Research Topics
| E B HunzikerSummaryAffiliation: University of Bern Country: Switzerland Publications
| Collaborators
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Detail Information
Publications
Articular cartilage repair: are the intrinsic biological constraints undermining this process insuperable?E B Hunziker
M E Müller Institute for Biomechanics, University of Bern, Switzerland
Osteoarthritis Cartilage 7:15-28. 1999..Thus far, the application of cell suspensions has always been combined with the grafting of a periosteal flap. The strengths and weaknesses of each concept are discussed...- Growth-factor-induced healing of partial-thickness defects in adult articular cartilageE B Hunziker
M E Müller Institute for Biomechanics, University of Bern, Switzerland
Osteoarthritis Cartilage 9:22-32. 2001..We now wished to ascertain whether these synovial cells could be stimulated to transform into chondrocytes, and thus to lay down cartilage tissue, by the timely introduction of a differentiation factor... - Quantitative structural organization of normal adult human articular cartilageE B Hunziker
M E Müller Institute for Biomechanics, University of Bern, Murtenstrasse 35, P O Box 30, Switzerland
Osteoarthritis Cartilage 10:564-72. 2002..A comprehensive set of such baseline data is, however, not available for humans. It was the purpose of the present study to furnish the necessary information... - Articular cartilage repair: basic science and clinical progress. A review of the current status and prospectsE B Hunziker
M E Müller Institute for Biomechanics, University of Bern, Murtenstrasse 35, Switzerland
Osteoarthritis Cartilage 10:432-63. 2002..Current scientific trends and possible directions for the future will also be discussed... - Chondrogenic potential of human synovial mesenchymal stem cells in alginateT Kurth
ITI Research Institute for Dental and Skeletal Biology, University of Bern, Bern, Switzerland
Osteoarthritis Cartilage 15:1178-89. 2007..The purpose of the present study was to establish the conditions under which synovial MSCs derived from aging human donors can be induced to undergo chondrogenic differentiation using the same alginate system... - Repair of partial-thickness defects in articular cartilage: cell recruitment from the synovial membraneE B Hunziker
M E Müller Institute for Biomechanics, University of Bern, Switzerland
J Bone Joint Surg Am 78:721-33. 1996..At forty-eight weeks, the entire cavity of the defect remained filled with a fibrous connective tissue... - VEGF incorporated into calcium phosphate ceramics promotes vascularisation and bone formation in vivoE Wernike
Department of Clinical Research, University of Bern, Bern, Switzerland
Eur Cell Mater 19:30-40. 2010..Sustained release of VEGF increased the efficacy of VEGF delivery demonstrating that a prolonged bioavailability of low concentrations of VEGF is beneficial for bone regeneration... - Delivery mode and efficacy of BMP-2 in association with implantsY Liu
ITI Research Institute for Dental and Skeletal Biology, University of Bern, Switzerland
J Dent Res 86:84-9. 2007..When BMP-2 was incorporated into calcium-phosphate coatings, it was a potent bone-inducer, whose efficacy was compromised, not potentiated, by the additional deposition of an adsorbed pool... - Differential effects of dexamethasone on the chondrogenesis of mesenchymal stromal cells: influence of microenvironment, tissue origin and growth factorN Shintani
Center of Regenerative Medicine for Skeletal Tissues, Department of Clinical Research, University of Bern, Bern, Switzerland
Eur Cell Mater 22:302-19; discussion 319-20. 2011..Their influence is context dependent (tissue source of the MSCs, their microenvironment and the nature of the growth-factor). This finding has important implications for MSC based approaches to cartilage repair... - Surface and subsurface morphology of bovine humeral articular cartilage as assessed by atomic force and transmission electron microscopyJ S Jurvelin
M E Müller Institute for Biomechanics, University of Bern, Switzerland
J Struct Biol 117:45-54. 1996..It confirms the existence of an amorphous, nonfibrous articular surface which may be vital for its normal lubrication and wearing properties in vivo... - Surgical suturing of articular cartilage induces osteoarthritis-like changesE B Hunziker
DST Research Center, Department of Clinical Research, University of Bern, Murtenstrasse 35, P O Box 54, 3010 Bern, Switzerland
Osteoarthritis Cartilage 16:1067-73. 2008..We hypothesize that the suturing of articular cartilage is associated with a loss of chondrocytes from, and osteoarthritis-like changes within, the perisutural area... - Matrix and cell injury due to sub-impact loading of adult bovine articular cartilage explants: effects of strain rate and peak stressT M Quinn
M E Mueller Institute for Biomechanics, University of Bern, Switzerland
J Orthop Res 19:242-9. 2001..These patterns of injury may also differ in terms of their long-term implications for progression of degradative disease and possibilities for cartilage repair... - BMP-2 induces the expression of chondrocyte-specific genes in bovine synovium-derived progenitor cells cultured in three-dimensional alginate hydrogelY Park
ITI Research Institute for Dental and Skeletal Biology, University of Bern, Murtenstrasse 35, P.O. Box 54, 3010 Bern, Switzerland
