A Gamma

Summary

Affiliation: University of Zurich
Country: Switzerland

Publications

  1. ncbi Major depression predicts an increase in long-term body weight variability in young adults
    Gregor Hasler
    Psychiatric University Hospital, Zurich, Switzerland
    Obes Res 13:1991-8. 2005
  2. ncbi The spectra of neurasthenia and depression: course, stability and transitions
    Alex Gamma
    Zurich University Psychiatric Hospital, Research Department, Lenggstr 31, 8032 Zurich, Switzerland
    Eur Arch Psychiatry Clin Neurosci 257:120-7. 2007
  3. ncbi Are hypomanics the happier normals?
    Alex Gamma
    Zurich University Psychiatric Hospital, Lenggstrasse 31, CH 8032 Zurich, Switzerland
    J Affect Disord 111:235-43. 2008
  4. ncbi No difference in brain activation during cognitive performance between ecstasy (3,4-methylenedioxymethamphetamine) users and control subjects: a [H2(15)O]-positron emission tomography study
    A Gamma
    Research Unit, University Hospital of Psychiatry, Zurich, Switzerland
    J Clin Psychopharmacol 21:66-71. 2001
  5. ncbi Is ecstasy perceived to be safe? A critical survey
    Alex Gamma
    Research Department, University Hospital of Psychiatry, Lenggstrasse 31, 8029 Zurich, Switzerland
    Drug Alcohol Depend 77:185-93. 2005
  6. ncbi Subjective distress predicts treatment seeking for depression, bipolar, anxiety, panic, neurasthenia and insomnia severity spectra
    J Angst
    Zurich University Psychiatric Hospital, Switzerland
    Acta Psychiatr Scand 122:488-98. 2010
  7. ncbi Recurrence of bipolar disorders and major depression. A life-long perspective
    Jules Angst
    Zurich University Psychiatric Hospital, Lenggstrasse 31, 8029 Zurich, Switzerland
    Eur Arch Psychiatry Clin Neurosci 253:236-40. 2003
  8. ncbi Concurrent psychiatric comorbidity and multimorbidity in a community study: gender differences and quality of life
    A Gamma
    Zurich University Psychiatric Hospital, Switzerland
    Eur Arch Psychiatry Clin Neurosci 251:II43-6. 2001
  9. ncbi Psychological and physiological effects of MDMA ("Ecstasy") after pretreatment with the 5-HT(2) antagonist ketanserin in healthy humans
    M E Liechti
    University Hospital of Psychiatry Zurich, P O Box 68, CH 8029, Zurich, Switzerland
    Neuropsychopharmacology 23:396-404. 2000
  10. ncbi Does psychomotor agitation in major depressive episodes indicate bipolarity? Evidence from the Zurich Study
    Jules Angst
    Psychiatric Hospital, Zurich University, Lenggstrasse 31, P O Box 1931, 8032 Zurich, Switzerland
    Eur Arch Psychiatry Clin Neurosci 259:55-63. 2009

Detail Information

Publications51

  1. ncbi Major depression predicts an increase in long-term body weight variability in young adults
    Gregor Hasler
    Psychiatric University Hospital, Zurich, Switzerland
    Obes Res 13:1991-8. 2005
    ..To test the hypothesis that major depression predicts an increase in long-term body weight variability (BWV)...
  2. ncbi The spectra of neurasthenia and depression: course, stability and transitions
    Alex Gamma
    Zurich University Psychiatric Hospital, Research Department, Lenggstr 31, 8032 Zurich, Switzerland
    Eur Arch Psychiatry Clin Neurosci 257:120-7. 2007
    ..Neurasthenia is recognized by ICD-10, but not by DSM-IV. Its course, longitudinal stability and relationship to depression is not well understood...
  3. ncbi Are hypomanics the happier normals?
