Research Topics
Species | D I AnderssonSummaryAffiliation: Uppsala University Country: Sweden Publications
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Publications
The biological cost of mutational antibiotic resistance: any practical conclusions?Dan I Andersson
Department of Medical Biochemistry and Microbiology, Uppsala University, Box 582, S 751 23 Uppsala, Sweden
Curr Opin Microbiol 9:461-5. 2006..Conceivably we can use this knowledge to rationally choose and design targets and drugs where the costs of resistance are the highest, and where the likelihood of compensation is the lowest...- Persistence of antibiotic resistance in bacterial populationsDan I Andersson
Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
FEMS Microbiol Rev 35:901-11. 2011..Several mechanisms are contributing to the stability of antibiotic resistance in bacterial populations and even if antibiotic use is reduced it is likely that most resistance mechanisms will persist for considerable times... - Gene amplification and adaptive evolution in bacteriaDan I Andersson
Department of Medical Biochemistry and Microbiology, Uppsala, S 751 23, Sweden
Annu Rev Genet 43:167-95. 2009..Due to the high intrinsic instability and fitness costs associated with GDAs, they are generally transient in nature, and consequently their evolutionary and medical importance is often underestimated... - Biological roles of translesion synthesis DNA polymerases in eubacteriaDan I Andersson
Uppsala University, Department of Medical Biochemistry and Microbiology, SE 75123 Uppsala, Sweden
Mol Microbiol 77:540-8. 2010.... - Antibiotic resistance and its cost: is it possible to reverse resistance?Dan I Andersson
Department of Medical Biochemistry and Microbiology, Uppsala University, Box 582, SE 751 23, Uppsala, Sweden
Nat Rev Microbiol 8:260-71. 2010..Here, we review the factors that influence the fitness costs of antibiotic resistance, the ways by which bacteria can reduce these costs and the possibility of exploiting them... - Bacterial gene amplification: implications for the evolution of antibiotic resistanceLinus Sandegren
Department of Medical Biochemistry and Microbiology, Uppsala University, Box 582, Uppsala, S751 23, Sweden
Nat Rev Microbiol 7:578-88. 2009..In this Review, we highlight the dynamic properties of gene amplifications and describe how they can facilitate adaptive evolution in response to toxic drugs... - An adenosyl-cobalamin (coenzyme-B12)-repressed translational enhancer in the cob mRNA of Salmonella typhimuriumS Ravnum
Department of Cell and Molecular Biology, Uppsala University, S-751 24 Uppsala, Sweden
Mol Microbiol 39:1585-94. 2001..The above data suggest that normal cobalamin repression of the cob operon requires that the 5'-UTR has a defined secondary and tertiary structure... - Contribution of gene amplification to evolution of increased antibiotic resistance in Salmonella typhimuriumSong Sun
Department of Medical Biochemistry and Microbiology, Uppsala University, S 75123, Sweden
Genetics 182:1183-95. 2009..If later point mutations (allowed by amplification) provide sufficient adaptive improvement, the amplification may be lost... - Genetic analysis of colistin resistance in Salmonella enterica serovar TyphimuriumSong Sun
Department of Medical Biochemistry and Microbiology, Uppsala University, S 751 23 Uppsala, Sweden
Antimicrob Agents Chemother 53:2298-305. 2009..The low fitness costs and the high mutation rate suggest that mutants with reduced susceptibility to colistin could emerge in clinical settings... - Effect of translesion DNA polymerases, endonucleases and RpoS on mutation rates in Salmonella typhimuriumSanna Koskiniemi
Department of Cell and Molecular Biology, Uppsala University, S 75123 Uppsala, Sweden
Genetics 185:783-95. 2010.... - Fusidic acid-resistant mutants of Salmonella enterica serovar Typhimurium with low fitness in vivo are defective in RpoS inductionMirjana Macvanin
Department of Cell and Molecular Biology, The Biomedical Center, Uppsala University, S-751 24 Uppsala, Sweden
