Research Topics
| Leif AnderssonSummaryAffiliation: Uppsala University Country: Sweden Publications
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Detail Information
Publications
IGF2 antisense transcript expression in porcine postnatal muscle is affected by a quantitative trait nucleotide in intron 3Martin H Braunschweig
Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Box 597, SE 751 24 Uppsala, Sweden
Genomics 84:1021-9. 2004....- Genome-wide association analysis in domestic animals: a powerful approach for genetic dissection of trait lociLeif Andersson
Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
Genetica 136:341-9. 2009..This is an excellent illustration of how the characterization of alleles selected during animal domestication contributes to an improved understanding of genotype-phenotype relationships... - Studying phenotypic evolution in domestic animals: a walk in the footsteps of Charles DarwinL Andersson
Department of Medical Biochemistry and Microbiology, Uppsala University, SE 75124 Uppsala, Sweden
Cold Spring Harb Symp Quant Biol 74:319-25. 2009..In a recent study, we have identified the IGF2 repressor, and this previously unknown protein, named ZBED6, is specific for placental mammals and derived from a domesticated DNA transposon... - How selective sweeps in domestic animals provide new insight into biological mechanismsL Andersson
Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, ppsala, Sweden
J Intern Med 271:1-14. 2012..How the molecular characterization of trait loci in domestic animals can provide new basic knowledge of relevance for human medicine is discussed... - Melanocortin receptor variants with phenotypic effects in horse, pig, and chickenLeif Andersson
Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
Ann N Y Acad Sci 994:313-8. 2003..We could not confirm this association using an intercross between the wild boar and Large White domestic pigs, but it is possible that our F(2) generation was too small to detect the rather modest effect reported for this polymorphism... - Domestic-animal genomics: deciphering the genetics of complex traitsLeif Andersson
Department of Medical Biochemistry and Microbiology, Uppsala University, Box 597, SE-751 24 Uppsala, Sweden
Nat Rev Genet 5:202-12. 2004 - Mutations in SLC45A2 cause plumage color variation in chicken and Japanese quailUlrika Gunnarsson
Department of Medical Biochemistry and Microbiology, Uppsala University, SE 75124 Uppsala, Sweden
Genetics 175:867-77. 2007..It is an enigma why recessive null mutations at this locus cause an almost complete absence of both eumelanin and pheomelanin whereas some missense mutations are dominant and cause a specific inhibition of pheomelanin production... - Genetic analysis of an F(2) intercross between two chicken lines divergently selected for body-weightPer Wahlberg
Department of Medical Biochemistry and Microbiology, Uppsala University, BMC, Uppsala, Sweden
BMC Genomics 10:248. 2009..Furthermore, we utilized genotype data from ~13,000 SNPs to search the genome for potential selective sweeps that have occurred in the selected lines... - A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pigAnne Sophie Van Laere
Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala University, BMC, Box 597, SE 751 24 Uppsala, Sweden
Nature 425:832-6. 2003..The result supports the long-held view that regulatory mutations are important for controlling phenotypic variation... - Identification of a melanocyte-specific, microphthalmia-associated transcription factor-dependent regulatory element in the intronic duplication causing hair greying and melanoma in horsesElisabeth Sundström
Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden
Pigment Cell Melanoma Res 25:28-36. 2012..These results provide strong support for the causative nature of the duplication and constitute an explanation for the melanocyte-specific effects of the Grey allele... - Differential gene expression in femoral bone from red junglefowl and domestic chicken, differing for bone phenotypic traitsCarl Johan Rubin
Department of Medical Sciences, Uppsala University, Sweden
BMC Genomics 8:208. 2007.... - Identification of the yellow skin gene reveals a hybrid origin of the domestic chickenJonas Eriksson
Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
PLoS Genet 4:e1000010. 2008..This is the first conclusive evidence for a hybrid origin of the domestic chicken, and it has important implications for our views of the domestication process... - Genetic analysis of metabolic traits in an intercross between body weight-selected chicken linesWeronica Ek
Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden
Physiol Genomics 42:20-2. 2010.... - A complex genomic rearrangement involving the endothelin 3 locus causes dermal hyperpigmentation in the chickenBen Dorshorst
Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
