M L Fu

Summary

Affiliation: Sahlgrenska University Hospital
Country: Sweden

Publications

  1. ncbi Immunohistochemical localization of angiotensin II receptors (AT1) in the heart with anti-peptide antibodies showing a positive chronotropic effect
    M L Fu
    Wallenberg Laboratory, Sahlgren s Hospital, University of Goteborg, Sweden
    Receptors Channels 6:99-111. 1998
  2. ncbi Agonist-like activity of antibodies to angiotensin II receptor subtype 1 (AT1) from rats immunized with AT1 receptor peptide
    M L Fu
    Wallenberg Laboratory, University of Goteborg, Sweden
    Blood Press 8:317-24. 1999
  3. ncbi Myocardial hypertrophy in transgenic mice overexpressing the bovine growth hormone (bGH) gene
    M L Fu
    Wallenberg Laboratory, Sahlgrenska University Hospital Goteborg, Sweden
    J Intern Med 247:546-52. 2000
  4. ncbi Is cardiomyopathy an autoimmune disease?
    Michael Fu
    Wallenberg Laboratory, Sahlgrenska University Hospital, Goteborg, Sweden
    Keio J Med 51:208-12. 2002
  5. ncbi Transfer of rabbit autoimmune cardiomyopathy into severe combined immunodeficiency mice
    Shinobu Matsui
    Department of Cardiology, Kanazawa Medical University, Ishikawa, Japan
    J Cardiovasc Pharmacol 42:S99-103. 2003
  6. ncbi Specific removal of beta1-adrenoceptor autoantibodies by immunoabsorption in rabbits with autoimmune cardiomyopathy improved cardiac structure and function
    Shinobu Matsui
    Department of Cardiology, Kanazawa Medical University, 1 1, Daigaku, Uchinada, Ishikawa, Japan
    J Mol Cell Cardiol 41:78-85. 2006
  7. ncbi Amelioration of myocarditis by statin through inhibiting cross-talk between antigen presenting cells and lymphocytes in rats
    Jia Lu Wu
    Medical Research Institute, Kanazawa Medical University, Uchinada, Ishikawa 920 0293, Japan
    J Mol Cell Cardiol 44:1023-31. 2008
  8. ncbi Cardiomyocyte apoptosis in autoimmune cardiomyopathy: mediated via endoplasmic reticulum stress and exaggerated by norepinephrine
    Weike Mao
    University of Rochester Medical Center, Department of Medicine, Cardiology Division, Box 679, 601 Elmwood Ave, Rochester, NY 14642, USA
    Am J Physiol Heart Circ Physiol 293:H1636-45. 2007
  9. ncbi Pathological importance of anti-G-protein coupled receptor autoantibodies
    Shinobu Matsui
    Department of Cardiology, Kanazawa Medical University, Kanazawa, Japan
    Int J Cardiol 112:27-9. 2006
  10. ncbi Antigen-specific effects of autoantibodies against sarcolemmal Na-K-ATPase pump in immunized cardiomyopathic rabbits
    Akiyasu Baba
    Department of Medicine, Kitasato Institute Hospital, 5 9 1 Shirokane Minato ku, Tokyo 108 8642, Japan
    Int J Cardiol 112:15-20. 2006

Collaborators

  • W Schulze
  • G Wallukat
  • H Herlitz
  • P S Leung
  • G Bergstrom
  • Shinobu Matsui
  • S B Felix
  • Akiyasu Baba
  • A Staudt
  • Weike Mao
  • Jiahao Liu
  • Chang-Seng Liang
  • Shey Shing Sheu
  • Shey-Shing Sheu
  • Chang Seng Liang
  • Chikao Iwai
  • Lisa Larsson
  • Reza Mobini
  • Jia Lu Wu
  • Virendra K Sharma
  • Shuji Fukuoka
  • Jie Chen
  • Finn Waagstein
  • Hui Rong Liu
  • Tingchung Wang
  • Raju Vulapalli
  • Katsuzo Nishikawa
  • Huanlei Huang
  • Bao Gui Sun
  • Shogo Katsuda
  • Zhi-ping Zong
  • Zhi ping Zong
  • Bao-gui Sun
  • Jia-Lu Wu
  • Eva Angwald
  • Espen Haugen
  • Olga Fedorkova
  • Lars Gullestad
  • Ake Hjalmarson
  • Gert Baumann
  • Johanna Deinum
  • Helen Svensson
  • Xiang Ying Jiao
  • Rong Rui Zhao
  • Ying Yuan Wang

