Luca Giovanella

Summary

Affiliation: Oncology Institute of Southern Switzerland
Country: Switzerland

Publications

  1. ncbi 99mTc-sestamibi imaging and bone marrow karyotyping in the assessment of multiple myeloma and MGUS
    Luca Giovanella
    Department of Nuclear Medicine, Oncology Institute of Southern Switzerland, Bellinzona, CHUV University Hospital, Lausanne, Switzerland
    Nucl Med Commun 29:535-41. 2008
  2. ncbi Serum procalcitonin and calcitonin normal values before and after calcium gluconate infusion
    L Giovanella
    Department of Nuclear Medicine and Thyroid Centre, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
    Exp Clin Endocrinol Diabetes 120:169-70. 2012
  3. ncbi Relationship between serum thyroglobulin and (18) FDG-PET/CT in (131) I-negative differentiated thyroid carcinomas
    Luca Giovanella
    Department of Nuclear Medicine and Thyroid Diseases Centre, Oncology Institute of Southern Switzerland, Via Ospedale 12, CH 6500 Bellinzona, Switzerland
    Head Neck 34:626-31. 2012
  4. ncbi Multi-field-of-view SPECT is superior to whole-body scanning for assessing metastatic bone disease in patients with prostate cancer
    Luca Giovanella
    Department of Nuclear Medicine and PET CT Center, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
    Tumori 97:629-33. 2011
  5. ncbi (99m)Tc-sestamibi scanning in thyroid nodules with nondiagnostic cytology
    Luca Giovanella
    Department of Nuclear Medicine, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
    Head Neck 32:607-11. 2010
  6. ncbi Postsurgery serum thyroglobulin disappearance kinetic in patients with differentiated thyroid carcinoma
    Luca Giovanella
    Department of Nuclear Medicine, Oncology Institute of Southern Switzerland, Bellinzona
    Head Neck 32:568-71. 2010
  7. ncbi Unstimulated high sensitive thyroglobulin measurement predicts outcome of differentiated thyroid carcinoma
    Luca Giovanella
    Department of Nuclear Medicine, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
    Clin Chem Lab Med 47:1001-4. 2009
  8. ncbi Heterophile antibodies may falsely increase or decrease thyroglobulin measurement in patients with differentiated thyroid carcinoma
    Luca Giovanella
    Department of Nuclear Medicine and Thyroid Centre, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
    Clin Chem Lab Med 47:952-4. 2009
  9. ncbi [Thyroid nodules: clinical management and differential diagnosis]
    L Giovanella
    Istituto Oncologico della Svizzera Italiana, Medicina Nucleare, Bellinzona
    Praxis (Bern 1994) 98:83-90. 2009
  10. ncbi Thyroglobulin measurement on fine-needle washout fluids: Influence of sample collection methods
    Luca Giovanella
    Department of Nuclear Medicine and Thyroid Unit, Oncology Institute of Southern Switzerland, CH 6500 Bellinzona, Switzerland
    Diagn Cytopathol 37:42-4. 2009

Collaborators

Detail Information

Publications48

  1. ncbi 99mTc-sestamibi imaging and bone marrow karyotyping in the assessment of multiple myeloma and MGUS
    Luca Giovanella
    Department of Nuclear Medicine, Oncology Institute of Southern Switzerland, Bellinzona, CHUV University Hospital, Lausanne, Switzerland
    Nucl Med Commun 29:535-41. 2008
    ..This study was undertaken to evaluate the role of Tc-sestamibi imaging and cytogenetic analysis in prognosis prediction of MGUS and multiple myeloma...
  2. ncbi Serum procalcitonin and calcitonin normal values before and after calcium gluconate infusion
    L Giovanella
    Department of Nuclear Medicine and Thyroid Centre, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
    Exp Clin Endocrinol Diabetes 120:169-70. 2012
    ..To evaluate and compare serum procalcitonin (PCT) and calcitonin (hCT) levels before and after stimulation with intravenous calcium gluconate in selected thyroid healthy subjects...
  3. ncbi Relationship between serum thyroglobulin and (18) FDG-PET/CT in (131) I-negative differentiated thyroid carcinomas
    Luca Giovanella
    Department of Nuclear Medicine and Thyroid Diseases Centre, Oncology Institute of Southern Switzerland, Via Ospedale 12, CH 6500 Bellinzona, Switzerland
    Head Neck 34:626-31. 2012
    ....
  4. ncbi Multi-field-of-view SPECT is superior to whole-body scanning for assessing metastatic bone disease in patients with prostate cancer
    Luca Giovanella
    Department of Nuclear Medicine and PET CT Center, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
    Tumori 97:629-33. 2011
    ....