Antimicrob Agents Chemother 47:3743-9. 2003..The low fitness of Fusr mutants in vivo suggests that drugs that can alter the levels of global regulators of gene expression deserve attention as potential antimicrobial agents... - Compensatory gene amplification restores fitness after inter-species gene replacementsPeter A Lind
Department of Medical Biochemistry and Microbiology, Uppsala University, SE 75123 Uppsala, Sweden
Mol Microbiol 75:1078-89. 2010..Our findings can explain the observation that duplicated genes are over-represented among horizontally transferred genes, and suggest a potential coupling between compensatory gene amplification after HGT and the evolution of new genes... - Mechanism and fitness costs of PR-39 resistance in Salmonella enterica serovar Typhimurium LT2Maria Pränting
Department of Medical Biochemistry and Microbiology, Uppsala University, S 751 23 Uppsala, Sweden
Antimicrob Agents Chemother 52:2734-41. 2008.... - Error-prone initiation factor 2 mutations reduce the fitness cost of antibiotic resistanceAnna Zorzet
Department of Medical Biochemistry and Microbiology, Uppsala University, Box 582, SE 751 23 Uppsala, Sweden
Mol Microbiol 75:1299-313. 2010..More generally, our results suggest that bacterial protein synthesis is mRNA-limited and that compensatory mutations in IF2 could increase the persistence of PDFI-resistant bacteria in clinical settings... - Little evidence for reversibility of trimethoprim resistance after a drastic reduction in trimethoprim useM Sundqvist
Department of Medical Sciences, Section of Infectious Diseases, Uppsala University Hospital, Uppsala University, S 751 85 Uppsala, Sweden
J Antimicrob Chemother 65:350-60. 2010..Resistance may thus be reversible if antibiotic use is discontinued or reduced. To examine this concept, we performed a 24 month voluntary restriction on the use of trimethoprim-containing drugs in Kronoberg County, Sweden... - Novel ribosomal mutations affecting translational accuracy, antibiotic resistance and virulence of Salmonella typhimuriumJ Bjorkman
Department of Microbiology, Uppsala University, Sweden
Mol Microbiol 31:53-8. 1999..This is the first demonstration that such compensations do not require that the compensating rpsD allele has a ribosomal ambiguity (ram) phenotype... - Translesion DNA polymerases are required for spontaneous deletion formation in Salmonella typhimuriumSanna Koskiniemi
Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
Proc Natl Acad Sci U S A 106:10248-53. 2009..These findings suggest that the translesion polymerases are not involved in forming the DNA breaks, but that they require them to stimulate deletion formation... - Mechanisms and physiological effects of protamine resistance in Salmonella enterica serovar Typhimurium LT2Maria Pränting
Department of Medical Biochemistry and Microbiology, Uppsala University, SE 751 23 Uppsala, Sweden
J Antimicrob Chemother 65:876-87. 2010.... - Evolution of new gene functions: simulation and analysis of the amplification modelMats E Pettersson
Department of Molecular Evolution, Evolutionary Biology Centre, Uppsala University, Uppsala, SE 752 36, Sweden
Genetica 135:309-24. 2009..The results show that amplification of tandem repeats is likely to contribute to creation of new genes in nature... - The fitness cost of streptomycin resistance depends on rpsL mutation, carbon source and RpoS (sigmaS)Wilhelm Paulander
Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
Genetics 183:539-46, 1SI-2SI. 2009.... - Bacteria with increased mutation frequency and antibiotic resistance are enriched in the commensal flora of patients with high antibiotic usageIngegerd Gustafsson
Antibiotic Research Unit, Department of Medical Sciences, Section of Clinical Bacteriology, Uppsala University Hospital, Uppsala, Sweden
J Antimicrob Chemother 52:645-50. 2003..024) but not for rifampicin resistance (P=0.74). CONCLUSIONS: High antibiotic use selected for commensals with highly increased resistance and a slight increase in mutation frequency... - Antibiotic treatment in vitro of phenotypically tolerant bacterial populationsCamilla Wiuff
