Ernst Hafen

Summary

Affiliation: University of Zurich
Country: Switzerland

Publications

  1. ncbi Interplay between growth factor and nutrient signaling: lessons from Drosophila TOR
    E Hafen
    Zoologisches Institut, Universitat Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Curr Top Microbiol Immunol 279:153-67. 2004
  2. ncbi Cancer, type 2 diabetes, and ageing: news from flies and worms
    E Hafen
    Zoologisches Institut, Universitat Zurich, Switzerland
    Swiss Med Wkly 134:711-9. 2004
  3. ncbi How are the sizes of cells, organs, and bodies controlled?
    Ernst Hafen
    , , Switzerland
    PLoS Biol 1:E86. 2003
  4. ncbi Susi, a negative regulator of Drosophila PI3-kinase
    Franz Wittwer
    Zoologisches Institut, Universitat Zurich, Winterthurerstr 190, CH 8057 Zurich, Switzerland
    Dev Cell 8:817-27. 2005
  5. ncbi The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling
    Martin A Jünger
    Zoologisches Institut, Universitat Zurich, Winterthurerstr, 190, CH 8057 Zurich, Switzerland
    J Biol 2:20. 2003
  6. ncbi Rheb is an essential regulator of S6K in controlling cell growth in Drosophila
    Hugo Stocker
    Zoologisches Institut der Universitat Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Nat Cell Biol 5:559-65. 2003
  7. ncbi The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila
    Jan H Reiling
    Zoologisches Institut, Universitat Zurich, CH 8057 Zurich, Switzerland
    Genes Dev 18:2879-92. 2004
  8. ncbi The Drosophila insulin/IGF receptor controls growth and size by modulating PtdInsP(3) levels
    Sean Oldham
    Universitat Zurich, Zoologisches Institut, Winterthurerstrasse 190, CH 8057, Switzerland
    Development 129:4103-9. 2002
  9. ncbi Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistance
    Basil Honegger
    Zoological Institute, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Biol 7:10. 2008
  10. ncbi A universal method for automated gene mapping
    Peder Zipperlen
    Institute of Molecular Biology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Genome Biol 6:R19. 2005

Detail Information

Publications73

  1. ncbi Interplay between growth factor and nutrient signaling: lessons from Drosophila TOR
    E Hafen
    Zoologisches Institut, Universitat Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Curr Top Microbiol Immunol 279:153-67. 2004
    ..This review discusses recent advances in the understanding of the interaction between these pathways, with a special focus on the contribution of the genetic analysis of these pathways in Drosophila...
  2. ncbi Cancer, type 2 diabetes, and ageing: news from flies and worms
    E Hafen
    Zoologisches Institut, Universitat Zurich, Switzerland
    Swiss Med Wkly 134:711-9. 2004
    ..In this review, I will outline the contributions of model organism genetics to the understanding of these disease relevant pathways and highlight the evolutionary conservation of nutrient-dependent growth regulation...
  3. ncbi How are the sizes of cells, organs, and bodies controlled?
    Ernst Hafen
    , , Switzerland
    PLoS Biol 1:E86. 2003
  4. ncbi Susi, a negative regulator of Drosophila PI3-kinase
    Franz Wittwer
    Zoologisches Institut, Universitat Zurich, Winterthurerstr 190, CH 8057 Zurich, Switzerland
    Dev Cell 8:817-27. 2005
    ..The fact that Susi is expressed in a circadian rhythm, with highest levels during the night, suggests that Susi attenuates insulin signaling during the fasting period...
  5. ncbi The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling
    Martin A Jünger
    Zoologisches Institut, Universitat Zurich, Winterthurerstr, 190, CH 8057 Zurich, Switzerland
    J Biol 2:20. 2003
    ..In this study, we present a genetic characterization of dFOXO, the only Drosophila FOXO ortholog...
