Xiangdong Wang

Summary

Country: Sweden

Publications

  1. ncbi Potential mechanisms and significance of acute pancreatitis-associated liver injury
    Xiangdong Wang
    Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, China
    Scand J Gastroenterol 41:604-13. 2006
  2. ncbi Mast cells contribute to early pancreatitis-induced systemic endothelial barrier dysfunction
    Marwan Dib
    Department of Surgery, Lund University Hospital, Lund, Sweden
    Pancreatology 2:396-401. 2002
  3. ncbi Influence of mast cells on the expression of adhesion molecules on circulating and migrating leukocytes in acute pancreatitis-associated lung injury
    Xia Zhao
    Department of Pharmacology, Medical College of Zhejiang University, Hangzhou, China
    Lung 183:253-64. 2005
  4. ncbi Immune status and inflammatory response differ locally and systemically in severe acute pancreatitis
    Changbin Shi
    Department of Surgery, Lund University Hospital, Lund, Sweden
    Scand J Gastroenterol 41:472-80. 2006
  5. ncbi Endotoxin-induced proteolytic reduction in hepatic growth hormone (GH) receptor: a novel mechanism for GH insensitivity
    Xiangdong Wang
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0012, USA
    Mol Endocrinol 22:1427-37. 2008
  6. ncbi Significance of bioinformatics in research of chronic obstructive pulmonary disease
    Hong Chen
    Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China
    J Clin Bioinforma 1:35. 2011
  7. ncbi Evaluation of SLOG/TCI-III pediatric system on target control infusion of propofol
    Wan Hua Yang
    Department of Pharmacy, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    J Transl Med 9:187. 2011
  8. ncbi Therapeutic effects of pyrrolidine dithiocarbamate on acute lung injury in rabbits
    Meitang Wang
    Department of Emergency Medicine, The Second Military University Changhai Hospital, China
    J Transl Med 9:61. 2011
  9. ncbi Airway epithelial dysfunction in the development of acute lung injury and acute respiratory distress syndrome
    Xiangdong Wang
    Fudan University, Department of Pulmonary Medicine, Zhongshan Hospital, 180 Feng Lin Road, Shanghai 200032, PR China University of North Carolina, Department of Molecular Biomedical Sciences, Raleigh, NC, USA
    Expert Rev Respir Med 1:149-55. 2007
  10. ncbi Does hepatocyte growth factor/c-Met signal play synergetic role in lung cancer?
    Xiangdong Wang
    Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China
    J Cell Mol Med 14:833-9. 2010

Collaborators

Detail Information

Publications67

  1. ncbi Potential mechanisms and significance of acute pancreatitis-associated liver injury
    Xiangdong Wang
    Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, China
    Scand J Gastroenterol 41:604-13. 2006
  2. ncbi Mast cells contribute to early pancreatitis-induced systemic endothelial barrier dysfunction
    Marwan Dib
    Department of Surgery, Lund University Hospital, Lund, Sweden
    Pancreatology 2:396-401. 2002
    ..CONCLUSION: The results imply that mast cell activation could be involved in the initiation of AP and the early phase of AP-induced MODS. Mechanisms seem to be complex and are still to be elucidated...
  3. ncbi Influence of mast cells on the expression of adhesion molecules on circulating and migrating leukocytes in acute pancreatitis-associated lung injury
    Xia Zhao
    Department of Pharmacology, Medical College of Zhejiang University, Hangzhou, China
    Lung 183:253-64. 2005
    ..Thus, our data indicate that mast cells may play a critical role in the activation of leukocytes during the initiation of pancreatitis-associated lung injury by altering phenotypes of adhesion molecules...
  4. ncbi Immune status and inflammatory response differ locally and systemically in severe acute pancreatitis
    Changbin Shi
    Department of Surgery, Lund University Hospital, Lund, Sweden
    Scand J Gastroenterol 41:472-80. 2006
    ..The use of an NF-kappaB inhibitor, preferentially reaching the local inflammatory foci, could be a potential future way of intervention...