    Alex Gamma
    Zurich University Psychiatric Hospital, Lenggstrasse 31, CH 8032 Zurich, Switzerland
    J Affect Disord 111:235-43. 2008
    ..Not much is known about hypomanic states in subjects free of major and minor depressive mood disorders. Our aim was to identify and characterise a group of such "pure" hypomanics in relation to a normal control group...
  4. ncbi No difference in brain activation during cognitive performance between ecstasy (3,4-methylenedioxymethamphetamine) users and control subjects: a [H2(15)O]-positron emission tomography study
    A Gamma
    Research Unit, University Hospital of Psychiatry, Zurich, Switzerland
    J Clin Psychopharmacol 21:66-71. 2001
    ..However, this study cannot exclude the possibility that the observed differences are preexisting rather than a result of Ecstasy use...
  5. ncbi Is ecstasy perceived to be safe? A critical survey
    Alex Gamma
    Research Department, University Hospital of Psychiatry, Lenggstrasse 31, 8029 Zurich, Switzerland
    Drug Alcohol Depend 77:185-93. 2005
    ..We argue that these assumptions are inadequate and that drug information and harm reduction strategies should focus on more affective and personally significant aspects of risk perception...
  6. ncbi Subjective distress predicts treatment seeking for depression, bipolar, anxiety, panic, neurasthenia and insomnia severity spectra
    J Angst
    Zurich University Psychiatric Hospital, Switzerland
    Acta Psychiatr Scand 122:488-98. 2010
    ..To examine correlates of mental health treatment seeking such as gender, diagnosis, impairment, distress and mastery...
  7. ncbi Recurrence of bipolar disorders and major depression. A life-long perspective
    Jules Angst
    Zurich University Psychiatric Hospital, Lenggstrasse 31, 8029 Zurich, Switzerland
    Eur Arch Psychiatry Clin Neurosci 253:236-40. 2003
    ..CONCLUSION: If long-term trials confirm its efficacy, these results support lifelong prophylactic treatment of severe types of mood disorders...
  8. ncbi Concurrent psychiatric comorbidity and multimorbidity in a community study: gender differences and quality of life
    A Gamma
    Zurich University Psychiatric Hospital, Switzerland
    Eur Arch Psychiatry Clin Neurosci 251:II43-6. 2001
    ..The same factors predicted women's psychological and physical well-being, indicating a more holistic experience in women. Men's physical well-being did not correlate with any of the diagnostic or social variables measured...
  9. ncbi Psychological and physiological effects of MDMA ("Ecstasy") after pretreatment with the 5-HT(2) antagonist ketanserin in healthy humans
    M E Liechti
    University Hospital of Psychiatry Zurich, P O Box 68, CH 8029, Zurich, Switzerland
    Neuropsychopharmacology 23:396-404. 2000
    ..Body temperature was lower under MDMA plus ketanserin compared to MDMA alone. The results suggest a contributing role for 5-HT(2) receptors in the action of MDMA in humans...
  10. ncbi Does psychomotor agitation in major depressive episodes indicate bipolarity? Evidence from the Zurich Study
    Jules Angst
    Psychiatric Hospital, Zurich University, Lenggstrasse 31, P O Box 1931, 8032 Zurich, Switzerland
    Eur Arch Psychiatry Clin Neurosci 259:55-63. 2009
    ..This paper tested whether, how, and to what extent both psychomotor symptoms, agitation and retardation in depression are related to bipolarity and anxiety...
  11. ncbi Prevalence of exposure to potentially traumatic events and PTSD. The Zurich Cohort Study
    Urs Hepp
    Department of Psychiatry, University Hospital, Culmannstrasse 8, 8091, Zurich, Switzerland
    Eur Arch Psychiatry Clin Neurosci 256:151-8. 2006
    ..The aim of this study was to estimate the prevalence rate of exposure to potentially traumatic events (PTE) and posttraumatic stress disorder (PTSD) in a representative sample of the general population...
