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Genomes and Genes | D BurgerSummaryAffiliation: University Hospital Country: Switzerland Publications
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Publications
Is IL-1 a good therapeutic target in the treatment of arthritis?Danielle Burger
Clinical Immunology Unit, Division of Immunology and Allergy, Department of Internal Medicine, University Hospital, 24 Rue Micheli du Crest, CH 1211 Geneva 14, Switzerland
Best Pract Res Clin Rheumatol 20:879-96. 2006..Importantly, to be efficacious, anakinra required daily injections, suggesting that administered IL-1Ra displays very short-term effects. Better IL-1 antagonists are in the process of being developed...- High-density lipoproteins downregulate CCL2 production in human fibroblast-like synoviocytes stimulated by urate crystalsAnna Scanu
Department of Clinical and Experimental Medicine, University of Padova, Via Giustiniani 2, 35128 Padova, Italy
Arthritis Res Ther 12:R23. 2010.... - Differential induction of IL-1beta and TNF by CD40 ligand or cellular contact with stimulated T cells depends on the maturation stage of human monocytesDanielle Burger
Clinical Immunology Unit Hans Wilsdorf Laboratory, Division of Immunology and Allergy, Department of Internal Medicine, University Hospital, Geneva, Switzerland
J Immunol 173:1292-7. 2004..These results demonstrate that CD40L is not required in monocyte activation by direct cellular contact with stimulated T cells, although soluble CD40LT induces the production of TNF in IFN-gamma-macrophages... - Glatiramer acetate increases IL-1 receptor antagonist but decreases T cell-induced IL-1beta in human monocytes and multiple sclerosisDanielle Burger
Division of Immunology and Allergy, Clinical Immunology Unit Hans Wilsdorf Laboratory, Department of Internal Medicine, University Hospital and Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland
Proc Natl Acad Sci U S A 106:4355-9. 2009..This study sheds light on a mechanism that is likely to participate in the therapeutic effects of GA in MS... - High-density lipoprotein-associated apolipoprotein A-I: the missing link between infection and chronic inflammation?Danielle Burger
Division of Immunology and Allergy Hans Wilsdorf Laboratory, Department of Internal Medicine, University Hospital, 24 Rue Micheli du Crest, 1211 Geneva 14, Switzerland
Autoimmun Rev 1:111-7. 2002..e. individuals presenting with risk factors might develop chronic inflammatory diseases after infection. We thus hypothesize that HDL-associated apo A-I might be the missing link between infection and chronic inflammation... - The active metabolite of leflunomide, A77 1726, inhibits the production of prostaglandin E(2), matrix metalloproteinase 1 and interleukin 6 in human fibroblast-like synoviocytesD Burger
Division of Immunology and Allergy, Clinical Immunology Unit Hans Wilsdorf Laboratory, Department of Internal Medicine, University Hospital, 24 Rue Micheli du Crest, CH 1211 Geneva 4, Switzerland
Rheumatology (Oxford) 42:89-96. 2003.... - Cytokines, acute-phase proteins, and hormones: IL-1 and TNF-alpha production in contact-mediated activation of monocytes by T lymphocytesDanielle Burger
Division of Immunology and Allergy Hans Wilsdorf Laboratory, Department of Internal Medicine, University Hospital, CH 1211 Geneva 14, Switzerland
Ann N Y Acad Sci 966:464-73. 2002..The discrepancy between studies would suggest that the mechanisms are different in physiological and pathophysiological conditions... - The role of human T-lymphocyte-monocyte contact in inflammation and tissue destructionDanielle Burger
Division of Immunology and Allergy, Clinical Immunology Unit, University Hospital, Geneva, Switzerland
Arthritis Res 4:S169-76. 2002..This review aims to summarize the state of the art and importance of contact-mediated monocyte activation by stimulated TL in cytokine production in rheumatoid arthritis and mechanisms that might control it... - Cell contact interactions in rheumatology, The Kennedy Institute for Rheumatology, London, UK, 1-2 June 2000D Burger
Clinical Immunology Unit, Division of Immunology and Allergy, University Hospital, Geneva, Switzerland