Detail Information

Publications18

  1. ncbi Immunohistochemical localization of angiotensin II receptors (AT1) in the heart with anti-peptide antibodies showing a positive chronotropic effect
    M L Fu
    Wallenberg Laboratory, Sahlgren s Hospital, University of Goteborg, Sweden
    Receptors Channels 6:99-111. 1998
    ..In addition, they extend the observation that the second extracellular loop of the G-protein coupled membrane receptors is a specific target for antibodies with agonist-like activity...
  2. ncbi Agonist-like activity of antibodies to angiotensin II receptor subtype 1 (AT1) from rats immunized with AT1 receptor peptide
    M L Fu
    Wallenberg Laboratory, University of Goteborg, Sweden
    Blood Press 8:317-24. 1999
    ....
  3. ncbi Myocardial hypertrophy in transgenic mice overexpressing the bovine growth hormone (bGH) gene
    M L Fu
    Wallenberg Laboratory, Sahlgrenska University Hospital Goteborg, Sweden
    J Intern Med 247:546-52. 2000
    ..The main purpose of the present study was to characterize cardiac muscle hypertrophy using both qualitative and quantitative microscopy in mice overexpressing the bovine growth hormone...
  4. ncbi Is cardiomyopathy an autoimmune disease?
    Michael Fu
    Wallenberg Laboratory, Sahlgrenska University Hospital, Goteborg, Sweden
    Keio J Med 51:208-12. 2002
    ..It may be practical in the future to separate "autoimmune cardiomyopathy" from other "idiopathic" DCM...
  5. ncbi Transfer of rabbit autoimmune cardiomyopathy into severe combined immunodeficiency mice
    Shinobu Matsui
    Department of Cardiology, Kanazawa Medical University, Ishikawa, Japan
    J Cardiovasc Pharmacol 42:S99-103. 2003
    ..These data provide direct evidence that the autoimmune mechanism is important in the pathogenesis of dilated cardiomyopathy...
  6. ncbi Specific removal of beta1-adrenoceptor autoantibodies by immunoabsorption in rabbits with autoimmune cardiomyopathy improved cardiac structure and function
    Shinobu Matsui
    Department of Cardiology, Kanazawa Medical University, 1 1, Daigaku, Uchinada, Ishikawa, Japan
    J Mol Cell Cardiol 41:78-85. 2006
    ....
  7. ncbi Amelioration of myocarditis by statin through inhibiting cross-talk between antigen presenting cells and lymphocytes in rats
    Jia Lu Wu
    Medical Research Institute, Kanazawa Medical University, Uchinada, Ishikawa 920 0293, Japan
    J Mol Cell Cardiol 44:1023-31. 2008
    ..These results indicate that simvastatin was able to ameliorate EAM through the inhibition of cross-talk between lymphocytes and APCs, suggesting beneficial role of simvastatin in the treatment of autoimmune myocarditis...
  8. ncbi Cardiomyocyte apoptosis in autoimmune cardiomyopathy: mediated via endoplasmic reticulum stress and exaggerated by norepinephrine
    Weike Mao
    University of Rochester Medical Center, Department of Medicine, Cardiology Division, Box 679, 601 Elmwood Ave, Rochester, NY 14642, USA
    Am J Physiol Heart Circ Physiol 293:H1636-45. 2007
    ..Thus ER stress occurs in autoimmune cardiomyopathy induced by beta(1)-EC(II) peptide, and this is enhanced by increased NE and caused by activation of the beta(1)-adrenergic receptor-coupled CaMKII, p38 MAPK, and ATF6 pathway...
  9. ncbi Pathological importance of anti-G-protein coupled receptor autoantibodies
    Shinobu Matsui
    Department of Cardiology, Kanazawa Medical University, Kanazawa, Japan
    Int J Cardiol 112:27-9. 2006
    ..This concise review article will only summarize studies done in rabbits with consideration of other articles in this focused issue...
  10. ncbi Antigen-specific effects of autoantibodies against sarcolemmal Na-K-ATPase pump in immunized cardiomyopathic rabbits
    Akiyasu Baba
    Department of Medicine, Kitasato Institute Hospital, 5 9 1 Shirokane Minato ku, Tokyo 108 8642, Japan
