Research Topics
Species | Giandomenica IezziSummaryAffiliation: Swiss Federal Institute of Technology Country: Switzerland Publications
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Detail Information
Publications
Lymph node resident rather than skin-derived dendritic cells initiate specific T cell responses after Leishmania major infectionGiandomenica Iezzi
Institute of Integrative Biology, Molecular Biomedicine, Swiss Federal Institute of Technology, Wagistrasse 27, 8952 Zurich Schlieren, Switzerland
J Immunol 177:1250-6. 2006..Furthermore, prevention of migration through early removal of the infection site did not affect Ag presentation by CD11c(high) CD11b(high) DCs and activation of Leishmania major-specific naive CD4+ T cells in vivo...- CD40-CD40L cross-talk integrates strong antigenic signals and microbial stimuli to induce development of IL-17-producing CD4+ T cellsGiandomenica Iezzi
Institute of Integrative Biology, Molecular Biomedicine, ETH Zurich, Switzerland
Proc Natl Acad Sci U S A 106:876-81. 2009..Our data demonstrate that CD40-CD40L cross-talk is important for Th17 development by translating strong T cell receptor and microbial stimuli into IL-6 production... - GM-CSF mediates autoimmunity by enhancing IL-6-dependent Th17 cell development and survivalIvo Sonderegger
Institute of Integrative Biology, Molecular Biomedicine, ETH Zurich, 8952 Zurich, Switzerland
J Exp Med 205:2281-94. 2008..These results suggest a novel role for GM-CSF in promoting generation and maintenance of Th17 cells by regulation of IL-6 and IL-23 in vivo... - Type 2 cytotoxic T lymphocytes modulate the activity of dendritic cells toward type 2 immune responsesGiandomenica Iezzi
Cancer Immunotherapy and Gene Therapy Program, Istituto Scientifico H San Raffaele, Via Olgettina 58, 20132 Milan, Italy
J Immunol 177:2131-7. 2006..The type 2 loop may at least in part explain the unexpected high frequency of type 2 cells during a chronic exposure to the Ag... - Prolonged exposure of dendritic cells to maturation stimuli favors the induction of type-2 cytotoxic T lymphocytesAndrea Boni
Cancer Immunotherapy and Gene Therapy Program, Istituto Scientifico H San Raffaele, Milan, Italy
Eur J Immunol 36:3157-66. 2006..Our results indicate that polarization of naive CD8(+) T cells to Tc2 cells is dependent on the amount of time DC have been exposed to maturation stimuli, and might be favored in late and/or chronic phases of an immune response... - Tick saliva inhibits dendritic cell migration, maturation, and function while promoting development of Th2 responsesAnna Skallová
Institute of Parasitology, Biology Centre AS CR, Branisovska 31, Ceske Budejovice, Czech Republic
J Immunol 180:6186-92. 2008..Given the role of DCs as the key instigators of adaptive immune responses, alteration of their function might represent a major mechanism of tick-mediated immune evasion... - Activation of dendritic cells through the interleukin 1 receptor 1 is critical for the induction of autoimmune myocarditisUrs Eriksson
Medicine A, University Hospital, CH 4031 Basel, Switzerland
J Exp Med 197:323-31. 2003..Thus, IL-1R1 triggering is required for efficient activation of dendritic cells, which is in turn a prerequisite for induction of autoreactive CD4(+) T cells and autoimmunity... - Critical impact of the kinetics of dendritic cells activation on the in vivo induction of tumor-specific T lymphocytesAnnalisa Camporeale
Cancer Immunotherapy and Gene Therapy Program, Istituto Scientifico H San Raffaele, 20132 Milan, Italy
Cancer Res 63:3688-94. 2003..Our data are relevant for the design of DC-based vaccines... - Efficient stimulation of T cell responses by human IFN-alpha-induced dendritic cells does not require Toll-like receptor triggeringLaura Bracci
Institute for Surgical Research and Hospital Management, DBM, University Hospital, Basel, Switzerland
J Immunother 31:466-74. 2008....