Research Topics
| John WahrenSummaryCountry: Sweden Publications
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Publications
C-Peptide reverses nociceptive neuropathy in type 1 diabetesHideki Kamiya
Department of Pathology, Scott Hall 9275, 540 E. Canfield Ave, Detroit, MI 48201, USA
Diabetes 55:3581-7. 2006..We conclude that C-peptide exerts beneficial therapeutic effects on diabetic nociceptive neuropathy and that optimal effects require maintenance of physiological C-peptide concentrations for a major proportion of the day...- C-peptide: new findings and therapeutic implications in diabetesJohn Wahren
Section of Clinical Physiology, Department of Surgical Sciences, Karolinska Institute, N1 05, SE 171 76 Stockholm, Sweden
Clin Physiol Funct Imaging 24:180-9. 2004.... - Molecular and cellular effects of C-peptide--new perspectives on an old peptideJohn Wahren
Department of Surgical Sciences, Section of Clinical Physiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
Exp Diabesity Res 5:15-23. 2004..Clinical evidence suggests that replacement of C-peptide, together with regular insulin therapy, may be beneficial in patients with type 1 diabetes and serve to retard or prevent the development of long-term complications... - C-peptide improves adenosine-induced myocardial vasodilation in type 1 diabetes patientsBo-Lennart Johansson
Department of Surgical Sciences, Division of Clinical Physiology N1:05, Karolinska Institutet, Karolinska Hospital, SE-171 76 Stockholm, Sweden
Am J Physiol Endocrinol Metab 286:E14-9. 2004..05) and stroke volume (+7%, P < 0.05). It is concluded that short-term C-peptide infusion in physiological amounts increases the hyperemic MBF and left-ventricular function in type 1 diabetic patients... - C-Peptide replacement therapy and sensory nerve function in type 1 diabetic neuropathyKarin Ekberg
Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
Diabetes Care 30:71-6. 2007..The present study was undertaken to examine whether C-peptide administration to patients with type 1 diabetes and peripheral neuropathy improves sensory nerve function... - Amelioration of sensory nerve dysfunction by C-Peptide in patients with type 1 diabetesKarin Ekberg
Department of Surgical Sciences, Section of Clinical Physiology, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
Diabetes 52:536-41. 2003..In conclusion, C-peptide administered for 3 months as replacement therapy to patients with early signs of diabetic neuropathy ameliorates nerve dysfunction... - Molecular effects of proinsulin C-peptideJan Johansson
Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 171 77 Stockholm, Sweden
Biochem Biophys Res Commun 295:1035-40. 2002..Combined, the available observations show that C-peptide is biologically active and suggest a molecular model for its physiological effects... - C-peptide increases forearm blood flow in patients with type 1 diabetes via a nitric oxide-dependent mechanismBo-Lennart Johansson
Department of Surgical Sciences, Division of Clinical Physiology N1:05, Karolinska Hospital, SE-171 76 Stockholm, Sweden
Am J Physiol Endocrinol Metab 285:E864-70. 2003..It is concluded that the stimulatory effect of C-peptide on FBF in type 1 diabetic patients is mediated via the NO system and that C-peptide increases basal endothelial NO levels... - Splanchnic regulation of glucose productionJohn Wahren
Department of Molecular Medicine and Surgery, Karolinska Institute, SE 171 77 Stockholm, Sweden
Annu Rev Nutr 27:329-45. 2007..The hyperglycemia of type 2 diabetes is in part caused by an overproduction of glucose from the liver that is secondary to accelerated gluconeogenesis... - C-peptide exerts beneficial effects on myocardial blood flow and function in patients with type 1 diabetesAlexander Hansen
Section of Cardiology, Department of Medicine, Karolinska Hospital, Stockholm, Sweden
Diabetes 51:3077-82. 2002..3 +/- 0.4 to 5.3 +/- 0.9 (P < 0.05). The results demonstrate that type 1 diabetic patients have impaired myocardial function and perfusion in the basal state that can be improved by short-term replacement of C-peptide... - Large-surface biosensor technology for enhanced recovery in protein characterizationErmias Melles
Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