PLoS Genet 7:e1002412. 2011..This complex genomic rearrangement causing a specific monogenic trait in the chicken illustrates how novel mutations with major phenotypic effects have been reused during breed formation in domestic animals... - A missense mutation in PMEL17 is associated with the Silver coat color in the horseEmma Brunberg
Dept of Medical Biochemistry and Microbiology, Uppsala University, SE 751 24 Uppsala, Sweden
BMC Genet 7:46. 2006..Herein we describe the identification of the responsible gene and a missense mutation associated with the Silver phenotype... - Copy number variation in intron 1 of SOX5 causes the Pea-comb phenotype in chickensDominic Wright
Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
PLoS Genet 5:e1000512. 2009..The study provides novel insight into the nature of mutations that contribute to phenotypic evolution and is the first description of a spontaneous and fully viable mutation in this developmentally important gene... - QTL analysis of body composition and metabolic traits in an intercross between chicken lines divergently selected for growthHee Bok Park
Department of Medical Biochemistry and Microbiology, Uppsala University, Biomedical Center, Uppsala, Sweden
Physiol Genomics 25:216-23. 2006..The observed pattern indicated that these effects were caused by maternal effects or by genetic differences in mitochondrial DNA... - The Dark brown plumage color in chickens is caused by an 8.3-kb deletion upstream of SOX10Ulrika Gunnarsson
Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
Pigment Cell Melanoma Res 24:268-74. 2011..Lower tyrosinase activity leads to a shift toward a more pheomelanistic (reddish) plumage color, which is the characteristic feature of the DB phenotype... - Whole-genome resequencing reveals loci under selection during chicken domesticationCarl Johan Rubin
Department of Medical Biochemistry and Microbiology, Uppsala University, Box 582, SE 75123 Uppsala, Sweden
Nature 464:587-91. 2010..This study has direct application to animal breeding and enhances the importance of the domestic chicken as a model organism for biomedical research... - Differentially expressed genes in hypothalamus in relation to genomic regions under selection in two chicken lines resulting from divergent selection for high or low body weightSojeong Ka
Department of Neuroscience, Uppsala University, Uppsala, Sweden
Neurogenetics 12:211-21. 2011..Because of such differential gene expression in hypothalamus, the lines may adapt behaviourally different particularly to the post-hatch situation when independent feeding to obtain energy is established... - Fine mapping and replication of QTL in outbred chicken advanced intercross linesFrancois Besnier
Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden
Genet Sel Evol 43:3. 2011..Although this approach is seen as promising, both to replicate QTL analyses and fine-map QTL, only a few AIL datasets, all originating from inbred founders, have been reported in the literature... - Quantitative trait loci for BMD and bone strength in an intercross between domestic and wildtype chickensCarl Johan Rubin
Department of Medical Sciences, Uppsala University, and Department of Internal Medicine, The Sahlgrenska University Hospital, Goteborg, Sweden
J Bone Miner Res 22:375-84. 2007..We report the identification of four QTLs for femoral traits: one for bone strength, one for endosteal circumference, and two affecting mineral density of noncortical bone... - Contrasting mode of evolution at a coat color locus in wild and domestic pigsMeiying Fang
Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden
PLoS Genet 5:e1000341. 2009..This pattern demonstrates that coat color phenotypes result from direct human selection and not via a simple relaxation of natural selective pressures... - Genetic architecture of tameness in a rat model of animal domesticationFrank W Albert
Department of Genetics and Pathology, Uppsala University, 75123 Uppsala, Sweden
Genetics 182:541-54. 2009..The loci described here are important starting points for finding the genes that cause tameness in these rats and potentially in domestic animals in general... - A sensitive method for detecting variation in copy numbers of duplicated genesGerli Pielberg
Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden
Genome Res 13:2171-7. 2003..An extensive allelic variation, including the presence of a new allele carrying a single KIT copy expected to encode a truncated KIT receptor, was revealed when analyzing white pigs from commercial lines... - Refined localization of the FAT1 quantitative trait locus on pig chromosome 4 by marker-assisted backcrossingFrida Berg
Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, SE 751 24, Sweden
BMC Genet 7:17. 2006..In order to narrow down the QTL interval we have traced the inheritance of the wild boar allele associated with high fat deposition through six additional backcross generations... - Inactivation of Pmel alters melanosome shape but has only a subtle effect on visible pigmentationAnders R Hellström
Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