    Int J Cardiol 112:15-20. 2006
    ..We examine antigen-specific actions of autoantibodies directed against sarcolemmal Na-K-ATPase...
  11. ncbi Adoptive passive transfer of rabbit beta1-adrenoceptor peptide immune cardiomyopathy into the Rag2-/- mouse: participation of the ER stress
    Jiahao Liu
    Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Mol Cell Cardiol 44:304-14. 2008
    ..Thus, we conclude that ER stress plays an important role in cell death and cardiac dysfunction in beta(1)-EC(II) IgG cardiomyopathy, and the effects of beta(1)-EC(II) IgG are mediated via the beta(1)-adrenergic receptor...
  12. ncbi Transfer of immune components from rabbit autoimmune cardiomyopathy into severe combined immunodeficiency (SCID) mice induces cardiomyopathic changes
    Shinobu Matsui
    Kanazawa Medical University, Department of Cardiology, Uchinada, Ishikawa, Japan
    Autoimmunity 39:121-8. 2006
    ..The purpose of this study was to investigate whether passive transfer of IgG and/or lymphocytes from rabbits with autoimmune cardiomyopathy is able to reproduce cardiomyopathic changes in severe combined immunodeficiency (SCID) mice...
  13. ncbi Effects of autoantibodies removed by immunoadsorption from patients with dilated cardiomyopathy on neonatal rat cardiomyocytes
    Jie Chen
    Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, , Sweden
    Eur J Heart Fail 8:460-7. 2006
    ..This implies that removal of circulating autoantibodies might be part of the underlying mechanism for improved cardiac function...
  14. ncbi Beneficial effect on cardiac function by intravenous immunoglobulin treatment in patients with dilated cardiomyopathy is not due to neutralization of anti-receptor autoantibody
    Lisa Larsson
    Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, , Sweden
    Autoimmunity 37:489-93. 2004
    ..No changes in beta1AR autoantibodies after 12 months were detected. In summary, our results indicate that improvement of cardiac function by IVIG is not due to neutralization of beta1AR autoantibodies...
  15. ncbi Autoantibodies against M2-muscarinic acetylcholine receptors: new upstream targets in atrial fibrillation in patients with dilated cardiomyopathy
    Akiyasu Baba
    Department of Medicine, Kitasato Institute Hospital, Tokyo, Japan
    Eur Heart J 25:1108-15. 2004
    ..To characterise the clinical significance of M2-muscarinic acetylcholine receptor autoantibodies (M2-AAB) in patients with dilated cardiomyopathy (DCM)...
  16. ncbi Hemodynamic improvement and removal of autoantibodies against beta1-adrenergic receptor by immunoadsorption therapy in dilated cardiomyopathy
    Reza Mobini
    The Cardiovascular Institute, Sahlgrenska University Hospital, Goteborg, Sweden
    J Autoimmun 20:345-50. 2003
    ..These results suggest that different mechanisms are involved in the hemodynamic improvement induced by IA. The beneficial hemodynamic effects induced by IA are not directly associated with the removal of beta(1)AR autoantibodies...
  17. ncbi Relationship of myocardial remodeling to the genesis of serum autoantibodies to cardiac beta(1)-adrenoceptors and muscarinic type 2 acetylcholine receptors in rats
    Hui Rong Liu
    Laboratory of Cardiovascular Physiology, Shanxi Medical University, Taiyuan, China
    J Am Coll Cardiol 39:1866-73. 2002
    ....
  18. ncbi Darbepoetin alfa exerts a cardioprotective effect in autoimmune cardiomyopathy via reduction of ER stress and activation of the PI3K/Akt and STAT3 pathways
    Weike Mao
    Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Mol Cell Cardiol 45:250-60. 2008
    ..Thus, we conclude that darbepoetin alfa improves cardiac function and prevents progression of dilated cardiomyopathy probably by activating the PI3K/Akt and STAT3 pathways and reducing ER stress...