Research Topics
Genomes and Genes | Mirjam Christ-CrainSummaryAffiliation: University of Basel Country: Switzerland Publications
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Publications
Targeting AMP-activated protein kinase in adipocytes to modulate obesity-related adipokine production associated with insulin resistance and breast cancer cell proliferationJean Grisouard
Department of Biomedicine, University Hospital Basel, Basel, CH 4031, Switzerland
Diabetol Metab Syndr 3:16. 2011..abstract:..- Prohormones for prediction of adverse medical outcome in community-acquired pneumonia and lower respiratory tract infectionsPhilipp Schuetz
Department of Internal Medicine, Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
Crit Care 14:R106. 2010..Measurement of prohormones representing different pathophysiological pathways could enhance risk stratification in patients with community-acquired pneumonia (CAP) and other lower respiratory tract infections (LRTI)... - Copeptin: a new and promising diagnostic and prognostic markerMira Katan
Department of Endocrinology, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
Crit Care 12:117. 2008..Furthermore, vasopressin is an important hormone in salt and volume regulation. In this context, copeptin is also a diagnostic marker in patients with diabetes insipidus and in patients with disordered water states... - Which patients with lower respiratory tract infections need inpatient treatment? Perceptions of physicians, nurses, patients and relativesClaudia Baehni
Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
BMC Pulm Med 10:12. 2010..This survey analyzed perceptions of physicians, nurses, patients and relatives about feasibility of outpatient management and required duration of hospital stay... - Copeptin is associated with mortality and outcome in patients with acute intracerebral hemorrhageChristian Zweifel
Department of Neurosurgery, University Hospital of Basel, Spitalstrasse 21, 4031 Basel, Switzerland
BMC Neurol 10:34. 2010..Copeptin, the C-terminal part of provasopressin, has emerged as a new prognostic marker in a variety of diseases, but its prognostic value in ICH is unknown... - Enhancement of CURB65 score with proadrenomedullin (CURB65-A) for outcome prediction in lower respiratory tract infections: derivation of a clinical algorithmWerner C Albrich
Medical University Department of the University of Basel, Kantonsspital Aarau, Switzerland
BMC Infect Dis 11:112. 2011..We aimed to derive a practical algorithm combining the CURB65 score with ProADM-levels in patients with community-acquired pneumonia (CAP) and non-CAP-LRTI... - Clinical review: the role of biomarkers in the diagnosis and management of community-acquired pneumoniaMirjam Christ-Crain
Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
Crit Care 14:203. 2010..None should be used on its own; and none is anything more than an aid in the exercise of clinical judgment based upon a synthesis of available clinical, physiologic and laboratory features in each patient... - Biomarkers in the management of pneumoniaMirjam Christ Crain
University Hospitals, Petersgraben 4, CH 4031 Basel, Switzerland
Expert Rev Respir Med 2:565-72. 2008..Future studies will show whether an assessment with those novel biomarkers is able to guide prognostic decision-making and improve the allocation of healthcare resources and hospitalization costs... - Diagnostic and prognostic accuracy of clinical and laboratory parameters in community-acquired pneumoniaBeat Muller
Departments of Internal Medicine, University Hospital, Petersgraben 4, CH 4031, Basel, Switzerland
BMC Infect Dis 7:10. 2007..This study aims to evaluate the diagnostic and prognostic accuracy of clinical signs and symptoms and laboratory biomarkers for CAP... - Copeptin, C-reactive protein, and procalcitonin as prognostic biomarkers in acute exacerbation of COPDDaiana Stolz
Clinic of Pneumology and Pulmonary Cell Research, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
Chest 131:1058-67. 2007.... - Procalcitonin-guided antibiotic use versus a standard approach for acute respiratory tract infections in primary care: study protocol for a randomised controlled trial and baseline characteristics of participating general practitioners [ISRCTN73182671]Matthias Briel
