Urs A Boelsterli

Summary

Affiliation: HepaTox Consulting
Country: Switzerland

Publications

  1. ncbi Mechanisms of NSAID-induced hepatotoxicity: focus on nimesulide
    Urs A Boelsterli
    HepaTox Consulting, Pfeffingen, and Institute of Clinical Pharmacy, University of Basel, Basel, Switzerland
    Drug Saf 25:633-48. 2002
  2. ncbi Toxicological consequences of altered peroxisome proliferator-activated receptor gamma (PPARgamma) expression in the liver: insights from models of obesity and type 2 diabetes
    Urs A Boelsterli
    HepaTox Consulting, P O Box 14, CH 4148, Pfeffingen
    Biochem Pharmacol 63:1-10. 2002
  3. ncbi Xenobiotic acyl glucuronides and acyl CoA thioesters as protein-reactive metabolites with the potential to cause idiosyncratic drug reactions
    Urs A Boelsterli
    HepaTox Consulting, CH 4148 Pfeffingen, and Institute of Clinical Pharmacy, University of Basel, Basel, CH 4031, Switzerland
    Curr Drug Metab 3:439-50. 2002
  4. ncbi Disease-related determinants of susceptibility to drug-induced idiosyncratic hepatotoxicity
    Urs A Boelsterli
    HepaTox Consulting, PO Box 14, CH 4148 Pfeffingen, Switzerland
    Curr Opin Drug Discov Devel 6:81-91. 2003
  5. ncbi Diclofenac-induced liver injury: a paradigm of idiosyncratic drug toxicity
    Urs A Boelsterli
    HepaTox Consulting, CH 4148 Pfeffingen, and Institute of Clinical Pharmacy, University of Basel, CH 4031 Basel, Switzerland
    Toxicol Appl Pharmacol 192:307-22. 2003
  6. ncbi Animal models of human disease in drug safety assessment
    Urs A Boelsterli
    Institute of Clinical Pharmacy, University of Basel, Switzerland
    J Toxicol Sci 28:109-21. 2003
  7. ncbi Troglitazone-induced hepatic necrosis in an animal model of silent genetic mitochondrial abnormalities
    Michie M K Ong
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117 597
    Toxicol Sci 97:205-13. 2007
  8. ncbi Troglitazone-induced hepatic mitochondrial proteome expression dynamics in heterozygous Sod2(+/-) mice: two-stage oxidative injury
    Yie Hou Lee
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597
    Toxicol Appl Pharmacol 231:43-51. 2008
  9. ncbi Bioactivation and hepatotoxicity of nitroaromatic drugs
    Urs A Boelsterli
    Molecular Toxicology Lab, Department of Pharmacology, Yong Loo Lin School of Medicine, Singapore
    Curr Drug Metab 7:715-27. 2006
  10. ncbi Proteomics profiling of hepatic mitochondria in heterozygous Sod2+/- mice, an animal model of discreet mitochondrial oxidative stress
    Yie Hou Lee
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Proteomics 8:555-68. 2008

Collaborators

  • Shufeng Zhou
  • Michie M K Ong
  • Calivarathan Latchoumycandane
  • Priscilla L K Lim
  • Yie Hou Lee
  • Qingsong Lin
  • Woen Ping Siu
  • Maxey C M Chung
  • Yok Moi Khoo
  • Miao Shan Lim
  • Koon Yeow Leow
  • Audrey S Wang
  • Vincent K S Tay
  • Jianchao Liu
  • Pamela Boon Li Pun
  • Mei L Go
  • Walter Beerheide
  • Catherine W Goh
  • Theresa M C Tan
  • Jetsumon Sattabongkot
  • Weiqi Tan
  • Wei Chuen Mok
  • How Sung Lee
  • Seng Gee Lim
  • Rashi Gupta
  • Kim Ping Wong

