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Species | N WierupSummaryAffiliation: Lund University Country: Sweden Publications
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Publications
Cocaine- and amphetamine-regulated transcript (CART) is expressed in several islet cell types during rat developmentN Wierup
Department of Physiological Sciences, Section of Neuroendocrine Cell Biology, Lund University, Lund, Sweden
J Histochem Cytochem 52:169-77. 2004..We have demonstrated that CART is expressed in several islet cell types during rat development but is restricted to somatostatin cells and neurons in the adult rat...- Ghrelin is expressed in a novel endocrine cell type in developing rat islets and inhibits insulin secretion from INS-1 (832/13) cellsN Wierup
Department of Physiological Science, Lund University, Lund, Sweden
J Histochem Cytochem 52:301-10. 2004..We conclude that ghrelin is expressed in a novel developmentally regulated endocrine islet cell type in the rat pancreas and that ghrelin inhibits glucose-stimulated insulin secretion via a direct effect on the beta-cell... - CART knock out mice have impaired insulin secretion and glucose intolerance, altered beta cell morphology and increased body weightN Wierup
Department of Physiological Sciences, Lund University, Section for Neuroendocrine Cell Biology, BMC F10, 22 184, Lund, Sweden
Regul Pept 129:203-11. 2005..In addition, CART KO mice displayed increased body weight at the age of 40 weeks, without any difference in food intake. We conclude that CART is required for maintaining normal islet function in mice... - Ultrastructure of islet ghrelin cells in the human fetusNils Wierup
Department of Physiological Sciences, Section for Neuroendocrine Cell Biology, Lund University, BMC F10, 22184, Lund Sweden
Cell Tissue Res 319:423-8. 2005..We conclude that ghrelin cells constitute a novel islet cell type, distinct from the previously hormonally characterised islet cell types... - Glucagon receptor antagonism improves islet function in mice with insulin resistance induced by a high-fat dietM Sörhede Winzell
Department of Clinical Sciences, Lund, Division of Medicine, BMC, B11, Lund University, 221 84, Lund, Sweden
Diabetologia 50:1453-62. 2007..Here, we investigated whether chronic treatment with a glucagon receptor antagonist (GRA) improves islet dysfunction in female mice on a high-fat diet (HFD)... - The ghrelin cell: a novel developmentally regulated islet cell in the human pancreasN Wierup
Department of Physiological Sciences, Section of Neuroendocrine Cell Biology, Lund University, BMC F10, 22 184, Lund, Sweden
Regul Pept 107:63-9. 2002..Specimens from fetal to adult human pancreas and stomach were studied by immunocytochemistry, for ghrelin and islet hormones, and in situ hybridisation, for ghrelin mRNA... - Enhanced mitochondrial metabolism may account for the adaptation to insulin resistance in islets from C57BL/6J mice fed a high-fat dietM Fex
Department of Experimental Medical Science, Division of Diabetes, Metabolism, and Endocrinology, Lund University, Lund, Sweden
Diabetologia 50:74-83. 2007..When this fails, type 2 diabetes ensues. Because mitochondria play a key role in beta cell pathophysiology, we tested the hypothesis that mitochondrial metabolism is critical for beta cell adaptation to insulin resistance... - A low glycaemic diet improves oral glucose tolerance but has no effect on ?-cell function in C57BL/6J miceU Andersson
Department of Experimental Medical Science, Lund University, Lund, Sweden
Diabetes Obes Metab 12:976-82. 2010..Clinical studies have suggested a role for dietary glycaemic index (GI) in body weight regulation and diabetes risk. Here, we investigated the long-term metabolic effects of low and high glycaemic diets using the C57BL/6J mouse model... - Cocaine- and amphetamine-regulated transcript: distribution and function in rat gastrointestinal tractE Ekblad
Department of Physiological Sciences, BMC F10, Lund University, Lund, Sweden
Neurogastroenterol Motil 15:545-57. 2003..It may, moreover, be involved in intestinal adaptation, and an additional hormonal role is also possible... - CART-peptide immunoreactivity in enteric nerves in patients with Hirschsprung's diseaseA Gunnarsdottir