  5. ncbi (99m)Tc-sestamibi scanning in thyroid nodules with nondiagnostic cytology
    Luca Giovanella
    Department of Nuclear Medicine, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
    Head Neck 32:607-11. 2010
    ..Our aim in this study was to assess the relevance of (99m)Tc-sestaMIBI (MIBI) scan in the diagnostic evaluation of thyroid nodules with nondiagnostic cytology...
  6. ncbi Postsurgery serum thyroglobulin disappearance kinetic in patients with differentiated thyroid carcinoma
    Luca Giovanella
    Department of Nuclear Medicine, Oncology Institute of Southern Switzerland, Bellinzona
    Head Neck 32:568-71. 2010
    ..Heterogeneous results were previously reported, then we aimed to evaluate the postsurgery Tg kinetic in a large group of patients with DTC...
  7. ncbi Unstimulated high sensitive thyroglobulin measurement predicts outcome of differentiated thyroid carcinoma
    Luca Giovanella
    Department of Nuclear Medicine, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
    Clin Chem Lab Med 47:1001-4. 2009
    ..Here, we prospectively evaluated the impact of unstimulated high-sensitive Tg measurement in early and long-term outcome of patients with DTC...
  8. ncbi Heterophile antibodies may falsely increase or decrease thyroglobulin measurement in patients with differentiated thyroid carcinoma
    Luca Giovanella
    Department of Nuclear Medicine and Thyroid Centre, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
    Clin Chem Lab Med 47:952-4. 2009
    ..To examine the prevalence of significant interference from heterophile antibodies (HAb) in the measurement of serum thyroglobulin (Tg), we evaluated a large cohort of samples from patients with differentiated thyroid carcinoma (DTC)...
  9. ncbi [Thyroid nodules: clinical management and differential diagnosis]
    L Giovanella
    Istituto Oncologico della Svizzera Italiana, Medicina Nucleare, Bellinzona
    Praxis (Bern 1994) 98:83-90. 2009
    ..A radioisotope scan is useful if the TSH is low or suppressed to detect (benign) functioning nodules...
  10. ncbi Thyroglobulin measurement on fine-needle washout fluids: Influence of sample collection methods
    Luca Giovanella
    Department of Nuclear Medicine and Thyroid Unit, Oncology Institute of Southern Switzerland, CH 6500 Bellinzona, Switzerland
    Diagn Cytopathol 37:42-4. 2009
    ..A collection of standardized washout fluids volume into plain serum tubes is highly recommended. Serum separator tubes and lithium-heparin tubes may lower measured FNA-Tg concentration...
  11. ncbi Serum calcitonin-negative medullary thyroid carcinoma: role of CgA and CEA as complementary markers
    L Giovanella
    Nuclear Medicine and Thyroid Unit, Oncology Institute of Southern Switzerland, Bellinzona Switzerland
    Int J Biol Markers 23:129-31. 2008
    ..Finally, serum aliquots must be stored before thyroid surgery in order to measure circulating forms of complementary markers found by tissue immunostaining (CEA and CgA)...
  12. ncbi Circulating procalcitonin in aseptic carcinoma patients: a specificity study with (18)F-fluorodeoxyglucose positron-emission tomography/computed tomography as benchmark
    Luca Giovanella
    Department of Nuclear Medicine and PET CT Center, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
    Clin Chem Lab Med 48:1163-5. 2010
    ..The goal of the study was to evaluate the specificity of serum procalcitonin (PCT) in a large cohort of patients with solid carcinomas at different stages...
  13. ncbi Spurious increase in serum chromogranin A: the role of heterophilic antibodies
    Luca Giovanella
    Department of Nuclear Medicine, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
    Clin Chem Lab Med 48:1497-9. 2010
    ..The aim of the study was to examine the prevalence of heterophilic antibody (HAb) interference on serum chromogranin A (CgA) measurements...
  14. ncbi Postsurgical thyroid remnant estimation by (??m) Tc-pertechnetate scintigraphy predicts radioiodine ablation effectiveness in patients with differentiated thyroid carcinoma
    Luca Giovanella
    Department of Nuclear Medicine, PET CT Center and Thyroid Unit, Oncology Institute of Southern Switzerland, CH 6500 Bellinzona, Switzerland
    Head Neck 33:552-6. 2011
    ....
  15. ncbi Evaluation of serum parathyroid hormone-related peptide in hyperthyroid patients
    Luca Giovanella
    Nuclear Medicine and Thyroid Centre, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
    Eur J Clin Invest 41:93-7. 2011
    ..Hypercalcemia occurs in 10-20% of patients with hyperthyroidism, but its pathogenesis is still unclear...