PLoS Genet 7:e1002285. 2011..Despite a mild effect on visible pigmentation, inactivation of Pmel led to a substantial reduction in eumelanin content in hair, which demonstrates that PMEL has a critical role for maintaining efficient epidermal pigmentation... - ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growthEllen Markljung
Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
PLoS Biol 7:e1000256. 2009.... - Genome-wide identification of quantitative trait loci in a cross between Hampshire and Landrace II: meat quality traitsEllen Markljung
Department of Medical Biochemistry and Microbiology, Uppsala University, Box 597, SE 751 24 Uppsala, Sweden
BMC Genet 9:22. 2008..Hampshire pigs are commonly used as the sire line in commercial pig breeding. This is the first time a pedigree including Hampshire pigs has been used for a QTL analysis of meat quality traits... - Proviral integrations and expression of endogenous avian leucosis virus during long term selection for high and low body weight in two chicken linesSojeong Ka
Department of Neuroscience, Uppsala University, Uppsala, Sweden
Retrovirology 6:68. 2009..The main differentially expressed transcripts were endogenous retroviral sequences identified as avian leucosis virus subgroup-E (ALVE)... - A novel unstable duplication upstream of HAS2 predisposes to a breed-defining skin phenotype and a periodic fever syndrome in Chinese Shar-Pei dogsMia Olsson
Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
PLoS Genet 7:e1001332. 2011..The identification of HA as a major risk factor for this canine disease raises the potential of this glycosaminoglycan as a risk factor for human periodic fevers and as an important driver of chronic inflammation... - Major growth QTLs in fowl are related to fearful behavior: possible genetic links between fear responses and production traits in a red junglefowl x white leghorn intercrossKarin E Schütz
Department of Animal Environment and Health, Section of Ethology, Swedish University of Agricultural Sciences, Uppsala, Sweden
Behav Genet 34:121-30. 2004..The results show that loci affecting important production traits are located in the same chromosomal region as loci affecting different fear-related behaviors... - High-resolution comparative mapping of pig Chromosome 4, emphasizing the FAT1 regionMaria Moller
Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Box 597, 75124, Uppsala, Sweden
Mamm Genome 15:717-31. 2004..This refined SSC4 map and the comparative analysis will be a great aid in the search for the genes underlying the FAT1 locus... - Gene copy number detection in animal studiesGerli Pielberg
Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
Methods Mol Biol 373:147-56. 2007..We also discuss our method for determining the copy numbers at a duplicated locus. This method has been applied to study genetic variation at the KIT locus in pigs, which have a major effect on coat color variation in this species... - Expression analysis of growth and energy regulation-associated genes in two divergent chicken strainsSojeong Ka
Department of Neuroscience, Uppsala University, Sweden
Ann N Y Acad Sci 1040:357-9. 2005..Several transcripts from genes in metabolic networks as well as from retroviruses were differentially expressed... - Epistasis and the release of genetic variation during long-term selectionOrjan Carlborg
Linnaeus Centre for Bioinformatics, Uppsala University, Box 598, SE 75124 Uppsala, Sweden
Nat Genet 38:418-20. 2006..The interactions in this radial network mediate a considerably larger selection response than predicted by a single-locus model... - Sensory ataxic neuropathy in golden retriever dogs is caused by a deletion in the mitochondrial tRNATyr geneIzabella Baranowska
Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden
PLoS Genet 5:e1000499. 2009..Altogether, these results provide conclusive evidence that the deletion in the mitochondrial tRNA(Tyr) gene is the causative mutation for SAN... - A cis-acting regulatory mutation causes premature hair graying and susceptibility to melanoma in the horseGerli Rosengren Pielberg
Department of Medical Biochemistry and Microbiology, Uppsala University, Box 597, SE 751 24 Uppsala, Sweden
Nat Genet 40:1004-9. 2008..The Gray horse provides a notable example of how humans have cherry-picked mutations with favorable phenotypic effects in domestic animals... - A large duplication associated with dominant white color in pigs originated by homologous recombination between LINE elements flanking KITElisabetta Giuffra
Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Box 597, S-751 24 Uppsala, Sweden
Mamm Genome 13:569-77. 2002.... - Duplication of FGF3, FGF4, FGF19 and ORAOV1 causes hair ridge and predisposition to dermoid sinus in Ridgeback dogsNicolette H C Salmon Hillbertz
Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences SLU, Biomedical Centre, Box 597, SE 751 24 Uppsala, Sweden
