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Genomes and Genes | Matthias BartonSummaryAffiliation: University Hospital Country: Switzerland Publications
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Publications
Endothelin, hypercholesterolemia and atherosclerosisMatthias Barton
Medical Policlinic, Department of Internal Medicine, University Hospital, , Switzerland
Coron Artery Dis 14:477-90. 2003- Endothelin: 20 years from discovery to therapyMatthias Barton
Klinik und Poliklinik für Innere Medizin, Departement fur Innere Medizin, Universitatsspital Zurich, Zurich, Switzerland
Can J Physiol Pharmacol 86:485-98. 2008..Possible future indications include resistant arterial hypertension, proteinuric renal disease, cancer, and connective tissue diseases... - Reversal of proteinuric renal disease and the emerging role of endothelinMatthias Barton
Department of Internal Medicine, Klinik und Poliklinik für Innere Medizin, Universitatsspital Zurich, Zurich, Switzerland
Nat Clin Pract Nephrol 4:490-501. 2008..Additional clinical studies are needed... - Fat intake modifies vascular responsiveness and receptor expression of vasoconstrictors: implications for diet-induced obesityAlexa L Mundy
Department of Medicine, Internal Medicine I, Medical Policlinic, University Hospital Zurich, Ramistrasse 100, CH 8091 Zurich, Switzerland
Cardiovasc Res 73:368-75. 2007..The aim of this study was to investigate the effects of dietary fat content on vasoreactivity and receptor expression at the level of gene and protein expression... - Impaired vascular function in normoglycemic mice prone to autoimmune diabetes: role of nitric oxideTobias Traupe
Department of Medicine, Internal Medicine I, Medical Policlinic, University Hospital Zurich, Switzerland
Eur J Pharmacol 557:161-7. 2007..Early proinflammatory activation due to iNOS in diabetes-prone NOD mice appears to be one of the mechanisms contributing to impaired vasoreactivity... - Regional heterogeneity of functional changes in conduit arteries after high-fat dietIndranil Bhattacharya
Department of Medicine, Internal Medicine I, Medical Policlinic, University Hospital, Zurich, Switzerland
Obesity (Silver Spring) 16:743-8. 2008..To determine effects of dietary fat content on vascular responses in different conduit arteries in mice... - Antioxidant activity and sex differences of acute vascular effects of amiodarone in advanced atherosclerosisTobias Traupe
Department of Internal Medicine, Internal Medicine I, Medical Policlinic, University Hospital Zurich, Zurich, Switzerland
J Cardiovasc Pharmacol 50:578-84. 2007..Antioxidant and vasodilator effects following amiodarone administration may contribute to its antiarrhythmic effects... - Differential effects of 17beta-estradiol on function and expression of estrogen receptor alpha, estrogen receptor beta, and GPR30 in arteries and veins of patients with atherosclerosisElvira Haas
Department of Internal Medicine, Internal Medicine I, Medical Policlinic, Zurich, Switzerland
Hypertension 49:1358-63. 2007..These data indicate that effects of natural estrogens in humans differ between arterial and venous vascular beds, which may contribute to the vascular risks associated with menopause or hormone therapy... - Downregulation of renal endothelin-converting enzyme 2 expression in early autoimmune diabetesJana Ortmann
Medical Policlinic, Department of Internal Medicine, , Switzerland
Exp Biol Med (Maywood) 231:1030-3. 2006..Blockade of ET(A) receptors inhibits diabetes-associated gene regulation and delays the onset of diabetes, suggesting its therapeutic potential for the treatment of autoimmune forms of diabetes... - Upregulation of endothelin converting enzyme-1 in host liver during chronic cardiac allograft rejectionThomas Lattmann
Medical Policlinic, Department of Medicine, University Hospital, , , Switzerland
