Research Topics
Genomes and Genes | Cathrin BriskenSummaryAffiliation: University of Lausanne Country: Switzerland Publications
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Publications
Hormonal control of alveolar development and its implications for breast carcinogenesisCathrin Brisken
Surgical Oncology, MGH Cancer Center, Harvard Medical School, Boston, Massachusetts 02114, USA
J Mammary Gland Biol Neoplasia 7:39-48. 2002..This paper focuses on this final stage of proliferation, the formation of alveolar structures and its control by systemic hormones...- Stem cells and the stem cell niche in the breast: an integrated hormonal and developmental perspectiveCathrin Brisken
NCCR Molecular Oncology, Swiss Institute for Experimental Cancer Research ISREC, 155 Chemin des Boveresses, Epalinges s Lausanne, CH 1066, Switzerland
Stem Cell Rev 3:147-56. 2007.... - Prolactin signaling and Stat5: going their own separate ways?Cathrin Brisken
Swiss Institute for Experimental Cancer Research, Epalinges, Switzerland
Breast Cancer Res 4:209-12. 2002..revealed defects in the epithelial architecture of the smallest ducts of Stat5ab-/- transplants not apparent in the PrlR-/- transplants, suggesting that Stat5 is more than a simple mediator of PrlR action... - IGF-2 is a mediator of prolactin-induced morphogenesis in the breastCathrin Brisken
Department of Surgical Oncology, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114, USA
Dev Cell 3:877-87. 2002..Thus, IGF-2 is a mediator of prolactin-induced alveologenesis; prolactin, IGF-2, and cyclin D1, all of which are overexpressed in breast cancers, are components of a developmental pathway in the mammary gland... - Amphiregulin is an essential mediator of estrogen receptor alpha function in mammary gland developmentLaura Ciarloni
Swiss Institute for Experimental Cancer Research, National Center of Competence in Research, Molecular Oncology, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
Proc Natl Acad Sci U S A 104:5455-60. 2007..Thus, amphiregulin is an important paracrine mediator of estrogen function specifically required for puberty-induced ductal elongation, but not for any earlier or later developmental stages... - Cyclin D1 enhances the response to estrogen and progesterone by regulating progesterone receptor expressionChuanwei Yang
Cancer Research Center at Massachusetts General Hospital, 55 Fruit Street, GRJ 9th floor, Boston, MA 02114, USA
Mol Cell Biol 30:3111-25. 2010..Additionally, its regulation of the progesterone receptor identifies a novel role for cyclin D1 in ovarian hormone control of breast development and breast carcinogenesis... - Paracrine signaling through the epithelial estrogen receptor alpha is required for proliferation and morphogenesis in the mammary glandSonia Mallepell
National Center of Competence in Research Molecular Oncology, Swiss Institute for Experimental Cancer Research, 155 Chemin des Boveresses, CH 1066 Epalinges s Lausanne, Switzerland
Proc Natl Acad Sci U S A 103:2196-201. 2006.... - Alveolar and lactogenic differentiationCathrin Brisken
National Center of Competence in Research NCCR Molecular Oncology, Swiss Institute for Experimental Cancer Research ISREC, 155 Chemin des Boveresses, CH 1066, Epalinges, Lausanne, Switzerland
J Mammary Gland Biol Neoplasia 11:239-48. 2006..The powerful tools of mouse genetics have been instrumental in uncovering many of the signaling components involved in controlling alveolar and lactogenic differentiation... - Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanismAyyakannu Ayyanan
Swiss Institute for Experimental Cancer Research, National Center of Competence in Research in Molecular Oncology, 155 Chemin des Boveresses, CH 1066 Epalinges Lausanne, Switzerland
Proc Natl Acad Sci U S A 103:3799-804. 2006.... - Control of hair follicle cell fate by underlying mesenchyme through a CSL-Wnt5a-FoxN1 regulatory axisBing Hu
Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
Genes Dev 24:1519-32. 2010..Thus, Notch/CSL signaling plays a unique function in control of hair follicle differentiation by the underlying mesenchyme, with Wnt5a signaling and FoxN1 as mediators... - Using gene expression arrays to elucidate transcriptional profiles underlying prolactin functionSandra Gass
Swiss Institute for Experimental Cancer Research, National Center of Competence in Research Molecular Oncology, Epalinges s/Lausanne, Switzerland
J Mammary Gland Biol Neoplasia 8:269-85. 2003..Some of the candidates have been implicated in tumorigenesis. The relevance and validation of microarray data, as well as comparison of the results obtained by different groups, will be discussed... - The signaling domain of the erythropoietin receptor rescues prolactin receptor-mutant mammary epitheliumCathrin Brisken
Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
Proc Natl Acad Sci U S A 99:14241-5. 2002.... - The epithelial-mesenchymal transition generates cells with properties of stem cellsSendurai A Mani
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
Cell 133:704-15. 2008..These findings illustrate a direct link between the EMT and the gain of epithelial stem cell properties... - An oestrogen-dependent model of breast cancer created by transformation of normal human mammary epithelial cellsStephan Duss
NCCR Molecular Oncology, Swiss Institute for Experimental Cancer Research ISREC, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
Breast Cancer Res 9:R38. 2007..To create an ERalpha-positive breast cancer model, we have forced normal HMECs derived from reduction mammoplasty tissue to express ERalpha in combination with other relevant breast cancer genes... - Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesisEmily Y Chu
Departments of Dermatology and Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Development 131:4819-29. 2004..WNT signals play similar roles in hair follicle formation and thus may be broadly required for induction of skin appendage morphogenesis... - Identification of molecular apocrine breast tumours by microarray analysisPierre Farmer
Swiss Institute of Bioinformatics, Lausanne, Switzerland
Oncogene 24:4660-71. 2005..Our data show that it is possible with microarray data to divide mammary tumour cells into three groups based on steroid receptor activity: luminal (ER+ AR+), basal (ER- AR-) and molecular apocrine (ER- AR+)... - p21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activationVikram Devgan
Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
Genes Dev 19:1485-95. 2005..Thus, p21 acts as a selective negative regulator of transcription and links the Notch and Wnt signaling pathways in keratinocyte growth control... - The Ret receptor tyrosine kinase pathway functionally interacts with the ERalpha pathway in breast cancerAnne Boulay
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
Cancer Res 68:3743-51. 2008..In summary, we showed that Ret is a novel proliferative pathway interacting with ER signaling in vitro. Expression of Ret in primary breast tumors suggests that Ret might be a novel therapeutic target in breast cancer...