Nat Genet 39:1318-20. 2007..FGFs play a crucial role in development, suggesting that the ridge and dermoid sinus are caused by dysregulation of one or more of the three FGF genes during development... - Comparative sequence analysis of the INS-IGF2-H19 gene cluster in pigsValerie Amarger
Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Box 597, SE 751 24 Uppsala, Sweden
Mamm Genome 13:388-98. 2002..The high GC and CpG content were more pronounced in the pig than in the two other species. The results will facilitate the further characterization of this important QTL in the pig... - A nonsense mutation in the FMO3 gene underlies fishy off-flavor in cow's milkAnne Lundén
Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden
Genome Res 12:1885-8. 2002..RT-PCR analysis indicated that the mutant transcript is present in a very low amount. The mutation was found to be surprisingly common (q = 0.155) in one breed of cattle... - The Dominant white, Dun and Smoky color variants in chicken are associated with insertion/deletion polymorphisms in the PMEL17 geneSusanne Kerje
Department of Medical Biochemistry and Microbiology, Uppsala University, SE 751 24 Uppsala, Sweden
Genetics 168:1507-18. 2004..These mutations are, together with the recessive silver mutation in the mouse, the only PMEL17 mutations with phenotypic effects that have been described so far in any species... - The uncoupling protein 1 gene (UCP1) is disrupted in the pig lineage: a genetic explanation for poor thermoregulation in pigletsFrida Berg
Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
PLoS Genet 2:e129. 2006.... - Use of randomization testing to detect multiple epistatic QTLsOrjan Carlborg
Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, BMC, Box 597, S 751 24 Uppsala, Sweden
Genet Res 79:175-84. 2002..We believe that this method will facilitate the evaluation of the importance at epistatic interaction among QTLs controlling multifactorial traits and disorders... - Sex-linked barring in chickens is controlled by the CDKN2A /B tumour suppressor locusAnders R Hellström
Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
Pigment Cell Melanoma Res 23:521-30. 2010..This novel finding provides the first evidence that the tumour suppressor locus CDKN2A/B can affect pigmentation phenotypes and sheds new light on the functional significance of this gene... - Mitochondrial diversity in European and Chinese pigs is consistent with population expansions that occurred prior to domesticationMeiying Fang
Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden
Proc Biol Sci 273:1803-10. 2006..Mismatch analysis supported this notion and suggested that the expansion was initiated before domestication... - Chicken genomics: feather-pecking and victim pigmentationLinda Keeling
Department of Animal Environment and Health, Swedish University of Agricultural Sciences, PO Box 234, 53223 Skara, Sweden
Nature 431:645-6. 2004.... - [Studies of relationship between the melanocortin-3 receptor gene and body weight in chicken for high and low weight lines' intercross]Si Wen Jiang
Huazhong Agricultural University, Wuhan 430070, China
Yi Chuan Xue Bao 29:322-5. 2002..The result suggests that the MC3R as a candidate gene can explain significant difference for body weight in the intercross chickens... - Haplotype sharing refines the location of an imprinted quantitative trait locus with major effect on muscle mass to a 250-kb chromosome segment containing the porcine IGF2 geneCarine Nezer
Department of Genetics, Faculty of Veterinary Medicine, University of Liege, 4000 Liege, Belgium
Genetics 165:277-85. 2003..This considerably reinforces the candidacy of these genes, justifying their detailed analysis... - A global search reveals epistatic interaction between QTL for early growth in the chickenOrjan Carlborg
Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, S-751 24 Uppsala, Sweden
Genome Res 13:413-21. 2003..Several of the detected loci affected either early or late growth but not both. Very few loci affected the entire growth process, which points out that early and late growth, at least to some extent, have different genetic regulation... - QTL analysis of a red junglefowl x White Leghorn intercross reveals trade-off in resource allocation between behavior and production traitsKarin Schutz
Swedish University of Agricultural Sciences, Department of Animal Environment and Health, Section of Ethology, POB 234, SE 532 23 Skara, Sweden
Behav Genet 32:423-33. 2002..The results suggest a trade-off between energy-demanding behavior and high production and that some of this may be caused by genetic linkage or pleiotropic gene effects... - Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolutionLadeana W Hillier
Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA
Nature 432:695-716. 2004..The distinctive properties of avian microchromosomes, together with the inferred patterns of conserved synteny, provide additional insights into vertebrate chromosome architecture... - A genetic variation map for chicken with 2.8 million single-nucleotide polymorphismsGane Ka-Shu Wong