  5. ncbi Endotoxin-induced proteolytic reduction in hepatic growth hormone (GH) receptor: a novel mechanism for GH insensitivity
    Xiangdong Wang
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0012, USA
    Mol Endocrinol 22:1427-37. 2008
    ..These data are the first to demonstrate inducible in vivo GHR proteolysis and suggest this is a mechanism to regulate GH sensitivity and its anabolic effects during sepsis or inflammation...
  6. ncbi Significance of bioinformatics in research of chronic obstructive pulmonary disease
    Hong Chen
    Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China
    J Clin Bioinforma 1:35. 2011
    ..We also presented the requirements and challenges in implementing bioinformatics to COPD research and interpreted these results as clinical physicians...
  7. ncbi Evaluation of SLOG/TCI-III pediatric system on target control infusion of propofol
    Wan Hua Yang
    Department of Pharmacy, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    J Transl Med 9:187. 2011
    ..The target-controlled infusion-III (SLOG/TCI-III) system was derived from a model set up by the local pediatric population for target control infusion of propofol...
  8. ncbi Therapeutic effects of pyrrolidine dithiocarbamate on acute lung injury in rabbits
    Meitang Wang
    Department of Emergency Medicine, The Second Military University Changhai Hospital, China
    J Transl Med 9:61. 2011
    ..The present study aims to evaluate therapeutic effects and mechanisms of pyrrolidine dithiocarbamate (PDTC) on ALI...
  9. ncbi Airway epithelial dysfunction in the development of acute lung injury and acute respiratory distress syndrome
    Xiangdong Wang
    Fudan University, Department of Pulmonary Medicine, Zhongshan Hospital, 180 Feng Lin Road, Shanghai 200032, PR China University of North Carolina, Department of Molecular Biomedical Sciences, Raleigh, NC, USA
    Expert Rev Respir Med 1:149-55. 2007
    ..The airway epithelial cell may be a valuable therapeutic target for discovering and developing new drugs and/or new therapeutic strategies for ALI/ARDS...
  10. ncbi Does hepatocyte growth factor/c-Met signal play synergetic role in lung cancer?
    Xiangdong Wang
    Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China
    J Cell Mol Med 14:833-9. 2010
    ....
  11. ncbi Translational Medicine is developing in China: a new venue for collaboration
    Xiangdong Wang
    Department of Respiratory Medicine, Biomedical Research Center, Fudan University Zhongshan Hospital, Shanghai, PR China
    J Transl Med 9:3. 2011
    ..Translational Medicine as an inter-disciplinary science is developing rapidly and widely and, in this article, we will place a special emphasis on China...
  12. ncbi Better understanding of organ dysfunction requires proteomic involvement
    Xiangdong Wang
    Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, China
    J Proteome Res 5:1060-2. 2006
    ....
  13. ncbi Protection against the allergic airway inflammation depends on the modulation of spleen dendritic cell function and induction of regulatory T cells in mice
    Yaoli Wang
    Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China
    Genet Vaccines Ther 8:2. 2010
    ..CONCLUSION: DNA vaccine encoding both Fc and OVA showed more effective than DNA vaccine encoding Fc or OVA alone, through the balance of DCs and Treg...
  14. ncbi Role of clinical bioinformatics in the development of network-based Biomarkers
    Xiangdong Wang
    Biomedical Research Center, Department of Respiratory Medicine, Fudan University Zhongshan Hospital, China
    J Clin Bioinforma 1:28. 2011
    ....
  15. ncbi Proteomics and leukocytes: an approach to understanding potential molecular mechanisms of inflammatory responses
    Xiangdong Wang
    College of Medicine, Zhe Jiang University, Hang Zhou, Peoples Republic of China
    J Proteome Res 3:921-9. 2004
    ..A number of newly identified proteins from leukocyte proteomics may offer new mechanism-orientated targets for drug discovery and development...
  16. ncbi Potential clinical application of KGF-2 (FGF-10) for acute lung injury/acute respiratory distress syndrome
    Xiaocong Fang
    Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China
    Expert Rev Clin Pharmacol 3:797-805. 2010
    ..Preclinical and clinical studies have suggested that KGF-2 may be the candidate of novel therapies for alveolar epithelial damage during ALI/ARDS...