J Biomol Tech 16:392-7. 2005..Recovery of affinity partners at the multi-pmole level is demonstrated for protein purification in SPR approaches... - Crossing the barrier: net flux of 27-hydroxycholesterol into the human brainMaura Heverin
Department of Surgical Sciences, Karolinska University Hospital, Solna, Sweden
J Lipid Res 46:1047-52. 2005.... - Precise determination of glucose-d(2)/glucose ratio in human serum and plasma by APCI LC-MS/MSShahid Ullah
Department of Medicine, Division of Clinical Pharmacology, Karolinska Institute and University Hospital, Stockholm, Sweden
Scand J Clin Lab Invest 69:837-42. 2009..Determinations of glucose turnover based on infusion of deuterium-labelled glucose are frequently undertaken in studies involving the pathophysiology of diabetes or obesity or the metabolic response to physical exercise... - In vivo biodistribution and pharmacokinetics of (18)F-labeled human C-peptide: evaluation in monkeys using positron emission tomographyAnna Fredriksson
Karolinska Pharmacy, Karolinska Hospital and Institute, SE 171 76 Stockholm, Sweden
Life Sci 71:1361-70. 2002..The organs with the highest radioactivity concentrations have been identified, enabling dose estimations for studies in humans with low or no C-peptide... - C-peptide increases Na,K-ATPase expression via PKC- and MAP kinase-dependent activation of transcription factor ZEB in human renal tubular cellsDana Galuska
Section of Integrative Physiology, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
PLoS ONE 6:e28294. 2011..We determined the molecular mechanism by which long term exposure to C-peptide stimulates Na,K-ATPase expression and activity in primary human renal tubular cells (HRTC) in control and hyperglycemic conditions... - C-peptide and its C-terminal fragments improve erythrocyte deformability in type 1 diabetes patientsThomas Hach
Department of Internal Medicine, University of Mainz, 55101 Mainz, Germany thomas
Exp Diabetes Res 2008:730594. 2008..This study aimed to investigate the influence of C-peptide and fragments thereof on erythrocyte deformability and to elucidate the relevant signal transduction pathway... - C-peptide improves neuropathy in type 1 diabetic BB/Wor-ratsWeixian Zhang
Department of Pathology, Wayne State University, School of Medicine, Detroit, MI 48201, USA
Diabetes Metab Res Rev 23:63-70. 2007..Here we examine the therapeutic effects of C-peptide, delivered as continuous infusion or once daily subcutaneous injections on established DPN... - Effects of proinsulin C-peptide in experimental diabetic neuropathy: vascular actions and modulation by nitric oxide synthase inhibitionMary A Cotter
Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Scotland, UK
Diabetes 52:1812-7. 2003..Thus, C-peptide replacement improves nerve function in experimental diabetes, and the data are compatible with the notion that this is mediated by a NO-sensitive vascular mechanism... - [Actions of the tobacco industry and Swedish physicians]John Wahren
Lakartidningen 99:2974. 2002 - New tricks by an old dogThomas Forst
Exp Diabetes Res 2008:384219. 2008 - C-peptide makes a comebackJohn Wahren
Diabetes Metab Res Rev 19:345-7. 2003..The possibility that replacement of C-peptide in patients with type 1 diabetes may serve to retard or prevent the development of long-term complications should be evaluated... - Direct measurements of the permeability surface area for insulin and glucose in human skeletal muscleSoffia Gudbjornsdottir
Lundberg Laboratory for Diabetes Research, Sahlgrenska University Hospital, S 413 45 Goteborg, Sweden
J Clin Endocrinol Metab 88:4559-64. 2003.... - Influence of C-peptide on early glomerular changes in diabetic miceYoshiro Maezawa
Department of Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chiba 260-8670, Japan
Diabetes Metab Res Rev 22:313-22. 2006.... - C-peptide and captopril are equally effective in lowering glomerular hyperfiltration in diabetic ratsBjörn Samnegård
Department of Nephrology, Danderyd Hospital, SE 182 88 Stockholm, Sweden
Nephrol Dial Transplant 19:1385-91. 2004.... - C-peptide prevents glomerular hypertrophy and mesangial matrix expansion in diabetic ratsBjörn Samnegård
Department of Nephrology, Danderyd Hospital, SE 182 88 Stockholm, Sweden
Nephrol Dial Transplant 20:532-8. 2005..The aim of this study was to clarify further the effects of C-peptide on renal structural changes in type-1 diabetic rats...