Exp Biol Med (Maywood) 231:899-901. 2006..Because the liver represents both a key organ for cytokine production and for endothelin metabolism, increased hepatic ECE-1-mediated ET-1 synthesis may contribute to host responses and cytokine production during allograft rejection... - Endothelin ETA receptor blockade with darusentan increases sodium and potassium excretion in aging ratsTobias Traupe
, Medizinische Poliklinik, , , Switzerland
J Cardiovasc Pharmacol 47:456-62. 2006..These findings may provide new pathogenetic links between aging and sodium sensitivity... - Transcriptional regulation of vascular bone morphogenetic protein by endothelin receptors in early autoimmune diabetes mellitusPhilipp C Nett
Medical Policlinic, , Switzerland
Life Sci 78:2213-8. 2006.... - Endothelin stimulates vascular hydroxyl radical formation: effect of obesityAlexa L Mundy
Molecular Internal Medicine, Medical Policlinic, Department of Internal Medicine, University Hospital Zurich, Zurich, Switzerland
Am J Physiol Regul Integr Comp Physiol 293:R2218-24. 2007.... - Amiodarone acutely inhibits vascular activity of endothelin-converting enzymesTobias Traupe
Medizinishe Poliklinik and Departement für Innere Medizin, Universitatsspital Zurich, Zurich, Switzerland
J Cardiovasc Pharmacol 44:S113-6. 2004..Acute effects of amiodarone on endothelin-converting enzymes may contribute to its antiarrhythmic properties... - Regulatory role of G protein-coupled estrogen receptor for vascular function and obesityElvira Haas
Departement fur Innere Medizin, Klinik und Poliklinik für Innere Medizin, Universitatsspital Zurich, Ramistrasse 100, CH 8091 Zurich, Switzerland
Circ Res 104:288-91. 2009..Deletion of the GPER gene in mice abrogates vascular effects of GPER activation and is associated with visceral obesity. These findings suggest novel roles for GPER in protecting from cardiovascular disease and obesity... - Dilation of epicardial coronary arteries by the G protein-coupled estrogen receptor agonists G-1 and ICI 182,780Matthias R Meyer
Molecular Internal Medicine, University of Zurich, Zurich, Switzerland
Pharmacology 86:58-64. 2010..s.). In summary, these findings provide evidence for direct and indirect coronary artery dilator effects of GPER independent of ERalpha and ERbeta, and are the first demonstration of arterial vasodilation in response to ICI 182,780... - Fat intake and cardiovascular responseMarlen Damjanovic
Klinik und Poliklinik für Innere Medizin, Departement fur Innere Medizin, Universitatsspital Zurich, Ramistrasse 100, 8091 Zurich, Switzerland
Curr Hypertens Rep 10:25-31. 2008..The beneficial effects of vasoactive mediators on vascular function could play a role for susceptibility to obesity-dependent hypertension, which is present in many, but not all, obese patients... - Early aging and anatomic heterogeneity determine cyclooxygenase-mediated vasoconstriction to angiotensin II in miceMartin Kretz
Department of Medicine, Internal Medicine I, Medical Policlinic, University Hospital, , Switzerland
J Cardiovasc Pharmacol 48:30-3. 2006..AngII-induced vasoconstriction in vessels more distal to the heart such as femoral and renal arteries is only in part mediated by COX-dependent mechanisms that remain unaffected by early aging... - Endothelin inhibition delays onset of hyperglycemia and associated vascular injury in type I diabetes: evidence for endothelin release by pancreatic islet beta-cellsJana Ortmann
Medical Policlinic, University Hospital Zurich, Switzerland
Biochem Biophys Res Commun 334:689-95. 2005..These data suggest a critical role for ET(A) receptor signaling in the development of autoimmune forms of diabetes and the early vascular injury associated with it... - Anatomically distinct activation of endothelin-3 and the L-arginine/nitric oxide pathway in the kidney with advanced agingThomas Lattmann
Medical Policlinic, Department of Medicine, University Hospital, Zurich, Switzerland
