Research Topics
Genomes and GenesSpecies | H JernstromSummaryAffiliation: Lund University Country: Sweden Publications
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Detail Information
Publications
Impact of teenage oral contraceptive use in a population-based series of early-onset breast cancer cases who have undergone BRCA mutation testingHelena Jernstrom
Department of Oncology, Clinical Sciences, Lund University Hospital, SE 221 85 Lund, Sweden
Eur J Cancer 41:2312-20. 2005..Each year of OC use prior to age 20 years conferred a significantly increased risk for early-onset breast cancer, while there was no risk associated with use after age 20 years...- Clinical profiles predict early nonadherence to adjuvant endocrine treatment in a prospective breast cancer cohortAndrea Markkula
Department of Oncology, Clinical Sciences, Lund University, Barngatan 2B, SE 221 85 Lund, Sweden
Cancer Prev Res (Phila) 5:735-45. 2012..In conclusion, two clinical profiles predicted early nonadherence and may allow for targeted interventions to increase adherence if validated in an independent cohort. Cancer Prev Res; 5(5); 735-45. ©2012 AACR... - CYP2C8 and CYP2C9 polymorphisms in relation to tumour characteristics and early breast cancer related events among 652 breast cancer patientsH Jernstrom
Department of Oncology, Clinical Sciences, Lund University, Barngatan 2B, Lund SE 221 85, Sweden
Br J Cancer 101:1817-23. 2009..We aimed to investigate the frequency of CYP2C8/9 polymorphisms in relation to breast tumour characteristics and disease-free survival... - Coffee intake and CYP1A2*1F genotype predict breast volume in young women: implications for breast cancerH Jernstrom
Department of Oncology, Clinical Sciences, Lund University, Barngatan 2B, SE 221 85 Lund, Sweden
Br J Cancer 99:1534-8. 2008..02), which is consistent with reports that coffee protects only C-allele carriers against breast cancer... - High follicular phase luteinizing hormone levels in young healthy BRCA1 mutation carriers: implications for breast and ovarian cancer riskHelena Jernstrom
Department of Oncology, Institute for Clinical Sciences, Lund University, Lund, Sweden
Mol Genet Metab 86:320-7. 2005..This is a small study and confirmatory studies are warranted to establish whether elevated LH levels are part of the BRCA1 phenotype and may be manipulated in order to reduce cancer risks in BRCA1 mutation carriers... - Differences in IGFBP-3 regulation between young healthy women from BRCAX families and those belonging to BRCA1/2 familiesHelena Jernstrom
Department of Oncology, Lund University, Lund, Sweden
Eur J Cancer Prev 15:233-41. 2006..It is possible that a subgroup of the BRCAX families has an increased risk of breast cancer because of high IGFBP-3 levels... - Insulin-like growth factor-1 genotype predicts breast volume after pregnancy and hormonal contraception and is associated with circulating insulin-like growth factor-1 levels: implications for risk of early-onset breast cancer in young women from hereditaH Jernstrom
Department of Oncology, Lund University, Lund, Sweden
Int J Gynecol Cancer 16:497. 2006..It has also been hypothesized that women whose breast size increases while exposed to OCs may be at increased risk of future breast cancer... - Absence of the common Insulin-like growth factor-1 19-repeat allele is associated with early age at breast cancer diagnosis in multiparous womenE Bågeman
Department of Oncology, Clinical Sciences, Lund University, SE 221 85 Lund, Sweden
Br J Cancer 96:712-7. 2007..006). Multiparity combined with IGF1-19/-19 was associated with an early age at breast cancer diagnosis. If confirmed, IGF1-19/-19 may help identify a subgroup of women for earlier breast cancer screening... - Testosterone levels in relation to oral contraceptive use and the androgen receptor CAG and GGC length polymorphisms in healthy young womenM Hietala
Department of Oncology, Lund University, Sweden