  17. ncbi Potential effects of peroxisome proliferator-activated receptor activator on LPS-induced lung injury in rats
    Xiangdong Wang
    Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, PR China
    Pulm Pharmacol Ther 22:318-25. 2009
    ..PPAR-gamma agonist ameliorated these changes related with the dose used.LPS-induced lung disease model shows some similarities with human disease, and PPAR-gamma agonist maybe an alternative for COPD therapy...
  18. ncbi Role of aquaporin 5 in antigen-induced airway inflammation and mucous hyperproduction in mice
    Yao Shen
    Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China
    J Cell Mol Med 15:1355-63. 2011
    ..Thus, our results implicate involvement of AQP5 in the development of airway inflammation and mucous hyperproduction during chronic asthma...
  19. ncbi Roles of CC chemokine receptors (CCRs) on lipopolysaccharide-induced acute lung injury
    Dong Yang
    Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, PR China
    Respir Physiol Neurobiol 170:253-9. 2010
    ..This was most prominent in the CCR2 knockout mice where no LPS-induced lung edema and no increase of IL-6 in BAL fluid occurred. Our results indicate that CCR2, and to some extent CCR1, play pivotal roles in the development of ALI...
  20. ncbi Deletion of peroxiredoxin 6 potentiates lipopolysaccharide-induced acute lung injury in mice
    Dong Yang
    Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China
    Crit Care Med 39:756-64. 2011
    ..To investigate the role and signaling pathway of peroxiredoxin 6, a newly identified peroxidase, in lipopolysaccharide-induced acute lung injury...
  21. ncbi Preventive and therapeutic effects of phosphoinositide 3-kinase inhibitors on acute lung injury
    Chengshui Chen
    Department of Respiratory Medicine, The First Hospital, Wenzhou Medical College, Zhejiang, China
    Chest 140:391-400. 2011
    ..Recent preclinical studies demonstrated that the PI3K-dominant signal pathway could play an important role in the development of acute lung injury, although the mechanism remains unclear...
  22. ncbi Therapeutic role of terbutaline in a rat whole-lung lavage model
    Xiaodan Wu
    Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China
    Exp Lung Res 37:542-8. 2011
    ..The modified lavage method, with the use of terbutaline and oxygen ventilation, is one of potential therapies for patients with PAP...
  23. ncbi Aquaporin 5 expression inhibited by LPS via p38/JNK signaling pathways in SPC-A1 cells
    Yao Shen
    Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, No 180 Fenglin Road, Shanghai 200032, China
    Respir Physiol Neurobiol 171:212-7. 2010
    ....
  24. ncbi Involvement of Gax gene in hypoxia-induced pulmonary hypertension, proliferation, and apoptosis of arterial smooth muscle cells
    Shijin Xia
    Shanghai Institute of Geriatrics, Huadong Hospital, Fudan University, No 180 Fenglin Road, Shanghai, P R China
    Am J Respir Cell Mol Biol 44:66-73. 2011
    ..Gax may be a potential new therapeutic target for pulmonary hypertension...
  25. ncbi Proteomics-based biomarkers in chronic obstructive pulmonary disease
    Hong Chen
    Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China
    J Proteome Res 9:2798-808. 2010
    ....
  26. ncbi Epithelial proteomics in multiple organs and tissues: similarities and variations between cells, organs, and diseases
    Hong Zhao
    Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, China
    J Proteome Res 5:743-55. 2006
    ..Epithelial proteomics will provide powerful information on the relationships between biological molecules and disease mechanisms. Epithelial proteomics strategies and approaches should become more global, multidimensional, and systemic...
  27. ncbi Lean body mass, interleukin 18, and metabolic syndrome in apparently healthy Chinese
    Liang Sun
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
    PLoS ONE 6:e18104. 2011
    ..We aimed to investigate how lean body mass is related to circulating Interleukin 18 (IL-18) and its association with metabolic syndrome (MetS) among apparently healthy Chinese...
  28. ncbi Pulmonary epithelial CCR3 promotes LPS-induced lung inflammation by mediating release of IL-8
    Bo Li
    Department of Pulmonary Medicine, Institute of Respiratory Disease, Zhongshan Hospital, Fudan University, Shanghai, China
    J Cell Physiol 226:2398-405. 2011
    ..These results suggest that pulmonary epithelial CCR3 be involved in progression of LPS-induced lung inflammation by mediating release of IL-8. CCR3 in pulmonary epithelia may be an attractive target for development of therapies for ALI...