Arthritis Res 2:472-6. 2000..Therefore, factors capable of affecting the level of T lymphocyte activation, such as IFN-beta, IL-15 antagonist, or SDF-1alpha antagonist, might be of interest in RA therapy... - Modulation of soluble and membrane-bound TNF-induced phenotypic and functional changes of human brain microvascular endothelial cells by recombinant TNF binding protein IJ Lou
Dept of APSIC, University Medical Center, Geneva, Switzerland
J Neuroimmunol 77:107-15. 1997..These results indicate a therapeutic potential for TBP I in diseases of the central nervous system associated with TNF overproduction... - Direct contact between T lymphocytes and human dermal fibroblasts or synoviocytes down-regulates types I and III collagen production via cell-associated cytokinesR Rezzonico
Division of Immunology and Allergy, Clinical Immunology Unit Hans Wilsdorf Laboratory, Department of Internal Medicine, University Hospital, Geneva, Switzerland
J Biol Chem 273:18720-8. 1998.... - Th2 cell membrane factors in association with IL-4 enhance matrix metalloproteinase-1 (MMP-1) while decreasing MMP-9 production by granulocyte-macrophage colony-stimulating factor-differentiated human monocytesC Chizzolini
Division of Immunology and Allergy Hans Wilsdorf Laboratory, Department of Internal Medicine, University Hospital, Geneva, Switzerland
J Immunol 164:5952-60. 2000..This IL-4 activity may be relevant to pathological conditions dominated by Th2 inflammatory responses, resulting in tissue remodeling and destruction... - Human Th1 cells preferentially induce interleukin (IL)-1beta while Th2 cells induce IL-1 receptor antagonist production upon cell/cell contact with monocytesC Chizzolini
Department of Internal Medicine, Hopital Cantonal Universitaire, Geneva, Switzerland
Eur J Immunol 27:171-7. 1997..This differential induction of molecules with opposite effects on inflammation stresses the functional heterogeneity in CD4+ T cells... - Apolipoprotein A-I inhibits the production of interleukin-1beta and tumor necrosis factor-alpha by blocking contact-mediated activation of monocytes by T lymphocytesN Hyka
Division of Immunology and Allergy (Hans Wilsdorf Laboratory, Department of Internal Medicine, University Hospital, , Switzerland
Blood 97:2381-9. 2001..The novel anti-inflammatory function of apo A-I reported here might lead to new therapeutic approaches in inflammatory diseases such as rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, and atherosclerosis... - IFN-beta inhibits the ability of T lymphocytes to induce TNF-alpha and IL-1beta production in monocytes upon direct cell-cell contactF Jungo
Division of Immunology and Allergy, Clinical Immunology Unit (Hans Wilsdorf Laboratory, Department of Internal Medicine, University Hospital, Geneva, Switzerland
Cytokine 14:272-82. 2001.... - Anti-interleukin-1 therapy in rheumatic diseasesJ M Dayer
Division of Immunology and Allergy, University Hospital, Geneva, Switzerland
Curr Opin Rheumatol 13:170-6. 2001.... - Stimulated T cells generate microparticles, which mimic cellular contact activation of human monocytes: differential regulation of pro- and anti-inflammatory cytokine production by high-density lipoproteinsAnna Scanu
Division of Immunology and Allergy, Clinical Immunology Unit, Department of Internal Medicine, University Hospital and School of Medicine, Geneva, Switzerland
J Leukoc Biol 83:921-7. 2008..Furthermore, this study demonstrates that HDL exert an anti-inflammatory effect in nonseptic activation of human monocytes, not only by inhibiting the production of IL-1beta and TNF but also, by leaving sIL-1Ra production unchanged... - Crucial role of tumor necrosis factor (TNF) receptor 2 and membrane-bound TNF in experimental cerebral malariaR Lucas
Department of Anesthesiology, Pharmacology and Surgical Intensive Care, University Medical Center, Geneva, Switzerland
Eur J Immunol 27:1719-25. 1997..In conclusion, these results indicate that the interaction between membrane TNF and TNFR2 is crucial in the development of this neurological syndrome... - Differential regulation of cytokine production by PI3Kdelta in human monocytes upon acute and chronic inflammatory conditionsNicolas Molnarfi
Division of Immunology and Allergy, Clinical Immunology Unit, Hans Wilsdorf Laboratory, Department of Internal Medicine, University Hospital and School of Medicine, University of Geneva, 24 Rue Micheli du Crest, CH 1211 Geneva 14, Switzerland
