M H Brutsche

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. ncbi Analysis with respect to instrumental variables for the exploration of microarray data structures
    Florent Baty
    Pulmonary Gene Research, Universitatsspital Basel, Petersgraben 4, 4031 Basel, Switzerland
    BMC Bioinformatics 7:422. 2006
  2. ncbi Stability of gene contributions and identification of outliers in multivariate analysis of microarray data
    Florent Baty
    Pulmonary Gene Research, University Hospital Basel, Petersgraben 4, Basel, Switzerland
    BMC Bioinformatics 9:289. 2008
  3. ncbi Apoptosis signals in atopy and asthma measured with cDNA arrays
    M H Brutsche
    North West Lung Research Centre, South Manchester University Hospital Wythenshawe, University of Manchester, Manchester, UK
    Clin Exp Immunol 123:181-7. 2001
  4. ncbi Bronchial hyperresponsiveness and the development of asthma and COPD in asymptomatic individuals: SAPALDIA cohort study
    M H Brutsche
    Pneumologie, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    Thorax 61:671-7. 2006
  5. ncbi Treatment of sonographically stratified multiloculated thoracic empyema by medical thoracoscopy
    Martin H Brutsche
    Department of Pneumology, University Hospital Basel, Switzerland
    Chest 128:3303-9. 2005
  6. ncbi Impact of laughter on air trapping in severe chronic obstructive lung disease
    Martin H Brutsche
    University Hospital Basel, Switzerland
    Int J Chron Obstruct Pulmon Dis 3:185-92. 2008
  7. ncbi B-cell isotype control in atopy and asthma assessed with cDNA array technology
    M H Brutsche
    Pulmonology, University Hospital of Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    Am J Physiol Lung Cell Mol Physiol 280:L627-37. 2001
  8. ncbi Interstitial lung disease in an intravenous drug user
    D Conen
    Department of Internal Medicine, University Hospital, Basel, Switzerland
    Respiration 70:101-3. 2003
  9. ncbi Outcome of treated advanced non-small cell lung cancer with and without central airway obstruction
    Prashant N Chhajed
    Pulmonary Medicine, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    Chest 130:1803-7. 2006
  10. ncbi B-type natriuretic peptides for the evaluation of exercise intolerance
    Christian Mueller
    Department of Internal Medicine, University Hospital Basel, Switzerland
    Am J Med 122:265-72. 2009

Detail Information

Publications26

  1. ncbi Analysis with respect to instrumental variables for the exploration of microarray data structures
    Florent Baty
    Pulmonary Gene Research, Universitatsspital Basel, Petersgraben 4, 4031 Basel, Switzerland
    BMC Bioinformatics 7:422. 2006
    ..Complex experimental designs generally include various factors structuring the data which should be taken into account. The objective of these experiments is the exploration of some given factors while controlling other factors...
  2. ncbi Stability of gene contributions and identification of outliers in multivariate analysis of microarray data
    Florent Baty
    Pulmonary Gene Research, University Hospital Basel, Petersgraben 4, Basel, Switzerland
    BMC Bioinformatics 9:289. 2008
    ..These methods have several advantages compared to common gene-by-gene approaches. However, due to their exploratory nature, multivariate ordination methods do not allow direct statistical testing of the stability of genes...
  3. ncbi Apoptosis signals in atopy and asthma measured with cDNA arrays
    M H Brutsche
    North West Lung Research Centre, South Manchester University Hospital Wythenshawe, University of Manchester, Manchester, UK
    Clin Exp Immunol 123:181-7. 2001
    ..cDNA array technology proved to be useful and may be complementary to DNA-based studies in order to analyse interactive and multidimensional pathways as shown here for apoptosis...
  4. ncbi Bronchial hyperresponsiveness and the development of asthma and COPD in asymptomatic individuals: SAPALDIA cohort study
    M H Brutsche
    Pneumologie, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    Thorax 61:671-7. 2006
    ..We hypothesised that BHR might play a role in the development of chronic obstructive pulmonary disease (COPD) as well as asthma...
