K S Hoek

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. ncbi Loss of full length CtBP1 expression enhances the invasive potential of human melanoma
    Andreas Winklmeier
    Institute of Pathology, University Regensburg, 93053 Regensburg, Germany
    BMC Cancer 9:52. 2009
  2. ncbi Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature
    Keith S Hoek
    Department of Dermatology, University Hospital of Zurich, 8091 Zurich, Switzerland
    Pigment Cell Res 19:290-302. 2006
  3. ncbi Exploring melanoma's massively parallel universe
    Keith S Hoek
    Pigment Cell Melanoma Res 23:306-7. 2010
  4. ncbi Melanoma progression, gene expression and DNA microarrays
    K S Hoek
    Department of Dermatology, University of Zurich, Zurich, Switzerland
    G Ital Dermatol Venereol 144:39-49. 2009
  5. ncbi DNA microarray analyses of melanoma gene expression: a decade in the mines
    Keith S Hoek
    Department of Dermatology, University Hospital of Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland
    Pigment Cell Res 20:466-84. 2007
  6. ncbi In vivo switching of human melanoma cells between proliferative and invasive states
    Keith S Hoek
    Department of Dermatology, University Hospital of Zurich, Switzerland
    Cancer Res 68:650-6. 2008
  7. ncbi Novel MITF targets identified using a two-step DNA microarray strategy
    Keith S Hoek
    Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
    Pigment Cell Melanoma Res 21:665-76. 2008
  8. ncbi The immunohistochemistry of invasive and proliferative phenotype switching in melanoma: a case report
    Ossia M Eichhoff
    Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
    Melanoma Res 20:349-55. 2010
  9. ncbi Id2 suppression of p15 counters TGF-beta-mediated growth inhibition of melanoma cells
    Natalie C Schlegel
    Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
    Pigment Cell Melanoma Res 22:445-53. 2009
  10. ncbi Reduced pSmad2 immunodetection correlates with increased primary melanoma thickness
    Christian D Mnich
    Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
    Melanoma Res 17:131-6. 2007

Collaborators

Detail Information

Publications13

  1. ncbi Loss of full length CtBP1 expression enhances the invasive potential of human melanoma
    Andreas Winklmeier
    Institute of Pathology, University Regensburg, 93053 Regensburg, Germany
    BMC Cancer 9:52. 2009
    ..The present study was performed to evaluate a more general role of CtBP1 in human melanoma and identify further CtBP1-regulated target genes...
  2. ncbi Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature
    Keith S Hoek
    Department of Dermatology, University Hospital of Zurich, 8091 Zurich, Switzerland
    Pigment Cell Res 19:290-302. 2006
    ....
  3. ncbi Exploring melanoma's massively parallel universe
    Keith S Hoek
    Pigment Cell Melanoma Res 23:306-7. 2010
    ..Coverage on: Berger, M.F. et al. (2010).Integrative analysis of the melanoma transcriptome.Genome Res. (doi: 10.1101/gr.103697.109)...
  4. ncbi Melanoma progression, gene expression and DNA microarrays
    K S Hoek
    Department of Dermatology, University of Zurich, Zurich, Switzerland
    G Ital Dermatol Venereol 144:39-49. 2009
    ..This review compares the two approaches, discusses what was learned about the molecular nature of melanoma progression, and considers why stage-specific gene expression may be more complicated than originally thought...
  5. ncbi DNA microarray analyses of melanoma gene expression: a decade in the mines
    Keith S Hoek
    Department of Dermatology, University Hospital of Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland
    Pigment Cell Res 20:466-84. 2007
    ....
  6. ncbi In vivo switching of human melanoma cells between proliferative and invasive states
    Keith S Hoek
    Department of Dermatology, University Hospital of Zurich, Switzerland
    Cancer Res 68:650-6. 2008
    ..We present a new model for melanoma progression that accounts for transcription signature plasticity and provides a more rational context for explaining observed melanoma biology...
  7. ncbi Novel MITF targets identified using a two-step DNA microarray strategy
    Keith S Hoek
    Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
    Pigment Cell Melanoma Res 21:665-76. 2008
    ..Many of these new targets have known relevance to pigmentation and melanoma biology, and further emphasize the critical role of MITF in these processes...
  8. ncbi The immunohistochemistry of invasive and proliferative phenotype switching in melanoma: a case report
    Ossia M Eichhoff
    Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
    Melanoma Res 20:349-55. 2010
    ..These results highlight the likelihood that disease progression involves melanoma cells retaining the capacity to regulate the expression of metastatic potential critical factors according to changing microenvironmental conditions...
  9. ncbi Id2 suppression of p15 counters TGF-beta-mediated growth inhibition of melanoma cells
    Natalie C Schlegel
    Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
    Pigment Cell Melanoma Res 22:445-53. 2009
    ..We conclude that transition to increased aggressiveness in melanoma cells requires Id2 upregulation to suppress TGF-beta induction of p15(Ink4b) and thus help to circumvent TGF-beta-mediated inhibition of proliferation...
  10. ncbi Reduced pSmad2 immunodetection correlates with increased primary melanoma thickness
    Christian D Mnich
    Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
    Melanoma Res 17:131-6. 2007
    ..We hypothesize that the observed decrease in transforming growth factor beta signalling in thicker primary melanomas is due to the increased production of signalling inhibitors...
  11. ncbi Green tea extract reduces induction of p53 and apoptosis in UVB-irradiated human skin independent of transcriptional controls
    Christian D Mnich
    Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
    Exp Dermatol 18:69-77. 2009
    ..Topical GTE (OM24) reduces UVB-mediated epithelial damage already at low, cosmetically usable concentrations, without tachyphylaxis over 5 weeks, suggesting GTE as suitable everyday photochemopreventive agents...
  12. ncbi Mitf regulation of Dia1 controls melanoma proliferation and invasiveness
    Suzanne Carreira
    Signalling and Development Laboratory, Marie Curie Research Institute, Oxted, Surrey, RH8 0TL, United Kingdom
    Genes Dev 20:3426-39. 2006
    ..The results imply variations in the repertoire of environmental cues that determine Mitf activity will dictate the differentiation, proliferative, and invasive/migratory potential of melanoma cells through a dynamic epigenetic mechanism...
  13. ncbi Genesifter, leading the blind
    Keith S Hoek
    Pigment Cell Melanoma Res 21:588-9. 2008