  29. ncbi Telocyte morphologies and potential roles in diseases
    Yonghua Zheng
    Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China
    J Cell Physiol 227:2311-7. 2012
    ..Future efforts are required to clarify pathophysiological functions of TCs in the disease. J. Cell. Physiol. 227: 2311-2317, 2012. © 2011 Wiley Periodicals, Inc...
  30. ncbi Regulation of MUC5AC mucin secretion by depletion of AQP5 in SPC-A1 cells
    Zhihong Chen
    Department of Pulmonary Medicine, Research Institute of Respiratory Disease, Fudan University, Zhongshan Hospital, Shanghai 200032, PR China
    Biochem Biophys Res Commun 342:775-81. 2006
    ..Further study of the regulatory mechanism between AQPs and mucins may provide new strategies for development of novel antihypersecretory drugs in airway diseases...
  31. ncbi The value of the lipopolysaccharide-induced acute lung injury model in respiratory medicine
    Hong Chen
    Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China
    Expert Rev Respir Med 4:773-83. 2010
    ..Advantages and disadvantages of such models in pulmonary research and new directions for future investigations are also discussed...
  32. ncbi Role of airway epithelial cells in development of asthma and allergic rhinitis
    Yaoli Wang
    Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai 20032, China
    Respir Med 102:949-55. 2008
    ..Thus, airway epithelial cells may be valuable therapeutic targets for discovery and development of new drugs and/or new therapeutic strategies to treat asthma and allergic rhinitis...
  33. ncbi Anti-asthmatic agents alleviate pulmonary edema by upregulating AQP1 and AQP5 expression in the lungs of mice with OVA-induced asthma
    Chunling Dong
    Department of Pulmonary Medicine, Research Institute of Respiratory Disease, Zhongshan Hospital, Fudan University, Shanghai 200032, China
    Respir Physiol Neurobiol 181:21-8. 2012
    ..Anti-asthmatic agents could alleviate pulmonary edema through upregulating the expression of AQP1 and AQP5 in mouse lungs that have OVA-induced asthma...
  34. ncbi Development of fiber optic fluorescence oxygen sensor in both in vitro and in vivo systems
    Jinjun Jiang
    Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, PR China
    Respir Physiol Neurobiol 161:160-6. 2008
    ..Our results suggest that this oxygen-sensitive fluorescence indicator, which has a high biocompatibility, may have the potential for use in real-time monitoring of blood oxygen partial pressure in various clinical settings...
  35. ncbi Analysis of transcriptional factors and regulation networks in patients with acute renal allograft rejection
    Duojiao Wu
    Fudan University Zhongshan Hospital, Shanghai, China
    J Proteome Res 10:175-81. 2011
    ..Thus, our study provides a new description and insight into the molecular events in AR and potential strategies for identifying diagnostic biomarkers...
  36. ncbi Potential mechanism of interleukin-8 production from lung cancer cells: an involvement of EGF-EGFR-PI3K-Akt-Erk pathway
    Yong Zhang
    Department of Pulmonary Medicine, Center for Biomedical Research, Zhongshan Hospital, Fudan University Medical School, Shanghai, China
    J Cell Physiol 227:35-43. 2012
    ..Thus, it seems that the signal pathway of EGFR-PI3K-Akt-Erk can be the potential target of therapies for inflammatory microenvironment in lung cancer...
  37. ncbi Role of HLA-G and NCR in protection of umbilical cord blood haematopoietic stem cells from NK cell mediated cytotoxicity
    Ming Wang
    Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China
    J Cell Mol Med 15:2040-5. 2011
    ..Thus, we conclude that natural cytotoxicity receptors and HLA-G on HSCs may contribute to the escape from NK cells, and activate and inhibitory NK cell receptors and their ligands can be novel therapeutic targets in cell transplantation...
