U Heininger

..Bordetella pertussis, which causes whooping cough, has not been studied in this context. We aimed to assess the role of Bordetella infections in patients with AECB...

..Our goal was to determine positive and negative predictive values of varicella history in a prospective cross-sectional study...

..Similar immunisation programmes have been adopted by some other countries, including Uruguay, Germany, Taiwan, Canada, and Australia, and are expected to be implemented more widely in future...

..Recently, neuraminidase inhibitors with curative and preventive efficacy against influenza virus types A and B have become available. They serve as second line weapons for influenza prophylaxis under specific circumstances...

..This survey provided information on prevalent parental attitudes towards immunization, which should be used to plan information strategies to counteract existing misperceptions...

..The goal of this study was to determine compliance with official standard immunization recommendations in adolescents attending secondary schools in the city of Erlangen, Germany...

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..To investigate the persistence of maternal IgG antibodies against Varicella-Zoster virus (VZV) in infants and young children...

..This may lead to fatal disease in individuals, epidemics in the community, and threatens national and international targets of disease elimination, such as measles and congenital rubella syndrome...

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..This was a prospective, controlled, multicenter study to investigate the relationship between Bordetella pertussis infections and sudden unexpected deaths among German infants...

..These activities are indispensable for successful implementation and continuation of current immunization programs...

..The present review provides an update on recent progress...

..Little is known about the seroprevalence of anti-varicella-zoster virus (VZV) serum antibodies in adolescents in Switzerland as in most other European countries...

..CONCLUSION: The major achievements in the field of pertussis research are reviewed and discussed. They have great impact on the current and future practice of paediatric, adolescent and adult medicine...

..pertussis could be eliminated...

..To evaluate the long-term safety and effectiveness of lopinavir/ritonavir (LPV/r) in a population-based cohort of HIV-1-infected children...

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..In conclusion, the great majority of medical students had immunization gaps. Systematic immunization programmes for medical students should be implemented...

..Both magnitude of transplacental antibody passage and cord blood antibody values correlated with gestational age. After 6 months preterm infants born before 32 weeks of gestation had lost maternal antibodies...

..The high rate of misdiagnosed cases indicates that this entity is not sufficiently known. Lesions are self-limited; surgical interventions can be harmful and should be avoided. Recurrences occur as frequently as in adults...

..To assess whether prevalence of active commuting and regular car trips to school varies across communities and language regions in Switzerland and to determine personal and environmental correlates...

..Therefore, vaccination should be promoted as part of the consultation during a routine appointment with the specialist...

..pertussis, pertactin, is decreased...

..Most apnoea or bradycardia events required intervention but did not have serious consequences. Monitoring of all preterm infants following immunisation in the neonatal intensive care unit is recommended...

..Acid-fast bacilli were cultured from submandibular lymph nodes and identified by molecular methods as Mycobacterium bohemicum. Surgical treatment was successful and complemented by oral treatment with clarithromycin and rifampicin...

..To assess the attitude toward influenza immunization of doctors among physicians in our hospital...

..Vaccines distributed in Switzerland have proven to be generally safe. Limitations of the passive surveillance system, however, warrant improvements in the future...

..Ideally, journal editors would agree on a minimum set of guidelines for structured presentation of vaccine safety data in publications...

..CONCLUSION: Our data indicate that the diagnostic procedures of choice should be 1) early bone scan or MRI, 2) BC and 3) TC. Of supportive laboratory parameters, ESR and CRP were most valuable in our hands...

..Healthcare workers (HCWs) are at high risk for acquisition and/or transmission of Bordetella pertussis. We report an outbreak of pertussis in a children's hospital involving three HCWs...

..Comparability requires the availability of standardized case definitions for adverse events following immunization (AEFI) and guidelines for case determination, recording and data presentation...

..This apparently requires more than immunization of children--that is, expanding routine immunization into adolescence and adulthood...

..S. aureus was isolated in 562 of 1363 cases. In a stepwise multivariate analysis, the variables age, duration of antibiotic use, and hospitalization of a household member were independently associated with carriage of S. aureus...

..To evaluate the combined effects and relative importance of socio-cultural factors as well as parents' subjectively perceived and objectively assessed environment on time children spent vigorously playing outdoors...

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..Acute Chlamydia pneumoniae infection was substantially less common than Mycoplasma pneumoniae infection in our study cohort...

..Although studies of adults who have been vaccinated with acellular pertussis vaccines have had shorter follow-up periods than studies of adults with pertussis infection, the antibody decay patterns are similar in both groups...

