Research Topics
Genomes and Genes | Ning XuSummaryAffiliation: Lund University Country: Sweden Publications
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Publications
TO901317 regulating apolipoprotein M expression mediates via the farnesoid X receptor pathway in Caco-2 cellsChunhua Zhu
Department of Cardiothoracic Surgery, Third Affiliated Hospital of Suzhou University, Changzhou 213003, P R China
Lipids Health Dis 10:199. 2011..In the present study we further investigated regulation of apoM expression in Caco-2 cells stimulated by a liver X receptor (LXR) agonist, TO901317...- Lipid synthesis and secretion in HepG2 cells is not affected by ACTHMaria Skoog
Section of Clinical Chemistry and Pharmacology, Institute of Laboratory Medicine, Lunds University, S 22185 Lund, Sweden
Lipids Health Dis 9:48. 2010..The present study suggests that ACTH lowers plasma lipids in humans mainly mediated by the inhibition of apoB synthesis and did not via the reduced lipid synthesis... - Impaired plasma lipid profiles in acute hepatitisLibo Luo
First People s Hospital of Changzhou, Jiangsu 213003, China
Lipids Health Dis 9:5. 2010..It may conclude that examinations of plasma lipid profile could be considered as a clinical index to reflect liver damage in the active phase of hepatitis... - Expression and localization of apolipoprotein M in human colorectal tissuesGuanghua Luo
Comprehensive Laboratory, Third Affiliated Hospital, Suzhou University, Changzhou, China
Lipids Health Dis 9:102. 2010..In the present study, we therefore examined apoM expression in human colorectal tissues including cancer tissues, cancer adjacent normal tissues, polyp tissues and normal mucosa as well as inflammatory mucosa... - Increased plasma apoM levels in the patients suffered from hepatocellular carcinoma and other chronic liver diseasesJingting Jiang
Department of Tumor Biological Treatment, The Third Affiliated Hospital of Suzhou University, Changzhou 213003, PR China
Lipids Health Dis 7:25. 2008..To determine plasma apolipoprotein M (apoM) levels and other lipid profiles in hepatocellular carcinoma (HCC) patients compared to other chronic liver diseases and normal subjects... - Suppression of apolipoprotein M expression and secretion in alloxan-diabetic mouse: Partial reversal by insulinNing Xu
Division of Clinical Chemistry and Pharmacology, Institute of Laboratory Medicine, Lund University, Lund, S 221 85 Lund, Sweden
Biochem Biophys Res Commun 342:1174-7. 2006..Based on these results, we suggest that insulin regulates apoM synthesis in vivo and, therefore, that the reduction of apoM expression is a general phenomenon in diabetes models... - Down-regulation of apolipoprotein M expression is mediated by phosphatidylinositol 3-kinase in HepG2 cellsNing Xu
Section of Clinical Chemistry and Pharmacology, Department of Laboratory Medicine, Lunds University, S 221 85 Lund, Sweden
Biochim Biophys Acta 1761:256-60. 2006..In conclusion, this study shows that apoM expression is regulated by PI3-kinase in HepG2-cells... - Transforming growth factor-beta down-regulates apolipoprotein M in HepG2 cellsNing Xu
Department of Clinical Chemistry, Institute of Laboratory Medicine, University Hospital of Lund, Klinikgatan 19, S 221 85 Lund, Sweden
Biochim Biophys Acta 1683:33-7. 2004..Further, all four cytokines had more pronounced effects on apoM mRNA expression than apoB mRNA expression. The present study suggested that apoM, like apoB, may be involved in the hepatic lipoprotein assembly in vivo... - Both leptin and leptin-receptor are essential for apolipoprotein M expression in vivoNing Xu
Department of Clinical Chemistry, Institute of Laboratory Medicine, University Hospital of Lund, S 221 85 Lund, Sweden
Biochem Biophys Res Commun 321:916-21. 2004..We conclude that both leptin and leptin-receptor are essential for the apoM expression, indicating that leptin is physiologically regulating apoM synthesis in vivo... - Effects of simvastatin on apolipoprotein M in vivo and in vitroXiaoying Zhang
Division of Clinical Chemistry and Pharmacology, Department of Laboratory Medicine, Lund University, S 221 85 Lund, Sweden
Lipids Health Dis 10:112. 2011..To investigate effects of lipid lowering drug, simvastatin, on apolipoprotein M expression in the hyperlipidemic mice and in hepatic cell line, HepG2 cells... - Influence of liver cancer on lipid and lipoprotein metabolismJingting Jiang
Section of Clinical Chemistry and Pharmacology, Institute of Laboratory Medicine, Lund University, S 221 85 Lund, Sweden
Lipids Health Dis 5:4. 2006..LDL and HDL have therefore been proposed as a carrier for the water-insoluble anti-cancer agents... - Correlation of apolipoprotein M with leptin and cholesterol in normal and obese subjectsNing Xu
