Anders Vahlne

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi Mutation in the loop C-terminal to the cyclophilin A binding site of HIV-1 capsid protein disrupts proper virus assembly and infectivity
    Samir Abdurahman
    Division of Clinical Microbiology, Karolinska Institutet, Karolinska University Hospial, Stockholm, Sweden
    Retrovirology 4:19. 2007
  2. ncbi A historical reflection on the discovery of human retroviruses
    Anders Vahlne
    Clinical Virology and Division of Clinical Microbiology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Retrovirology 6:40. 2009
  3. ncbi Activity of the small modified amino acid alpha-hydroxy glycineamide on in vitro and in vivo human immunodeficiency virus type 1 capsid assembly and infectivity
    Samir Abdurahman
    Division of Clinical Microbiology, Karolinska Institutet, F68 Karolinska University Hospital Huddinge, SE 141 86 Stockholm, Sweden
    Antimicrob Agents Chemother 52:3737-44. 2008
  4. ncbi Isolation and characterization of a small antiretroviral molecule affecting HIV-1 capsid morphology
    Samir Abdurahman
    Division of Clinical Microbiology, Karolinska Institutet, F68 Karolinska University Hospital Huddinge, SE 141 86 Stockholm, Sweden
    Retrovirology 6:34. 2009
  5. ncbi Selected amino acid substitutions in the C-terminal region of human immunodeficiency virus type 1 capsid protein affect virus assembly and release
    Samir Abdurahman
    Division of Clinical Virology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    J Gen Virol 85:2903-13. 2004
  6. ncbi GPG-NH2 acts via the metabolite alphaHGA to target HIV-1 Env to the ER-associated protein degradation pathway
    Alenka Jejcic
    Department of Laboratory Medicine, Division of Clinical Microbiology, Karolinska Institutet, SE 141 86 Stockholm, Sweden
    Retrovirology 7:20. 2010
  7. ncbi Characterization of the invariable residue 51 mutations of human immunodeficiency virus type 1 capsid protein on in vitro CA assembly and infectivity
    Samir Abdurahman
    Division of Clinical Virology, Karolinska Institutet, F68 Karolinska University Hospital, SE 141 86 Stockholm, Sweden
    Retrovirology 4:69. 2007
  8. ncbi Small molecule targets Env for endoplasmic reticulum-associated protein degradation and inhibits human immunodeficiency virus type 1 propagation
    Alenka Jejcic
    Department of Laboratory Medicine, Division of Clinical Microbiology, Karolinska Institutet, Stockholm, SE 141 86, Sweden
    J Virol 83:10075-84. 2009
  9. ncbi Neutralization of HIV-1 by redirection of natural antibodies
    Maria F Perdomo
    Division of Clinical Microbiology, Karolinska Institutet, Karolinska University Hospital at Huddinge F 68, SE 141 86 Stockholm, Sweden
    Proc Natl Acad Sci U S A 105:12515-20. 2008
  10. ncbi Intracellular high mobility group B1 protein (HMGB1) represses HIV-1 LTR-directed transcription in a promoter- and cell-specific manner
    Mojgan H Naghavi
    Division of Clinical Virology, F68, Karolinska Institutet, Huddinge University Hospital, S 141 86 Stockholm, Sweden
    Virology 314:179-89. 2003

