Research Topics
| John WahrenSummaryAffiliation: Karolinska Institutet Country: Sweden Publications
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Publications
Splanchnic regulation of glucose productionJohn Wahren
Department of Molecular Medicine and Surgery, Karolinska Institute, SE 171 77 Stockholm, Sweden
Annu Rev Nutr 27:329-45. 2007..The hyperglycemia of type 2 diabetes is in part caused by an overproduction of glucose from the liver that is secondary to accelerated gluconeogenesis...- C-peptide is a bioactive peptideJ Wahren
Department of Molecular Medicine and Surgery, Karolinska Hospital, 171 76, Stockholm, Sweden
Diabetologia 50:503-9. 2007 - C-peptide improves adenosine-induced myocardial vasodilation in type 1 diabetes patientsBo-Lennart Johansson
Department of Surgical Sciences, Division of Clinical Physiology N1:05, Karolinska Institutet, Karolinska Hospital, SE-171 76 Stockholm, Sweden
Am J Physiol Endocrinol Metab 286:E14-9. 2004..05) and stroke volume (+7%, P < 0.05). It is concluded that short-term C-peptide infusion in physiological amounts increases the hyperemic MBF and left-ventricular function in type 1 diabetic patients... - C-Peptide replacement therapy and sensory nerve function in type 1 diabetic neuropathyKarin Ekberg
Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
Diabetes Care 30:71-6. 2007..The present study was undertaken to examine whether C-peptide administration to patients with type 1 diabetes and peripheral neuropathy improves sensory nerve function... - Molecular and cellular effects of C-peptide--new perspectives on an old peptideJohn Wahren
Department of Surgical Sciences, Section of Clinical Physiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
Exp Diabesity Res 5:15-23. 2004..Clinical evidence suggests that replacement of C-peptide, together with regular insulin therapy, may be beneficial in patients with type 1 diabetes and serve to retard or prevent the development of long-term complications... - Amelioration of sensory nerve dysfunction by C-Peptide in patients with type 1 diabetesKarin Ekberg
Department of Surgical Sciences, Section of Clinical Physiology, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
Diabetes 52:536-41. 2003..In conclusion, C-peptide administered for 3 months as replacement therapy to patients with early signs of diabetic neuropathy ameliorates nerve dysfunction... - C-peptide increases forearm blood flow in patients with type 1 diabetes via a nitric oxide-dependent mechanismBo-Lennart Johansson
Department of Surgical Sciences, Division of Clinical Physiology N1:05, Karolinska Hospital, SE-171 76 Stockholm, Sweden
Am J Physiol Endocrinol Metab 285:E864-70. 2003..It is concluded that the stimulatory effect of C-peptide on FBF in type 1 diabetic patients is mediated via the NO system and that C-peptide increases basal endothelial NO levels... - C-peptide exerts beneficial effects on myocardial blood flow and function in patients with type 1 diabetesAlexander Hansen
Section of Cardiology, Department of Medicine, Karolinska Hospital, Stockholm, Sweden
Diabetes 51:3077-82. 2002..3 +/- 0.4 to 5.3 +/- 0.9 (P < 0.05). The results demonstrate that type 1 diabetic patients have impaired myocardial function and perfusion in the basal state that can be improved by short-term replacement of C-peptide... - C-peptide: new findings and therapeutic implications in diabetesJohn Wahren
Section of Clinical Physiology, Department of Surgical Sciences, Karolinska Institute, N1 05, SE 171 76 Stockholm, Sweden
Clin Physiol Funct Imaging 24:180-9. 2004.... - Ernst-Friedrich-Pfeiffer Memorial Lecture. New aspects of C-peptide physiologyJ Wahren
Department of Surgical Sciences, Karolinska Hospital, Stockholm, Sweden
Horm Metab Res 30:A2-5. 1998..In conclusion, the combined findings indicate that C-peptide is a biologically active hormone. The possibility that C-peptide therapy in IDDM patients may be beneficial should be considered... - Molecular effects of proinsulin C-peptideJan Johansson
Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 171 77 Stockholm, Sweden
Biochem Biophys Res Commun 295:1035-40. 2002..Combined, the available observations show that C-peptide is biologically active and suggest a molecular model for its physiological effects... - Proinsulin C-peptide elicits disaggregation of insulin resulting in enhanced physiological insulin effectsJ Shafqat
Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