Department of Clinical Chemistry, Institute of Laboratory Medicine, University Hospital of Lund, S 221 85 Lund, Sweden
J Nutr Biochem 15:579-82. 2004..These two parameters yielded a value of r(2) = 0.28, thereby explaining approximately 30% of the variance in apoM. Hence, we show that apoM is positively related to leptin and negatively related to cholesterol in humans... - ACTH reduces the rise in ApoB-48 levels after fat intakeMaria Skoog
Division of Clinical Chemistry and Pharmacology, Department of Laboratory Medicine, ILM, Lunds University, S 221 85 Lund, Sweden
Atherosclerosis 191:433-9. 2007..This study confirms earlier reports on the lipid-lowering effects of ACTH and supports our theory, based on in vitro studies, that the lipid-lowering effects of ACTH administration in man involves an inhibition of ApoB production... - Clinical application of determining serum AFP-IgM complexes for diagnosis of small hepatocellular carcinomaJingting Jiang
Department of Tumor Biological Treatment, The Third Affiliated Hospital, Soochow University, Changzhou 213003, PR China
Anticancer Res 31:687-91. 2011..4 ± 571.8 AU/ml) than in the patients with tumor diameter >3 cm (604.9 ± 749.9 AU/ml). It is concluded that determining serum levels of both AFP-IgM immune complex and AFP may have potential benefit for the diagnosis of small HCC... - Effects of platelet-activating factor, tumor necrosis factor, and interleukin-1alpha on the expression of apolipoprotein M in HepG2 cellsNing Xu
Department of Clinical Chemistry, University Hospital of Lund, Lund, S 221 85, Sweden
Biochem Biophys Res Commun 292:944-50. 2002..The cellular mechanism of the effects of PAF or Lexipafant on apoM metabolism requires further investigations... - Identification of human intestinal alkaline sphingomyelinase as a novel ecto-enzyme related to the nucleotide phosphodiesterase familyRui Dong Duan
Gastroenterology Laboratory, Biomedical Center, B11, Lund University, S 221 84 Lund, Sweden
J Biol Chem 278:38528-36. 2003..In conclusion, we identified the amino acid and cDNA sequences of human intestinal alk-SMase, and found that it is a novel ecto-enzyme related to the NPP family with specific features essential for its SMase activity... - Association of prothrombin and protein S with plasma triglyceride-rich lipoproteins in humans after test meals rich in milk fat or soybean oilLi Zhou
Gastroenterology Division, Department of Medicine, Lund University, Tornavägen, Sweden
Thromb Res 108:209-13. 2002..In the present study, we examined the effects of saturated and unsaturated fat meals on the association of prothrombin and protein S with TG-rich lipoproteins in vivo... - Mutations of PTEN gene in gliomas correlate to tumor differentiation and short-term survival rateYiling Yang
Section of Clinical Chemistry and Pharmacology, Institute of Laboratory Medicine, Lunds University, S 221 85 Lund, Sweden
Anticancer Res 30:981-5. 2010..038, odds ratio=7.80), respectively. The present study suggests that PTEN mutations are late events in the malignant progression of glioma and the occurrence of PTEN mutations are significantly correlated to patients' short-term survival... - Hyperglycemia down-regulates apolipoprotein M expression in vivo and in vitroXiaoying Zhang
Comprehensive Laboratory, The Third Affiliated Hospital, Suzhou University, Changzhou 213003, China
Biochim Biophys Acta 1771:879-82. 2007..However, in HepG2 cells both glucose and insulin markedly inhibited apoM expression these effects were additive. Thus, the possible effects of insulin in vivo seem to be mediated indirectly... - Heterogeneous transportation of alpha1B-adrenoceptor in living cellsYinghua Guan
Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, and Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
Biophys Chem 127:149-54. 2007.... - Nucleotide sequence of the p53 cDNA of beluga whale (Delphinapterus leucas)Ning Xu
Division of Molecular Epidemiology, Kobe University Graduate School of Medicine, 7 5 1, Kusunoki cho, Chuo Ku, Japan
Gene 288:159-66. 2002..The similarities with the former two animals at the amino acid level were also more than 85%. Lower similarity of the beluga whale p53 gene was also found with those of lower tetrapods, fish and invertebrates... - Specific tissue expression and cellular localization of human apolipoprotein M as determined by in situ hybridizationXiao Ying Zhang
Laboratory of Molecular Medicine, The Third Affiliated Hospital, Suzhou University, Changzhou, China
Acta Histochem 105:67-72. 2003..The present study helps to elucidate the pathophysiological functions of apoM in vivo... - Expression pattern of apolipoprotein M during mouse and human embryogenesisXiao Ying Zhang
Laboratory of Molecular Medicine, The Third Affiliated Hospital, Suzhou University, Changzhou, China
