Research Topics
Genomes and GenesSpecies | J A Kremer HovingaSummaryAffiliation: University Hospital Country: Switzerland Publications
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Publications
Splenectomy in relapsing and plasma-refractory acquired thrombotic thrombocytopenic purpuraJohanna A Kremer Hovinga
Central Hematology Laboratory, Inselspital, University of Bern, Bern, Switzerland
Haematologica 89:320-4. 2004....- Evidence for a role of anti-ADAMTS13 autoantibodies despite normal ADAMTS13 activity in recurrent thrombotic thrombocytopenic purpuraRahel Froehlich-Zahnd
University Clinic of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital and the University of Bern, CH 3010 Bern
Haematologica 97:297-303. 2012..Anti-ADAMTS13 autoantibodies may be important in vivo despite normal ADAMTS13 activity in routine assays. Consequently, treatment decisions should not be based solely on activity assay results... - Current management of thrombotic thrombocytopenic purpuraJohanna A Kremer Hovinga
Department of Hematology and Central Hematology Laboratory, Bern University Hospital and University of Bern, Inselspital, Bern, Switzerland
Curr Opin Hematol 15:445-50. 2008..These new aspects with implications on management of thrombotic thrombocytopenic purpura patients are reviewed here... - ADAMTS-13, von Willebrand factor and related parameters in severe sepsis and septic shockJ A Kremer Hovinga
Department of Hematology and Central Hematology Laboratory, Inselspital, University of Bern, Bern, Switzerland
J Thromb Haemost 5:2284-90. 2007.... - The von Willebrand factor-cleaving protease (ADAMTS-13) and the diagnosis of thrombotic thrombocytopenic purpura (TTP)Johanna A Kremer Hovinga
Department of Hematology and Central Hematology Laboratory, Inselspital, University of Bern, Bern, Switzerland
Pathophysiol Haemost Thromb 33:417-21. 2003..Despite improved treatment modalities, patients suffering from acute bouts of TTP constitute a challenge for any clinician as mortality and morbidity rates are still considerably high... - Schistocytic anaemia, severe thrombocytopenia, and renal dysfunction: thrombotic microangiopathy due to severe acquired ADAMTS-13 deficiency. Case 2A Winkler
Central Haematology Laboratory, Inselspital, University Hospital, Bern, Switzerland
Hamostaseologie 23:103-8. 2003..She relapsed seven months later, and splenectomy led to lasting remission. Pathomechanisms of thrombotic thrombocytopenic purpura, especially the role of ADAMTS-13, are discussed and therapeutic measures outlined... - Thrombotic thrombocytopenic purpuraB Lammle
Department of Hematology and Central Hematology Laboratory, Inselspital, University Hospital, Bern, Switzerland
J Thromb Haemost 3:1663-75. 2005..There remains a large research agenda to improve diagnosis of TMA, gain further insight into the pathophysiology of the various TMA and to improve and possibly tailor the management of affected patients... - Von Willebrand factor-cleaving protease (ADAMTS-13) activity in thrombotic microangiopathies: diagnostic experience 2001/2002 of a single research laboratoryJ-D Studt
Central Haematology Laboratory, Inselspital, University of Bern, Bern, Switzerland
Swiss Med Wkly 133:325-32. 2003..Detection of inhibitory antibodies against ADAMTS-13 helps to differentiate between acquired and constitutional forms of TTP, which may be important for treatment strategies... - Treatment of thrombotic thrombocytopenic purpuraS Fontana
Department of Haematology and Central Haematology Laboratory, University Hospital, Inselspital, Bern, Switzerland
Vox Sang 90:245-54. 2006.... - Acute pancreatitis and thrombotic thrombocytopenic purpuraI P Bergmann
Department of Nephrology and Hypertension, Inselspital, University of Bern, Freiburgstrasse 10, CH 3010 Bern, Switzerland
Eur J Med Res 13:481-2. 2008.... - A first case of congenital TTP on the African continent due to a new homozygous mutation in the catalytic domain of ADAMTS13Sara C Meyer
Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland
Ann Hematol 87:663-6. 2008..An initially oligo-symptomatic presentation was followed by acute exacerbation with ischemic stroke and acute renal failure highlighting the severity of this syndrome... - Rituximab for acute plasma-refractory thrombotic thrombocytopenic purpura. A case report and concise review of the literatureAxel Rüfer
Division of Haematology, Department of Medicine, Kantonsspital Luzern, Luzern, and University of Bern, Switzerland
Swiss Med Wkly 137:518-24. 2007..We conclude that rituximab should be considered in TTP patients with acquired ADAMTS-13 deficiency who fail to respond clinically after 7-14 days of standard treatment with daily PE and glucocorticoids... - ADAMTS13 autoantibodies in patients with thrombotic microangiopathies and other immunomediated diseasesManfred Rieger
Baxter BioScience, Biomedical Reserach Center, Orth, Austria
Blood 106:1262-7. 2005..In conclusion, the ELISA method detected anti-ADAMTS13 IgG antibodies in a very large proportion of patients with acquired TMA associated with severe ADAMTS13 deficiency, and was more sensitive than the inhibitor assay... - Relation between ADAMTS13 activity and ADAMTS13 antigen levels in healthy donors and patients with thrombotic microangiopathies (TMA)Manfred Rieger
Department of Discovery Research, Baxter BioScience, Wagramer Strasse 17-19, A-1220 Vienna, Austria
Thromb Haemost 95:212-20. 2006.... - Sporadic bloody diarrhoea-associated thrombotic thrombocytopenic purpura-haemolytic uraemic syndrome: an adult and paediatric comparisonCharity A Karpac
College of Public Health, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA
Br J Haematol 141:696-707. 2008..05 for all differences). Awareness of the continuous occurrence of sporadic bloody diarrhoea-associated TTP-HUS in adults is important for prompt diagnosis and appropriate management... - The Oklahoma Thrombotic Thrombocytopenic Purpura-Hemolytic Uremic Syndrome Registry: the Swiss connectionJames N George
Colleges of Public Health, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
Eur J Haematol 80:277-86. 2008..With effective treatment it is more frequently diagnosed, the clinical presentations are more diverse, and long-term sequelae are becoming recognized... - A common origin of the 4143insA ADAMTS13 mutationReinhard Schneppenheim
University Medical Center Hamburg Eppendorf, Department of Pediatric Hematology and Oncology, Martinistrasse 52, D 20246 Hamburg, Germany
Thromb Haemost 96:3-6. 2006..We conclude that 4143insA has a common genetic background and is frequent among patients with hereditary ADAMTS13 deficiency in Northern and Central European countries... - Pancreatitis preceding acute episodes of thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: report of five patients with a systematic review of published reportsKaren K Swisher
Hematology Oncology Section, Department of Medicine, College of Medicine, The University of Oklahoma Health Science Center, Oklahoma City, OK 73190, USA
Haematologica 92:936-43. 2007..We describe the occurrence of TTP-HUS following pancreatitis and consider whether pancreatitis may be a triggering event for acute episodes of TTP-HUS...