Research Topics
Genomes and Genes
| Isabella ArtnerSummaryAffiliation: Lund University Country: Sweden Publications
| Collaborators
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Detail Information
Publications
MafA is a dedicated activator of the insulin gene in vivoIsabella Artner
Departments of, Molecular Physiology and Biophysics Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37205, USA
J Endocrinol 198:271-9. 2008..Collectively, these results demonstrate a unique ability for MafA to independently activate Insulin transcription...- MafA and MafB regulate genes critical to beta-cells in a unique temporal mannerIsabella Artner
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Diabetes 59:2530-9. 2010..Our aim was to define the functional relationship between these closely related activators to the ?-cell... - MafB is required for islet beta cell maturationIsabella Artner
Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, 723 Light Hall, Nashville, TN 37232, USA
Proc Natl Acad Sci U S A 104:3853-8. 2007..These results demonstrate that MafB plays a previously uncharacterized role by regulating transcription of key factors during development that are required for the production of mature alpha and beta cells... - Islet beta-cell-specific MafA transcription requires the 5'-flanking conserved region 3 control domainJeffrey C Raum
Vanderbilt University Medical Center, Department of Molecular Physiology and Biophysics, Nashville, TN 37232, USA
Mol Cell Biol 30:4234-44. 2010..These data highlight the nature of the cis- and trans-acting factors controlling the beta-cell-specific expression of MafA... - MafB: an activator of the glucagon gene expressed in developing islet alpha- and beta-cellsIsabella Artner
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Diabetes 55:297-304. 2006..These results indicate that MafB is not only important to islet alpha-cell function but may also be involved in regulating genes required in both endocrine alpha- and beta-cell differentiation... - FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start siteJeffrey C Raum
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medical Center, 723 Light Hall, Nashville, TN 37232, USA
Mol Cell Biol 26:5735-43. 2006..2 null animals. These results suggest that beta-cell-type-specific mafA transcription is principally controlled by region 3-acting transcription factors that are essential in the formation of functional beta cells... - MafA and MafB regulate Pdx1 transcription through the Area II control region in pancreatic beta cellsAmanda M Vanhoose
Department of Molecular Physiology and Biophysics, Vanderbilt Medical School, Nashville, Tennessee 37232, USA
J Biol Chem 283:22612-9. 2008..These findings illustrate the significance of large Maf proteins to Pdx1 expression in beta cells, and in particular MafB during pancreatic development... - Interactions between areas I and II direct pdx-1 expression specifically to islet cell types of the mature and developing pancreasJennifer C Van Velkinburgh
Department of Molecular Physiology and Biophysics, Vanderbilt Medical Center, Nashville, Tennessee 37232, USA
J Biol Chem 280:38438-44. 2005..These results suggest that Area II is a central pdx-1 control region, whose islet cell activity is uniquely modified by Area I regulatory factors... - The MafA transcription factor appears to be responsible for tissue-specific expression of insulinTaka Aki Matsuoka
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 723 Light Hall, Nashville, TN 37232, USA
Proc Natl Acad Sci U S A 101:2930-3. 2004..1(-/-) pancreata, which lack the majority of second-phase beta cells. These results demonstrate that MafA is a potent insulin activator that is likely to function downstream of Nkx6.1 during islet insulin-producing cell development... - Maintenance of hepatic nuclear factor 6 in postnatal islets impairs terminal differentiation and function of beta-cellsElizabeth Tweedie
Department of Medicine, Division of Diabetes, Endocrinology, and Metabolism, Vanderbilt University Medical Center, 2220 Pierce Ave, 746 PRB, Nashville, TN 37232 6303, USA
Diabetes 55:3264-70. 2006..These results suggest that downregulation of Hnf6 expression in beta-cells during development is essential to achieve a mature, glucose-responsive beta-cell... - Members of the large Maf transcription family regulate insulin gene transcription in islet beta cellsTaka Aki Matsuoka
Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
Mol Cell Biol 23:6049-62. 2003..Because MafA, MafB, and c-Maf were each capable of specifically binding to and activating insulin C1 element-mediated expression, our results suggest that all of these factors play a role in islet beta-cell function...