Magnus J Hansson

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. ncbi Cyclophilin D-sensitive mitochondrial permeability transition in adult human brain and liver mitochondria
    Magnus J Hansson
    Mitochondrial Pathophysiology Unit, Laboratory for Experimental Brain Research, Department of Clinical Sciences, Lund University, Lund, Sweden
    J Neurotrauma 28:143-53. 2011
  2. ncbi Increased potassium conductance of brain mitochondria induces resistance to permeability transition by enhancing matrix volume
    Magnus J Hansson
    Mitochondrial Pathophysiology Unit, Laboratory for Experimental Brain Research, Department of Clinical Sciences, Lund University, SE 221 84 Lund, Sweden
    J Biol Chem 285:741-50. 2010
  3. ncbi Calcium-induced generation of reactive oxygen species in brain mitochondria is mediated by permeability transition
    Magnus J Hansson
    Department of Clinical Sciences, Lund University, SE 221 84 Lund, Sweden
    Free Radic Biol Med 45:284-94. 2008
  4. ncbi Brain-derived respiring mitochondria exhibit homogeneous, complete and cyclosporin-sensitive permeability transition
    Magnus J Hansson
    Laboratory for Experimental Brain Research, Wallenberg Neuroscience Center, Lund University, Sweden
    J Neurochem 89:715-29. 2004
  5. ncbi Evaluation of putative inhibitors of mitochondrial permeability transition for brain disorders--specificity vs. toxicity
    Saori Morota
    Department of Clinical Sciences, Lund University, Sweden
    Exp Neurol 218:353-62. 2009
  6. ncbi Re-evaluation of mitochondrial permeability transition as a primary neuroprotective target of minocycline
    Roland Månsson
    Laboratory for Experimental Brain Research, Department of Clinical Sciences, Lund University, Sweden
    Neurobiol Dis 25:198-205. 2007
  7. ncbi The temperature dependence and involvement of mitochondria permeability transition and caspase activation in damage to organotypic hippocampal slices following in vitro ischemia
    Anna Rytter
    Laboratory for Experimental Brain Research, Lund University, Sweden
    J Neurochem 95:1108-17. 2005
  8. ncbi Powerful cyclosporin inhibition of calcium-induced permeability transition in brain mitochondria
    Magnus J Hansson
    Laboratory for Experimental Brain Research, Wallenberg Neuroscience Center, Lund University, BMC A13, SE 221 84, Lund, Sweden
    Brain Res 960:99-111. 2003
  9. ncbi The nonimmunosuppressive cyclosporin analogs NIM811 and UNIL025 display nanomolar potencies on permeability transition in brain-derived mitochondria
    Magnus J Hansson
    Laboratory for Experimental Brain Research, Wallenberg Neuroscience Center, Lund University, BMC A13, SE-221 84 Lund, Sweden
    J Bioenerg Biomembr 36:407-13. 2004
  10. ncbi Temporal increase of platelet mitochondrial respiration is negatively associated with clinical outcome in patients with sepsis
    Fredrik Sjövall
    Mitochondrial Pathophysiology Unit, Laboratory for Experimental Brain Research, Department of Clinical Sciences, Lund University, Solvegatan 17, SE 221 84, Lund, Sweden
    Crit Care 14:R214. 2010