Department of Medical Biochemistry and Microbiology, Uppsala University, Box 582, S 751 23 Uppsala, Sweden
J Antimicrob Chemother 59:254-63. 2007..We compared the microbiological efficacy of six antibiotics against tolerant cells and by mathematical modelling explored the potential clinical implications of tolerance... - Whole-genome mutational biases in bacteriaPeter A Lind
Department of Medical Biochemistry and Microbiology, Uppsala University, S 75123 Uppsala, Sweden
Proc Natl Acad Sci U S A 105:17878-83. 2008.... - Pharmacodynamic model to describe the concentration-dependent selection of cefotaxime-resistant Escherichia coliSara K Olofsson
Antibiotic Research Unit, Department of Medical Sciences, Clinical Bacteriology and Infectious Diseases, Uppsala University, Sweden
Antimicrob Agents Chemother 49:5081-91. 2005.... - Fitness of antibiotic resistant Staphylococcus epidermidis assessed by competition on the skin of human volunteersIngegerd Gustafsson
Department of Medical Sciences, Clinical Bacteriology, Box 552, Uppsala University, S 751 22 Uppsala, Sweden
J Antimicrob Chemother 52:258-63. 2003..However, there are limited experimental data on the relative fitness of resistant and susceptible bacteria during growth in their natural environment... - Mutational robustness of ribosomal protein genesPeter A Lind
Department of Medical Biochemistry and Microbiology, Uppsala University, SE 75123 Uppsala, Sweden
Science 330:825-7. 2010..The DFEs for synonymous and nonsynonymous substitutions are similar, suggesting that in some genes, strong fitness constraints are present at the level of the messenger RNA... - Nitrofurantoin resistance mechanism and fitness cost in Escherichia coliLinus Sandegren
Department of Medical Biochemistry and Microbiology, Uppsala University, S 75123 Uppsala, Sweden
J Antimicrob Chemother 62:495-503. 2008..We identified mutations conferring nitrofurantoin resistance and examined their effect on the fitness of clinical Escherichia coli isolates... - Predicting antibiotic resistanceJose L Martinez
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública and Unidad Asociada al CSIC Resistencia a los Antibióticos y Virulencia Bacteriana, Cantoblanco, 28049 Madrid, Spain
Nat Rev Microbiol 5:958-65. 2007..To this end, we propose the establishment of methodological guidelines that will allow researchers to predict the emergence of resistance to a new antibiotic before its clinical introduction... - Adaptation to the deleterious effects of antimicrobial drug resistance mutations by compensatory evolutionSophie Maisnier-Patin
Department of Bacteriology, Swedish Institute for Infectious Disease Control, 171 82 Solna, Sweden
Res Microbiol 155:360-9. 2004.... - Persistence of antibiotic resistant bacteriaDan I Andersson
Swedish Institute for Infectious Disease Control, Dept of Bacteriology, Nobels Väg 18, S 171 82, Stockholm, Sweden
Curr Opin Microbiol 6:452-6. 2003..Thus, it is of importance that we forcefully implement strategies to reduce the rate of appearance and spread of resistant bacteria to allow new drug discovery to catch up with bacterial resistance development... - Origin of mutations under selection: the adaptive mutation controversyJohn R Roth
Microbiology Section, Division of Biological Sciences, University of California, Davis, California 95616, USA
Annu Rev Microbiol 60:477-501. 2006..We suggest that the adaptive mutation controversy has persisted because the distinction between these two uses of selection has not been appreciated... - Biological costs and mechanisms of fosfomycin resistance in Escherichia coliAnnika I Nilsson
Department of Bacteriology, Swedish Institute for Infectious Disease Control, S 171 82 Stockholm, Sweden
Antimicrob Agents Chemother 47:2850-8. 2003..According to the mathematical model, the reduced growth rate of the resistant strains will prevent them from establishing in the bladder, which could explain why fosfomycin resistance remains rare in clinical isolates... - Rebuttal: adaptive point mutation (Rosenberg and Hastings)John R Roth