  6. ncbi Rheb is an essential regulator of S6K in controlling cell growth in Drosophila
    Hugo Stocker
    Zoologisches Institut der Universitat Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Nat Cell Biol 5:559-65. 2003
    ....
  7. ncbi The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila
    Jan H Reiling
    Zoologisches Institut, Universitat Zurich, CH 8057 Zurich, Switzerland
    Genes Dev 18:2879-92. 2004
    ....
  8. ncbi The Drosophila insulin/IGF receptor controls growth and size by modulating PtdInsP(3) levels
    Sean Oldham
    Universitat Zurich, Zoologisches Institut, Winterthurerstrasse 190, CH 8057, Switzerland
    Development 129:4103-9. 2002
    ..This reduction of Pten activity is also sufficient to vastly increase organism size. These results suggest that PtdInsP(3) is a second messenger for growth and that levels of PtdInsP(3) during development regulate organismal size...
  9. ncbi Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistance
    Basil Honegger
    Zoological Institute, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Biol 7:10. 2008
    ..In mammals, insulin-like growth factor binding proteins (IGFBPs) bind IGFs with high affinity and modulate their mitogenic, anti-apoptotic and metabolic actions, but no functional homologs have been identified in invertebrates so far...
  10. ncbi A universal method for automated gene mapping
    Peder Zipperlen
    Institute of Molecular Biology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Genome Biol 6:R19. 2005
    ..We have established genome-wide FLP maps for both Caenorhabditis elegans and Drosophila melanogaster that facilitate genetic mapping with a minimum of manual input and at comparatively low cost...
  11. ncbi Diet-dependent effects of the Drosophila Mnk1/Mnk2 homolog Lk6 on growth via eIF4E
    Jan H Reiling
    Zoologisches Institut, Universitat Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Curr Biol 15:24-30. 2005
    ..Overexpression of Lk6 also results in growth inhibition in an eIF4E-dependent manner. We propose a model of eIF4E regulation that may reconcile the contradictory findings with regard to the role of phosphorylation by Mnk1/2...
  12. ncbi The Drosophila dual-specificity ERK phosphatase DMKP3 cooperates with the ERK tyrosine phosphatase PTP-ER
    Felix Rintelen
    Zoologisches Institut der Universitat Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Development 130:3479-90. 2003
    ..In addition, DMKP3 function appears to be required in surrounding non-neuronal cells for ommatidial patterning and photoreceptor differentiation...
  13. ncbi Exploring the effects of mechanical feedback on epithelial topology
    Tinri Aegerter-Wilmsen
    Institute of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Development 137:499-506. 2010
    ..Thus, a possible growth regulation by mechanical force could have a function in releasing the mechanical stress that evolves when all cells have similar growth rates...
  14. ncbi Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB
    Hugo Stocker
    Zoologisches Institut der Universitat Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Science 295:2088-91. 2002
    ..Thus, Akt appears to be the only critical target activated by increased PIP3 concentrations in Drosophila...
  15. ncbi Model for the regulation of size in the wing imaginal disc of Drosophila
    Tinri Aegerter-Wilmsen
    Zoological Institute, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Mech Dev 124:318-26. 2007
    ..With numerical simulations we show that the model indeed yields uniform growth. Furthermore, the model can also account for other experimental data on growth in the wing disc...
  16. ncbi Overgrowth caused by misexpression of a microRNA with dispensable wild-type function
    Knud Nairz
    Zoologisches Institut der Universitat Zurich, Winterthurer Strasse 190, 8057 Zurich, Switzerland
    Dev Biol 291:314-24. 2006
    ..This result demonstrates that misexpressed miRNAs may acquire novel functions that cause unscheduled proliferation in vivo and thus exemplifies the potential of miRNAs to promote tumor formation...
