Benny Pacheco

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. ncbi Identification of the active site of DS-epimerase 1 and requirement of N-glycosylation for enzyme function
    Benny Pacheco
    Department of Experimental Medical Science, Lund University, Biomedical Center D12, SE 221 84 Lund, Sweden
    J Biol Chem 284:1741-7. 2009
  2. ncbi Dermatan 4-O-sulfotransferase 1 is pivotal in the formation of iduronic acid blocks in dermatan sulfate
    Benny Pacheco
    Department of Experimental Medical Science, Lund University, Lund, Sweden
    Glycobiology 19:1197-203. 2009
  3. ncbi Two dermatan sulfate epimerases form iduronic acid domains in dermatan sulfate
    Benny Pacheco
    Department of Experimental Medical Science, Biomedical Center D12, Lund University, Tornavagen 10, SE 221 84 Lund, Sweden
    J Biol Chem 284:9788-95. 2009

Detail Information

Publications3

  1. ncbi Identification of the active site of DS-epimerase 1 and requirement of N-glycosylation for enzyme function
    Benny Pacheco
    Department of Experimental Medical Science, Lund University, Biomedical Center D12, SE 221 84 Lund, Sweden
    J Biol Chem 284:1741-7. 2009
    ..In addition, we show that proper N-glycosylation of DS-epimerase 1 is required for enzyme activity. This study represents the first description of the structural basis for epimerization by a glycosaminoglycan epimerase...
  2. ncbi Dermatan 4-O-sulfotransferase 1 is pivotal in the formation of iduronic acid blocks in dermatan sulfate
    Benny Pacheco
    Department of Experimental Medical Science, Lund University, Lund, Sweden
    Glycobiology 19:1197-203. 2009
    ..In conclusion, D4ST-1 is a key enzyme and is indispensable in the formation of important functional domains in dermatan sulfate and cannot be compensated by other 4-O-sulfotransferases...
  3. ncbi Two dermatan sulfate epimerases form iduronic acid domains in dermatan sulfate
    Benny Pacheco
    Department of Experimental Medical Science, Biomedical Center D12, Lund University, Tornavagen 10, SE 221 84 Lund, Sweden
    J Biol Chem 284:9788-95. 2009
    ..DS-epi2 has been genetically linked to bipolar disorder, which suggests that the dermatan sulfate domains generated by a defective enzyme may be involved in the etiology of the disease...