  12. ncbi Acute psychological effects of 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") are attenuated by the serotonin uptake inhibitor citalopram
    M E Liechti
    Psychiatric University Hospital Zürich Research Department, P O Box 68, CH 8029, Zurich, Switzerland
    Neuropsychopharmacology 22:513-21. 2000
    ..This finding suggests that the psychological effects of MDMA are mediated via action at the 5-HT uptake site to increase 5-HT release through the carrier, as expected from animal studies...
  13. ncbi Parsing the clinical phenotype of depression: the need to integrate brief depressive episodes
    J Angst
    Zurich University Psychiatric Hospital, Zurich, Switzerland
    Acta Psychiatr Scand 115:221-8. 2007
    ..To expand the concept of recurrent brief depression (RBD) to brief depression (BD) and to test its clinical relevance...
  14. ncbi Gender differences in the subjective effects of MDMA
    M E Liechti
    University Hospital of Psychiatry Zurich, Switzerland
    Psychopharmacology (Berl) 154:161-8. 2001
    ..5-HT is known to play an important role in mood and anxiety disorders, for which there is a female preponderance. To date, there are no systematic data on gender differences in the subjective effects of MDMA...
  15. ncbi Psychotic experiences in the general population: a twenty-year prospective community study
    Wulf Rossler
    Psychiatric University Hospital Zurich CH, Switzerland
    Schizophr Res 92:1-14. 2007
    ..Thus we analyzed the prevalence, determinants, patterns and impact of subclinical psychotic symptoms in a community cohort over a 20-year period...
  16. ncbi Atypical depressive syndromes in varying definitions
    Jules Angst
    Zurich University Psychiatric Hospital, Lenggstrasse 31, PO Box 1931, 8032 Zurich, Switzerland
    Eur Arch Psychiatry Clin Neurosci 256:44-54. 2006
    ..Using prospective data from a community sample, this paper identifies criteria (and correlates) for an AD syndrome that maximizes the association with female sex and bipolar-II...
  17. ncbi The HCL-32: towards a self-assessment tool for hypomanic symptoms in outpatients
    Jules Angst
    Zurich University Psychiatric Hospital, Lenggstrasse 31, P O Box 1931, 8032 Zurich, Switzerland
    J Affect Disord 88:217-33. 2005
    ..As such, an instrument for self-assessment of hypomanic symptoms might increase the detection of suspected and of manifest, but under-treated, cases of bipolar disorders...
  18. ncbi Long-term depression versus episodic major depression: results from the prospective Zurich study of a community sample
    Jules Angst
    Zurich University Psychiatric Hospital, Lenggstrasse 31, P O Box 1931, CH 8032 Zurich, Switzerland
    J Affect Disord 115:112-21. 2009
    ..Our study aims to characterise LTD in comparison with episodic (non-chronic) major depressive episodes (MDE) on the basis of data from a community sample...
  19. ncbi Varying temporal criteria for generalized anxiety disorder: prevalence and clinical characteristics in a young age cohort
    Jules Angst
    Zurich University Psychiatric Hospital, Zurich, Switzerland
    Psychol Med 36:1283-92. 2006
    ..This study questions the 6-month duration criterion for generalized anxiety disorder (GAD) used in DSM-III-R and DSM-IV...
  20. ncbi Is the association of alcohol use disorders with major depressive disorder a consequence of undiagnosed bipolar-II disorder?
    Jules Angst
    Zurich University Psychiatric Hospital, Lenggstrasse 31, Mail Box 1931, 8032, Zurich, Switzerland
    Eur Arch Psychiatry Clin Neurosci 256:452-7. 2006
    ....
  21. ncbi How ubiquitous are physical and psychological complaints in young and middle adulthood? A longitudinal perspective
    Vladeta Ajdacic-Gross
    Psychiatric University Hospital, Militarstr 8, 8004, Zurich, Switzerland
    Soc Psychiatry Psychiatr Epidemiol 41:881-8. 2006
    ..To investigate continuity and change of self-reported physical and psychological complaints in young adults over a period of 20 years...
