Samer Sourial

Summary

Affiliation: Microbiology and Tumor Biology Center
Country: Sweden

Publications

  1. ncbi Cloning, expression, and purification of HIV-2 gp125: A target for HIV vaccination
    Samer Sourial
    Microbiology and Tumor Biology Center, Karolinska Institutet, S 171 77, Stockholm, Sweden
    Mol Biotechnol 30:155-62. 2005
  2. ncbi Potent neutralizing serum immunoglobulin A (IgA) in human immunodeficiency virus type 2-exposed IgG-seronegative individuals
    Qin Lizeng
    Research Center, South Hospital, Stockholm, Sweden
    J Virol 78:7016-22. 2004
  3. ncbi Deletion of the V1/V2 region does not increase the accessibility of the V3 region of recombinant gp125
    Samer Sourial
    Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
    Curr HIV Res 4:229-37. 2006
  4. ncbi HIV-2 neutralization by intact V3-specific Fab fragments
    Samer Sourial
    Department of Microbiology, Tumor and Cellbiology, Karolinska Institute, Stockholm, Sweden
    Virol J 5:96. 2008
  5. ncbi Production, purification, crystallization and preliminary X-ray diffraction analysis of the HIV-2-neutralizing V3 loop-specific Fab fragment 7C8
    Hannes Uchtenhagen
    Center for Infectious Medicine CIM, F59 Department of Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, SE 141 86 Stockholm, Sweden
    Acta Crystallogr Sect F Struct Biol Cryst Commun 65:705-8. 2009
  6. ncbi Serum immunoglobulin A (IgA)-mediated immunity in human immunodeficiency virus type 2 (HIV-2) infection
    Qin Lizeng
    Microbiology and Tumorbiology Center, Karolinska Institutet, Stockholm, Sweden
    Virology 308:225-32. 2003

Collaborators

  • Adnane Achour
  • Anna Lena Spetz
  • Qin Lizeng
  • Mariethe Ehnlund
  • Hannes Uchtenhagen
  • Charlotta Nilsson
  • Rosmarie Friemann
  • Robert A Harris
  • Chaithanya Madhurantakam
  • Peter Aaby
  • Olav Larsen
  • Nuno Taveira
  • Pia Skott

Detail Information

Publications6

  1. ncbi Cloning, expression, and purification of HIV-2 gp125: A target for HIV vaccination
    Samer Sourial
    Microbiology and Tumor Biology Center, Karolinska Institutet, S 171 77, Stockholm, Sweden
    Mol Biotechnol 30:155-62. 2005
    ..The high yield and purity of these constructs makes them suitable for structural and functional analyses, as well as vaccine studies...
  2. ncbi Potent neutralizing serum immunoglobulin A (IgA) in human immunodeficiency virus type 2-exposed IgG-seronegative individuals
    Qin Lizeng
    Research Center, South Hospital, Stockholm, Sweden
    J Virol 78:7016-22. 2004
    ..05). Thus, we describe HIV-2-specific serum IgA antigen reactivity and show a more potent serum IgA-mediated HIV-2-neutralizing activity in EGSN individuals than in HIV-2-infected patients...
  3. ncbi Deletion of the V1/V2 region does not increase the accessibility of the V3 region of recombinant gp125
    Samer Sourial
    Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
    Curr HIV Res 4:229-37. 2006
    ..We hypothesize that the V3 region is accessible in HIV-2 gp125 and thus may not require interaction with CD4 to induce conformational reorientation of the V1/V2 region...
  4. ncbi HIV-2 neutralization by intact V3-specific Fab fragments
    Samer Sourial
    Department of Microbiology, Tumor and Cellbiology, Karolinska Institute, Stockholm, Sweden
    Virol J 5:96. 2008
    ..Our findings suggest that whole 7C8 and 3C4 mAbs are sterically hindered from neutralizing HIV-2, whereas the smaller size of Fab fragments enables access to the V3 region on the virion surface...
  5. ncbi Production, purification, crystallization and preliminary X-ray diffraction analysis of the HIV-2-neutralizing V3 loop-specific Fab fragment 7C8
    Hannes Uchtenhagen
    Center for Infectious Medicine CIM, F59 Department of Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, SE 141 86 Stockholm, Sweden
    Acta Crystallogr Sect F Struct Biol Cryst Commun 65:705-8. 2009
    ..5, 25%(w/v) PEG 8000 and 2.5%(w/v) PEG 400 at 275 K. The analysed crystals belonged to the rhombohedral space group P3(2)21, with unit-cell parameters a = b = 100.1, c = 196.8 A, and diffracted to 2.7 A resolution...
  6. ncbi Serum immunoglobulin A (IgA)-mediated immunity in human immunodeficiency virus type 2 (HIV-2) infection
    Qin Lizeng
    Microbiology and Tumorbiology Center, Karolinska Institutet, Stockholm, Sweden
    Virology 308:225-32. 2003
    ..This work describes the HIV-2-specific sIgA antigenic response. Moreover, our findings show, for the first time, that sIgA may play a role in the in vitro neutralization of HIV-2...