  17. ncbi An efficient method to generate chromosomal rearrangements by targeted DNA double-strand breaks in Drosophila melanogaster
    Dieter Egli
    Institut fur Molekularbiologie, CH 8057 Zurich, Switzerland
    Genome Res 14:1382-93. 2004
    ..We therefore speculate that physical constraints on chromosomal movement are modulated during DSB repair, to facilitate the homology search throughout the genome...
  18. ncbi Nutrient-dependent expression of insulin-like peptides from neuroendocrine cells in the CNS contributes to growth regulation in Drosophila
    Tomoatsu Ikeya
    Zoologisches Institut, Universitat Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    Curr Biol 12:1293-300. 2002
    ....
  19. ncbi Genetic dissection of signal transduction mediated by the sevenless receptor tyrosine kinase in Drosophila
    E Hafen
    Zoologisches Institut, Universitat Zurich, Switzerland
    Philos Trans R Soc Lond B Biol Sci 340:273-8. 1993
    ..In contrast to the receptor and its ligand, these components are shared between different signal transduction pathways not only in Drosophila but are also homologous to components involved in signal transduction in other organisms...
  20. ncbi A reverse genetic screen in Drosophila using a deletion-inducing mutagen
    Knud Nairz
    Zoologisches Institut, Universitat Zurich, Winterthurerstrasse 190, Zurich CH 8057, Switzerland
    Genome Biol 5:R83. 2004
    ..As the spectrum of HMPA-induced mutations is similar in a variety of organisms, it should be possible to transfer this mutagenesis and detection procedure to other model systems...
  21. ncbi The Drosophila mitochondrial ribosomal protein mRpL12 is required for Cyclin D/Cdk4-driven growth
    Christian Frei
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    EMBO J 24:623-34. 2005
    ..Both functions depend on mRpL12 dosage, suggesting that CycD/Cdk4, mRpL12 and Hph function together in a common pathway that controls cell growth via affecting mitochondrial activity...
  22. ncbi PDK1 regulates growth through Akt and S6K in Drosophila
    F Rintelen
    Zoologisches Institut, Universitat Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 98:15020-5. 2001
    ..Thus, the results suggest that dPDK1 is required for dRSK but not dPKN activation and that it regulates insulin-mediated growth through two main effector branches, dAkt and dS6K...
  23. ncbi The ETS domain protein pointed-P2 is a target of MAP kinase in the sevenless signal transduction pathway
    D Brunner
    Zoologisches Institut, Universitat Zurich, Switzerland
    Nature 370:386-9. 1994
    ..Furthermore, we present genetic and biochemical data suggesting that MAP kinase controls neural development through phosphorylation of two antagonizing transcription factors of the ETS family, Yan and PntP2...
  24. ncbi Raf functions downstream of Ras1 in the Sevenless signal transduction pathway
    B Dickson
    Zoologisches Institut, Universitat Zurich, Switzerland
    Nature 360:600-3. 1992
    ..We also present genetic evidence suggesting that Raf acts downstream of Ras1 and upstream of Sina in this signal transduction cascade...
  25. ncbi Control of Drosophila photoreceptor cell fates by phyllopod, a novel nuclear protein acting downstream of the Raf kinase
    B J Dickson
    Zoologisches Institut, Universitat Zurich, Switzerland
    Cell 80:453-62. 1995
    ..phyl thus represents a possible target gene of the Raf pathway during eye development, controlling the fates of a novel subset of photoreceptors...
  26. ncbi Drosophila Jun kinase regulates expression of decapentaplegic via the ETS-domain protein Aop and the AP-1 transcription factor DJun during dorsal closure
    J R Riesgo-Escovar
    Zoologisches Institut, Universitat Zurich, Switzerland
    Genes Dev 11:1717-27. 1997
    ..Interestingly, in vertebrates, transforming growth factor-beta and c-Jun regulate collagenase gene expression during wound healing, a process that also involves the closing of an epithelial sheath...