Acta Histochem 106:123-8. 2004..ApoM was also detected in stomach and skeletal muscle in early stages of embryogenesis (3-5 months)... - Liver X receptor agonist downregulates hepatic apoM expression in vivo and in vitroXiaoying Zhang
Comprehensive Laboratory, The Third Affiliated Hospital of Suzhou University, Changzhou 213003, China
Biochem Biophys Res Commun 371:114-7. 2008..The combination of RA and T0901317 showed additive effects, which suggests that apoM expression can be modulated by LXR/RXR pathway... - Human alpha-defensin-1 inhibits growth of human lung adenocarcinoma xenograft in nude miceNing Xu
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, People s Republic of China
Mol Cancer Ther 7:1588-97. 2008..The antiangiogenesis effect of HNP1 may contribute to its inhibitory activity in vivo, and HNP1 might involve the host immune response to tumor. These findings provide a rationale for developing HNP1-based gene therapy for cancer... - Metabolism of high density lipoproteins in liver cancerJing Ting Jiang
Department of Tumor Biological Treatment, The Third Affiliated Hospital of Suzhou University, Changzhou 213003, Jiangsu Province, China
World J Gastroenterol 13:3159-63. 2007..It depends on the integrity of cellular function of liver, which ensures homeostasis of lipid and lipoprotein metabolism. When liver cancer occurs these processes are impaired and high-density lipoproteins are changed... - Lipids changes in liver cancerJing Ting Jiang
Department of Tumor Biological Treatment, The Third Affiliated Hospital, Suzhou University, Changzhou, China
J Zhejiang Univ Sci B 8:398-409. 2007..In this review we summarize the clinical significance of lipid and lipoprotein metabolism under liver cancer... - The transport of alpha(1A)-adrenergic receptor with 33-nm step size in live cellsZhang Yi Liang
State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing, China
Biochem Biophys Res Commun 353:231-7. 2007..These results provided insight into the mechanism of GPCR transport in vivo... - Role of endothelin-1 and nitric oxide bioavailability in transplant-related vascular injury: comparative effects of rapamycin and cyclosporineDanny Ramzy
Heart Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
Circulation 114:I214-9. 2006..We conclude that SRL is less deleterious to the vasculature than CyA and may prevent TxV by these mechanisms... - [Application of PCR-based tRNAval Pol III-shRNA expression cassettes in screening of efficient siRNA for inhibiting hepatitis B virus]Xiu-cheng Pan
Institute of Infectious Disease, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China
Zhejiang Da Xue Xue Bao Yi Xue Ban 35:154-60. 2006..tRNAval Pol III-shRNA expression cassettes produced by one-step overlapping extension PCR strategy should be useful for identification of optimal siRNA... - Leptin inhibits apolipoprotein M transcription and secretion in human hepatoma cell line, HepG2 cellsGuanghua Luo
Laboratory of Molecular Medicine, The Third Affiliated Hospital, Suzhou University, Changzhou 213003, China
Biochim Biophys Acta 1734:198-202. 2005..The mechanism on the contradictory effects of leptin on apoM expression in vivo and in vitro needs further investigation... - [Inhibition of HBV core antigen gene expression in human embryonic kidney cell line AD293 by plasmid-based RNAi.]Ning Xu
Institute of Infectious Diseases, The First Affiliated Hospital, Key Laboratory of Infectious Diseases Ministry of Health, College of Medicine, Zhejiang University, Hangzhou 310003, China
Zhejiang Da Xue Xue Bao Yi Xue Ban 34:104-9. 2005..1 % by real-time PCR. CONCLUSION: Effective inhibition of HBV core antigen gene expression by plasmid-based RNAi provides an alternative for anti-HBV study in vitro, which has potential clinical application... - Inhibition of hepatitis B virus surface antigen expression by small hairpin RNA in vitroZheng-Gang Yang
Institute of Infectious Diseases, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China
World J Gastroenterol 11:498-502. 2005..CONCLUSION: RNAi using shRNA expression vector can inhibit the expression of HBsAg, providing a fresh approach to screening the efficient small interfering RNAs (siRNAs)... - Time-dependent reversal of sepsis-induced PMN uptake and lung vascular injury by expression of CD18 antagonistNing Xu
Department of Pharmacology, College of Medicine, The University of Illinois, 835 S Wolcott Avenue, Chicago, IL 60612, USA
Am J Physiol Lung Cell Mol Physiol 282:L796-802. 2002..The results support the model that initial engagement of CD18 integrins enables the further recruitment of additional PMN into lung tissues such that PMN continue to sequester and migrate after E. coli challenge...