Basel Institute for Clinical Epidemiology, University Hospital Basel, CH 4031 Basel, Switzerland
BMC Fam Pract 6:34. 2005..The aim of this trial is to compare a ProCT-guided antibiotic therapy with a standard approach based on evidence-based guidelines for patients with ARTI in primary care... - Pro-adrenomedullin to predict severity and outcome in community-acquired pneumonia [ISRCTN04176397]Mirjam Christ-Crain
Department of Internal Medicine, University Hospital Basel, Switzerland
Crit Care 10:R96. 2006..A major cause of sepsis is community-acquired pneumonia (CAP). The aim of this study was to investigate the value of proADM levels for severity assessment and outcome prediction in CAP... - Use of B-type natriuretic peptide in the risk stratification of acute exacerbations of COPDDaiana Stolz
Clinic for Pneumology and Respiratory Cell Research, University Hospital Basel, Switzerland
Chest 133:1088-94. 2008..In patients with COPD, prognosis might be determined at least in part by the extent of cardiac stress induced by hypoxia and pulmonary arterial hypertension... - Endothelin-1 precursor peptides correlate with severity of disease and outcome in patients with community acquired pneumoniaPhilipp Schuetz
Department of Internal Medicine, University Hospital Basel, Switzerland
BMC Infect Dis 8:22. 2008..The objective of this study was to assess the diagnostic and prognostic value of proET-1 in a prospective cohort of mainly septic patients with community-acquired pneumonia... - Antibiotic treatment of exacerbations of COPD: a randomized, controlled trial comparing procalcitonin-guidance with standard therapyDaiana Stolz
Clinics of Respiratory Medicine and Pulmonary Cell Research, University Hospital Basel, Basel, Switzerland
Chest 131:9-19. 2007..We evaluated the efficacy and safety of procalcitonin guidance compared to standard therapy with antibiotic prescriptions in patients experiencing exacerbations of COPD... - Elevated C-reactive protein and homocysteine values: cardiovascular risk factors in hypothyroidism? A cross-sectional and a double-blind, placebo-controlled trialMirjam Christ-Crain
Division of Endocrinology, Diabetology, and Clinical Nutrition, University Hospitals, CH 4031 Basel, Switzerland
Atherosclerosis 166:379-86. 2003..In contrast to overt disease, only CRP, but not tHcy values, are affected in SCH, yet without significant improvement after L-thyroxine therapy... - Procalcitonin levels predict bacteremia in patients with community-acquired pneumonia: a prospective cohort trialFabian Müller
Department of Internal Medicine, Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Basel, Switzerland
Chest 138:121-9. 2010..However, the yield of true-positive results is low. We investigated the benefit of procalcitonin (PCT) on hospital admission to predict blood culture positivity in CAP... - Midregional proatrial natriuretic peptide predicts survival in exacerbations of COPDMaurizio Bernasconi
Clinic of Pulmonary Medicine and Respiratory Cell Research, University Hospital Basel, Basel, Switzerland
Chest 140:91-9. 2011..We investigated whether midregional proatrial natriuretic peptide (MR-proANP) predicts survival in patients with COPD when they are admitted to the hospital for exacerbation... - Circulating precursor levels of endothelin-1 and adrenomedullin, two endothelium-derived, counteracting substances, in sepsisPhilipp Schuetz
Department of Internal Medicine, University Hospital Basel, Switzerland
Endothelium 14:345-51. 2007..The ratio of the two counteracting peptides correlates with mortality and shows a prognostic accuracy to predict adverse outcome comparable to the APACHE II score... - Guidance of antibiotic therapy with procalcitonin in lower respiratory tract infections: insights into the ProHOSP studyPhilipp Schuetz
Department of Internal Medicine, Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Basel, Switzerland
Virulence 1:88-92. 2010..In lower respiratory tract infections, PCT guidance had a differential effect on antibiotic exposure depending on the underlying type and severity of respiratory tract infection... - Prolactin dysregulation in women with subclinical hypothyroidism: effect of levothyroxine replacement therapyChristian Meier