  27. ncbi Lilliputian: an AF4/FMR2-related protein that controls cell identity and cell growth
    F Wittwer
    Zoologisches Institut, Universitat Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Development 128:791-800. 2001
    ..These results suggest that Lilli acts in parallel with the Ras/MAPK and the PI3K/PKB pathways in the control of cell identity and cellular growth...
  28. ncbi Knockout of 'metal-responsive transcription factor' MTF-1 in Drosophila by homologous recombination reveals its central role in heavy metal homeostasis
    Dieter Egli
    Institut für Molekularbiologie and Zoologisches Institut der Universität Zürich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    EMBO J 22:100-8. 2003
    ..These findings expand the roles of MTF-1 in the control of heavy metal homeostasis...
  29. ncbi High-resolution SNP mapping by denaturing HPLC
    Knud Nairz
    Zoologisches Institut der Universitat Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 99:10575-80. 2002
    ..Furthermore, we show that recombination events are not uniformly dispersed over the investigated region but rather occur at hot spots...
  30. ncbi Biochemical and genetic analysis of the Drk SH2/SH3 adaptor protein of Drosophila
    T Raabe
    Zoologisches Institut, Universitat Zurich, Switzerland
    EMBO J 14:2509-18. 1995
    ..We show that the N-terminal Drk SH3 domain is primarily responsible for binding to the tail of Sos in vitro, and for signalling to Ras in vivo...
  31. ncbi Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin
    S Oldham
    Zoologisches Institut, Universitat Zurich, 8057 Zurich, Switzerland
    Genes Dev 14:2689-94. 2000
    ..These results are consistent with dTOR residing on a parallel amino acid sensing pathway...
  32. ncbi Ligand-independent activation of the sevenless receptor tyrosine kinase changes the fate of cells in the developing Drosophila eye
    K Basler
    Zoologisches Institut, Universitat Zurich, Switzerland
    Cell 64:1069-81. 1991
    ..These results illustrate the central role receptor tyrosine kinases can play in the specification of cell fate during development...
  33. ncbi Mutations Modulating Raf signaling in Drosophila eye development
    B J Dickson
    Zoologisches Institut, Universitat Zurich, Switzerland
    Genetics 142:163-71. 1996
    ..We present the results of this screen in detail, as well as a preliminary genetic analysis of the six loci still to be characterized molecularly...
  34. ncbi Sending and receiving the hedgehog signal: control by the Drosophila Gli protein Cubitus interruptus
    M Dominguez
    Zoologisches Institut, Universitat Zurich, Switzerland
    Science 272:1621-5. 1996
    ..Thus, expression of Ci in anterior cells controls limb development (i) by restricting hh secretion to posterior cells and (ii) by conferring competence to respond to Hh by mediating the transduction of this signal...
  35. ncbi The sevenless signalling cassette mediates Drosophila EGF receptor function during epidermal development
    F J Diaz-Benjumea
    Zoologisches Institut, Universitat Zurich, Switzerland
    Development 120:569-78. 1994
    ..It appears that these components form a signalling cassette, which mediates all aspects of DER signalling but that is not required for other signalling processes during epidermal development...
  36. ncbi The spatial and temporal expression pattern of sevenless is exclusively controlled by gene-internal elements
    K Basler
    Zoologisches Institut, Universitat Zurich, Switzerland
    EMBO J 8:2381-6. 1989
    ..These gene-internal sequences function in both orientations on heterologous promoters, also when placed at the 3' end of a lacZ reporter gene...
  37. ncbi Patterning by cell recruitment in the Drosophila eye
    E Hafen
    Zoologisches Institut, Universitat Zurich, Switzerland
    Curr Opin Genet Dev 1:268-74. 1991
    ..Recent molecular genetic characterization of these interactions in Drosophila and some emerging principles of how cell fate is determined in this system are the subject of this review...
  38. ncbi An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control
    W Brogiolo
    Zoologisches Institut, Universitat Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    Curr Biol 11:213-21. 2001
    ....