Biochem Biophys Res Commun 327:234-41. 2005..These findings could be important for pathologies and possibly therapy associated with renal aging... - Activation of pro-inflammatory and anti-inflammatory cytokines in host organs during chronic allograft rejection: role of endothelin receptor signalingThomas Lattmann
Medical Policlinic, Department of Medicine, University Hospital, , Switzerland
Am J Transplant 5:1042-9. 2005..These data provide evidence for distinct pro-inflammatory local activation in host organs during chronic rejection and suggest a role for ET(A) receptors contributing to regulation of cytokine plasma levels and transcriptional activity... - Obesity and aging: determinants of endothelial cell dysfunction and atherosclerosisMatthias Barton
Molecular Internal Medicine, University of Zurich, LTK Y44 G22, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
Pflugers Arch 460:825-37. 2010..Pathomechanisms as well as the clinical issues of obesity- and aging-associated vascular changes important for atherosclerosis development and prevention are discussed... - Non-genomic regulation of vascular cell function and growth by estrogenMatthias R Meyer
Departement fur Innere Medizin, Klinik und Poliklinik für Innere Medizin, Universitatsspital, Zurich, Switzerland
Mol Cell Endocrinol 308:9-16. 2009..This review discusses recent advances in understanding of the mechanisms of non-genomic estrogen receptor signaling in the vascular wall... - Obesity-associated activation of angiotensin and endothelin in the cardiovascular systemMatthias Barton
Medical Policlinic, Department of Internal Medicine, University Hospital Zurich, Ramistrasse 100, CH 8091 Zurich, Switzerland
Int J Biochem Cell Biol 35:826-37. 2003.... - Upregulation of vascular ET(B) receptor gene expression after chronic ET(A) receptor blockade in prediabetic NOD miceJana Ortmann
Medical Policlinic, University Hospital Zurich, Zurich, Switzerland
J Cardiovasc Pharmacol 44:S105-8. 2004..Furthermore, ETA receptor blockade is effective in increasing ETB receptor gene expression, suggesting a potential role for endothelin ETA antagonists in the treatment of type 1 diabetes... - Acute effects of 17 beta-oestradiol on functional activity of endothelin-converting enzymes in human arteries and veinsAndres Heigl
Medical Policlinic and Clinical Atherosclerosis Research Laboratory, Medical Policlinic, Department of Internal Medicine, University Hospital, , , Switzerland
Clin Sci (Lond) 103:438S-441S. 2002..Whether changes in FEA play a role in the vascular effects of 17 beta-oestradiol in vivo remains to be determined... - Need for research on estrogen receptor function: importance for postmenopausal hormone therapy and atherosclerosisMatthias R Meyer
Departement fur Innere Medizin, Molekulare Innere Medizin, Klinik und Poliklinik für Innere Medizin, Universitatsspital, Zurich, Switzerland
Gend Med 5:S19-33. 2008..Although rare in premenopausal women, its incidence rises sharply after menopause, indicating atheroprotective effects of endogenous estrogens... - Obesity increases prostanoid-mediated vasoconstriction and vascular thromboxane receptor gene expressionTobias Traupe
Medical Policlinic and Clinical Atherosclerosis Research Laboratory, Department of Internal Medicine, University Hospital Zurich, Zurich, Switzerland
J Hypertens 20:2239-45. 2002..Vasoconstrictor prostanoids have been implicated in abnormal vasomotion in atherosclerosis and hypertension... - Endothelial therapy of atherosclerosis and its risk factorsTobias Traupe
Medical Policlinic, Department of Medicine, , Switzerland
Curr Vasc Pharmacol 1:111-21. 2003..These treatments also have therapeutic benefit for patients at risk or with overt atherosclerosis, to reduce vascular and myocardial complications of this disease... - Rapid endocytosis of copper-zinc superoxide dismutase into human endothelial cells: role for its vascular activityErnst R Waelti
