-enhancing factor/visfatin, a new marker of inflammation in rheumatoid arthritis with proinflammatory and matrix-degrading activitiesFabia Brentano
University Hospital, Zurich, Switzerland
Arthritis Rheum 56:2829-39. 2007.... - SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistanceFabienne Niederer
Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland
Ann Rheum Dis 70:1866-73. 2011..To analyse the expression of SIRT1 in synovial tissues and cells of patients with rheumatoid arthritis (RA) and to study the function of SIRT1 in inflammation and apoptosis in RA... - Deficient expression of interleukin-10 receptor alpha chain in rheumatoid arthritis synovium: limitation of animal models of inflammationMichel Neidhart
University Hospital Zurich, Zurich, Switzerland
Arthritis Rheum 52:3315-8. 2005 - Technology insight: gene transfer and the design of novel treatments for rheumatoid arthritisFalk Moritz
Center of Experimental Rheumatology, Department of Rheumatology, University of Zurich, Switzerland
Nat Clin Pract Rheumatol 2:153-62. 2006.... - Synovial cell activationJoanna Stanczyk
Center of Experimental Rheumatology and World Health Organization Collaborating Center for Molecular Biology and Novel Therapeutic Strategies, Department of Rheumatology, University Hospital Zurich, Switzerland
Curr Opin Rheumatol 18:262-7. 2006..Moreover, it has become evident that integration of a large body of information is indispensable to get a comprehensive outlook on synovial activation in the pathology of rheumatoid arthritis... - The pattern-recognition receptor nucleotide-binding oligomerization domain-containing protein 1 promotes production of inflammatory mediators in rheumatoid arthritis synovial fibroblastsKazuhiro Yokota
University Hospital Zurich, Zurich Center of Integrative Human Physiology, and University of Zurich, Zurich, Switzerland
Arthritis Rheum 64:1329-37. 2012..The aim of this study was to analyze the expression, regulation, and function of the PRR NOD-1 in RA synovial fibroblasts (RASFs), and to examine its interaction with other PRRs... - Is there a future for small molecule drugs in the treatment of rheumatic diseases?Joanna Stanczyk
Center of Experimental Rheumatology, University Hospital Zurich, Zurich Center of Integrative Human Physiology, University of Zurich, Switzerland
Curr Opin Rheumatol 20:257-62. 2008..We also stress the fact that novel techniques are available to evaluate the safety of new therapeutics at an early stage of development... - What can we learn from epigenetics in the year 2009?Astrid Jungel
Center of Experimental Rheumatology, University Hospital and Zurich Center of Integrative Human Physiology, Switzerland
Curr Opin Rheumatol 22:284-92. 2010..Even though current therapies with biologics such as tumor necrosis factor-alpha blockers yield significant improvement for the patients, the disease is not curable yet. Therefore, we need novel strategies for better therapies... - Proteinases in the joint: clinical relevance of proteinases in joint destructionYvonne Rengel
Center of Experimental Rheumatology, University Hospital Zurich, Gloriastrasse, CH 8091 Zurich, Switzerland
Arthritis Res Ther 9:221. 2007..Despite disappointing early results with synthetic inhibitors of MMPs, there is still much scope for developing effective and safe MMPs inhibitors, and consequently to deliver new options to inhibit joint destruction... - Abundant expression of the interleukin (IL)23 subunit p19, but low levels of bioactive IL23 in the rheumatoid synovium: differential expression and Toll-like receptor-(TLR) dependent regulation of the IL23 subunits, p19 and p40, in rheumatoid arthritisF Brentano
Center of Experimental Rheumatology, University Hospital and Zurich Center of Integrative Human Physiology ZIHP, University of Zurich, Zurich, Switzerland
Ann Rheum Dis 68:143-50. 2009..However, previous studies on IL23 expression in human tissues were based on the p19 subunit only. We aimed to study the expression and regulation of IL23 subunits p19 and p40 in RA compared to patients with osteoarthritis (OA)... - Functional autoantibodies against serpin E2 in rheumatoid arthritisH Maciejewska-Rodrigues
University Hospital, University of Zurich, Zurich, Switzerland
Arthritis Rheum 62:93-104. 2010..To search for novel autoantibodies in patients with rheumatoid arthritis (RA) in an effort to better understand the processes of joint destruction in this disease... - Cells of the synovium in rheumatoid arthritis. Synovial fibroblastsUlf Müller-Ladner
Justus Liebig University Giessen, Department of Rheumatology and Clinical Immunology, Kerckhoff Clinic Bad Nauheim, Benekestrasse, D 61231 Bad Nauheim, Germany
Arthritis Res Ther 9:223. 2007.... - Epigenetic clues to rheumatoid arthritisOlga Sanchez-Pernaute
Fundacion Jimenez Diaz, Madrid, Spain
J Autoimmun 30:12-20. 2008..On the whole, the concourse of epigenetic mechanisms can precipitate the aggressive behaviour of cells and the rupture of peripheral tolerance. Targeting these emerging regulatory pathways is a promising approach for RA therapeutics... - Time course of coagulation parameters, cytokines and adhesion molecules in Plasmodium falciparum malariaAlexander Vogetseder
University Hospital Innsbruck, Department of Neurology and Central Laboratories, Innsbruck, Austria
Trop Med Int Health 9:767-73. 2004..IL-6 and IL-10 decreased significantly over 5 days during schizontocidal therapy. Our data show an impairment of the coagulation system which correlates with pro-inflammatory cytokines and therefore with the severity of the disease...