Cell Mol Life Sci 63:1805-11. 2006..It is compatible with the normal co-release of C-peptide and insulin and may contribute to the beneficial effect of C-peptide and insulin replacement in type 1 diabetics... - C-peptide increases Na,K-ATPase expression via PKC- and MAP kinase-dependent activation of transcription factor ZEB in human renal tubular cellsDana Galuska
Section of Integrative Physiology, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
PLoS ONE 6:e28294. 2011..We determined the molecular mechanism by which long term exposure to C-peptide stimulates Na,K-ATPase expression and activity in primary human renal tubular cells (HRTC) in control and hyperglycemic conditions... - Precise determination of glucose-d(2)/glucose ratio in human serum and plasma by APCI LC-MS/MSShahid Ullah
Department of Medicine, Division of Clinical Pharmacology, Karolinska Institute and University Hospital, Stockholm, Sweden
Scand J Clin Lab Invest 69:837-42. 2009..Determinations of glucose turnover based on infusion of deuterium-labelled glucose are frequently undertaken in studies involving the pathophysiology of diabetes or obesity or the metabolic response to physical exercise... - Large-surface biosensor technology for enhanced recovery in protein characterizationErmias Melles
Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
J Biomol Tech 16:392-7. 2005..Recovery of affinity partners at the multi-pmole level is demonstrated for protein purification in SPR approaches... - C-peptide: a new potential in the treatment of diabetic nephropathyJ Wahren
Department of Surgical Sciences, Karolinska Hospital, Stockholm SE 171 76, Sweden
Curr Diab Rep 1:261-6. 2001..C-peptide replacement together with insulin therapy may be beneficial in type 1 diabetes patients with nephropathy... - C-peptide binding to human cell membranes: importance of Glu27A Pramanik
Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, SE-171 77, Sweden
Biochem Biophys Res Commun 284:94-8. 2001..These results indicate that Glu27 of C-peptide is critically involved in binding to cellular targets... - Role of C-peptide in human physiologyJ Wahren
Department of Surgical Sciences, Section of Clinical Physiology, Karolinska Hospital, SE 171 76 Stockholm, Sweden
Am J Physiol Endocrinol Metab 278:E759-68. 2000..The possibility exists that C-peptide replacement, together with insulin administration, may prevent the development or retard the progression of long-term complications in type 1 diabetes... - Cellular internalization of proinsulin C-peptideE Lindahl
Department of Medical Biochemistry and Biophysics MBB, Karolinska Institutet, 171 77, Stockholm, Sweden
Cell Mol Life Sci 64:479-86. 2007..Hence, the data suggest the possibility of one further C-peptide site of action... - Unordered structured of proinsulin C-peptide in aqueous solution and in the presence of lipid vesiclesM Henriksson
Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
Cell Mol Life Sci 57:337-42. 2000..In conclusion, C-peptide is unlikely to elicit physiological effects through stable conformation-dependent interactions with lipid membranes... - Separate functional features of proinsulin C-peptideM Henriksson
Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77, Stockholm, Sweden
Cell Mol Life Sci 62:1772-8. 2005..Previous findings have ascribed functional roles to the C-terminal pentapeptide segment, and all results combined therefore now show the importance of different segments, suggesting that C-peptide interactions are complex or multiple... - Proinsulin C-peptide and its analogues induce intracellular Ca2+ increases in human renal tubular cellsJ Shafqat
Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
Cell Mol Life Sci 59:1185-9. 2002..Combined, all data show that C-peptide is a bioactive peptide and suggest that it elicits changes in [Ca2+]i via G-protein-coupled pathways, giving downstream enzyme effects... - Insulin binding monitored by fluorescence correlation spectroscopyZ H Zhong
Department of Surgical Sciences, Karolinska Hospital, Stockholm, Sweden
Diabetologia 44:1184-8. 2001..Because of its high sensitivity (single molecule detection), FCS, provides additional data allowing a more precise evaluation of the kinetics of ligand-receptor interactions at low expression levels in living cells... - Diminished skin blood flow in Type I diabetes: evidence for non-endothelium-dependent dysfunctionA Katz