  38. ncbi Preventive effects of curcumin and dexamethasone on lung transplantation-associated lung injury in rats
    Jiayuan Sun
    Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, PR China
    Crit Care Med 36:1205-13. 2008
    ..To investigate potential effects of curcumin or dexamethasone on lung transplantation-associated lung injury...
  39. ncbi Potential significance of telocytes in the pathogenesis of lung diseases
    Yonghua Zheng
    Zhongshan Hospital, Fudan University, Shanghai, China
    Expert Rev Respir Med 6:45-9. 2012
    ..All characteristics of telocytes in lung tissue indicate that telocytes may play a potential, but important, role in the pathogenesis of lung diseases...
  40. ncbi Characteristics of Chinese patients with cough in primary care centre
    Qunying Hong
    Department of Pulmonary Medicine, Fudan University Zhongshan Hospital, Shanghai, China
    J Transl Med 9:149. 2011
    ..The present study aimed at investigating clinical epidemiology of cough through a national study of two questionnaire surveys sent to primary care physicians in China...
  41. ncbi Prediction of acute cellular renal allograft rejection by urinary metabolomics using MALDI-FTMS
    Ji Na Wang
    Department of Urology, Zhongshan Hospital Affiliated to Fudan University, Shanghai, China
    J Proteome Res 7:3597-601. 2008
    ..In conclusion, the combination of MALDI-FTMS technology with a clear definition of patient groups can detect urine small molecule associated with ACR...
  42. ncbi COPD in China: the burden and importance of proper management
    Xiaocong Fang
    Department of Pulmonary Medicine, Research Institute of Respiratory Disease, Zhongshan Hospital, Fudan University, Shanghai, China
    Chest 139:920-9. 2011
    ..COPD is one of the most challenging medical issues facing China because of its influence on both personal and public health and its impact on the economy. Optimal management strategies should be adopted and strengthened immediately...
  43. ncbi Role of CCR2 and IL-8 in acute lung injury: a new mechanism and therapeutic target
    Yao Shen
    Department of Pulmonary Medicine, Center for Biomedical Research, Zhongshan Hospital, Fudan University, PR China
    Expert Rev Respir Med 5:107-14. 2011
    ..This article will focus on the role of CC chemokine receptor 2 and IL-8 in the pathogenesis and resolution in ALI/ARDS...
  44. ncbi Ethanol binging exacerbates sinusoidal endothelial and parenchymal injury elicited by acetaminophen
    Robert S McCuskey
    Department of Cell Biology and Anatomy, College of Medicine, P O Box 245044, University of Arizona, 1501 N Campbell Avenue, Tucson, AZ 85724 5044, USA
    J Hepatol 42:371-7. 2005
    ..To evaluate if ethanol binging sensitizes hepatic sinusoidal endothelial cells (SEC) and liver to APAP toxicity...
  45. ncbi Potential role of short hairpin RNA targeting epidermal growth factor receptor in growth and sensitivity to drugs of human lung adenocarcinoma cells
    Li Bai
    Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China
    Biochem Pharmacol 71:1265-71. 2006
    ..Our data suggest that vector-based shRNA could be considered as an alternative to effectively inhibit EGFR expression in HLACs, probably with the higher efficacy in combination therapies with conventional chemotherapeutic drugs...
  46. ncbi Association between polymorphism of glutathione S-transferase P1 and chronic obstructive pulmonary disease: a meta-analysis
    Fugui Yan
    Department of Respiratory Medicine, First Affiliated Hospital, Wenzhou Medical College, Wenzhou, PR China
    Respir Med 104:473-80. 2010
    ..The present study aimed at investigating the correlation between GSTP1 105Val/Val genotype and chronic obstruct pulmonary disease (COPD) using a meta-analysis of existed studies...
  47. ncbi Effects of mitochondrial potassium channel and membrane potential on hypoxic human pulmonary artery smooth muscle cells
    Hong Ling Hu
    Department of Respiratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China
    Am J Respir Cell Mol Biol 42:661-6. 2010
    ....
  48. ncbi Associations of inflammatory factors with glycaemic status among middle-aged and older Chinese people
    Xingwang Ye
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Clin Endocrinol (Oxf) 70:854-62. 2009
    ..Low-grade chronic inflammation is associated with risk for type 2 diabetes. We investigated the associations between inflammatory factors and glycaemic status in a middle-aged and older Chinese population...