..7%) received rehydration by mouth. RVGE causes a substantial burden in children with an estimated risk for hospitalization due to RVGE of one in 37 children <3 years of age...

..In conclusion, hMPV leads to endemic and epidemic respiratory disease with features similar to those of RSV and should be considered in the differential diagnosis of upper and lower respiratory tract disease...

..Transfer ratios increased with gestational age of the newborns. Based on these findings, maternal and neonatal immunization strategies should be considered to protect young infants from pertussis...

..In conclusion, this study describes the spectrum of varicella in an out-patient setting with a sizeable rate of complications and raises the question of the value of prophylactic immunization...

..We attempted to obtain baseline data on the incidence of intussusception and its association with gastroenteritis in a cross-sectional observational study in children...

..CONCLUSION: This study describes a sizeable hospitalisation and complication rate of varicella-zoster virus infections and provides a solid basis for future immunisation recommendations in Switzerland...

..Calculated efficacy for the 6-year follow-up period based upon physician diagnosed pertussis was 89% (95% CI=79 94) for DTaP and was 92% (95% CI=84-96) for DTP. CONCLUSION: no evidence of decreasing efficacy over time was noted...

..Active promotion and educational efforts were successful in increasing the immunization rate of physicians but not nurses and other HCWs...

..To evaluate the long-term safety and effectiveness of ritonavir, nelfinavir, and lopinavir/ritonavir in antiretroviral-experienced, initially protease inhibitor (PI)-naive, human immunodeficiency virus (HIV)-1-infected children...

..Human-to-human transmission of Fusobacterium necrophorum has not been described before...

..In conclusion, the case definition was useful and applicable to assess the background rate of intussusception in the light of potential future rotavirus immunization...

..One month after hospital discharge, significantly more children in the intervention group (27%) than the controls (8%) had received catch-up immunizations (P < .001)...

..The purpose of this study was to determine the compliance with official recommendations for prevention of perinatal HBV transmission in hepatitis B surface antigen (HBsAg) exposed infants...

..7 years, interquartile range 1.3-10.4 years) and 562 (41.3%) grew S. aureus. Only one isolate was MRSA (0.18%) which encoded mecA and femA genes as well as SCCmec type IV, whereas Panton-Valentine leukocidin (PVL) was absent...

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..mild illness. CONCLUSIONS: Differences in virulence of circulating B. pertussis strains can be absent or might not correlate with specific PFGE patterns. Other methods should be evaluated to identify differences in virulence...

..To investigate the efficacy of penicillin compared with cefuroxime for group A beta-hemolytic Streptococcus pyogenes (GABHS) perianal dermatitis...

..Therefore, continuous evaluation of risks and benefits of vaccines is required and results of these need to be communicated broadly to strengthen the confidence in immunisation programmes...

..A variety of microorganisms have been shown to cause peripheral facial nerve palsy (PFNP) and/or aseptic meningitis in children. Clinical findings and history may help to predict the specific etiology of these entities...

..The aim of this article is to highlight the evidence on new and ongoing vaccine safety concerns in the light of several vaccines recently licensed and others made available and recommended more widely...

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..Waning might also be an issue with the newly recommended two dose vaccination schedule. Sustained surveillance for varicella outbreaks in populations with varicella immunization programs therefore is mandatory...

..The health score for the diarrheal episode was 54.6 for mild and 33.9 for severe cases. Parents perceive a high disease burden of diarrhea and clinically less meaningful aspects play a significant role...

..pertussis (by lack of motility and cytotoxicity to a macrophage-like cell line). These results begin to provide phenotypes that can be related to genetic differences identified in the genomic sequences of bordetellae...

..In particular, polymerase chain reaction and single serum serology are 2 techniques that should be more widely adopted...

..The majority of toddlers previously immunized with MCC and challenged 1 year later with PS antigen mounted protective levels of bactericidal antibody within 2 to 4 days...

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..In 2003 and 2004, in contrast to previous years, surprisingly many negative results (33% and 54%, respectively) were observed...

..To assess whether the influenza peak in populations precedes the annual peak for invasive pneumococcal infections (IPI) in winter...

..The Global Pertussis Initiative, an expert scientific forum, was established to address the ongoing problems associated with pertussis disease worldwide...

..The lack of a significant ACT antibody response in children in whom the vaccine failed is of interest but would seem to preclude the use of ACT in diagnostic tests...

..The effectiveness of vaccination against RV from 2 months of age onward remains to be evaluated...

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..There was no evidence of a significant increase in adverse pulmonary outcomes for CAIV-T compared with TIV. CAIV-T had a significantly greater relative efficacy of 35% compared with TIV in this high-risk population...