Division of Endocrinology, Diabetology, and Clinical Nutrition, Department of Internal Medicine, University Hospitals, Basel, Switzerland
Thyroid 13:979-85. 2003.... - Midregional pro-atrial natriuretic peptide and outcome in patients with acute ischemic strokeMira Katan
Department of Endocrinology, University Hospital Basel, Basel, Switzerland
J Am Coll Cardiol 56:1045-53. 2010..The purpose of this study was to examine the prognostic value of midregional pro-atrial natriuretic peptide (MR-proANP) in patients with acute ischemic stroke... - What cardiologists do need to know about procalcitoninChristian Mueller
Department of Internal Medicine, University Hospital Basel, Switzerland
Clin Lab 51:1-4. 2005..49 (p < 0.001), as compared to the standard group. Thus, using a sensitive assay, procalcitonin-guidance substantially and safely reduced antibiotic usage in LRTI... - Glucose-dependent insulinotropic polypeptide (GIP) induces calcitonin gene-related peptide (CGRP)-I and procalcitonin (Pro-CT) production in human adipocytesKatharina Timper
University Hospital Basel, Department of Biomedicine, Metabolism Group, Hebelstrasse 20, CH 4031 Basel, Switzerland
J Clin Endocrinol Metab 96:E297-303. 2011..Adipocytes express functional GIP receptors and the CT peptides Pro-CT and CGRP-I. However, a link between GIP and CT peptides has not been studied yet... - Role of calcium in lipopolysaccharide-induced calcitonin gene expression in human adipocytesTanja M Radimerski
Department of Biomedicine, University Hospital Basel, Basel, Switzerland
Innate Immun 17:403-13. 2011.... - Mannose-binding lectin deficiency is associated with smaller infarction size and favorable outcome in ischemic stroke patientsMichael Osthoff
Laboratory of Clinical Immunology, Department of Biomedicine and Clinic for Internal Medicine, University Hospital Basel, Basel, Switzerland
PLoS ONE 6:e21338. 2011.... - Procalcitonin guided antibiotic therapy and hospitalization in patients with lower respiratory tract infections: a prospective, multicenter, randomized controlled trialPhilipp Schuetz
Department of Internal Medicine, Diabetes and Clinical Nutrition, University Hospital Basel, Petersgraben 4, Basel, Switzerland
BMC Health Serv Res 7:102. 2007.... - Copeptin: a novel, independent prognostic marker in patients with ischemic strokeMira Katan
Department of Endocrinology, University Hospital Basel, Switzerland
Ann Neurol 66:799-808. 2009..Vasopressin is a stress hormone. Its production rate is mirrored in circulating levels of copeptin, a fragment of provasopressin. We evaluated the prognostic value of copeptin in acute stroke patients... - Low triiodothyronine syndrome: a prognostic marker for outcome in sepsis?Stefanie Meyer
Department of Internal Medicine, Division of Endocrinology Diabetes and Clinical Nutrition, University Hospital Basel, Basel, Switzerland
Endocrine 39:167-74. 2011..04 and P = 0.02). T3 and fT4 levels on admission were not prognostic in this cohort of critically ill patients. A decrease in fT4 levels in the course of disease, however, may point to adverse outcome... - Both inflammatory and classical lipolytic pathways are involved in lipopolysaccharide-induced lipolysis in human adipocytesJean Grisouard
Department of Biomedicine, Metabolism Group, University Hospital Basel, Basel, Switzerland
Innate Immun 18:25-34. 2012..In turn, LPS-induced lipolysis reinforces the expression of pro-inflammatory cytokines and, thereby, triggers its own lipolytic activity... - Dexamethasone suppression test predicts later development of an impaired adrenal function after a 14-day course of prednisone in healthy volunteersStefanie Neidert
Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
Eur J Endocrinol 162:943-9. 2010..Identification of patients at risk is of clinical importance. We hypothesized that the dexamethasone suppression test predicts the development of corticosteroid-induced impaired adrenal function... - Effect of a 14-day course of systemic corticosteroids on the hypothalamic-pituitary-adrenal-axis in patients with acute exacerbation of chronic obstructive pulmonary diseasePhilipp Schuetz
Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