  39. ncbi Prepattern in the developing Drosophila eye revealed by an activated torso--sevenless chimeric receptor
    B Dickson
    Zoologisches Institut, Universitat Zurich, Switzerland
    Genes Dev 6:2327-39. 1992
    ..Therefore, the expression of sevenless marks a preexisting pattern of developmental potential in the disc epithelium...
  40. ncbi The heat shock protein 83 (Hsp83) is required for Raf-mediated signalling in Drosophila
    A van der Straten
    Zoologisches Institut, Universitat Zurich, Switzerland
    EMBO J 16:1961-9. 1997
    ..Our results indicate that Hsp83 is essential for Raf function in vivo...
  41. ncbi A high-quality catalog of the Drosophila melanogaster proteome
    Erich Brunner
    Center for Model Organism Proteomes, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Nat Biotechnol 25:576-83. 2007
    ..melanogaster gene models. This library of proteotypic peptides should enable fast, targeted and quantitative proteomic studies to elucidate the systems biology of this model organism...
  42. ncbi A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways
    D Brunner
    Zoologisches Institut, Universitat Zurich, Switzerland
    Cell 76:875-88. 1994
    ..Activation of MAP kinase by the rlSem mutation is both necessary and sufficient to activate multiple signaling pathways controlled by receptor tyrosine kinases...
  43. ncbi Biochemical characterization of rolledSem, an activated form of Drosophila mitogen-activated protein kinase
    N Oellers
    Zoologisches Institut, Universitat Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Biol Chem 271:24939-44. 1996
    ..We also demonstrate that Dsor1, which has been placed upstream of rl genetically, is able to phosphorylate and activate Rl in vitro...
  44. ncbi The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye
    J R Riesgo-Escovar
    Zoologisches Institut, Universitat Zurich, Switzerland
    Genes Dev 10:2759-68. 1996
    ..Although DJNK efficiently phosphorylates DJun in vitro, bsk function is not required for the specification of cell fate in the developing eye, a process that requires MAP kinase and DJun function...
  45. ncbi Common and distinct roles of DFos and DJun during Drosophila development
    J R Riesgo-Escovar
    Zoologisches Institut, Universitat Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Science 278:669-72. 1997
    ....
  46. ncbi The dominant mutation Glazed is a gain-of-function allele of wingless that, similar to loss of APC, interferes with normal eye development
    E Brunner
    Zoologisches Institut, Universitat Zurich, Zurich, 8057, Switzerland
    Dev Biol 206:178-88. 1999
    ..Gla represents not only the first dominant allele of wg, but it may also be the first allele ever described for wg...
  47. ncbi Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4
    R Bohni
    Zoologisches Institut, Universitat Zurich, Switzerland
    Cell 97:865-75. 1999
    ....
  48. ncbi Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells
    R Burke
    Institut fur Molekularbiologie, Universitat Zurich, Switzerland
    Cell 99:803-15. 1999
    ..Despite their opposite roles, Disp and Ptc share structural homology in the form of a sterol-sensing domain, suggesting that release and sequestration of cholesterol-modified Hh may be based on related molecular pathways...
  49. ncbi Mechanisms of positional signalling in the developing eye of Drosophila studied by ectopic expression of sevenless and rough
    E Hafen
    Zoologisches Institut, Universitat Zurich, Switzerland
    J Cell Sci Suppl 13:157-68. 1990
    ..This indicates that rough acts, similar to other homeobox genes, as a selector gene that determines the fate of single cells...
  50. ncbi Dynamics of Drosophila eye development and temporal requirements of sevenless expression
    K Basler
    Zoologisches Institut, Universitat Zurich, Switzerland
    Development 107:723-31. 1989
    ..Furthermore, using rescue of R7 cells as an internal marker to monitor the progression of eye development we could examine when and at what rate ommatidial columns form...
