Research Topics
Genomes and GenesSpecies | Hans Peter HauriSummaryAffiliation: University of Basel Country: Switzerland Publications
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Detail Information
Publications
Role of cytoplasmic C-terminal amino acids of membrane proteins in ER exportOliver Nufer
Biozentrum, University of Basel, CH-4056 Basel, Switzerland
J Cell Sci 115:619-28. 2002....- Subdomain-specific localization of CLIMP-63 (p63) in the endoplasmic reticulum is mediated by its luminal alpha-helical segmentD R Klopfenstein
Department of Pharmacology and Neurobiology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
J Cell Biol 153:1287-300. 2001..Concentration of CLIMP-63 into patches may enhance microtubule binding on the cytosolic side and contribute to ER morphology by the formation of a protein scaffold in the lumen of the ER... - ERGIC-53 and traffic in the secretory pathwayH P Hauri
Department of Pharmacology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
J Cell Sci 113:587-96. 2000..Understanding these fundamental processes of cell biology will be crucial for the elucidation and treatment of many inherited and acquired diseases, such as cystic fibrosis, Alzheimer's disease and viral infections... - The ER-Golgi intermediate compartment (ERGIC): in search of its identity and functionChristian Appenzeller-Herzog
Biozentrum, University of Basel, Switzerland
J Cell Sci 119:2173-83. 2006..The ERGIC also contributes to the concentration, folding, and quality control of newly synthesized proteins... - ER export of ERGIC-53 is controlled by cooperation of targeting determinants in all three of its domainsOliver Nufer
Biozentrum, University of Basel, CH 4056 Basel, Switzerland
J Cell Sci 116:4429-40. 2003..The results suggest an ER-export mechanism in which transmembrane and luminal determinants mediate oligomerization required for efficient recruitment of ERGIC-53 into budding vesicles via the C-terminal COPII-binding phenylalanine motif... - Role of the lectin VIP36 in post-ER quality control of human alpha1-antitrypsinVeronika Reiterer
Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
Traffic 11:1044-55. 2010..The complex formed by VIP36 and alpha1-AT in the Golgi recycled back to the ER. The combined data are most consistent with a function of VIP36 in post-ER quality control of alpha1-AT... - Cargo selectivity of the ERGIC-53/MCFD2 transport receptor complexBeat Nyfeler
Biozentrum, University of Basel, CH 4056 Basel, Switzerland
Traffic 7:1473-81. 2006..The results indicate that ERGIC-53 can bind cargo glycoproteins in an MCFD2-independent fashion and suggest that MCFD2 is a recruitment factor for blood coagulation factors V and VIII... - MAPK signaling to the early secretory pathway revealed by kinase/phosphatase functional screeningHesso Farhan
Biozentrum, Universitat Basel, 4056 Basel, Switzerland
J Cell Biol 189:997-1011. 2010..Our analysis reveals an unanticipated complexity of kinase/phosphatase-mediated regulation of the secretory pathway, uncovering a link between growth factor signaling and ER export... - Selective export of human GPI-anchored proteins from the endoplasmic reticulumCarine Bonnon
Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
J Cell Sci 123:1705-15. 2010..The results suggest that the 24p-23p complex acts as a cargo receptor for GPI-anchored proteins by facilitating their export from the ER in a Sec24-isoform-selective manner involving lipid rafts as early sorting platforms... - Identification of ERGIC-53 as an intracellular transport receptor of alpha1-antitrypsinBeat Nyfeler
Biozentrum, University of Basel, CH 4056 Basel, Switzerland
J Cell Biol 180:705-12. 2008..The results reveal ERGIC-53 to be an intracellular transport receptor of alpha1-AT and provide direct evidence for active receptor-mediated ER export of a soluble secretory protein in higher eukaryotes... - The cargo receptors Surf4, endoplasmic reticulum-Golgi intermediate compartment (ERGIC)-53, and p25 are required to maintain the architecture of ERGIC and GolgiSandra Mitrovic
Biozentrum, University of Basel, CH 4056 Basel Switzerland