BMC Pulm Med 8:1. 2008.... - Outcome of radioiodine therapy without, on or 3 days off carbimazole: a prospective interventional three-group comparisonMartin A Walter
Institute of Nuclear Medicine, University Hospital, Petersgraben 4, 4031, Basel, Switzerland
Eur J Nucl Med Mol Imaging 33:730-7. 2006..By generating three groups with comparable radioiodine uptake, we also investigated whether the effect of carbimazole depends on the radioiodine uptake... - The use of copeptin, the stable peptide of the vasopressin precursor, in the differential diagnosis of sodium imbalance in patients with acute diseasesNicole Nigro
Department of Endocrinology, University Hospital Basel, Basel, CH, Switzerland
Swiss Med Wkly 141:w13270. 2011..This study assessed copeptin concentrations in sick patients with serum sodium imbalance of different aetiology on admission to the emergency department... - Long-term stability of procalcitonin in frozen samples and comparison of Kryptor and VIDAS automated immunoassaysPhilipp Schuetz
Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
Clin Biochem 43:341-4. 2010..To assess long-term stability of PCT in deep-frozen samples and assess whether Kryptor procalcitonin cutoff ranges can be transferred on the bioMérieux VIDAS system... - Biomarkers to improve diagnostic and prognostic accuracy in systemic infectionsPhilipp Schuetz
Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
Curr Opin Crit Care 13:578-85. 2007..We review the advantages and drawbacks of biomarkers in the diagnostic and prognostic assessment of systemic infections... - Plasma pro-adrenomedullin but not plasma pro-endothelin predicts survival in exacerbations of COPDDaiana Stolz
Clinic of Pneumology, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
Chest 134:263-72. 2008..We investigated whether plasma pro-endothelin-1 (proET-1) and/or pro-adrenomedullin (proADM) on admission to the hospital for acute exacerbation predict survival in patients with COPD... - Circulating levels of GH predict mortality and complement prognostic scores in critically ill medical patientsPhilipp Schuetz
Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Internal Medicine, Diabetes and Clinical Nutrition, University Hospital Basel, Basel, Switzerland
Eur J Endocrinol 160:157-63. 2009..We assessed the prognostic implications of GH on admission and during follow-up in critically ill adult patients admitted to a medical intensive care unit... - Changes in plasma copeptin, the c-terminal portion of arginine vasopressin during water deprivation and excess in healthy subjectsGabor Szinnai
Division of Endocrinology, Diabetology, and Clinical Nutrition, University Hospital, CH 4031 Basel, Switzerland
J Clin Endocrinol Metab 92:3973-8. 2007..Copeptin is the C-terminal part of provasopressin and has been shown to be a useful tool to indicate AVP concentration in critically ill patients... - Copeptin, a stable peptide derived from the vasopressin precursor, correlates with the individual stress levelMira Katan
Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Basel, Basel, Switzerland
Neuro Endocrinol Lett 29:341-6. 2008..Copeptin is a more stable peptide stoichiometrically released from the same precursor molecule. The aim of our study was to compare copeptin and cortisol levels in different stress situations... - Restoration of euthyroidism accelerates bone turnover in patients with subclinical hypothyroidism: a randomized controlled trialChristian Meier
Division of Endocrinology, Department of Medicine, University Hospitals, CH 4031, Basel, Switzerland
Osteoporos Int 15:209-16. 2004..However, long-term studies are needed to confirm this assumption... - Clinical predictors for Legionella in patients presenting with community-acquired pneumonia to the emergency departmentRico Fiumefreddo
Department of Internal Medicine, Kantonsspital Aarau, Tellstrasse, CH 5001 Aarau, Switzerland
BMC Pulm Med 9:4. 2009..Accurate clinical predictors to assess the likelihood of Legionella community-acquired pneumonia (CAP) in patients presenting to the emergency department are lacking... - Free and total cortisol levels as predictors of severity and outcome in community-acquired pneumoniaMirjam Christ-Crain
