Research Topics
Genomes and Genes | Solbritt Rantapaa-DahlqvistSummaryAffiliation: University Hospital Country: Sweden Publications
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Publications
Polymorphisms of the Genes Encoding CD40 and Growth Differentiation Factor 15 and in the 9p21.3 Region in Patients with Rheumatoid Arthritis and Cardiovascular DiseaseLisbeth Arlestig
Department of Public Health and Clinical Medicine, Rheumatology, University Hospital, SE 901 85 Umea, Sweden
J Rheumatol 39:939-45. 2012..Genes or gene products associated with coronary artery disease in the general population were analyzed in rheumatoid arthritis (RA) patients with atherothrombotic manifestations (ATM)...- Antibodies against cyclic citrullinated peptides of IgG, IgA and IgM isotype and rheumatoid factor of IgM and IgA isotype are increased in unaffected members of multicase rheumatoid arthritis families from northern SwedenLisbeth Arlestig
Correspondence to Solbritt Rantapää Dahlqvist, Department of Public Health and Clinical Medicine, Rheumatology, University Hospital, SE 901 85 Umea, Sweden
Ann Rheum Dis 71:825-9. 2012..Rheumatoid factors (RFs) and antibodies against cyclic citrullinated peptides (CCPs) of IgG, IgA and IgM isotype have been shown to precede disease onset by years... - Antibodies of IgG, IgA and IgM isotypes against cyclic citrullinated peptide precede the development of rheumatoid arthritisHeidi Kokkonen
Departments of Public Health and Clinical Medicine Rheumatology, Umea University, SE 90185 Umeå, Sweden
Arthritis Res Ther 13:R13. 2011.... - Diagnostic properties of metabolic perturbations in rheumatoid arthritisRasmus K Madsen
Computational Life Science Cluster CLIC, Department of Chemistry, Umea University, SE 90187 Umea, Sweden
Arthritis Res Ther 13:R19. 2011..The aim of this study was to assess the feasibility of diagnosing early rheumatoid arthritis (RA) by measuring selected metabolic biomarkers... - Autoantibodies predate the onset of systemic lupus erythematosus in northern SwedenCatharina Eriksson
Department of Clinical Immunology, Umea University, SE 90185 Umeå, Sweden
Arthritis Res Ther 13:R30. 2011..Therefore, we sought to identify autoantibodies in a northern European population predating the onset of symptoms of SLE and their relationship to presenting symptoms... - Up regulation of monocyte chemoattractant protein-1 expression in anti-citrulline antibody and immunoglobulin M rheumatoid factor positive subjects precedes onset of inflammatory response and development of overt rheumatoid arthritisS Rantapaa-Dahlqvist
Department of Rheumatology, University Hospital, SE 901 85 Umea, Sweden
Ann Rheum Dis 66:121-3. 2007..Previously, it has been shown in these individuals that antibodies against cyclic citrullinated peptide (anti-CCP) detectable years before the onset of symptoms have a high predictive value for development of rheumatoid arthritis... - Conversion towards an atherogenic lipid profile in rheumatoid arthritis patients during long-term infliximab therapyS Rantapää Dahlqvist
Department of Public Health and Clinical Medicine, Rheumatology, University Hospital, Umea, Sweden
Scand J Rheumatol 35:107-11. 2006..To analyse the effects of infliximab infusions on serum levels of lipids in patients with rheumatoid arthritis (RA) treated for 2 years... - Diagnostic and prognostic significance of autoantibodies in early rheumatoid arthritisS Rantapaa-Dahlqvist
Department of Rheumatology, University Hospital, Umea, Sweden
Scand J Rheumatol 34:83-96. 2005..The antibodies are presented with the two clinically most relevant antibody tests first, followed by others in alphabetic order... - A combination of autoantibodies to cyclic citrullinated peptide (CCP) and HLA-DRB1 locus antigens is strongly associated with future onset of rheumatoid arthritisEwa Berglin
Department of Public Health and Clinical Medicine, Division of Rheumatology, University Hospital, Umea, Sweden
Arthritis Res Ther 6:R303-8. 2004..9, 95% confidence interval 0.9-4.2). This study showed that the presence of anti-CCP antibodies together with SE gene carriage is associated with a very high relative risk for future development of RA... - Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritisSolbritt Rantapaa-Dahlqvist
Umea Universitet, Umea, Sweden
Arthritis Rheum 48:2741-9. 2003.... - What happens before the onset of rheumatoid arthritis?Solbritt Rantapaa-Dahlqvist
Department of Rheumatology, University Hospital, Umeå SE 901 85, Sweden
Curr Opin Rheumatol 21:272-8. 2009.... - PTPN22 polymorphism and anti-cyclic citrullinated peptide antibodies in combination strongly predicts future onset of rheumatoid arthritis and has a specificity of 100% for the diseaseMartin Johansson
Department of Rheumatology, University Hospital, Umea, Sweden
Arthritis Res Ther 8:R19. 2006..The combination gave a specificity of 100% for diagnosing RA... - The PTPN22 1858C/T polymorphism is associated with anti-cyclic citrullinated peptide antibody-positive early rheumatoid arthritis in northern SwedenHeidi Kokkonen