  16. ncbi Undetectable thyroglobulin in patients with differentiated thyroid carcinoma and residual radioiodine uptake on a postablation whole-body scan
    Luca Giovanella
    Department of Nuclear Medicine and Thyroid Centre, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
    Clin Nucl Med 36:109-12. 2011
    ..To assess the impact of laboratory interferences and pitfalls in producing falsely undetectable Tg in differentiated thyroid carcinoma (DTC) patients with residual iodine-avid thyroid tissue on a posttreatment whole-body scan (PT-WBS)...
  17. ncbi Comparison of thyroglobulin antibody interference in first- and second-generation thyroglobulin immunoassays
    Luca Giovanella
    Nuclear Medicine and Thyroid Centre, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
    Clin Chem Lab Med 49:1025-7. 2011
    ..This study evaluated the impact of thyroglobulin (Tg) antibodies (TgAb) interference on Tg measurements performed with a second-generation immunometric Tg assay, in comparison to a first-generation method...
  18. ncbi 18FDG-positron emission tomography/computed tomography (PET/CT) scanning in thyroid nodules with nondiagnostic cytology
    Luca Giovanella
    Department of Nuclear Medicine and Thyroid Centre, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
    Clin Endocrinol (Oxf) 74:644-8. 2011
    ..To assess the role of positron emission tomography/computed tomography (PET/CT) scans with (18) FDG ((18)FDG-PET/CT) in the evaluation of thyroid nodules with nondiagnostic cytology...
  19. ncbi Thyroid remnant estimation by Tc-99m-sestamibi scanning predicts the effectiveness of rhTSH-stimulated I-131 ablation in patients with differentiated thyroid carcinoma
    Luca Giovanella
    Department of Nuclear Medicine, PET CT Center and Thyroid Unit, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
    Clin Nucl Med 36:781-5. 2011
    ....
  20. ncbi Thyroglobulin and thyroglobulin autoantibodies measurement using the automated KRYPTOR® platform in patients with differentiated thyroid carcinoma
    L Giovanella
    Department of Nuclear Medicine and Thyroid Centre, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
    Horm Metab Res 43:728-30. 2011
    ..However, since quantitative discordances still occurred in some patients a re-baseline of TgAb positive patients is strongly supported before changing the TgAb assay method...
  21. ncbi Highly sensitive thyroglobulin measurements in differentiated thyroid carcinoma management
    Luca Giovanella
    Department of Nuclear Medicine, PET Center and Thyroid Unit, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
    Clin Chem Lab Med 46:1067-73. 2008
    ..This will result in a limited follow-up protocol, warranting the detection of recurrences of differentiated thyroid cancer and reducing patient burden and medical costs...
  22. ncbi Thyroglobulin assay during thyroxine treatment in low-risk differentiated thyroid cancer management: comparison with recombinant human thyrotropin-stimulated assay and imaging procedures
    Luca Giovanella
    Cantonal Department of Nuclear Medicine and Thyroid Diseases, Oncology Institute of Southern Switzerland, 6500 Bellinzona, Switzerland
    Clin Chem Lab Med 44:648-52. 2006
    ..The present study was undertaken to compare onT(4)-TG with the rhTSH-stimulated TG assay (rhTSH-TG), (131)I scanning and neck ultrasound (US) with fine-needle aspiration biopsy...
  23. ncbi Chromogranin A immunoradiometric assay in diagnosis of pheochromocytoma: comparison with plasma metanephrines and 123I-MIBG scan
    L Giovanella
    Division of Nuclear Medicine and Molecular Imaging, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
    Q J Nucl Med Mol Imaging 50:344-7. 2006
    ..The aim of this study is to investigate the diagnostic performance of serum chromogranin A (CgA) and plasma metanephrines (MN) assays in the diagnosis of pheochromocytoma...
  24. ncbi Spurious hypercalcitoninemia and heterophilic antibodies in patients with thyroid nodules
    Luca Giovanella
    Department of Nuclear Medicine and Thyroid Centre, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
    Head Neck 33:95-7. 2011
    ..The purpose of our study was to examine the prevalence of significant heterophilic antibody (HAb) interferences in serum calcitonin measurement in a large cohort of patients with thyroid nodules...
  25. ncbi Diagnostic value of serum chromogranin-A combined with MIBG scintigraphy inpatients with adrenal incidentalomas
    L Giovanella
    Department of Nuclear Medicne, Oncology Institute of Southerm Switzerland, Bellinzona, Switzerland
    Q J Nucl Med Mol Imaging 52:84-88. 2008
    ..Chromogranin-A (CgA) is a member of the granin family contained in secretory vesicles of chromaffin system. This study investigated the performance of serum CgA in detecting or excluding pheochromocytoma among patients with AI...