Department of Endocrinology, William Harvey Research Institute, Barts and The London, Queen Mary s School of Medicine and Dentistry, London, United Kingdom
Am J Respir Crit Care Med 176:913-20. 2007..Whether FC concentrations better reflect outcome is uncertain. Objectives: To investigate the predictive value of TC and FC in community-acquired pneumonia (CAP)... - Serum estradiol after single dose hCG administration correlates with Leydig cell reserve in hypogonadal men: reassessment of the hCG stimulation testChristian Meier
Clinic for Endocrinology, Diabetology and Clinical Nutrition, University Hospital, Basel, Switzerland
Clin Lab 51:509-15. 2005..Assessment of E2 increments would render the test procedure more practical, less time-consuming and more cost-effective than assessing peak T levels after 72 hours... - Somatostatin is expressed and secreted by human adipose tissue upon infection and inflammationDalma Seboek
Department of Research, University Hospitals, Hebelstrasse 20, CH 4031 Basel, Switzerland
J Clin Endocrinol Metab 89:4833-9. 2004..It is tempting to speculate that visceral adipose tissue-derived SRIF plays a modulatory role in the immunological and metabolic response to inflammation... - Procalcitonin-guided antibiotic use vs a standard approach for acute respiratory tract infections in primary careMatthias Briel
Department of Internal Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
Arch Intern Med 168:2000-7; discussion 2007-8. 2008..We consider whether antibiotic therapy guided by procalcitonin reduces the use of antibiotics without increasing the restrictions experienced by patients by more than 1 day... - Anterior and posterior pituitary function testing with simultaneous insulin tolerance test and a novel copeptin assayMira Katan
Department of Endocrinology, University Hospitals, Petersgraben 4, CH 4031 Basel, Switzerland
J Clin Endocrinol Metab 92:2640-3. 2007..However, AVP measurement is cumbersome. Copeptin, the stable C-terminal glycopeptide of the AVP prohormone, is stoichiometrically secreted from the posterior pituitary... - Effects of antithyroid drugs on radioiodine treatment: systematic review and meta-analysis of randomised controlled trialsMartin A Walter
Institute of Nuclear Medicine, University Hospital Basel, Switzerland
BMJ 334:514. 2007..To determine the effect of adjunctive antithyroid drugs on the risk of treatment failure, hypothyroidism, and adverse events after radioiodine treatment... - Effect of procalcitonin-guided treatment on antibiotic use and outcome in lower respiratory tract infections: cluster-randomised, single-blinded intervention trialMirjam Christ-Crain
Division of Pneumology, University Hospitals, Petersgraben 4, CH-4031 Basel, Switzerland
Lancet 363:600-7. 2004..In view of the current overuse of antimicrobial therapy in often self-limiting acute respiratory tract infections, treatment based on procalcitonin measurement could have important clinical and financial implications... - Is there a clinical relevance of partial androgen deficiency of the aging male?Mirjam Christ-Crain
Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Medicine, University Hospitals, Basel, Switzerland
J Urol 172:624-7. 2004..We investigate the association between various T measures and clinical and biochemical parameters of the aging male... - Mid-regional pro-adrenomedullin as a prognostic marker in sepsis: an observational studyMirjam Christ-Crain
Department of Internal Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
Crit Care 9:R816-24. 2005..The prognostic value of MR-proADM was independent of the sepsis classification system used. CONCLUSION: MR-proADM may be helpful in individual risk assessment in septic patients... - Mechanisms of metformin action on glucose transport and metabolism in human adipocytesJean Grisouard
Department of Biomedicine, Metabolism Group, Div of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, CH 4031 Basel, Switzerland
Biochem Pharmacol 80:1736-45. 2010..In addition, metformin induced glucose oxidation. In conclusion, activation of AMPK?1 without impairment of cell respiration is crucial for metformin-mediated increase in GLUT-4 protein content and glucose uptake in human adipocytes...