Osteoarthritis Cartilage 13:527-36. 2005..However, the differentiation process is not complete under the chosen conditions. The stimulation conditions required for full transformation must now be delineated... - The structural architecture of adult mammalian articular cartilage evolves by a synchronized process of tissue resorption and neoformation during postnatal developmentE B Hunziker
University of Bern, ITI Research Institute for Dental and Skeletal Biology, Murtenstrasse 35, PO Box 54, Bern, Switzerland
Osteoarthritis Cartilage 15:403-13. 2007..We also wished to pinpoint the articular cartilage source of the stem cells for clonal expansion and the zonal location of the chondrocyte pool with high proliferative activity... - Cell-mediated protein release from calcium-phosphate-coated titanium implantsY M Liu
ITI Research Institute for Dental and Skeletal Biology, Bern University, Murtenstrasse 35, 3010 Bern, Switzerland
J Control Release 101:346-7. 2005 - Functional barrier principle for growth-factor-based articular cartilage repairE B Hunziker
ITI Research Institute for Dental and Skeletal Biology, University of Bern, Murtenstrasse 35, P O Box 54, CH 3010 Bern, Switzerland
Osteoarthritis Cartilage 11:320-7. 2003.... - Proteoglycan deposition around chondrocytes in agarose culture: construction of a physical and biological interface for mechanotransduction in cartilageT M Quinn
Biomedical Engineering Laboratory, Swiss Federal Institute of Technology, Lausanne, Switzerland
Biorheology 39:27-37. 2002..These findings provide cell-scale insight into the mechanisms of assembly of matrix proteins and proteoglycans in de novo matrix, and may aid in the development of tissue engineering methods for cartilage repair... - Insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) is closely associated with the chondrocyte nucleus in human articular cartilageE B Hunziker
ITI Research Institute for Dental and Skeletal Biology, Bern, Switzerland
Osteoarthritis Cartilage 16:185-94. 2008..These studies were undertaken to localize IGFBP-3 in human articular cartilage, particularly within cells... - GDF-5 deficiency in mice alters the ultrastructure, mechanical properties and composition of the Achilles tendonB Mikic
Department of Orthopaedic Surgery, University of Virginia, Charlottesville 22908, USA
J Orthop Res 19:365-71. 2001..Our findings suggest that increased tendon and ligament laxity may be the cause of the joint dislocations seen in patients with Hunter-Thompson and Grebe type dysplasia, rather than developmental abnormalities in the joints themselves... - Structural characterization and reliable biomechanical assessment of integrative cartilage repairM Moretti
Department of Surgery, Institute for Surgical Research and Hospital Management, University Hospital Basel, Hebelstrasse 20, ZLF, Room 405, 4031 Basel, Switzerland
J Biomech 38:1846-54. 2005.... - GDF-5 deficiency in mice leads to disruption of tail tendon form and functionR T Clark
Department of Orthopaedic Surgery, University of Virginia, USA
Connect Tissue Res 42:175-86. 2001..These findings provide additional evidence to support the conclusion that GDF-5 may play a role in tendon homeostasis in mice... - Altered hypertrophic chondrocyte kinetics in GDF-5 deficient murine tibial growth platesB Mikic
Picker Engineering Program, Smith College, 51 College Lane, Northampton, MA 01063, USA
J Orthop Res 22:552-6. 2004..006). These data suggest that one way in which GDF-5 might modulate the rate of endochondral bone growth could be by affecting the duration of the hypertrophic phase in growth plate chondrocytes... - Osteoinductive implants: the mise-en-scène for drug-bearing biomimetic coatingsY Liu
ITI Research Institute, Bern University, Switzerland
Ann Biomed Eng 32:398-406. 2004..This feature enhances the capacity of these coatings to act as a carrier system for osteogenic agents... - Ultrastructural quantification of cell death after injurious compression of bovine calf articular cartilageP Patwari
Continuum Electromechanics Lab, Center for Biomedical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Osteoarthritis Cartilage 12:245-52. 2004..For comparison, the TUNEL assay was also performed... - The role of collagen II and cartilage fibril-associated molecules in skeletal developmentA Aszodi
Department of Experimental Pathology, Lund University, Sweden
Osteoarthritis Cartilage 9:S150-9. 2001..To understand the role some of these molecules in skeletal development, we have generated transgenic mouse strains harboring ablated genes for collagens II and IX, and matrilin-1... - Mechanical anisotropy of the human knee articular cartilage in compressionJ S Jurvelin
Department of Applied Physics, University of Kuopio, Kuopio, Finland
Proc Inst Mech Eng [H] 217:215-9. 2003..Anisotropy during compression may be essential for normal cartilage function. This property has to be considered when developing advanced theoretical models for cartilage biomechanics... - Importance of the superficial tissue layer for the indentation stiffness of articular cartilageR K Korhonen
Department of Applied Physics, University of Kuopio, Kuopio, Finland
Med Eng Phys 24:99-108. 2002..The present results suggest that indentation testing is an efficient technique for the characterization of the superficial degeneration of articular cartilage... - GDF-5 deficiency in mice delays Achilles tendon healingA Chhabra
Department of Orthopaedics, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
J Orthop Res 21:826-35. 2003....