  49. ncbi Potential effects of PKC or protease inhibitors on acute pancreatitis-induced tissue injury in rats
    Changbin Shi
    Department of Surgery, Clinical Sciences, Lund University Hospital, SE 221 85 Lund, Sweden
    Vascul Pharmacol 46:406-11. 2007
    ..Effective therapies for AP are still limited, mainly due to unclear mechanisms by which AP initiates both pancreatic and extrapancreatic organ injury...
  50. ncbi Alterations of adhesion molecule expression and inflammatory mediators in acute lung injury induced by septic and non-septic challenges
    Xia Zhao
    Department of Surgery, Lund University, Lund, Sweden
    Lung 183:87-100. 2005
    ..Activating phenotypes of circulating, lung tissue and bronchoalveolar leukocytes may thus be responsible for the-development and severity of secondary lung injury...
  51. ncbi Role of nuclear factor-kappaB, reactive oxygen species and cellular signaling in the early phase of acute pancreatitis
    Changbin Shi
    Department of Surgery, Lund University Hospital, Lund, Sweden
    Scand J Gastroenterol 40:103-8. 2005
    ..The regulation of signaling pathways during the sequestration of neutrophils in acute pancreatitis seems to vary between organs...
  52. ncbi Severity of pancreatitis-associated gut barrier dysfunction is reduced following treatment with the PAF inhibitor lexipafant
    Per Leveau
    Department of Surgery, Lund University Hospital, SE-22185 Lund, Sweden
    Biochem Pharmacol 69:1325-31. 2005
    ..The findings imply that PAF plays a critical role in the development of pancreatitis-associated gut barrier dysfunction and that PAF antagonist in some forms may represent potential candidates for future therapeutic intervention...
  53. ncbi Prevention of hepatic fibrosis in a murine model of metabolic syndrome with nonalcoholic steatohepatitis
    Laurie D DeLeve
    Division of Gastrointestinal and Liver Diseases and the Research Center for Liver Diseases, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Am J Pathol 173:993-1001. 2008
    ..Either compound therefore has the potential to be of clinical benefit...
  54. ncbi Rat liver endothelial cells isolated by anti-CD31 immunomagnetic separation lack fenestrae and sieve plates
    Laurie D DeLeve
    Research Center for Liver Diseases and the Division of Gastrointestinal and Liver Diseases, Keck School of Medicine at the University of Southern California, Los Angeles, California 90033, USA
    Am J Physiol Gastrointest Liver Physiol 291:G1187-9. 2006
    ..In conclusion, cells isolated by anti-CD31 and immunomagnetic sorting lacked the hallmark features of SEC...
  55. ncbi Embolization by sinusoidal lining cells obstructs the microcirculation in rat sinusoidal obstruction syndrome
    Laurie D DeLeve
    Division of Gastrointestinal and Liver Disease and the Research Center for Liver Diseases, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
    Am J Physiol Gastrointest Liver Physiol 284:G1045-52. 2003
    ..Glutathione prevents SOS by preserving an intact sinusoidal barrier...
  56. ncbi Decreased hepatic nitric oxide production contributes to the development of rat sinusoidal obstruction syndrome
    Laurie D DeLeve
    Research Center for Liver Diseases, Division of Gastrointestinal and Liver Diseases, Kenneth Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
    Hepatology 38:900-8. 2003
    ..These findings show that a decrease in NO contributes to SOS by allowing up-regulation of MMP activity, loss of sinusoidal integrity, and subsequent disruption of sinusoidal perfusion...
  57. ncbi Rat liver sinusoidal endothelial cell phenotype is maintained by paracrine and autocrine regulation
    Laurie D DeLeve
    Research Center for Liver Diseases and the Division of Gastrointestinal and Liver Diseases, USC Keck School of Medicine, Div of Gastrointestinal and Liver Diseases, 2011 Zonal Ave HMR 603, Los Angeles, CA 90033, USA
    Am J Physiol Gastrointest Liver Physiol 287:G757-63. 2004
    ..The VEGF-mediated paracrine effect of hepatocytes or stellate cells on maintenance of SEC phenotype requires autocrine production of nitric oxide by SEC...