University of California Davis, Microbiology Section, One Shields Ave, Davis, CA 95616, USA
J Bacteriol 186:4844. 2004 - Rebuttal: adaptive mutation in Escherichia coli (Foster)John R Roth
University of California, Davis, Microbiology Section, One Shields Ave, Davis, CA 95616, USA
J Bacteriol 186:4854. 2004 - Adaptive mutation: how growth under selection stimulates Lac(+) reversion by increasing target copy numberJohn R Roth
University of California Davis, Microbiology Section, One Shields Ave, Davis, CA 95616, USA
J Bacteriol 186:4855-60. 2004 - Polymorphic mutation frequencies in Escherichia coli: emergence of weak mutators in clinical isolatesMaria Rosario Baquero
Servicio de Microbiologia, Hospital Ramon y Cajal, Madrid, Spain
J Bacteriol 186:5538-42. 2004..7% were strongly hypermutable (f > or = 4 x 10(-7)). Weak mutators were apparently more frequent in southern Europe and in blood isolates (38%) than in urinary tract isolates (25%) and feces of healthy volunteers (11%)... - Comparative proteome analysis of Mycobacterium tuberculosis grown under aerobic and anaerobic conditionsJoakim Starck
Department of Bacteriology, Swedish Institute for Infectious Disease Control, S-17182, Solna, Sweden
Microbiology 150:3821-9. 2004..Some protein spots were found to be proteolytic fragments, e.g. HspX and GroEL2. These data suggest that M. tuberculosis induces expression of about 1 % of its genes in response to dormancy... - Experimental adaptation of Salmonella typhimurium to miceAnnika I Nilsson
Department of Bacteriology, Swedish Institute for Infectious Disease Control, S-171 82 Solna, Sweden
Genetics 168:1119-30. 2004..These data show that S. typhimurium can rapidly and extensively increase its fitness in mice but this niche specialization is, at least in mutators, associated with a cost... - Genomic buffering mitigates the effects of deleterious mutations in bacteriaSophie Maisnier-Patin
Department of Bacteriology, Swedish Institute for Infectious Disease Control and Microbiology and Tumor Center, Karolinska Institute, S-171 82 Stockholm, Sweden
Nat Genet 37:1376-9. 2005..These findings suggest that overexpression of chaperones contributes to antagonistic epistasis... - Restored fitness leads to long-term persistence of resistant Bacteroides strains in the human intestineSonja Lofmark
Department of Laboratory Medicine, Division of Clinical Microbiology, F82, Karolinska University Hospital, Karolinska Institutet, SE 141 86 Stockholm, Sweden
Anaerobe 14:157-60. 2008..The results indicate that the biological cost associated with a resistance gene can rapidly be compensated during in vivo growth. Thus, once the resistant clone has gained its resistance determinant it will be difficult to eliminate... - Multiple mechanisms to ameliorate the fitness burden of mupirocin resistance in Salmonella typhimuriumWilhelm Paulander
Department of Bacteriology, Swedish Institute for Infectious Disease Control and Microbiology, Tumor and Cell Biology Center, Karolinska Institute, S 171 82 Solna, Sweden
Mol Microbiol 64:1038-48. 2007..Our findings show that the fitness costs of ileS mutations conferring mupirocin resistance can be reduced by several types of mechanisms that may contribute to the stability of mupirocin resistance in clinical settings... - Reducing the fitness cost of antibiotic resistance by amplification of initiator tRNA genesAnnika I Nilsson
Department of Bacteriology, Swedish Institute for Infectious Disease Control, S-171 82 Solna, Sweden
Proc Natl Acad Sci U S A 103:6976-81. 2006..Amplified units varied in size from 1.9 to 94 kbp. Suppression of deleterious mutations by gene amplification may be involved in the evolution of new gene functions... - Compensatory adaptation to the deleterious effect of antibiotic resistance in Salmonella typhimuriumSophie Maisnier-Patin
Department of Bacteriology, Swedish Insitute for Infectious Disease Control, Solna, Sweden
Mol Microbiol 46:355-66. 2002..Our results show that the deleterious effects of a resistance mutation can be compensated by an unexpected variety of mutations...