  26. ncbi Preoperative undetectable serum thyroglobulin in differentiated thyroid carcinoma: incidence, causes and management strategy
    Luca Giovanella
    Nuclear Medicine and Thyroid Unit, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
    Clin Endocrinol (Oxf) 67:547-51. 2007
    ..Clearly, a negative Tg measurement may falsely reassure both the patient and the clinician in these cases...
  27. ncbi Imaging in endocrinology: Langherans cell histiocytosis of the thyroid gland detected by 18FDG-PET/CT
    Luca Giovanella
    Department of Nuclear Medicine, Oncology Institute of Southern Switzerland, Via Ospedale 12, CH-6500 Bellinzona, Switzerland
    J Clin Endocrinol Metab 92:2866-7. 2007
  28. ncbi Redefining functional sensitivity of thyroglobulin assay on Immulite platform: implications in thyroid cancer management
    Luca Giovanella
    Department of Nuclear Medicine, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
    Clin Chem Lab Med 45:1523-4. 2007
    ..In conclusion, the Immulite Tg assay showed a lower functional sensitivity than expected and performed comparably to high-sensitive immunoradiometric assay in patients with thyroid carcinoma...
  29. ncbi Thyroglobulin measurement before rhTSH-aided 131I ablation in detecting metastases from differentiated thyroid carcinoma
    Luca Giovanella
    Department of Nuclear Medicine and Thyroid Unit, Oncology Institute of Southern Switzerland, CH 6500 Bellinzona, Switzerland
    Clin Endocrinol (Oxf) 69:659-63. 2008
    ..The present study was undertaken to evaluate if post-thyroidectomy Tg values, measured before rhTSH-stimulated radioiodine ablation is of prognostic value in patients affected by DTC...
  30. ncbi Circulating cytokeratin 19 fragments in patients with benign nodules and carcinomas of the thyroid gland
    L Giovanella
    Department of Nuclear Medicine and Thyroid Unit, Oncology Institute of Southern Switzerland, Bellinzona Switzerland
    Int J Biol Markers 23:54-7. 2008
    ..Additionally, a role of Cyfra 21.1 as a dedifferentiation marker in patients with classical differentiated thyroid carcinomas may be postulated and should be explored by further focused studies...
  31. ncbi Second-generation thyrotropin receptor antibodies assay and quantitative thyroid scintigraphy in autoimmune hyperthyroidism
    L Giovanella
    Department of Nuclear Medicine, PET CT Center and Thyroid Unit, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
    Horm Metab Res 40:484-6. 2008
    ..The role of baseline TRAb measurement by second-generation assays to predict patients' outcome needs to be further evaluated and compared with TcTUs in prospective studies...
  32. ncbi Thyroglobulin assay 4 weeks after thyroidectomy predicts outcome in low-risk papillary thyroid carcinoma
    Luca Giovanella
    Division of Nuclear Medicine and Thyroid Unit, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
    Clin Chem Lab Med 43:843-7. 2005
    ..However, thyroglobulin assay performed after surgery but before radioiodine treatment has been proven to be useful in predicting the presence/absence of distant metastasis...
  33. ncbi Symptomatic sternal metastasis mimicking cardiac angina discovered by Tc-99m sestamibi myocardial perfusion scintigraphy
    Luca Ceriani
    Department of Nuclear Medicine, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
    Tumori 94:437-9. 2008
    ....
  34. ncbi Accessory spleen mimicking a pancreatic neuroendocrine tumor
    Sergio Suriano
    Nuclear Medicine and PET CT Center, Oncology Institute of Southern Switzerland, Via Ospedale 12, Bellinzona, Switzerland
    Tumori 97:39e-41e. 2011
    ..The present case suggests that intrapancreatic accessory spleen be considered in the differential diagnosis of pancreatic lesions positive on [111In] DTPA-octreotide scan...
  35. ncbi Three-dimensional ordered-subset expectation maximization iterative protocol for evaluation of left ventricular volumes and function by quantitative gated SPECT: a dynamic phantom study
    Luca Ceriani
    Department of Nuclear Medicine and PET CT Centre, Oncology Institute of Southern Switzerland IOSI, Bellinzona, Switzerland
    J Nucl Med Technol 38:18-23. 2010
    ....