  22. ncbi The generalized anxiety spectrum: prevalence, onset, course and outcome
    Jules Angst
    Zurich University Psychiatric Hospital, Lenggstrasse 31, P O Box 1931, 8032 Zurich, Switzerland
    Eur Arch Psychiatry Clin Neurosci 259:37-45. 2009
    ....
  23. ncbi The use of complementary and alternative medicine in the general population: results from a longitudinal community study
    Wulf Rossler
    Psychiatric University Hospital, Zurich, Switzerland
    Psychol Med 37:73-84. 2007
    ..We have examined data from the Zurich Study to determine trends and predictors of CAM use in Switzerland...
  24. ncbi Suicide in 406 mood-disorder patients with and without long-term medication: a 40 to 44 years' follow-up
    Jules Angst
    Zurich University Psychiatric Hospital, Switzerland
    Arch Suicide Res 9:279-300. 2005
    ..Long-term treatment also reduced overall mortality, and combined treatments proved more effective than mono-therapy...
  25. ncbi Prevalence of mental disorders in the Zurich Cohort Study: a twenty year prospective study
    Jules Angst
    Zurich University Psychiatric Hospital, Zurich, Switzerland
    Epidemiol Psichiatr Soc 14:68-76. 2005
    ..In order to minimise retrospective recall in developing estimates of the prevalence of mental disorders in the general population, we conducted a prospective study of a cohort of youth from Zurich, Switzerland...
  26. ncbi Toward a re-definition of subthreshold bipolarity: epidemiology and proposed criteria for bipolar-II, minor bipolar disorders and hypomania
    Jules Angst
    Zurich University Psychiatric Hospital, Lenggstrasse 31, P O Box 68, CH 8029, Zurich, Switzerland
    J Affect Disord 73:133-46. 2003
    ..to develop and validate criteria for the definition of softer expressions of bipolar-II (BP-II) disorder and hypomania, (3). to demonstrate the prevalence, clinical validity and comorbidity of the entire soft bipolar spectrum...
  27. ncbi Acute psychological and neurophysiological effects of MDMA in humans
    Franz X Vollenweider
    Privatdozent of Psychiatry, University of Zurich, Psychiatric University Hospital Zurich, Clinical Research Unit and Heffter Research Center, Zurich, Switzerland
    J Psychoactive Drugs 34:171-84. 2002
    ..The present contribution summarizes the acute effect of MDMA on psychological and cognitive measures, information processing, and regional brain activity in healthy human volunteers...
  28. ncbi Diagnostic issues in bipolar disorder
    Jules Angst
    Zurich University Psychiatric Hospital, Lenggstrasse 31 CH 8029, Zurich, Switzerland
    Eur Neuropsychopharmacol 13:S43-50. 2003
    ..There is increasing evidence for the existence of a broad spectrum of bipolar disorders, and data demonstrating the clinical validity of modifying some of the criteria for hypomania are reviewed here...
  29. ncbi Is bipolar I disorder heterogeneous?
    Jules Angst
    Zurich University, Psychiatric Hospital, Lenggstrasse 31, 68, 8029 Zurich, Switzerland
    Eur Arch Psychiatry Clin Neurosci 254:82-91. 2004
    ..This paper seeks to elucidate this question by contributing further data...
  30. ncbi Obsessive-compulsive severity spectrum in the community: prevalence, comorbidity, and course
    Jules Angst
    Zurich University Psychiatric Hospital, Lenggstrasse 31, 68, 8029 Zurich, Switzerland
    Eur Arch Psychiatry Clin Neurosci 254:156-64. 2004
    ..To describe lifetime prevalence rates, course and comorbidity of obsessive-compulsive disorder (OCD), obsessive-compulsive syndromes (OCS) and OC-symptoms (OC-sx) up to age 41...