Mol Immunol 45:3419-27. 2008.... - Blockade of T cell contact-activation of human monocytes by high-density lipoproteins reveals a new pattern of cytokine and inflammatory genesLyssia Gruaz
Division of Immunology and Allergy, Inflammation and Allergy Research Group, Hans Wilsdorf Laboratory, Department of Internal Medicine and Faculty of Medicine, University of Geneva, Geneva, Switzerland
PLoS ONE 5:e9418. 2010..High-density lipoproteins (HDL) specifically inhibit the production of pro-inflammatory cytokines induced by T cell contact... - Direct cell/cell contact with stimulated T lymphocytes induces the expression of cell adhesion molecules and cytokines by human brain microvascular endothelial cellsJ Lou
Division of Investigative Anesthesiology, APSIC Department, University Hospital, Geneva, Switzerland
Eur J Immunol 26:3107-13. 1996..This novel mechanism of inducing the expression of cell adhesion molecules may prompt the initial adhesion of stimulated T lymphocytes to brain endothelium... - Assays of T-cell contact dependent monocyte-macrophage functionsDanielle Burger
Clinical Immunology Unit, University Hospital, Geneva, Switzerland
Methods Mol Med 136:139-48. 2007..This chapter aims at reviewing and describing the latter methods and strategies... - Opposite effects of IFN beta on cytokine homeostasis in LPS- and T cell contact-activated human monocytesNicolas Molnarfi
Division of Immunology and Allergy, Clinical Immunology Unit (Hans Wilsdorf Laboratory, Department of Internal Medicine, University Hospital, 24 rue Micheli-du-Crest, CH-1211 Geneva 14, Switzerland
J Neuroimmunol 146:76-83. 2004..This study demonstrates that IFNbeta displays opposite effects depending on the type of activation of human monocytes, suggesting that it may affect different pathogenic mechanisms in opposite ways... - From cellular receptors to transduction-transcription pathways for cytokines: at which level should the inhibition be targeted in inflammation?Jean Michel Dayer
University Hospital and Faculty of Medicine, 24, Rue Micheli du Crest, 1211 Geneva 14, Switzerland
Expert Opin Biol Ther 5:S83-96. 2005..This review examines the different therapeutic approaches that may be considered for the treatment of immuno-inflammatory diseases, and discusses the advantages and disadvantages of targeting extracellular or intracellular mechanisms... - Cell-cell interactions and tissue damage in rheumatoid arthritisJ M Dayer
Service of Immunology and Allergy, University Hospital, 24 Rue Micheli du Crest, CH-1211 Geneva 14, Switzerland
Autoimmun Rev 3:S14-6. 2004 - Anti-fibroblast antibodies detected by cell-based ELISA in systemic sclerosis enhance the collagenolytic activity and matrix metalloproteinase-1 production in dermal fibroblastsS Fineschi
Immunology and Allergy, Department of Internal Medicine, University Hospital and School of Medicine, Geneva, Switzerland
Rheumatology (Oxford) 46:1779-85. 2007..We aimed to assess the effect of AFA on extracellular matrix (ECM) turnover and whether AFA were associated with anti-topoisomerase-I antibody... - The production of IL-1 receptor antagonist in IFN-beta-stimulated human monocytes depends on the activation of phosphatidylinositol 3-kinase but not of STAT1Nicolas Molnarfi
Division of Immunology and Allergy, Clinical Immunology Unit, Faculty of Medicine, University Hospital, Geneva, Switzerland
J Immunol 174:2974-80. 2005..Taken together, the present data demonstrate that the induction of sIL-1Ra transcription and production by IFN-beta in human monocytes involved PI3K, but not STAT1 activation... - HDL interfere with the binding of T cell microparticles to human monocytes to inhibit pro-inflammatory cytokine productionRakel Carpintero
Hans Wilsdorf Laboratory, Inflammation and Allergy Research Group, Division of Immunology and Allergy, Department of Internal Medicine, Faculty of Medicine and University Hospital, University of Geneva, Geneva, Switzerland
PLoS ONE 5:e11869. 2010..We previously demonstrated that high-density lipoproteins (HDL) inhibited T cell contact- and MPT-induced production of IL-1beta but not of its natural inhibitor, the secreted form of IL-1 receptor antagonist (sIL-1Ra)... - T cell contact-mediated activation of respiratory burst in human polymorphonuclear leukocytes is inhibited by high-density lipoproteins and involves CD18Philippe Cettour-Rose