Collaborators

Detail Information

Publications12

  1. ncbi Cyclophilin D-sensitive mitochondrial permeability transition in adult human brain and liver mitochondria
    Magnus J Hansson
    Mitochondrial Pathophysiology Unit, Laboratory for Experimental Brain Research, Department of Clinical Sciences, Lund University, Lund, Sweden
    J Neurotrauma 28:143-53. 2011
    ..We concluded that adult viable human brain and liver mitochondria possess an active CypD-sensitive mPT. Our findings support the rationale of CypD and mPT inhibition as pharmacological targets in acute and chronic neurodegeneration...
  2. ncbi Increased potassium conductance of brain mitochondria induces resistance to permeability transition by enhancing matrix volume
    Magnus J Hansson
    Mitochondrial Pathophysiology Unit, Laboratory for Experimental Brain Research, Department of Clinical Sciences, Lund University, SE 221 84 Lund, Sweden
    J Biol Chem 285:741-50. 2010
    ..We propose that increased potassium conductance in brain mitochondria may cause a direct physiological effect on matrix volume inducing resistance to pathological calcium challenges...
  3. ncbi Calcium-induced generation of reactive oxygen species in brain mitochondria is mediated by permeability transition
    Magnus J Hansson
    Department of Clinical Sciences, Lund University, SE 221 84 Lund, Sweden
    Free Radic Biol Med 45:284-94. 2008
    ..We propose that mPT is a significant cause of pathological ROS generation in excitotoxic cell death...
  4. ncbi Brain-derived respiring mitochondria exhibit homogeneous, complete and cyclosporin-sensitive permeability transition
    Magnus J Hansson
    Laboratory for Experimental Brain Research, Wallenberg Neuroscience Center, Lund University, Sweden
    J Neurochem 89:715-29. 2004
    ....
  5. ncbi Evaluation of putative inhibitors of mitochondrial permeability transition for brain disorders--specificity vs. toxicity
    Saori Morota
    Department of Clinical Sciences, Lund University, Sweden
    Exp Neurol 218:353-62. 2009
    ..We conclude that a clinically relevant mPT inhibitor should have a mitochondrial target and increase mitochondrial calcium retention at concentrations which can be translated to human use...
  6. ncbi Re-evaluation of mitochondrial permeability transition as a primary neuroprotective target of minocycline
    Roland Månsson
    Laboratory for Experimental Brain Research, Department of Clinical Sciences, Lund University, Sweden
    Neurobiol Dis 25:198-205. 2007
    ....
  7. ncbi The temperature dependence and involvement of mitochondria permeability transition and caspase activation in damage to organotypic hippocampal slices following in vitro ischemia
    Anna Rytter
    Laboratory for Experimental Brain Research, Lund University, Sweden
    J Neurochem 95:1108-17. 2005
    ..In contrast, cell death following hyperglycemic IVI, although completely prevented by hypothermia, is not mediated by mechanisms that involve MPT or caspase activation...
  8. ncbi Powerful cyclosporin inhibition of calcium-induced permeability transition in brain mitochondria
    Magnus J Hansson
    Laboratory for Experimental Brain Research, Wallenberg Neuroscience Center, Lund University, BMC A13, SE 221 84, Lund, Sweden
    Brain Res 960:99-111. 2003
    ..The importance of CsA causing a shift of the mitochondrial sensitivity to Ca(2+) in neurological disorders is discussed...
  9. ncbi The nonimmunosuppressive cyclosporin analogs NIM811 and UNIL025 display nanomolar potencies on permeability transition in brain-derived mitochondria
    Magnus J Hansson
    Laboratory for Experimental Brain Research, Wallenberg Neuroscience Center, Lund University, BMC A13, SE-221 84 Lund, Sweden
    J Bioenerg Biomembr 36:407-13. 2004
    ..These compounds will be instrumental in the evaluation of mPT as a central target for neuroprotection in vivo...
  10. ncbi Temporal increase of platelet mitochondrial respiration is negatively associated with clinical outcome in patients with sepsis
    Fredrik Sjövall
    Mitochondrial Pathophysiology Unit, Laboratory for Experimental Brain Research, Department of Clinical Sciences, Lund University, Solvegatan 17, SE 221 84, Lund, Sweden
    Crit Care 14:R214. 2010
    ..Here we investigated temporal changes in platelet mitochondrial respiratory function in patients with sepsis during the first week after disease onset...
  11. ncbi Spinal cord mitochondria display lower calcium retention capacity compared with brain mitochondria without inherent differences in sensitivity to cyclophilin D inhibition
    Saori Morota
    Department of Anesthesiology, Tokyo Medical University Hachioji Medical Center, Tatemachi, Hachioji, Japan
    J Neurochem 103:2066-76. 2007
    ..A hampered transport and retention capacity of calcium may translate into an increased susceptibility of the spinal cord to neurodegenerative processes involving calcium-mediated damage...
  12. ncbi Life span extension and reduced neuronal death after weekly intraventricular cyclosporin injections in the G93A transgenic mouse model of amyotrophic lateral sclerosis
    Jenny Karlsson
    Laboratory of Matrix Pathobiology, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii
    J Neurosurg 101:128-37. 2004
    ..The remarkably low intrathecal CsA dose required for neuroprotection reduces potential adverse effects of systemic immunosuppression or nephrotoxicity seen with chronic systemic delivery of the drug...