  31. ncbi Toward validation of atypical depression in the community: results of the Zurich cohort study
    Jules Angst
    Zurich University Psychiatric Hospital, Lenggstrasse 31, P O Box 68, 8029, Zurich, Switzerland
    J Affect Disord 72:125-38. 2002
    ....
  32. ncbi Diagnostic conversion from depression to bipolar disorders: results of a long-term prospective study of hospital admissions
    Jules Angst
    Epidemiological Research, Zurich University Psychiatric Hospital, Lenggstrasse 31, P O Box 68, 8029 Zurich, Switzerland
    J Affect Disord 84:149-57. 2005
    ..To analyse the time course and some risk factors for a diagnostic change from major depression to bipolar disorders (BP) over an average of 20 years from the onset of the disorders...
  33. ncbi Obsessive-compulsive syndromes and disorders: significance of comorbidity with bipolar and anxiety syndromes
    Jules Angst
    Zurich University Psychiatric Hospital, Lenggstrasse 31, P O Box 68, 8029 Zurich, Switzerland
    Eur Arch Psychiatry Clin Neurosci 255:65-71. 2005
    ..To determine the prevalence and clinical characteristics of comorbid obsessive compulsive disorders and syndromes (OCD/OCS), compared with pure OCD/OCS among adults in the community...
  34. ncbi Localization of MDMA-induced brain activity in healthy volunteers using low resolution brain electromagnetic tomography (LORETA)
    E Frei
    University Hospital of Psychiatry, Zurich, Switzerland
    Hum Brain Mapp 14:152-65. 2001
    ....
  35. ncbi Is depression a risk factor for heart complaints? Longitudinal aspects in the Zurich study
    Dominique Eich
    Department of Clinical and Social Psychiatry, Zurich University Psychiatric Hospital, Lenggstrasse 31, PO Box 1931, 8032 Zurich, Switzerland
    Eur Arch Psychiatry Clin Neurosci 257:396-401. 2007
    ..The objective of this longitudinal study was to assess the association between major depression and heart complaints in a population of young and healthy adults...
  36. ncbi Diagnosis and course of affective psychoses: was Kraepelin right?
    Jules Angst
    Psychiatrische Universitatsklinik, Lenggstrasse 31, Postfach 1931, 8032, Zurich, Switzerland
    Eur Arch Psychiatry Clin Neurosci 258:107-10. 2008
    ..In contrast to Kraepelin's unitarian view the long-term prognosis of subgroups of mood disorders varies considerably. Overall it is nevertheless astonishing how much of Kraepelin's legacy has survived...
  37. ncbi Adult versus adolescent onset of smoking: how are mood disorders and other risk factors involved?
    Vladeta Ajdacic-Gross
    Psychiatric University Hospital, University of Zurich, Zurich, Switzerland
    Addiction 104:1411-9. 2009
    ....
  38. ncbi A new bipolar spectrum concept: a brief review
    Jules Angst
    Zurich University Psychiatric Hospital, Zurich, Switzerland
    Bipolar Disord 4:11-4. 2002
    ..Some methodological pitfalls of research on drug-induced hypomania as an element of the bipolar spectrum are also summarized...
  39. ncbi Diagnostic criteria for bipolarity based on an international sample of 5,635 patients with DSM-IV major depressive episodes
    J Angst
    Psychiatrische Universitatsklinik, Zurich University Psychiatric Hospital, Lenggstrasse 31, P O Box 1931, 8032, Zurich, Switzerland
    Eur Arch Psychiatry Clin Neurosci 262:3-11. 2012
    ....
  40. ncbi Gender differences in depression. Epidemiological findings from the European DEPRES I and II studies
    J Angst
    Zurich University Psychiatric Hospital, Lenggstrasse 31, P O Box 68, 8029 Zurich, Switzerland
    Eur Arch Psychiatry Clin Neurosci 252:201-9. 2002
    ....