Detail Information

Publications18

  1. ncbi Mechanisms of NSAID-induced hepatotoxicity: focus on nimesulide
    Urs A Boelsterli
    HepaTox Consulting, Pfeffingen, and Institute of Clinical Pharmacy, University of Basel, Basel, Switzerland
    Drug Saf 25:633-48. 2002
    ....
  2. ncbi Toxicological consequences of altered peroxisome proliferator-activated receptor gamma (PPARgamma) expression in the liver: insights from models of obesity and type 2 diabetes
    Urs A Boelsterli
    HepaTox Consulting, P O Box 14, CH 4148, Pfeffingen
    Biochem Pharmacol 63:1-10. 2002
    ..Therefore, receptor expression in human liver tissue of obese and T2DM patients should deserve increased consideration in the future...
  3. ncbi Xenobiotic acyl glucuronides and acyl CoA thioesters as protein-reactive metabolites with the potential to cause idiosyncratic drug reactions
    Urs A Boelsterli
    HepaTox Consulting, CH 4148 Pfeffingen, and Institute of Clinical Pharmacy, University of Basel, Basel, CH 4031, Switzerland
    Curr Drug Metab 3:439-50. 2002
    ..More work is needed to provide a causal link between protein-reactive acyl glucuronides and acyl-CoA thioesters and the rare and unpredictable idiosyncratic drug reactions in humans...
  4. ncbi Disease-related determinants of susceptibility to drug-induced idiosyncratic hepatotoxicity
    Urs A Boelsterli
    HepaTox Consulting, PO Box 14, CH 4148 Pfeffingen, Switzerland
    Curr Opin Drug Discov Devel 6:81-91. 2003
    ..The need for an increased use of animal models of human disease in mechanistic investigations and drug candidate selection will also be emphasized...
  5. ncbi Diclofenac-induced liver injury: a paradigm of idiosyncratic drug toxicity
    Urs A Boelsterli
    HepaTox Consulting, CH 4148 Pfeffingen, and Institute of Clinical Pharmacy, University of Basel, CH 4031 Basel, Switzerland
    Toxicol Appl Pharmacol 192:307-22. 2003
    ..Increased efforts to identify both patient-specific risk factors and disease-related factors will help to define patient subsets at risk as well as increase the predictability of unexpected hepatotoxicity in drug development...
  6. ncbi Animal models of human disease in drug safety assessment
    Urs A Boelsterli
    Institute of Clinical Pharmacy, University of Basel, Switzerland
    J Toxicol Sci 28:109-21. 2003
    ....
  7. ncbi Troglitazone-induced hepatic necrosis in an animal model of silent genetic mitochondrial abnormalities
    Michie M K Ong
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117 597
    Toxicol Sci 97:205-13. 2007
    ..These data are consistent with our hypothesis that inherited or acquired mitochondrial abnormalities may be one of the contributing determinants of susceptibility to troglitazone-induced idiosyncratic liver injury...
  8. ncbi Troglitazone-induced hepatic mitochondrial proteome expression dynamics in heterozygous Sod2(+/-) mice: two-stage oxidative injury
    Yie Hou Lee
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597
    Toxicol Appl Pharmacol 231:43-51. 2008
    ....
  9. ncbi Bioactivation and hepatotoxicity of nitroaromatic drugs
    Urs A Boelsterli
    Molecular Toxicology Lab, Department of Pharmacology, Yong Loo Lin School of Medicine, Singapore
    Curr Drug Metab 7:715-27. 2006
    ..Most likely one of the next paradigm shifts will include the identification of determinants of susceptibility to nitroaromatic drug-induced hepatotoxicity...
  10. ncbi Proteomics profiling of hepatic mitochondria in heterozygous Sod2+/- mice, an animal model of discreet mitochondrial oxidative stress
    Yie Hou Lee
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Proteomics 8:555-68. 2008
    ..The results of this study are compatible with our hypothesis that the Sod2+/- mouse is a suitable animal model for studying clinically silent mitochondrial abnormalities...
  11. ncbi Bax-mediated mitochondrial outer membrane permeabilization (MOMP), distinct from the mitochondrial permeability transition, is a key mechanism in diclofenac-induced hepatocyte injury: Multiple protective roles of cyclosporin A
    Woen Ping Siu
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117 597
    Toxicol Appl Pharmacol 227:451-61. 2008
    ..These data support our concept that the Ca2+-Bid-Bax-MOMP axis is a critical pathway in diclofenac (metabolite)-induced hepatocyte injury...
  12. ncbi The mitochondrial superoxide/thioredoxin-2/Ask1 signaling pathway is critically involved in troglitazone-induced cell injury to human hepatocytes
    Priscilla L K Lim
    Department of Pharmacology, Yong Loo Lin School of Medicine National University of Singapore, Singapore 117595
    Toxicol Sci 101:341-9. 2008
    ..Furthermore, the data support our concept that targeted delivery of an antioxidant to mitochondria can inhibit upstream signaling and protect from troglitazone-induced lethal cell injury...
  13. ncbi Molecular and functional characterization of drug-metabolizing enzymes and transporter expression in the novel spontaneously immortalized human hepatocyte line HC-04
    Priscilla L K Lim
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore
    Toxicol In Vitro 21:1390-401. 2007
    ..Collectively, HC-04 cells provide a reliable, stable, and reproducible model for biomechanistic studies in drug toxicology...
  14. ncbi Mitochondrial protection by the JNK inhibitor leflunomide rescues mice from acetaminophen-induced liver injury
    Calivarathan Latchoumycandane
    Department of Pharmacology, Yong Loo Lin School of Medicine, Singapore
    Hepatology 45:412-21. 2007
    ..Conclusion: Leflunomide afforded protection against APAP-induced hepatotoxicity in mice through inhibition of JNK-mediated activation of mitochondrial permeabilization...
  15. ncbi Mitochondrial abnormalities--a link to idiosyncratic drug hepatotoxicity?
    Urs A Boelsterli
    Molecular Toxicology Lab, Department of Pharmacology, Yong Loo Lin School of Medicine, Singapore
    Toxicol Appl Pharmacol 220:92-107. 2007
    ..New animal models (e.g., the Sod2(+/-) mouse) provide supporting evidence for this concept. However, genetic analyses of DILI patient samples are needed to ultimately provide the proof-of-concept...
  16. ncbi Mitochondrial permeability transition as a source of superoxide anion induced by the nitroaromatic drug nimesulide in vitro
    Vincent K S Tay
    Department of Pharmacology, Faculty of Medicine, National University of Singapore, 18 Medical Drive, Singapore 117597
    Free Radic Biol Med 39:949-59. 2005
    ....
  17. ncbi Nimesulide-induced hepatic mitochondrial injury in heterozygous Sod2(+/-) mice
    Michie M K Ong
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Free Radic Biol Med 40:420-9. 2006
    ..In conclusion, repeated administration of nimesulide can superimpose an oxidant stress, potentiate mitochondrial damage, and activate proapoptotic factors in mice with genetically compromised mitochondrial function...
  18. ncbi Critical role of free cytosolic calcium, but not uncoupling, in mitochondrial permeability transition and cell death induced by diclofenac oxidative metabolites in immortalized human hepatocytes
    Miao Shan Lim
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore
    Toxicol Appl Pharmacol 217:322-31. 2006
    ....