Department of Rheumatology, University Hospital, SE 901 85 Umea, Sweden
Arthritis Res Ther 9:R56. 2007..05 and P < 0.01, respectively), while the combination of both resulted in an even earlier age at onset. Smoking was identified as a risk factor independent of the 1858T variant and anti-CCP antibodies... - CARD8 p.C10X polymorphism is associated with inflammatory activity in early rheumatoid arthritisAlf Kastbom
Division of Rheumatology, Linkoping University Hospital, Linkoping, Sweden
Ann Rheum Dis 69:723-6. 2010..CARD8 and NLRP3 are constituents of the inflammasome which regulates interleukin 1beta production. The influence of polymorphisms in CARD8 and NLRP3 on rheumatoid arthritis (RA) susceptibility and severity were evaluated... - T-cell expression of CD91 - a marker of unresponsiveness to anti-TNF therapy in rheumatoid arthritisCatharina Eriksson
Department of Clinical Immunology, University Hospital, Umea, Sweden
APMIS 118:837-45. 2010..The results suggest T-lymphocyte expression of CD91 to be a biomarker that signifies unresponsiveness to anti-TNF therapy in patients with RA and may be used to identify potential responders and non-responders... - Cardiovascular events in early RA are a result of inflammatory burden and traditional risk factors: a five year prospective studyLena Innala
Institution of Public Health and Clinical Medicine Rheumatology, University Hospital, Umea, 901 85, Sweden
Arthritis Res Ther 13:R131. 2011..We also evaluated their potential for predicting a new cardiovascular event (CVE) during the five-year follow-up period and the modulatory effect of pharmacological treatment... - Levels of gastrin-releasing peptide and substance P in synovial fluid and serum correlate with levels of cytokines in rheumatoid arthritisOla Grimsholm
Department of Integrative Medical Biology, Section for Anatomy, Umea University, Umea, Sweden
Arthritis Res Ther 7:R416-26. 2005..In conclusion, BN/GRP and SP are involved together with cytokines in the neuroimmunomodulation that occurs in the arthritic joint... - Activation of the immune system and inflammatory activity in relation to markers of atherothrombotic disease and atherosclerosis in rheumatoid arthritisSolveig Wallberg-Jonsson
Department of Rheumatology, University Hospital, Umea, Sweden
J Rheumatol 29:875-82. 2002.... - Association of a PDCD1 polymorphism with renal manifestations in systemic lupus erythematosusMartin Johansson
University Hospital, Umea, and Sunderbyn Hospital, Lulea, Sweden
Arthritis Rheum 52:1665-9. 2005..The PD-1.3A allele was analyzed in relation to disease manifestations and severity representing various phenotypes of SLE... - Treatment with tumor necrosis factor inhibitors and the risk of acute coronary syndromes in early rheumatoid arthritisLotta Ljung
Department of Medicine Rheumatology, Umea University Hospital, Umea, Sweden
Arthritis Rheum 64:42-52. 2012..The aim of this study was to determine the risk of acute coronary syndromes (ACS) in patients with early RA in relation to treatment with, and response to, anti-TNF... - Atherosclerosis in early rheumatoid arthritis: very early endothelial activation and rapid progression of intima media thicknessAnna Södergren
Department of Public Health and Clinical Medicine Rheumatology, University Hospital, 901 85 Umea, Sweden
Arthritis Res Ther 12:R158. 2010.... - BDNF in RA: downregulated in plasma following anti-TNF treatment but no correlation with inflammatory parametersOla Grimsholm
Department of Integrative Medical Biology, Section for Anatomy, Umea University, Umea, Sweden
Clin Rheumatol 27:1289-97. 2008.... - Up-regulation of cytokines and chemokines predates the onset of rheumatoid arthritisHeidi Kokkonen
Umea University Hospital, Umea, Sweden
Arthritis Rheum 62:383-91. 2010..To identify whether cytokines, cytokine-related factors, and chemokines are up-regulated prior to the development of rheumatoid arthritis (RA)... - Association between the PTPN22 +1858 C/T polymorphism and psoriatic arthritisKristina Juneblad
Department of Public Health and Clinical Medicine, Rheumatology, University Hospital, SE 901 85 Umea, Sweden
Arthritis Res Ther 13:R45. 2011.... - Novel information on the non-neuronal cholinergic system in orthopedics provides new possible treatment strategies for inflammatory and degenerative diseasesSture Forsgren
Dept of Integrative Medical Biology, Anatomy, Umea University, Umea, Sweden
Orthop Rev (Pavia) 1:e11. 2009..The conditions discussed are painful and degenerative tendon disease (tendinopathy/tendinosis), rheumatoid arthritis, and osteoarthritis... - Assessment of vascular function in systemic sclerosis: indications of the development of nitrate tolerance as a result of enhanced endothelial nitric oxide productionGrethe Neumann Andersen
Department of Rheumatology, University Hospital of Umea, Umea, Sweden
Arthritis Rheum 46:1324-32. 2002..To investigate the relationship between endothelium-dependent and endothelium-independent functions and the stiffness of conduit arteries as well as levels of endothelial activation markers in patients with systemic sclerosis (SSc)...