Hum Reprod 22:83-91. 2007..The combined effect from the androgen receptor (AR) CAG and GGC length polymorphisms on testosterone levels has not been studied in young women... - Insulin-like growth factor-1 (IGF1) genotype predicts breast volume after pregnancy and hormonal contraception and is associated with circulating IGF-1 levels: implications for risk of early-onset breast cancer in young women from hereditary breast cancerH Jernstrom
Department of Oncology, The Jubileum Institute, Lund University Hospital, Lund SE 221 85, Sweden
Br J Cancer 92:857-66. 2005..002). Our results suggest that lack of the IGF1 19-repeat allele modifies IGF-1 levels, breast volume and possibly early-onset breast cancer risk after hormone exposure in young high-risk women... - Androgen receptor genotypes predict response to endocrine treatment in breast cancer patientsK B Lundin
Department of Oncology, Clinical Sciences, Lund University, Barngatan 2B, Lund, Sweden
Br J Cancer 105:1676-83. 2011..The androgen receptor (AR) is frequently expressed in breast cancers. The AR genotype may affect disease-free survival and response to endocrine therapy... - Interactions between oral contraceptive status and GSTM1 and GSTT1 deletions on insulin-like growth factor-1 (IGF-1) plasma levels in young healthy womenM C K Henningson
Department of Oncology, Clinical Sciences, Lund University, Sweden
Growth Horm IGF Res 20:432-7. 2010..Glutathione S-transferases (GSTs) are involved in estrogen metabolism. We aimed to study IGF-1 levels and body size in relation to GSTM1 and GSTT1 deletions, and GSTP1*1B and current oral contraceptive (OC) status... - CYP17 genotype is associated with short menstrual cycles, early oral contraceptive use and BRCA mutation status in young healthy womenM Henningson
Department of Oncology, Lund University, Sweden
Mol Hum Reprod 13:231-6. 2007..In conclusion, this study suggests that short menstrual cycles, age at first OC use and BRCA mutation status may need to be considered in studies exploring the relationships between CYP17 and risk factors for early onset breast cancer... - Breast-feeding and the risk of breast cancer in BRCA1 and BRCA2 mutation carriersH Jernstrom
Jubileum Institute, Department of Oncology, Lund University Hospital, Lund, Sweden
J Natl Cancer Inst 96:1094-8. 2004..Whether breast-feeding is associated with a reduced risk of hereditary breast cancer in women who carry deleterious BRCA1 and BRCA2 mutations is currently unknown... - Absence of the common IGF1 19 CA-repeat allele is more common among BRCA1 mutation carriers than among non-carriers from BRCA1 familiesMaria Henningson
Department of Oncology, Clinical Sciences, Lund University, Barngatan 2 1, 221 85, Lund, Sweden
Fam Cancer 6:445-52. 2007.... - Coffee consumption and CYP1A2*1F genotype modify age at breast cancer diagnosis and estrogen receptor statusErika Bågeman
Department of Oncology, Clinical Sciences, Lund University, Lund, Sweden
Cancer Epidemiol Biomarkers Prev 17:895-901. 2008..2; 95% confidence interval, 1.9-9.3; P = 0.0002). These findings raise the hypothesis that coffee slows the growth of ER-positive tumors in patients with CYP1A2*1F A/A and may have implications for breast cancer if confirmed... - Prolactin levels, breast-feeding and milk production in a cohort of young healthy women from high-risk breast cancer families: implications for breast cancer riskMaria Hietala
Department of Oncology, Clinical Sciences, Lund University, Barngatan 2 B, 221 85, Lund, Sweden
Fam Cancer 7:221-8. 2008..Since prolactin modifies the risk for breast cancer, adequate counseling in favor of breast-feeding is essential... - A prospective study of different types of hormone replacement therapy use and the risk of subsequent breast cancer: the women's health in the Lund area (WHILA) study (Sweden)Helena Jernstrom
Department of Oncology, The Jubileum Institute, Lund University Hospital, S 221 85 Lund, Sweden
Cancer Causes Control 14:673-80. 2003..Reports suggest that combined estrogen plus progestin hormone replacement therapy (HRT) confers a higher breast cancer risk than estrogen alone. We aimed to establish whether breast cancer risk depends on the type of HRT formula...