  51. ncbi Genetic control of cell size
    H Stocker
    Zoologisches Institut, Universitat Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    Curr Opin Genet Dev 10:529-35. 2000
    ..Evidence is emerging for a signalling cascade conserved in evolution that links external nutrient sources to cell size...
  52. ncbi Reprogramming cell fate in the developing Drosophila retina: transformation of R7 cells by ectopic expression of rough
    K Basler
    Zoologisches Institut, Universitat Zurich, Switzerland
    Genes Dev 4:728-39. 1990
    ..We propose that in wild type, rough functions autonomously in the specification of R2/5 photoreceptor cell identity but by itself cannot initiate neural development...
  53. ncbi Specification of cell fate in the developing eye of Drosophila
    E Hafen
    Zoologisches Institut, Universitat Zurich, Switzerland
    Dev Suppl 1:123-30. 1991
    ....
  54. ncbi Ras controls growth, survival and differentiation in the Drosophila eye by different thresholds of MAP kinase activity
    K Halfar
    Zoologisches Institut, Universitat Zurich, Winterthurerstrasse 190, Switzerland
    Development 128:1687-96. 2001
    ..Low MAPK activity prolongs cell survival and permits differentiation of R8 photoreceptor cells while high or persistent MAPK activity is sufficient to precociously induce R1-R7 photoreceptor differentiation in dividing cells...
  55. ncbi The Cdi/TESK1 kinase is required for Sevenless signaling and epithelial organization in the Drosophila eye
    Marta Sesé
    Departament de Genetica, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
    J Cell Sci 119:5047-56. 2006
    ..Our results reveal a critical interplay between the localization of molecules involved in epithelial organization and signal transduction...
  56. ncbi Bunched, the Drosophila homolog of the mammalian tumor suppressor TSC-22, promotes cellular growth
    Silvia Gluderer
    Institute of Molecular Systems Biology, ETH Zurich, Wolfgang Pauli Str, 16, 8093 Zurich, Switzerland
    BMC Dev Biol 8:10. 2008
    ..Possible redundancy among the members of the TSC-22/Dip/Bun protein family complicates a genetic analysis. In Drosophila, all proteins homologous to the TSC-22/Dip/Bun family members are derived from a single locus called bunched (bun)...
  57. ncbi Drosophila cbl is essential for control of cell death and cell differentiation during eye development
    Yuan Wang
    Department of Biochemistry and Molecular Biology, The University of Texas, M D Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 3:e1447. 2008
    ....
  58. ncbi The Drosophila homolog of human tumor suppressor TSC-22 promotes cellular growth, proliferation, and survival
    Xiaodong Wu
    Cutaneous Biology Research Center and Massachusetts General Hospital Cancer Center, Massachusetts General Hospital Harvard Medical School, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 105:5414-9. 2008
    ..We speculate that reduced TSC22D1 expression generally reduces cellular fitness and only contributes to carcinogenesis in specific tissue environments...
  59. ncbi Csk differentially regulates Src64 during distinct morphological events in Drosophila germ cells
    ALANA M O'REILLY
    Department of Biological Sciences, Stanford University, 385 Serra Mall, Stanford, CA 94305, USA
    Development 133:2627-38. 2006
    ....
  60. ncbi Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands
    Susan J Broughton
    Department of Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 102:3105-10. 2005
    ..However, the ablated flies show an extension of median and maximal lifespan and increased resistance to oxidative stress and starvation...
  61. ncbi Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control
    Sean Oldham
    The Burnham Institute, La Jolla, CA 92037, USA
    Trends Cell Biol 13:79-85. 2003
    ..This review summarizes current studies primarily from Drosophila regarding the function of the insulin/IGF system in the control of growth...
  62. ncbi Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2
    Attila Garami
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland
    Mol Cell 11:1457-66. 2003
    ..Finally, coexpression of a human TSC2 cDNA harboring a disease-associated point mutation in the GAP domain, failed to stimulate Rheb GTPase activity or block Rheb activation of S6K1...