Department of Medicine, Internal Medicine I, Medical Policlinic, University Hospital Zurich, Zurich, Switzerland
Pharmacology 78:198-201. 2006..Intracellular uptake via endocytosis may contribute to the vascular effects of CuZn-SOD, including vasodilation, and is likely to play a role in regulation of vascular tone and diseases such as atherosclerosis... - Vascular consequences of menopause and hormone therapy: importance of timing of treatment and type of estrogenRaghvendra K Dubey
Center for Clinical Pharmacology, University of Pittsburgh, Pittsburgh, PA, USA
Cardiovasc Res 66:295-306. 2005.... - Marked heterogeneity of endothelin-mediated contractility and contraction dynamics in mouse renal and femoral arteriesCorinne C Widmer
Medical Policlinic, , Switzerland
Exp Biol Med (Maywood) 231:777-81. 2006..These findings may be important for studying the effects of endothelin in mouse models of human disease... - Recent developments on endothelin antagonists as immunomodulatory drugs--from infection to transplantation medicinePhilipp C Nett
Department of Medicine, Internal Medical I, Medical Policlinic, , , , Switzerland
Recent Patents Cardiovasc Drug Discov 1:265-76. 2006.... - The G protein-coupled estrogen receptor GPER/GPR30 as a regulator of cardiovascular functionMatthias R Meyer
Molecular Internal Medicine, University of Zurich, Zurich, Switzerland
Vascul Pharmacol 55:17-25. 2011.... - Role of podocytes for reversal of glomerulosclerosis and proteinuria in the aging kidney after endothelin inhibitionJana Ortmann
Medizinische Poliklinik, , Switzerland
Hypertension 44:974-81. 2004..The results further suggest that age-dependent glomerulosclerosis is not merely a "degenerative" but a reversible process locally confined to the glomerulus involving recovery of podocytes from previous injury... - Lovastatin stimulates human vascular smooth muscle cell expression of bone morphogenetic protein-2, a potent inhibitor of low-density lipoprotein-stimulated cell growthLuca Emmanuele
Department of Internal Medicine, Medical Policlinic, , , , Switzerland
Biochem Biophys Res Commun 302:67-72. 2003..05). Induction of BMPs and subsequent inhibition of VSMC growth and/or induction of vascular bone formation could contribute to the mechanisms by which statins increase plaque stability in patients with coronary atherosclerosis... - Gender differences of cardiovascular disease: new perspectives for estrogen receptor signalingMatthias R Meyer
Department of Internal Medicine, Medical Policlinic, University Hospital Zurich, Switzerland
Hypertension 47:1019-26. 2006 - Oral contraceptives and the risk of thrombosis and atherosclerosisMatthias Barton
Department of Internal Medicine, Medical Policlinic, and Clinical Atherosclerosis Laboratory, University Hospital Zurich, Ramistrasse 100, CH 8091 Zürich Switzerland
Expert Opin Investig Drugs 11:329-32. 2002..This article discusses mechanistic and clinical issues and reviews the need for novel approaches targeting the considerable side effects in order to reduce cardiovascular morbidity in women using oral contraceptives... - Beneficial cardiovascular effects of endothelin ET(A) receptor blockade in established long-term heart failure after myocardial infarctionDiana Vetter
Medizinische Poliklinik, , , , Switzerland
Exp Biol Med (Maywood) 231:857-60. 2006..The changes observed occurred independently of tissue ET-1 concentrations and heart rate, suggesting mechanisms independent of local cardiac or pulmonary ET-1 synthesis, which are yet to be identified... - Increased expression of endothelin-converting enzyme-1 in failing human myocardiumHenning Morawietz
Institute of Pathophysiology, Faculty of Medicine, Martin Luther University Halle Wittenberg, Magdeburger Strasse 18, D 06097 Halle, Germany
Clin Sci (Lond) 103:237S-240S. 2002..Pharmacological inhibition of augmented ECE-1 expression might provide a new therapeutic perspective in the treatment of heart failure... - Effects of obesity on endothelium-dependent reactivity during acute nitric oxide synthase inhibition: modulatory role of endothelinTobias Traupe