Department of Surgical Sciences, Division of Clinical Physiology, Karolinska Institute, Karolinska Hospital, 171 76 Stockholm, Sweden
Clin Sci (Lond) 101:59-64. 2001..These data demonstrate that Type I diabetic patients have similar diminished SBF responses to iontophoresis of ACh and SNP, which suggests that non-endothelial-dependent factors are primarily responsible for the diminished SBF responses... - C-peptide stimulates ERK1/2 and JNK MAP kinases via activation of protein kinase C in human renal tubular cellsZ Zhong
Section of Clinical Physiology, Department of Surgical Sciences, Karolinska Institute, Stockholm, Sweden
Diabetologia 48:187-97. 2005.... - C-peptide improves neuropathy in type 1 diabetic BB/Wor-ratsWeixian Zhang
Department of Pathology, Wayne State University, School of Medicine, Detroit, MI 48201, USA
Diabetes Metab Res Rev 23:63-70. 2007..Here we examine the therapeutic effects of C-peptide, delivered as continuous infusion or once daily subcutaneous injections on established DPN... - C-Peptide reverses nociceptive neuropathy in type 1 diabetesHideki Kamiya
Department of Pathology, Scott Hall 9275, 540 E. Canfield Ave, Detroit, MI 48201, USA
Diabetes 55:3581-7. 2006..We conclude that C-peptide exerts beneficial therapeutic effects on diabetic nociceptive neuropathy and that optimal effects require maintenance of physiological C-peptide concentrations for a major proportion of the day... - New tricks by an old dogThomas Forst
Exp Diabetes Res 2008:384219. 2008 - Effects of proinsulin C-peptide in experimental diabetic neuropathy: vascular actions and modulation by nitric oxide synthase inhibitionMary A Cotter
Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Scotland, UK
Diabetes 52:1812-7. 2003..Thus, C-peptide replacement improves nerve function in experimental diabetes, and the data are compatible with the notion that this is mediated by a NO-sensitive vascular mechanism... - C-peptide and its C-terminal fragments improve erythrocyte deformability in type 1 diabetes patientsThomas Hach
Department of Internal Medicine, University of Mainz, 55101 Mainz, Germany thomas
Exp Diabetes Res 2008:730594. 2008..This study aimed to investigate the influence of C-peptide and fragments thereof on erythrocyte deformability and to elucidate the relevant signal transduction pathway... - C-peptide makes a comebackJohn Wahren
Diabetes Metab Res Rev 19:345-7. 2003..The possibility that replacement of C-peptide in patients with type 1 diabetes may serve to retard or prevent the development of long-term complications should be evaluated... - In vivo biodistribution and pharmacokinetics of (18)F-labeled human C-peptide: evaluation in monkeys using positron emission tomographyAnna Fredriksson
Karolinska Pharmacy, Karolinska Hospital and Institute, SE 171 76 Stockholm, Sweden
Life Sci 71:1361-70. 2002..The organs with the highest radioactivity concentrations have been identified, enabling dose estimations for studies in humans with low or no C-peptide... - Direct measurements of the permeability surface area for insulin and glucose in human skeletal muscleSoffia Gudbjornsdottir
Lundberg Laboratory for Diabetes Research, Sahlgrenska University Hospital, S 413 45 Goteborg, Sweden
J Clin Endocrinol Metab 88:4559-64. 2003.... - C-peptide and captopril are equally effective in lowering glomerular hyperfiltration in diabetic ratsBjörn Samnegård
Department of Nephrology, Danderyd Hospital, SE 182 88 Stockholm, Sweden
Nephrol Dial Transplant 19:1385-91. 2004.... - Influence of C-peptide on early glomerular changes in diabetic miceYoshiro Maezawa
Department of Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chiba 260-8670, Japan
Diabetes Metab Res Rev 22:313-22. 2006.... - The contribution of visceral adipose tissue to splanchnic cortisol production in healthy humansRuth Andrew
Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK
Diabetes 54:1364-70. 2005..Thus, in addition to free fatty acids and adipokines, the portal vein delivers cortisol to the liver, and inhibition of 11HSD1 in visceral adipose tissue may indeed be valuable in ameliorating insulin resistance in obesity... - C-peptide prevents glomerular hypertrophy and mesangial matrix expansion in diabetic ratsBjörn Samnegård
Department of Nephrology, Danderyd Hospital, SE 182 88 Stockholm, Sweden
Nephrol Dial Transplant 20:532-8. 2005..The aim of this study was to clarify further the effects of C-peptide on renal structural changes in type-1 diabetic rats...