Division of Immunology and Allergy, Department of Internal Medicine, University Hospital, 24 rue Micheli-du-Crest, 1211 Geneva 14, Switzerland
J Leukoc Biol 77:52-8. 2005..The present results emphasize the importance of direct cell-cell contact with stimulated T cells in inflammatory processes... - The active metabolite of leflunomide, A77 1726, increases the production of IL-1 receptor antagonist in human synovial fibroblasts and articular chondrocytesGaby Palmer
Division of Rheumatology, University Hospital, and Department of Pathology, University of Geneva School of Medicine, Geneva, Switzerland
Arthritis Res Ther 6:R181-9. 2004..The effect of A77 1726 may be partially mediated by inhibition of COX-2, but other mechanisms likely concur to stimulate IL-1Ra production... - Adipose tissue is a major source of interleukin-1 receptor antagonist: upregulation in obesity and inflammationCristiana E Juge-Aubry
Endocrine Unit, Division of Endocrinology, Diabetes and Nutrition, Department of Internal Medicine, University Hospital Geneva, 24 Rue Micheli du Crest, CH 1211 Geneva 14, Switzerland
Diabetes 52:1104-10. 2003.... - Glatiramer acetate triggers PI3K?/Akt and MEK/ERK pathways to induce IL-1 receptor antagonist in human monocytesRakel Carpintero
Division of Immunology and Allergy, Hans Wilsdorf Laboratory, Inflammation and Allergy Research Group, Department of Internal Medicine, University Hospital and Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland
Proc Natl Acad Sci U S A 107:17692-7. 2010..Together, our findings demonstrate the existence of signal transduction triggered by GA, further highlighting the mechanisms of action of this drug in MS... - Opposite regulation of IL-1beta and secreted IL-1 receptor antagonist production by phosphatidylinositide-3 kinases in human monocytes activated by lipopolysaccharides or contact with T cellsNicolas Molnarfi
Division of Immunology and Allergy, Clinical Immunology Unit, Department of Internal Medicine, Faculty of Medicine, University Hospital, Geneva, Switzerland
J Immunol 178:446-54. 2007.... - Regulatory effects of interleukin (IL)-1, interferon-beta, and IL-4 on the production of IL-1 receptor antagonist by human adipose tissueCristiana E Juge-Aubry
Endocrine Unit, Department of Internal Medicine, University Hospital, CH 1211 Geneva 14, Switzerland
J Clin Endocrinol Metab 89:2652-8. 2004..Finally, human WAT actively secretes these regulatory cytokines, suggesting that they up-regulate IL-1Ra through a local autocrine/paracrine action, which is hypothesized to play a regulatory role in adipogenesis and metabolism... - A novel MEK2/PI3K? pathway controls the expression of IL-1 receptor antagonist in IFN-?-activated human monocytesKarim J Brandt
Division of Immunology and Allergy, Inflammation and Allergy Research Group, Hans Wilsdorf Laboratory, Department of Internal Medicine, University Hospital and Faculty of Medicine, University of Geneva, Geneva, Switzerland
J Leukoc Biol 88:1191-200. 2010.... - Presence of autoantibodies to apolipoprotein A-1 in patients with acute coronary syndrome further links autoimmunity to cardiovascular diseaseNicolas Vuilleumier
Division of Immunology and Allergy and Department of Internal Medicine, Geneva University Hospital, 24 Micheli-du-Crest, 1211 Geneva 14, Switzerland
J Autoimmun 23:353-60. 2004..76, P=0.0066) and anti-Apo A-1 IgG titre in ACS patients. The presence of anti-Apo A-1 autoantibodies in patients with ACS highlights an additional link between autoimmunity, inflammation and atherosclerosis... - Low apolipoprotein A-I level at intensive care unit admission and systemic inflammatory response syndrome exacerbationCatherine Chenaud
Division of Surgical Intensive Care, Department of Anesthesiology, Pharmacology, and Surgical Intensive Care, University of Geneva Hospitals, Geneva, Switzerland
Crit Care Med 32:632-7. 2004..84 [69-94] mg/dL, p =.028). CONCLUSION: A low serum level of apolipoprotein A-I at ICU admission is associated with an increase of the number of SIRS criteria during the ICU stay... - Apolipoprotein A-I infiltration in rheumatoid arthritis synovial tissue: a control mechanism of cytokine production?Barry Bresnihan
Department of Rheumatology, St Vincents University Hospital, Dublin, Ireland
Arthritis Res Ther 6:R563-6. 2004....