Department of Internal Medicine and Medical Policlinic, , , Switzerland
Clin Sci (Lond) 103:13S-15S. 2002..This effect can be completely prevented by chronic ET(A) receptor blockade, suggesting that endothelin modulates increased endothelium-dependent vasoconstriction in obesity... - Postmenopausal hormone-replacement therapyMatthias Barton
N Engl J Med 346:63-5. 2002 - Inflammation and atherosclerosisMatthias Barton
Circ Res 101:750-1. 2007 - Hormone replacement therapy and atherosclerosis in postmenopausal women: does aging limit therapeutic benefits?Matthias Barton
Arterioscler Thromb Vasc Biol 27:1669-72. 2007 - Role of endothelin during experimental Trypanosoma cruzi infection in ratsElizabeth R S Camargos
Department of Morphology, , Federal University of Minas Gerais, , Belo Horizonte, Minas Gerais, Brazil
Clin Sci (Lond) 103:64S-67S. 2002..cruzi infection. Moreover, these data suggest that endothelin-1 is a mediator of impaired endothelium-dependent vasomotion in the coronary microcirculation associated with acute T. cruzi infection... - Protease-activated receptors and EDHF: the icing on the cake?Tobias Traupe
Cardiovasc Res 61:645-7. 2004 - Protective role of ETA endothelin receptors during the acute phase of Trypanosoma cruzi infection in ratsElizabeth R S Camargos
Departamento de Morfologia, , Universidade Federal de Minas Gerais (UFMG, Av. Antonio Carlos 6627, P.O. Box 486, CEP: 31270-901 Belo Horizonte, MG, Brazil
Microbes Infect 6:650-6. 2004..Impairment of the endothelium-dependent vasodilatation favors hazardous effects. However, blocking endothelin ET(A) receptors can prevent the latter... - In-vivo interaction of nitric oxide and endothelinThomas Lattmann
J Hypertens 22:1839-40; author reply 1840-3. 2004 - Ageing as a determinant of renal and vascular disease: role of endothelial factorsMatthias Barton
Nephrol Dial Transplant 20:485-90. 2005 - Native and oxidized low-density lipoproteins stimulate endothelin-converting enzyme-1 expression in human endothelial cellsBernd Niemann
Department of Vascular Endothelium and Microcirculation, Medical Faculty Carl Gustav Carus, University of Technology Dresden, D 01307 Dresden, Germany
Biochem Biophys Res Commun 334:747-53. 2005..Our data provide evidence for a new mechanism how increased LDL plasma levels might contribute to enhanced endothelin-1 release in patients with hypercholesterolemia... - Upregulation of endothelin receptor B in human endothelial cells by low-density lipoproteinsGregor Muller
Department of Vascular Endothelium and Microcirculation, University of Technology Dresden, Fetscherstrasse 74, D-01307 Dresden, Germany
Exp Biol Med (Maywood) 231:766-71. 2006..Given the nitric oxide-releasing capacity of endothelial ET(B) receptors, this effect may represent a possible vasoprotective mechanism... - Role of endothelin receptors for renal protection and survival in hypertension: waiting for clinical trialsMatthias Barton
Hypertension 48:834-7. 2006 - Distinct roles of estrogen receptors alpha and beta mediating acute vasodilation of epicardial coronary arteriesTobias Traupe
University Hospital Zurich, Ramistrasse 100, CH 8091 Zurich, Switzerland
Hypertension 49:1364-70. 2007..The findings indicate that coronary vascular effects of sex hormones differ with regard to affinity to ERalpha and ERbeta, which will contribute to beneficial and adverse effects of hormone replacement therapy... - Chronic ET(A) receptor blockade prevents endothelial dysfunction of small arteries in apolipoprotein E-deficient miceMatthias Barton
Cardiovascular Research, Institute of Physiology, , , , Switzerland
Cardiovasc Res 53:487-95. 2002..Chronic ET(A) receptor blockade may provide a new therapeutic approach to improve NO-mediated endothelium-dependent vasomotion in small arteries...