Department of Pediatric Surgery, Lund University Hospital, Lund, Sweden
Eur J Pediatr Surg 17:184-9. 2007.... - DPP-4 inhibition improves glucose tolerance and increases insulin and GLP-1 responses to gastric glucose in association with normalized islet topography in mice with beta-cell-specific overexpression of human islet amyloid polypeptideBo Ahren
Department of Clinical Sciences, Lund University, Lund, Sweden
Regul Pept 143:97-103. 2007..Treatment with vildagliptin restored the islet topography. We therefore conclude that DPP-4 inhibition improves islet function and islet topography in mice with beta-cell specific transgenic overexpression of human IAPP... - Characterisation of CART-containing neurons and cells in the porcine pancreas, gastro-intestinal tract, adrenal and thyroid glandsNils Wierup
Department of Experimental Medical Science, Lund University, Lund, Sweden
BMC Neurosci 8:51. 2007..In addition, CART participates in the regulation of the hypothalamus-pituitary-adrenal-axis. We investigated CART expression in porcine pancreas, GI-tract, adrenal glands, and thyroid gland using immunocytochemistry... - The R6/2 transgenic mouse model of Huntington's disease develops diabetes due to deficient beta-cell mass and exocytosisMaria Björkqvist
Department of Cell and Molecular Biology, Lund, Sweden
Hum Mol Genet 14:565-74. 2005..The blunting of exocytosis could be attributed to a 96% reduction in the number of insulin-containing secretory vesicles. Thus, diabetes in R6/2 mice is caused by a combination of deficient beta-cell mass and disrupted exocytosis... - Rat insulin promoter 2-Cre recombinase mice bred onto a pure C57BL/6J background exhibit unaltered glucose toleranceMalin Fex
Department of Experimental Medical Science, Lund University, SE 22184 Lund, Sweden
J Endocrinol 194:551-5. 2007..As our RIP2-Cre mice are on a near 100% pure genetic background (C57BL/6J), we suggest that the perturbations in glucose homeostasis previously reported in RIP2-Cre mouse lines can be accounted for by differences in genetic background... - Increased metabolism in the R6/2 mouse model of Huntington's diseaseJorien M M van der Burg
Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University BMC A10, Lund, Sweden
Neurobiol Dis 29:41-51. 2008..Together, these data demonstrate that weight loss in R6/2 mice is associated with increased metabolism and changes in several weight-regulating factors... - Islet beta-cell area and hormone expression are unaltered in Huntington's diseaseKarl Bacos
Unit of Molecular Metabolism, Department of Experimental Medical Science, Lund University, CRC 91 11, 205 02 Malmo, Sweden
Histochem Cell Biol 129:623-9. 2008..This may lead to a better understanding of HD and provide novel therapeutic targets for symptomatic treatment in HD... - Lack of cholesterol mobilization in islets of hormone-sensitive lipase deficient mice impairs insulin secretionSara Larsson
Department of Experimental Medical Science, Division of Diabetes, Metabolism and Endocrinology, Lund University, BMC C11, SE 221 84 Lund, Sweden
Biochem Biophys Res Commun 376:558-62. 2008..These results indicate that HSL plays an important role in insulin secretion by providing free cholesterol for the formation and maintenance of cholesterol-rich patches for docking of SNARE-proteins to the plasma membrane... - CART is a novel islet regulatory peptideNils Wierup
Department of Experimental Medical Science, Division of Diabetes, Metabolism, and Endocrinology, Lund University, Lund, Sweden
Peptides 27:2031-6. 2006..These data favor a role of CART in normal islet function and in the pathophysiology of type 2 diabetes... - Capsaicin-sensitive sensory fibers in the islets of Langerhans contribute to defective insulin secretion in Zucker diabetic rat, an animal model for some aspects of human type 2 diabetesDorte X Gram
Research and Development, Novo Nordisk A S, Novo Nordisk Park, F6 1 30, DK 2760 Måløv, Denmark
Eur J Neurosci 25:213-23. 2007..Based on these data we propose that the activity of islet-innervating capsaicin-sensitive fibers may have a role in the development of reduced insulin secretion in human type 2 diabetes mellitus... - Beta-cell-targeted overexpression of phosphodiesterase 3B in mice causes impaired insulin secretion, glucose intolerance, and deranged islet morphologyLinda Härndahl