  5. ncbi Treatment of sonographically stratified multiloculated thoracic empyema by medical thoracoscopy
    Martin H Brutsche
    Department of Pneumology, University Hospital Basel, Switzerland
    Chest 128:3303-9. 2005
    ..What the best approach is and when and how to intervene is a matter of debate...
  6. ncbi Impact of laughter on air trapping in severe chronic obstructive lung disease
    Martin H Brutsche
    University Hospital Basel, Switzerland
    Int J Chron Obstruct Pulmon Dis 3:185-92. 2008
    ..In conclusion, smiling induced by a humor intervention was able to reduce hyperinflation in patients with severe COPD. A smiling-derived breathing technique might complement pursed-lips breathing in patients with symptomatic obstruction...
  7. ncbi B-cell isotype control in atopy and asthma assessed with cDNA array technology
    M H Brutsche
    Pulmonology, University Hospital of Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    Am J Physiol Lung Cell Mol Physiol 280:L627-37. 2001
    ..In conclusion, both atopic nonasthmatic and atopic asthmatic individuals had activated proinflammatory pathways, a minimal requirement for B-cell isotype switching, and a clear net pro-IgE cytokine climate...
  8. ncbi Interstitial lung disease in an intravenous drug user
    D Conen
    Department of Internal Medicine, University Hospital, Basel, Switzerland
    Respiration 70:101-3. 2003
  9. ncbi Outcome of treated advanced non-small cell lung cancer with and without central airway obstruction
    Prashant N Chhajed
    Pulmonary Medicine, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    Chest 130:1803-7. 2006
    ..In patients with advanced non-small cell lung cancer (NSCLC) treated with chemotherapy, we compared survival in patients with treated central airway obstruction to those who did not have central airway obstruction...
  10. ncbi B-type natriuretic peptides for the evaluation of exercise intolerance
    Christian Mueller
    Department of Internal Medicine, University Hospital Basel, Switzerland
    Am J Med 122:265-72. 2009
    ..This study sought to assess the utility of B-type natriuretic peptide (BNP) and N-terminal-pro-B-type natriuretic peptide (NT-proBNP) for the identification of a cardiocirculatory exercise limitation...
  11. ncbi Therapeutic bronchoscopy interventions before surgical resection of lung cancer
    Prashant N Chhajed
    Pulmonary Medicine, University Hospital Basel, Switzerland
    Ann Thorac Surg 81:1839-43. 2006
    ..The aim of this study was to assess the utility of therapeutic bronchoscopy as a complementary tool in the combined bronchoscopic and surgical management of malignant airway lesions before curative lung surgery...
  12. ncbi Sedative drug requirements during flexible bronchoscopy
    Prashant N Chhajed
    Pulmonary Medicine, University Hospital Basel, Petersgraben 4, CH 1031 Basel, Switzerland
    Respiration 72:617-21. 2005
    ..There is a paucity of data comparing doses of sedative medication during bronchoscopy in immunosuppressed and non-immunosuppressed patients...
  13. ncbi Prediction of treatment-response to inhaled corticosteroids by mannitol-challenge test in COPD. A proof of concept
    Jorg D Leuppi
    Pneumology, Department of Internal Medicine, University Hospital, Petersgraben 4, Basel CH 4031, Switzerland
    Pulm Pharmacol Ther 18:83-8. 2005
    ..There are no predictors known that can identify COPD patients who will respond to treatment with ICS...
  14. ncbi An individualized, adjustable maintenance regimen of budesonide/formoterol provides effective asthma symptom control at a lower overall dose than fixed dosing
    Jorg D Leuppi
    Department of Internal Medicine, University Hospital, Basel, Switzerland
    Swiss Med Wkly 133:302-9. 2003
    ..This study compared self-guided adjustable maintenance dosing with budesonide/formoterol in a single inhaler with fixed dosing...