Collaborators

Detail Information

Publications10

  1. ncbi Mutation in the loop C-terminal to the cyclophilin A binding site of HIV-1 capsid protein disrupts proper virus assembly and infectivity
    Samir Abdurahman
    Division of Clinical Microbiology, Karolinska Institutet, Karolinska University Hospial, Stockholm, Sweden
    Retrovirology 4:19. 2007
    ....
  2. ncbi A historical reflection on the discovery of human retroviruses
    Anders Vahlne
    Clinical Virology and Division of Clinical Microbiology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Retrovirology 6:40. 2009
    ..However, the proof that a new human retrovirus (HIV-1) was the cause of AIDS was first established in four publications by Gallo's group in the May 4th issue of Science in 1984...
  3. ncbi Activity of the small modified amino acid alpha-hydroxy glycineamide on in vitro and in vivo human immunodeficiency virus type 1 capsid assembly and infectivity
    Samir Abdurahman
    Division of Clinical Microbiology, Karolinska Institutet, F68 Karolinska University Hospital Huddinge, SE 141 86 Stockholm, Sweden
    Antimicrob Agents Chemother 52:3737-44. 2008
    ..As an antiviral compound, alpha-HGA has an unusually simple structure, a pronounced antiviral specificity, and a novel mechanism of antiviral action. As such, it might prove to be a lead compound for a new class of anti-HIV substances...
  4. ncbi Isolation and characterization of a small antiretroviral molecule affecting HIV-1 capsid morphology
    Samir Abdurahman
    Division of Clinical Microbiology, Karolinska Institutet, F68 Karolinska University Hospital Huddinge, SE 141 86 Stockholm, Sweden
    Retrovirology 6:34. 2009
    ..We have previously described that glycineamide (G-NH2) when added to the culture medium of infected cells induces non-infectious HIV-1 particles with aberrant core structures...
  5. ncbi Selected amino acid substitutions in the C-terminal region of human immunodeficiency virus type 1 capsid protein affect virus assembly and release
    Samir Abdurahman
    Division of Clinical Virology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    J Gen Virol 85:2903-13. 2004
    ..These results indicate that the two conserved sequences in the C-terminal CA domain are essential for proper morphogenesis and infectivity of HIV-1 particles...
  6. ncbi GPG-NH2 acts via the metabolite alphaHGA to target HIV-1 Env to the ER-associated protein degradation pathway
    Alenka Jejcic
    Department of Laboratory Medicine, Division of Clinical Microbiology, Karolinska Institutet, SE 141 86 Stockholm, Sweden
    Retrovirology 7:20. 2010
    ..In accordance, we wanted to investigate whether the targeting of gp160 to the ERAD pathway by GPG-NH2 was attributed to its metabolite alphaHGA...
  7. ncbi Characterization of the invariable residue 51 mutations of human immunodeficiency virus type 1 capsid protein on in vitro CA assembly and infectivity
    Samir Abdurahman
    Division of Clinical Virology, Karolinska Institutet, F68 Karolinska University Hospital, SE 141 86 Stockholm, Sweden
    Retrovirology 4:69. 2007
    ..Thus, previous substitution mutation of Asp51 to alanine (D51A) has shown to be lethal and that this invariable residue was found essential for tube formation in vitro, virus replication and virus capsid formation...
  8. ncbi Small molecule targets Env for endoplasmic reticulum-associated protein degradation and inhibits human immunodeficiency virus type 1 propagation
    Alenka Jejcic
    Department of Laboratory Medicine, Division of Clinical Microbiology, Karolinska Institutet, Stockholm, SE 141 86, Sweden
    J Virol 83:10075-84. 2009
    ..These findings illustrate that nontoxic drugs such as GPG-NH(2), which can selectively target glycoproteins to existing cellular degradation pathways, may be useful for pathogen therapy...
  9. ncbi Neutralization of HIV-1 by redirection of natural antibodies
    Maria F Perdomo
    Division of Clinical Microbiology, Karolinska Institutet, Karolinska University Hospital at Huddinge F 68, SE 141 86 Stockholm, Sweden
    Proc Natl Acad Sci U S A 105:12515-20. 2008
    ..Thus, the temporary redirection of naturally occurring antibodies and their biological activities to a new antigen represents a completely new way of targeting a human disease...
  10. ncbi Intracellular high mobility group B1 protein (HMGB1) represses HIV-1 LTR-directed transcription in a promoter- and cell-specific manner
    Mojgan H Naghavi
    Division of Clinical Virology, F68, Karolinska Institutet, Huddinge University Hospital, S 141 86 Stockholm, Sweden
    Virology 314:179-89. 2003
    ..Thus, intracellular HMGB1 affects HIV-1 LTR-directed transcription in a promoter- and cell-specific manner...