Mol Biol Cell 19:1976-90. 2008..These findings imply that cargo receptors are essential for maintaining the architecture of ERGIC and Golgi by controlling COP I recruitment... - Live imaging of bidirectional traffic from the ERGICHouchaima Ben-Tekaya
Department of Pharmacology and Neurobiology, Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
J Cell Sci 118:357-67. 2005..These results suggest that the ERGIC is stationary and not simply a collection of mobile carriers that mediate protein traffic from endoplasmic reticulum to Golgi... - Role of Sec24 isoforms in selective export of membrane proteins from the endoplasmic reticulumMarkus W Wendeler
Department of Pharmacology and Neurobiology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
EMBO Rep 8:258-64. 2007..Thus, human Sec24 isoforms expand the repertoire of cargo for signal-mediated ER export, but are in part functionally redundant... - Profile-based data base scanning for animal L-type lectins and characterization of VIPL, a novel VIP36-like endoplasmic reticulum proteinOliver Nufer
Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
J Biol Chem 278:15886-96. 2003..Overexpression of VIPL redistributed ERGIC-53 to the ER without affecting the cycling of the KDEL-receptor and the overall morphology of the early secretory pathway. The results suggest that VIPL may function as a regulator of ERGIC-53... - The cargo receptor ERGIC-53 is a target of the unfolded protein responseBeat Nyfeler
Department of Pharmacology and Neurobiology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
Biochem Biophys Res Commun 304:599-604. 2003..Thapsigargin-induced upregulation of ERGIC-53 could be fully accounted for by the ATF6 pathway of UPR. The results suggest that in mammalian cells the UPR also affects traffic from and beyond the ER... - ADP ribosylation factors 1 and 4 and group VIA phospholipase A? regulate morphology and intraorganellar traffic in the endoplasmic reticulum-Golgi intermediate compartmentHouchaima Ben-Tekaya
Biozentrum, University of Basel, CH 4056 Basel, Switzerland
Mol Biol Cell 21:4130-40. 2010..Our findings have identified key components in the molecular mechanism underlying the regulation of tubules in the ERGIC and uncover tubular carriers as tightly controlled machinery... - p28, a novel ERGIC/cis Golgi protein, required for Golgi ribbon formationEva Koegler
Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
Traffic 11:70-89. 2010..These results show that the formation of a Golgi ribbon requires the structural membrane protein p28 in addition to previously identified SNAREs, coat proteins and tethers... - Deletion of 3 residues from the C-terminus of MCFD2 affects binding to ERGIC-53 and causes combined factor V and factor VIII deficiencyBeat Nyfeler
Biozentrum, University of Basel, Basel, Switzerland
Blood 111:1299-301. 2008..Our results highlight the importance of the ERGIC-53/MCFD2 protein interaction for the efficient secretion of coagulation factors V and VIII... - Adaptation of endoplasmic reticulum exit sites to acute and chronic increases in cargo loadHesso Farhan
Department of Pharmacology and Neurobiology, Biozentrum, University of Basel, Basel, Switzerland
EMBO J 27:2043-54. 2008..These results indicate that chronic and acute increases in cargo load are handled differentially by ERES and are regulated by different factors... - Membrane biogenesis: networking at the ER with atlastinHesso Farhan
Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
Curr Biol 19:R906-8. 2009..Two studies now identify atlastin proteins as key mediators of homotypic fusion of endoplasmic reticulum membranes... - Phosphorylation controls CLIMP-63-mediated anchoring of the endoplasmic reticulum to microtubulesCécile Vedrenne
Biozentrum, University of Basel, Switzerland
Mol Biol Cell 16:1928-37. 2005.... - Improved maturation of CFTR by an ER export signalMarkus W Wendeler
Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