  41. ncbi Psychometric evaluation of the altered states of consciousness rating scale (OAV)
    Erich Studerus
    Neuropsychopharmacology and Brain Imaging and Heffter Research Center, University Hospital of Psychiatry Zurich, Zurich, Switzerland
    PLoS ONE 5:e12412. 2010
    ....
  42. ncbi Prevalence, course, and comorbidity of insomnia and depression in young adults
    Daniel J Buysse
    Department ofPsychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Sleep 31:473-80. 2008
    ..1) To describe the prevalence and prospective course of insomnia in a representative young-adult sample and (2) to describe the cross-sectional and longitudinal associations between insomnia and depression...
  43. ncbi Recurrent brief depression--past and future
    Lukas Pezawas
    Department of General Psychiatry, University of Vienna, Vienna, Austria
    Prog Neuropsychopharmacol Biol Psychiatry 27:75-83. 2003
    ..Obviously, future treatment studies without the limitations of previous studies are clearly required for RBD...
  44. ncbi Excessive daytime sleepiness in young adults: a 20-year prospective community study
    Gregor Hasler
    Mood and Anxiety Disorders Program, Intramural Research Program, National Institutes of Health, National Institute of Mental Health, Bethesda, MD 20892, USA
    J Clin Psychiatry 66:521-9. 2005
    ..The aim of this study was to explore associations between self-reported EDS, sleep disorder symptoms, major depression, and anxiety in a longitudinal community study of young adults...
  45. ncbi Are behavioral problems in childhood and adolescence associated with bipolar disorder in early adulthood?
    Jerome Endrass
    Psychiatric Psychological Service, Crime Prevention Research Unit, Feldstrasse 42, 8090 Zurich, Switzerland
    Eur Arch Psychiatry Clin Neurosci 257:217-21. 2007
    ..6-3.5 times more likely to experience a bipolar II disorder than those with no indication of conduct problems. Sensitivity analysis showed that the conduct problems were not the result of low socio-economic status...
  46. ncbi Inconsistency in reporting potentially traumatic events
    Urs Hepp
    Department of Psychiatry, University Hospital Zurich, Culmannstrasse 8, CH 8091 Zurich, Switzerland
    Br J Psychiatry 188:278-83. 2006
    ..Research on post-traumatic stress disorder (PTSD) relies mainly on self-reports of exposure to trauma and its consequences...
  47. ncbi Nosology and treatment of primary headache in a Swiss headache clinic
    Stanislaw Kozak
    Headache and Pain Unit, Neurology Department, , Frauenklinikstrasse 26, Switzerland
    J Headache Pain 6:121-7. 2005
    ..The diagnostic and therapeutic practices of referring physicians exposed a deficit of information on headache, and a need for relevant education...
  48. ncbi The association between short sleep duration and obesity in young adults: a 13-year prospective study
    Gregor Hasler
    Mood and Anxiety Disorders Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Sleep 27:661-6. 2004
    ..The objective of this study was to test the hypothesis that short sleep duration is associated with obesity and weight gain during young adulthood...
  49. ncbi Asthma and panic in young adults: a 20-year prospective community study
    Gregor Hasler
    National Institutes of Health, National Institute of Mental Health, Mood and Anxiety Disorders Program, 15K North Drive, Room 200, MSC 2670, Bethesda, MD 20892 2670, USA
    Am J Respir Crit Care Med 171:1224-30. 2005
    ..Psychologic factors are increasingly recognized to influence the onset and course of asthma. Previous cross-sectional community-based studies have provided evidence for a relatively specific association between asthma and panic...
  50. ncbi Keeping a clear head on effects of illicit drugs
    Alex Gamma
    Nature 430:399. 2004
  51. ncbi "Ecstasy" and neurotoxic effects on the brain
    Alex Gamma
    Toxicol Lett 136:229-30; author reply 231-2. 2003