  15. ncbi Therapeutic bronchoscopy for malignant airway stenoses: choice of modality and survival
    Prashant N Chhajed
    Pulmonary Medicine, University Hospital Basel, Switzerland
    J Cancer Res Ther 6:204-9. 2010
    ..There are no data regarding the factors influencing the choice of therapeutic bronchoscopic modality in the management of malignant airway stenoses...
  16. ncbi Gene profiling of clinical routine biopsies and prediction of survival in non-small cell lung cancer
    Florent Baty
    Pneumologie, Kantonsspital St Gallen, CH 9007 St Gallen, Switzerland
    Am J Respir Crit Care Med 181:181-8. 2010
    ..Global gene expression analysis provides a comprehensive molecular characterization of non-small cell lung cancer (NSCLC)...
  17. ncbi Long-term follow-up and survival after Ultraflex stent insertion in the management of complex malignant airway stenoses
    Albrecht Breitenbücher
    Department of Pulmonary Medicine, University Hospital Basel, Basel, Switzerland
    Respiration 75:443-9. 2008
    ..Despite being commercially available for a few years now, the literature regarding the outcome of Ultraflex stent insertion in complex malignant airway stenoses is sparse...
  18. ncbi Feasibility of mobile cardiopulmonary exercise testing
    Adrian Attinger
    Pneumology, University Hospital Basel, Basel, Switzerland
    Swiss Med Wkly 136:13-8. 2006
    ..After validation in patients, MCPET could be used for a rational evaluation of cardiopulmonary capacity and work ability in selected patients...
  19. ncbi Design and validation of an interpretative strategy for cardiopulmonary exercise tests
    Andreas Schmid
    Division of Respiratory Medicine and Pulmonary Cell Research, University Hospital Basel, Basel, Switzerland
    Respirology 12:916-23. 2007
    ..At present, there is no consensus on the best interpretative strategy and none of the available algorithms have been validated. The aim of this study was to develop and validate a standardized strategy for the interpretation of CPET...
  20. ncbi B-type natriuretic peptide and C-terminal-pro-endothelin-1 for the prediction of severely impaired peak oxygen consumption
    M T Maeder
    Division of Cardiology, University Hospital Basel, Basel, Switzerland
    J Intern Med 265:604-15. 2009
    ....
  21. ncbi Pulmonary function in idiopathic pulmonary fibrosis and referral for lung transplantation
    N Mogulkoc
    North West Lung Research Centre, and Department of Pathology, South Manchester University Hospitals NHS Trust, Manchester, United Kingdom
    Am J Respir Crit Care Med 164:103-8. 2001
    ..A model based on a combination of DL(CO) percent predicted and HRCT-fibrosis score may optimize the timing of referral for transplantation...
  22. ncbi Array-based diagnostic gene-expression score for atopy and asthma
    Martin H Brutsche
    Department of Pneumology, University Hospital, Basel, Switzerland
    J Allergy Clin Immunol 109:271-3. 2002
    ..051). The CAGE score was able to quantify phenotype-specific alteration in gene expression of atopic individuals. The CAGE score might be used as a diagnostic tool or to monitor the effects and side effects of therapy...
  23. ncbi Systemic Th1- and Th2-gene signals in atopy and asthma
    Ladina Joos
    Division of Respiratory Medicine and Pulmonary Cell Research, University Hospital Basel, Switzerland
    Swiss Med Wkly 134:159-64. 2004
    ..In contrast, asthmatic subjects had normal Th1-gene expression but a constant upregulation of Th2-specific genes, leading to Th2-predominance...
  24. ncbi Reduced exposure to PM10 and attenuated age-related decline in lung function
    Sara H Downs
    Institute of Social and Preventive Medicine, University of Basel, Basel, Switzerland
    N Engl J Med 357:2338-47. 2007
    ..Air pollution has been associated with impaired health, including reduced lung function in adults. Moving to cleaner areas has been shown to attenuate adverse effects of air pollution on lung function in children but not in adults...
  25. ncbi Complementary and alternative medicine in asthma--safety, effectiveness and costs
    Martin H Brutsche
    Swiss Med Wkly 132:329-31. 2002