  63. ncbi Long-lived Drosophila with overexpressed dFOXO in adult fat body
    Maria E Giannakou
    Department of Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK
    Science 305:361. 2004
    ..The role of FOXO transcription factors and the adipose tissue are therefore evolutionarily conserved in the regulation of aging, and reduction of IIS in the adult is sufficient to mediate its effects on life-span and fecundity...
  64. ncbi Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex
    James Brugarolas
    Dana Farber Cancer Institute and Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Genes Dev 18:2893-904. 2004
    ..Inhibition of mTOR function by hypoxia is likely to be important for tumor suppression as TSC2-deficient cells maintain abnormally high levels of cell proliferation under hypoxia...
  65. ncbi Targeted expression of the class II phosphoinositide 3-kinase in Drosophila melanogaster reveals lipid kinase-dependent effects on patterning and interactions with receptor signaling pathways
    Lindsay K MacDougall
    Biomolecular Sciences, University of Manchester Institute of Science and Technology, PO Box 88, Manchester M60 1QD, UK
    Mol Cell Biol 24:796-808. 2004
    ..The phenotypes obtained are markedly distinct from those generated by expression of the Drosophila class I PI3K, which affects growth but not pattern formation...
  66. ncbi dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1
    Thomas Radimerski
    Friedrich Miescher Institute, Novartis Research Foundation, Maulbeerstrasse 66, 4058 Basel, Switzerland
    Nat Cell Biol 4:251-5. 2002
    ....
  67. ncbi Dietary restriction in long-lived dwarf flies
    David J Clancy
    Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
    Science 296:319. 2002
  68. ncbi Maternal-effect loci involved in Drosophila oogenesis and embryogenesis: P element-induced mutations on the third chromosome
    Manolo Bellotto
    , Switzerland
    Int J Dev Biol 46:149-57. 2002
    ....
  69. ncbi Drosophila egg-laying site selection as a system to study simple decision-making processes
    Chung Hui Yang
    Howard Hughes Medical Institute, Department of Physiology, Biochemistry, and Biophysics, University of California at San Francisco, San Francisco, CA 94143 0725, USA
    Science 319:1679-83. 2008
    ..These findings suggest that selection of egg-laying site involves a simple decision-making process and provide an entry point toward a systematic dissection of this process...
  70. ncbi The DrosDel deletion collection: a Drosophila genomewide chromosomal deficiency resource
    Edward Ryder
    Department of Genetics, University of Cambridge, Cambridge CB2 3EH, United Kingdom
    Genetics 177:615-29. 2007
    ..Finally, we provide a computational resource that facilitates selection of other mapped FRT-bearing elements that, when combined with the DrosDel collection, can theoretically generate over half a million precisely mapped deletions...
  71. ncbi The DrosDel collection: a set of P-element insertions for generating custom chromosomal aberrations in Drosophila melanogaster
    Edward Ryder
    Department of Genetics, University of Cambridge, Cambridge CB2 3EH, United Kingdom
    Genetics 167:797-813. 2004
    ..In addition, a further 37,000 deletions, selectable by molecular screening, may be generated. We are now using the collection to generate a second-generation deficiency kit that is precisely mapped to the genome sequence...
  72. ncbi A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity
    Anne Claude Gingras
    Institute for Systems Biology, Seattle, Washington 98103, USA
    Mol Cell Proteomics 4:1725-40. 2005
    ..Finally we found that PP4R3 may target PP4cs to the DNA damage repair machinery at least in part via an interaction with Rad53 (CHK2)...
  73. ncbi Integration with the human genome of peptide sequences obtained by high-throughput mass spectrometry
    Frank Desiere
    Nestle Research Center, 1000 Lausanne 26, Switzerland
    Genome Biol 6:R9. 2005
    ..This resource could serve as an expandable repository for MS-derived proteome information...