FASEB J 21:2352-8. 2007..Moreover, failure of the valine signal to rescue CFTR-deltaF508 from ER degradation indicates that the inability of CFTR-deltaF508 to leave the ER is unlikely to be due to a malfunctioning ER export signal... - Signal-dependent export of GABA transporter 1 from the ER-Golgi intermediate compartment is specified by a C-terminal motifHesso Farhan
Institute of Pharmacology, Center of Biomolecular Medicine and Pharmacology, Medical University of Vienna, Waehringer Str 13a, 1090 Vienna, Austria
J Cell Sci 121:753-61. 2008..To the best of our knowledge, the VMI-motif of GAT1 provides the first example of a cargo-based motif that specifies export from the ERGIC... - Bap31 is an itinerant protein that moves between the peripheral endoplasmic reticulum (ER) and a juxtanuclear compartment related to ER-associated DegradationYuichi Wakana
School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192 0392, Japan
Mol Biol Cell 19:1825-36. 2008..Overexpression of Sar1p and Arf1 mutants affected Bap31 cycling, suggesting that this cycling pathway is related to the conventional vesicular transport pathways... - Molecular basis of sugar recognition by the human L-type lectins ERGIC-53, VIPL, and VIP36Yukiko Kamiya
Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya 467 8603, Japan
J Biol Chem 283:1857-61. 2008..Moreover, structure-based mutagenesis revealed that the sugar-binding properties of these L-type lectins can be switched by single amino acid substitutions... - pH-induced conversion of the transport lectin ERGIC-53 triggers glycoprotein releaseChristian Appenzeller-Herzog
Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland
J Biol Chem 279:12943-50. 2004..The results elucidate the molecular mechanism underlying reversible lectin/cargo interaction and establish the ERGIC as the earliest low pH site of the secretory pathway... - Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46Lionel Breuza
Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland
J Biol Chem 279:47242-53. 2004..Our novel approach for the isolation of the ERGIC from BFA-treated cells may ultimately lead to the identification of all proteins rapidly cycling early in the secretory pathway... - Carbohydrate- and conformation-dependent cargo capture for ER-exitChristian Appenzeller-Herzog
Department of Pharmacology and Neurobiology, Biozentrum, University of Basel, CH-4056 Basel, Switzerland
Mol Biol Cell 16:1258-67. 2005..To our knowledge this is the first documentation of an ER-exit signal in soluble cargo in conjunction with its decoding by a transport receptor... - Capturing protein interactions in the secretory pathway of living cellsBeat Nyfeler
Department of Pharmacology and Neurobiology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland
Proc Natl Acad Sci U S A 102:6350-5. 2005..The study extends the application of PCA to carbohydrate-mediated protein-protein interactions of low affinity... - Reticulon 3 is involved in membrane trafficking between the endoplasmic reticulum and GolgiYuichi Wakana
School of Life Science, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo 192 0392, Japan
Biochem Biophys Res Commun 334:1198-205. 2005..These results suggest that RTN3 plays a role in membrane trafficking in the early secretory pathway... - Climp-63-mediated binding of microtubules to the ER affects the lateral mobility of translocon complexesAndrei V Nikonov
Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
J Cell Sci 120:2248-58. 2007.... - A high-molecular-weight complex of membrane proteins BAP29/BAP31 is involved in the retention of membrane-bound IgD in the endoplasmic reticulumWolfgang W A Schamel
Department of Molecular Immunology, Biology III, University of Freiburg and Max Planck Institut für Immunobiologie, D 79108 Freiburg, Germany
Proc Natl Acad Sci U S A 100:9861-6. 2003..In conclusion, BAP29 and BAP31 might be the long sought after retention proteins and/or chaperones that act on transmembrane regions of various proteins... - ER export: call 14-3-3Oliver Nufer
Biozentrum, University of Basel, Klingelbergstrasse 70, Switzerland
Curr Biol 13:R391-3. 2003..Recent studies suggest that 14-3-3 proteins may mediate ER export of potassium channels destined for the plasma membrane by interfering with dibasic-motif-mediated retention...