Research Topics
Genomes and Genes | Dominique A GlauserSummaryAffiliation: University of Geneva Country: Switzerland Publications
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Publications
Transcriptional response of pancreatic beta cells to metabolic stimulation: large scale identification of immediate-early and secondary response genesDominique A Glauser
Fondation pour Recherches Medicales, University of Geneva, Geneva, Switzerland
BMC Mol Biol 8:54. 2007..The identity of these target genes has not been determined, and the sequence of events occurring during beta cell adaptation is still unclear...
Sequential actions of ERK1/2 on the AP-1 transcription factor allow temporal integration of metabolic signals in pancreatic beta cellsDominique A Glauser
Fondation pour Recherches Medicales, University of Geneva, Switzerland
FASEB J 21:3240-9. 2007..This ERK1/2-AP-1 module can function as a temporal integrator converting metabolic stimuli of different durations into differential transcriptional outputs...
The FoxO/Bcl-6/cyclin D2 pathway mediates metabolic and growth factor stimulation of proliferation in Min6 pancreatic beta-cellsDominique A Glauser
Medical Faculty, University of Geneva, Switzerland
J Recept Signal Transduct Res 29:293-8. 2009..Thus, in pancreatic beta-cells, the FoxO/Bcl6/cyclin D2 pathway connects nutrient and growth factor status to cell cycle control, and may therefore be considered for its therapeutic potential in diabetes...
Mechanisms of transcriptional regulation underlying temporal integration of signalsDominique A Glauser
, University of Geneva, Switzerland
Nucleic Acids Res 34:5175-83. 2006..These findings provide a novel and more comprehensive view of dynamic gene regulation...
The emerging role of FOXO transcription factors in pancreatic beta cellsDominique A Glauser
Fondation pour Recherches Medicales, University of Geneva, Av de la Roseraie 64, Geneva, Switzerland
J Endocrinol 193:195-207. 2007..Lastly in Part III, it will be attempted to combine general and beta cell-specific knowledge with the aim to envisage globally the role of FOXO factors in beta cell-linked physiology and disease...