  58. ncbi Evaluation of excised lung gas volume measurements in animals with genetic or induced emphysema
    Anne-Helene Jansson
    Department of Bioscience, AstraZeneca R and D Lund, S-221 87 Lund, Sweden
    Respir Physiol Neurobiol 150:240-50. 2006
    ..The present study demonstrates that ELGV measurement is a simple and sensitive method to monitor the development of emphysema...
  59. ncbi Angiogenesis, endothelial cell functions, and tumor cell growth in biodegradable and nonbiodegradable devices
    Xia Zhao
    Department of Surgery, Lund University Hospital, Lund, Sweden
    J Biomed Mater Res B Appl Biomater 74:774-81. 2005
    ..Biodegradable collagen matrix with three-dimensional structure is suitable for simultaneous transplantation with cells without prevascularization...
  60. ncbi Potential role of reactive oxygen species in pancreatitis-associated multiple organ dysfunction
    Changbin Shi
    Department of Surgery, Lund University Hospital, Lund, Sweden
    Pancreatology 5:492-500. 2005
    ..The role of antioxidant treatment, included as a part of multimodal management, remains to be investigated...
  61. ncbi Sinusoidal endothelial cells prevent rat stellate cell activation and promote reversion to quiescence
    Laurie D DeLeve
    University of Southern California USC Keck School of Medicine Division of Gastrointestinal and Liver Diseases and the USC Research Center for Liver Diseases, Los Angeles, CA, USA
    Hepatology 48:920-30. 2008
    ..Capillarized SECs do not promote HSC quiescence, because of loss of VEGF-stimulated NO production...
  62. ncbi Disturbance of serum interleukin-2 and interleukin-8 levels in posttraumatic and non-posttraumatic stress disorder earthquake survivors in northern China
    Yuqing Song
    Institute of Mental Health, Beijing University, Beijing, SAR, China
    Neuroimmunomodulation 14:248-54. 2007
    ..In addition, the relationship of these cytokines with psychological parameters of the disorder was examined as well...
  63. ncbi Protein kinase C modulates the pulmonary inflammatory response in acute pancreatitis
    Xia Zhao
    Departments of Surgery, Lund University Hospital, Clinical Sciences, SE-221 85 Lund, Sweden
    Respir Physiol Neurobiol 152:16-26. 2006
    ..The results indicate that the leukocyte response in acute pancreatitis vary depending on leukocyte subpopulation. It seems that activation of the PKC signalling pathway may play an important role in pancreatitis-associated lung injury...
  64. ncbi Proteomics in the study of organ dysfunction
    Xiangdong Wang
    Expert Rev Proteomics 4:1-3. 2007
  65. ncbi Effective treatment of gut barrier dysfunction using an antioxidant, a PAF inhibitor, and monoclonal antibodies against the adhesion molecule PECAM-1
    Zhengwu Sun
    Department of Surgery, Lund University Hospital, Lund University, S 221 85 Lund, Sweden
    J Surg Res 105:220-33. 2002
    ..The objective of this study was to evaluate the potential therapeutic value of single or combination therapy with NAC, lexipafant, and anti-PECAM-1-MAb administered late during intestinal I/R in the rat...
  66. ncbi In vivo imaging of hepatic growth hormone signaling
    Stuart J Frank
    University of Alabama at Birmingham, 1530 3rd Avenue South, BDB 861, Birmingham, Alabama 35294 0012, USA
    Mol Endocrinol 20:2819-30. 2006
    ..Our imaging system allows detailed in vivo analysis of GH signaling and action and may be a paradigm for studies of additional signaling pathways in liver and other tissues...
  67. ncbi Evaluation of nasal barrier dysfunction at acute- and late-phase reactions in a guinea pig model of allergic rhinitis
    Sofia Elovsson
    Department of Clinical Study Management, AstraZeneca R and D Lund, Sweden
    Vascul Pharmacol 43:267-76. 2005
    ..We suggest that this model of guinea pig allergic rhinitis with the early and late responses may be useful for high-throughout screening of new drugs...