  36. ncbi Simultaneous imaging of pericardial thymoma and parathyroid adenoma by sestamibi scan
    Luca Ceriani
    Department of Nuclear Medicine and PET/CT Centre, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
    Clin Nucl Med 33:542-4. 2008
  37. ncbi F-18 FDG PET-CT imaging in the care-management of a patient with pan-aortitis and coronary involvement
    Luca Ceriani
    Departments of Nuclear Medicine, EOC Regional Hospital of Bellinzona, CH-6500 Bellinzona, Switzerland
    Clin Nucl Med 32:562-4. 2007
  38. ncbi Could different hydration protocols affect the quality of 18F-FDG PET/CT images?
    Luca Ceriani
    Department of Nuclear Medicine and PET CT Centre, Oncology Institute of Southern Switzerland IOSI, Bellinzona, Switzerland
    J Nucl Med Technol 39:77-82. 2011
    ..In a group of oncologic patients undergoing (18)F-FDG PET/CT, we compared 4 different protocols of hydration to investigate their impact on image quality and to choose the best practice...
  39. ncbi Serum chromogranin-A assay in differential diagnosis of incidentally discovered adrenal masses
    Luca Giovanella
    Department of Nuclear Medicine, Oncology Institute of Southern Switzerland, CH 6500 Bellinzona, Switzerland
    Anticancer Res 25:1547-50. 2005
    ..Serum CgA assay is effective in evaluating the presence of chromaffin tumour among patients with adrenal incidentaloma. A negative serum CgA assay rules out successive 123I-MIBG imaging...
  40. ncbi Interference in thyroid-stimulating hormone determination
    Mauro Imperiali
    EOLAB Dipartimento di Medicina di Laboratorio, Ente Ospedaliero Cantonale, Bellinzona, Switzerland
    Eur J Clin Invest 40:756-8. 2010
    ..Despite the good quality of immunochemical tests measuring TSH levels, the presence of interfering substances can sometimes alter the TSH results...
  41. ncbi Cardiac natriuretic peptides after myocardial infarction: relationship with infarct size, left ventricular function and remodelling assessed by 99mTc-sestamibi gated-single photon emission tomography
    Luca Ceriani
    Department of Nuclear Medicine, Ente Ospedaliero Cantonale, Bellinzona, Switzerland
    Clin Chem Lab Med 45:226-31. 2007
    ....
  42. ncbi Lymph node thyroglobulin measurement in diagnosis of neck metastases of differentiated thyroid carcinoma
    Luca Giovanella
    Department of Nuclear Medicine and Thyroid Unit, Oncology Institute of Southern Switzerland, Street Ospedale 12, 6500 Bellinzona, Switzerland
    J Thyroid Res 2011:621839. 2011
    ..1?ng/mL (sensitivity 100%, specificity 100%). Conclusions. The diagnostic performance of needle washout FNAC-Tg measurement with a cut-off of 1.1?ng/mL compared favorably with cytology in detecting DTC node metastases...
  43. ncbi Serum cytokeratin fragment 21.1 (CYFRA 21.1) as tumour marker for breast cancer: comparison with carbohydrate antigen 15.3 (CA 15.3) and carcinoembryonic antigen (CEA)
    Luca Giovanella
    Laboratory of Endocrinology and Oncology, University Hospital Ospedale di Circolo e Fondazione Macchi, Varese, Italy
    Clin Chem Lab Med 40:298-303. 2002
    ..1 and CEA assays compared to CA 15.3 assay. Considering the ASCO statement on tumour markers in breast cancer, the CYFRA 21.1 assay should not be employed in clinical practice...
  44. ncbi High-sensitivity human thyroglobulin (hTG) immunoradiometric assay in the follow-up of patients with differentiated thyroid cancer
    Luca Giovanella
    Laboratory for Endocrinology and Oncology, University Hospital Ospedale di Circolo e Fondazione Macchi, Varese, Italy
    Clin Chem Lab Med 40:480-4. 2002
    ..Based on our data, we conclude that DYNOtest Tg-plus assay is effective and accurate in evaluation of patients with DTC...
  45. ncbi Undetectable serum thyroglobulin due to negative interference of heterophile antibodies in relapsing thyroid carcinoma
    Luca Giovanella
    Clin Chem 53:1871-2. 2007
  46. ncbi Increased cancer incidence after radioiodine treatment for hyperthyroidism
    Luca Giovanella
    Cancer 112:220; author reply 220-1. 2008
  47. ncbi Is simultaneous measurement of anti-thyroid peroxidase and anti-thyroglobulin antibodies clinically useful in patients with thyroid dysfunction?
    Luca Giovanella
    Clin Chem Lab Med 45:263. 2007
  48. ncbi Graves' disease, thymus enlargement, and hypercalcemia
    Luca Giovanella
    N Engl J Med 358:1078-9. 2008