Departments of Cell and Molecular Biology, Biomedical Center, C11, Land Sweden
J Biol Chem 279:15214-22. 2004..Furthermore, morphological examinations demonstrated deranged islet cytoarchitecture. In conclusion, these results are consistent with an essential role for PDE3B in cAMP-mediated regulation of insulin release and glucose homeostasis... - Loss-of-function mutation of the galanin gene is associated with perturbed islet function in miceBo Ahren
Department of Medicine, Lund University, B11 Biomedical Centre, SE 221 84 Lund, Sweden
Endocrinology 145:3190-6. 2004..032). We conclude that 1) galanin may contribute to sympathetic influences inhibiting insulin secretion in mice, and 2) galanin KO mice have a reduced glucose-induced insulin secretion... - Orexin loss in Huntington's diseaseAsa Petersen
Department of Physiological Sciences, Section for Neuronal Survival, Lund, Sweden
Hum Mol Genet 14:39-47. 2005..Our results show that the loss of orexin is a novel and potentially very important pathology in HD... - Reduced ghrelin, islet amyloid polypeptide, and peptide YY expression in the stomach of gastrin-cholecystokinin knockout miceLennart Friis-Hansen
Department of Clinical Biochemistry, KB 3011, Rigshospitalet, 9 Blegdamsvej, DK 2100 Copenhagen, Denmark
Endocrinology 146:4464-71. 2005..Both gastrin and combined gastrin-CCK deficiency reduced the gastric IAPP and PYY expression... - CART regulates islet hormone secretion and is expressed in the beta-cells of type 2 diabetic ratsNils Wierup
Department of Experimental Medical Science, Division of Diabetes, Metabolism, and Endocrinology, Lund University, Sweden
Diabetes 55:305-11. 2006..We conclude that CART is a regulator of islet hormone secretion and that CART is upregulated in the beta-cells of type 2 diabetic rats... - Gastric ghrelin cell development is hampered and plasma ghrelin is reduced by delayed weaning in ratsFrida Fåk
Department of Cell and Organism Biology, Lund University, Lund, Sweden
J Endocrinol 192:345-52. 2007..Therefore, we suggest that ghrelin may constitute a hormonal link between the duration of breastfeeding and body weight development... - Antral G-cell in gastrin and gastrin-cholecystokinin knockout animalsLennart Friis-Hansen
Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Cell Tissue Res 321:141-6. 2005.... - Early and rapid development of insulin resistance, islet dysfunction and glucose intolerance after high-fat feeding in mice overexpressing phosphodiesterase 3BHelena A Walz
Department of Experimental Medical Science, Biomedical Centre, C11, Lund University, SE 221 84 Lund, Sweden
J Endocrinol 189:629-41. 2006..We conclude that accurate regulation of beta-cell cAMP is necessary for adequate islet adaptation to a perturbed metabolic environment and protective for the development of glucose intolerance and insulin resistance... - Inflammatory response in white adipose tissue in the non-obese hormone-sensitive lipase null mouse modelOla Hansson
Department of Experimental Medical Science, Lund University, BMC C11, SE 221 84 Lund, Sweden
J Proteome Res 5:1701-10. 2006..A number of macrophage proteins, i.e., gal-3, Capg, and MCP-4, were expressed at increased levels and immunohistochemical analyses revealed an increased infiltration of F4/80+ cells... - Ghrelin and motilin are cosecreted from a prominent endocrine cell population in the small intestineNils Wierup
Lund University, Department of Experimental Medical Science, Division of Diabetes, Metabolism, and Endocrinology, Unit of Neuroendocrine Cell Biology, BMC B11, SE 22 184 Lund, Sweden
J Clin Endocrinol Metab 92:3573-81. 2007..Hitherto, mapping studies of ghrelin cells covering the entire gastrointestinal (GI) tract in humans have been lacking. Furthermore, the phenotype of extragastric ghrelin cells is not known... - Beta-cell PDE3B regulates Ca2+-stimulated exocytosis of insulinHelena A Walz
Department of Experimental Medical Science, Biomedical Center C11, Lund University, SE 221 84 Lund, Sweden
Cell Signal 19:1505-13. 2007..We conclude that PDE3B, through hydrolysis of cAMP in pools regulated by Ca(2+), plays a regulatory role in depolarization-induced insulin secretion and that the enzyme is associated with the exocytotic machinery in beta-cells...