Beijing Institute of Genomics of Chinese Academy of Sciences, Beijing Genomics Institute, Beijing Proteomics Institute, Beijing 101300, China
Nature 432:717-22. 2004..In fact, most of the SNPs originated before domestication, and there is little evidence of selective sweeps for adaptive alleles on length scales greater than 100 kilobases... - The IGF2-intron3-G3072A substitution explains a major imprinted QTL effect on backfat thickness in a Meishan x European white pig intercrossBart J Jungerius
Department of Animal Breeding and Genetics, Wageningen University, P O Box 40, 6700 AH Wageningen, The Netherlands
Genet Res 84:95-101. 2004..Finally, this study shows that this particular IGF2 mutation does not cause the paternally expressed QTL for teat number mapping to the same region of SSC2p as the BFT QTL... - Genomics meets ethology: a new route to understanding domestication, behavior, and sustainability in animal breedingPer Jensen
Department of Biology, IFM, Linkoping University, Sweden
Ambio 34:320-4. 2005..Modern genomics paired with analysis of behavior may help in designing more sustainable and robust breeding in the future... - Genetic analysis of anal atresia in pigs: evidence for segregation at two main lociPamela Cassini
Parco Tecnologico Padano, Centro Ricerche Studi Agroalimentari, Polo Universitario, via A Einstein 2, 26900, Lodi, Italy
Mamm Genome 16:164-70. 2005..GLI2 (GLI-Kruppel family member GLI2) was identified as a positional candidate gene based on comparative mapping; radiation hybrid mapping confirmed that this locus is located within the QTL region... - Many QTLs with minor additive effects are associated with a large difference in growth between two selection lines in chickensLina Jacobsson
Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, BMC, Uppsala
Genet Res 86:115-25. 2005..No QTL at all would have reached genome-wide significance using a less powerful design (e.g. approx. 200 F2 individuals) regardless of the nine-fold phenotypic difference between the founder lines for the selected trait... - Efficient mapping of mendelian traits in dogs through genome-wide associationElinor K Karlsson
Broad Institute of Harvard and Massachusetts Institute of Technology MIT, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
Nat Genet 39:1321-8. 2007.... - The genetic architecture of a female sexual ornamentDominic Wright
Edward Grey Institute, Department of Zoology, University of Oxford, Oxford, UK
Evolution 62:86-98. 2008..Together, these results shed light onto the physiological and genetic architecture of a female ornament... - Plumage color and feather pecking--behavioral differences associated with PMEL17 genotypes in chicken (Gallus gallus)Daniel Nätt
Department of Biology IFM, Linkoping University, SE 58183, Linkoping, Sweden
Behav Genet 37:399-407. 2007..Such behavioral differences might be important aspects of the mechanism which predispose i/i individuals for being victims of FP... - The mutation causing the black-and-tan pigmentation phenotype of Mangalitza pigs maps to the porcine ASIP locus but does not affect its coding sequenceCord Drogemuller
Institute of Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Hannover, 30559, Germany
Mamm Genome 17:58-66. 2006..The a(t) mutation is therefore probably a regulatory ASIP mutation that alters its dorsoventral expression pattern... - Estimating the frequency of Asian cytochrome B haplotypes in standard European and local Spanish pig breedsAlex Clop
, , , Bellaterra 08193, Spain
Genet Sel Evol 36:97-104. 2004..These findings illustrate how geographical confinement spared several local Spanish breeds from the extensive introgression event that took place during the 18th and 19th centuries in Europe... - The 5'-AMP-activated protein kinase gamma3 isoform has a key role in carbohydrate and lipid metabolism in glycolytic skeletal muscleBrian R Barnes
Department of Surgical Sciences and the Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
J Biol Chem 279:38441-7. 2004..Our results validate the muscle-specific AMPK gamma3 isoform as a therapeutic target for prevention and treatment of insulin resistance... - Worldwide phylogeography of wild boar reveals multiple centers of pig domesticationGreger Larson
Henry Wellcome Ancient Biomolecules Centre, University of Oxford, Department of Zoology, South Parks Road OX1 3PS, UK
Science 307:1618-21. 2005..In contrast, new genetic data reveal multiple centers of domestication across Eurasia and that European, rather than Near Eastern, wild boar are the principal source of modern European domestic pigs... - Avian models with spontaneous autoimmune diseasesGeorg Wick
Division of Experimental Pathophysiology and Immunology, Biocenter, Innsbruck Medical University, A-6020 Innsbruck, Austria
Adv Immunol 92:71-117. 2006..Special emphasis is given to the new opportunities to unravel the genetic basis of these diseases in view of the recently completed sequencing of the chicken genome...