Research Topics
Genomes and Genes | C LingSummaryAffiliation: Lund University Country: Sweden Publications
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Detail Information
Publications
Epigenetics and obesity: the devil is in the detailsPaul W Franks
Department of Clinical Sciences, Skane University Hospital, Lund University, Malmo, Sweden
BMC Med 8:88. 2010....- Impact of the peroxisome proliferator activated receptor-gamma coactivator-1beta (PGC-1beta) Ala203Pro polymorphism on in vivo metabolism, PGC-1beta expression and fibre type composition in human skeletal muscleC Ling
Department of Clinical Sciences Diabetes and Endocrinology, Lund University, CRC, University Hospital MAS, 205 02 Malmo, Sweden
Diabetologia 50:1615-20. 2007..The aim of this study was to investigate whether the PGC-1beta Ala203Pro polymorphism influences the age-related decline in skeletal muscle PGC-1beta expression, in vivo metabolism and markers for muscle fibre type composition... - Genetic and epigenetic factors are associated with expression of respiratory chain component NDUFB6 in human skeletal muscleCharlotte Ling
Department of Clinical Sciences, Lund University, University Hospital MAS, Malmo, Sweden
J Clin Invest 117:3427-35. 2007.... - Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretionC Ling
Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, CRC, 205 02 Malmo, Sweden
Diabetologia 51:615-22. 2008..We also tested if experimental downregulation of PPARGC1A expression in human islets influenced insulin secretion... - Calpain-10 expression is elevated in pancreatic islets from patients with type 2 diabetesCharlotte Ling
Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, Clinical Research Centre CRC, Malmo, Sweden
PLoS ONE 4:e6558. 2009..We also tested if polymorphisms in the CAPN10 gene are associated with gene expression and insulin secretion in vitro... - Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscleT Rönn
Department of Clinical Sciences, CRC Malmö University Hospital, Lund University, 205 02, Malmo, Sweden
Diabetologia 51:1159-68. 2008.... - Genetic and nongenetic regulation of CAPN10 mRNA expression in skeletal muscleEmma Carlsson
Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, Malmo University Hospital, S 205 02 Malmo, Sweden
Diabetes 54:3015-20. 2005..Glucose-tolerant but not glucose-intolerant individuals upregulate their CAPN10 mRNA levels in response to prolonged exposure to fat... - A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individualsT Rönn
Department of Clinical Sciences, CRC Malmö University Hospital, Lund University Diabetes Center, Malmo, Sweden
Diabetologia 52:830-3. 2009..In the present study, we investigated whether a single MTNR1B polymorphism was associated with type 2 diabetes in Han Chinese individuals, to elucidate whether this is a cross-populational effect... - Multiple environmental and genetic factors influence skeletal muscle PGC-1alpha and PGC-1beta gene expression in twinsCharlotte Ling
Department of Endocrinology, Lund University, Wallenberg Laboratory, Malmo University Hospital, Malmo, Sweden
J Clin Invest 114:1518-26. 2004.... - Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA(1c) levels in human pancreatic isletsB T Yang
Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, University Hospital Malmoe, 205 02 Malmoe, Sweden
Diabetologia 54:360-7. 2011..Here, we examined DNA methylation of the insulin gene promoter in pancreatic islets from patients with type 2 diabetes and non-diabetic human donors and related it to insulin expression, HbA(1c) levels, BMI and age... - Molecular correlates for maximal oxygen uptake and type 1 fibersHemang Parikh
Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, University Hospital Malmo, Malmo, Sweden
Am J Physiol Endocrinol Metab 294:E1152-9. 2008..In contrast, a high expression of AHNAK was associated with a low Vo(2max) and poor muscle fitness... - Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetesValeriya Lyssenko
Department of Clinical Sciences, Diabetes and Endocrinology, and Lund University Diabetes Center, Lund University, Malmo, Sweden
J Clin Invest 117:2155-63. 2007..In conclusion, the increased risk of T2D conferred by variants in TCF7L2 involves the enteroinsular axis, enhanced expression of the gene in islets, and impaired insulin secretion... - Genetic variation in ATP5O is associated with skeletal muscle ATP50 mRNA expression and glucose uptake in young twinsTina Rönn
Department of Clinical Sciences, Diabetes and Endocrinology Research Unit, CRC Malmö University Hospital, Lund University, Malmo, Sweden
PLoS ONE 4:e4793. 2009..Our aims were to investigate mechanisms regulating ATP5O expression in skeletal muscle and association with glucose metabolism, and the relationship between ATP5O single nucleotide polymorphisms (SNPs) and risk of T2D... - Tight coupling between glucose and mitochondrial metabolism in clonal beta-cells is required for robust insulin secretionSiri Malmgren
Department of Clinical Sciences in Malmo, Unit of Molecular Metabolism, Lund University Diabetes Centre, 205 02 Malmo, Sweden
J Biol Chem 284:32395-404. 2009..The 832 beta-cell lines may be helpful tools to resolve metabolic perturbations occurring in Type 2 diabetes... - Transcriptome and proteome analysis of soleus muscle of hormone-sensitive lipase-null miceOla Hansson
Department of Experimental Medical Science, Lund University, Lund, Sweden
J Lipid Res 46:2614-23. 2005..The results of this study suggest that in the absence of HSL, a metabolic switch from reliance on lipid to carbohydrate energy substrates takes place, supporting an important role of HSL in soleus muscle lipid metabolism... - Mitochondrial dysfunction in pancreatic beta-cells in Type 2 diabetesHindrik Mulder
Department of Clinical Sciences in Malmo, Unit of Molecular Metabolism, Lund University Diabetes Centre, Clinical Research Center, Malmo University Hospital, Lund University, SE 205 02 Malmo, Sweden
Mol Cell Endocrinol 297:34-40. 2009..The emerging picture is that alterations in mitochondria may be a culprit in the pathogenetic processes culminating in Type 2 Diabetes. Such processes may prove to be targets for therapeutic interventions in the disease... - Enhanced mitochondrial metabolism may account for the adaptation to insulin resistance in islets from C57BL/6J mice fed a high-fat dietM Fex
Department of Experimental Medical Science, Division of Diabetes, Metabolism, and Endocrinology, Lund University, Lund, Sweden
Diabetologia 50:74-83. 2007..When this fails, type 2 diabetes ensues. Because mitochondria play a key role in beta cell pathophysiology, we tested the hypothesis that mitochondrial metabolism is critical for beta cell adaptation to insulin resistance... - Regulation of skeletal muscle PPAR delta mRNA expression in twinsEmma Nilsson
Steno Diabetes Center, Niels Steensens Vej 1, DK 2820, Gentofte, Denmark
J Physiol 584:1011-7. 2007..In conclusion, we provide evidence that mRNA expression of PPARdelta in human skeletal muscle is under genetic control but also influenced by factors such as age, birth weight and central adiposity... - Relationships of plasma adiponectin level and adiponectin receptors 1 and 2 gene expression to insulin sensitivity and glucose and fat metabolism in monozygotic and dizygotic twinsHeidi Storgaard
Steno Diabetes Center, 2820 Gentofte, Denmark
J Clin Endocrinol Metab 92:2835-9. 2007..Adiponectin is a key insulin-sensitizing adipokine acting on muscle metabolism via two specific receptors [adiponectin receptors 1 and 2 (AdipoR1 and AdipoR2, respectively)]... - Genetic and nongenetic determinants of skeletal muscle glucose transporter 4 messenger ribonucleic acid levels and insulin action in twinsHeidi Storgaard
Steno Diabetes Center, Niels Steensens Vej 2, 2820 Gentofte, Denmark
J Clin Endocrinol Metab 91:702-8. 2006..Thus, skeletal muscle GLUT4 content plays an important role in whole-body insulin sensitivity... - Epigenetic differences arise during the lifetime of monozygotic twinsMario F Fraga
Epigenetics Laboratory, Spanish National Cancer Centre (CNIO, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
Proc Natl Acad Sci U S A 102:10604-9. 2005..These findings indicate how an appreciation of epigenetics is missing from our understanding of how different phenotypes can be originated from the same genotype... - Developmental and hormonal regulation of progesterone receptor A-form expression in female mouse lung in vivo: interaction with glucocorticoid receptorsRuijin Shao
Department of Physiology Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at Goteborg University, SE 40530 Goteborg, Sweden
J Endocrinol 190:857-70. 2006.... - Identification of functional prolactin (PRL) receptor gene expression: PRL inhibits lipoprotein lipase activity in human white adipose tissueCharlotte Ling
Department of Physiology, Sahlgrenska University Hospital, Goteborg University, 405 30 Goteborg, Sweden
J Clin Endocrinol Metab 88:1804-8. 2003..Taken together, these results demonstrate a direct effect of PRL, via functional PRLRs, in reducing the LPL activity in human adipose tissue, and these results suggest that LPL might also be regulated in this fashion during lactation...