Research Topics
Genomes and Genes | Jesper TegnerSummaryAffiliation: Karolinska Institutet Country: Sweden Publications
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Detail Information
Publications
Systems medicine and integrated care to combat chronic noncommunicable diseasesJean Bousquet
Department of Respiratory Diseases, Arnaud de Villeneuve Hospital, CHU Montpellier, INSERM CESP U1018, Villejuif, France
Genome Med 3:43. 2011..This systems medicine strategy, which will take a holistic approach to disease, is designed to allow the results to be used globally, taking into account the needs and specificities of local economies and health systems...- Bridging the gap between systems biology and medicineGilles Clermont
Department of Critical Care Medicine and CRISMA laboratory, University of Pittsburgh School of Medicine, Scaife 602, 3550 Terrace, Pittsburgh, PA 15261, USA
Genome Med 1:88. 2009.... - Decoding complex biological networks - tracing essential and modulatory parameters in complex and simplified models of the cell cycleOlivia Eriksson
Division of Mathematical Statistics, Department of Mathematics, Stockholm University, SE 106 91 Stockholm, Sweden
BMC Syst Biol 5:123. 2011..A simplified, piecewise linear approximation of the original model is combined with a sensitivity analysis of the same system, to obtain and validate analytical expressions describing the dynamical role of different model parameters... - On reliable discovery of molecular signaturesRoland Nilsson
Computational Biology, Department of Physics, Linkoping University, SE58183 Linköping, Sweden
BMC Bioinformatics 10:38. 2009..Moreover, signatures for cancer gene expression have been shown to be unstable, that is, difficult to replicate in independent studies, casting doubts on their reliability... - Can modular analysis identify disease-associated candidate genes for therapeutics?Jesper Tegner
Department of Medicine, Center for Molecular Medicine, Karolinska University Hospital, 171 76 Solna, Stockholm, Sweden
J Biol 8:48. 2009..Their strategy revealed a core of allergy-associated genes of potential therapeutic value... - Computational disease modeling - fact or fiction?Jesper N Tegnér
Computational Medicine group, Department of Medicine, Center for Molecular Medicine, Karolinska University Hospital, Solna, Stockholm, Sweden
BMC Syst Biol 3:56. 2009..On the other hand, the physics-inspired top-down modeling strategy identifies and selects features of (presumably) essential relevance to the phenomena of interest and combines available data in models of modest complexity... - Multi-organ expression profiling uncovers a gene module in coronary artery disease involving transendothelial migration of leukocytes and LIM domain binding 2: the Stockholm Atherosclerosis Gene Expression (STAGE) studySara Hägg
The Computational Medicine Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
PLoS Genet 5:e1000754. 2009..Thus, the A-module appears to be important for atherosclerosis development and, together with LDB2, merits further attention in CAD research... - Transcriptional profiling uncovers a network of cholesterol-responsive atherosclerosis target genesJosefin Skogsberg
The Computational Medicine Group, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden
PLoS Genet 4:e1000036. 2008..This network should be of interest for the development of novel atherosclerosis therapies... - Stronger synaptic connectivity as a mechanism behind development of working memory-related brain activity during childhoodFredrik Edin
Karolinska Institutet, Stockholm, Sweden
J Cogn Neurosci 19:750-60. 2007.... - Blood levels of dual-specificity phosphatase-1 independently predict risk for post-operative morbidities causing prolonged hospitalization after coronary artery bypass graftingSara Hägg
The Cardiovascular Genomics Group, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Solna, Stockholm, Sweden
Int J Mol Med 27:851-7. 2011.... - Carotid plaque age is a feature of plaque stability inversely related to levels of plasma insulinSara Hägg
The Cardiovascular Genomics Group, Department of Medical Biochemistry and Biophysics, Solna, Karolinska Institutet, Stockholm, Sweden
PLoS ONE 6:e18248. 2011..We took advantage of the atmospheric (14)C-declination curve (a result of the atomic bomb tests in the 1950s and 1960s) to determine the average biological age of carotid plaques... - ApoB100-LDL acts as a metabolic signal from liver to peripheral fat causing inhibition of lipolysis in adipocytesJosefin Skogsberg
The Computational Medicine Group, Karolinska Institutet, Karolinska University Hospital, Solna, Stockholm, Sweden
PLoS ONE 3:e3771. 2008..Whether there also exists a reciprocal metabolic arm affecting energy metabolism in white adipose tissue is unknown... - Mechanism for top-down control of working memory capacityFredrik Edin
Karolinska Institutet, 171 76 Stockholm, Sweden
Proc Natl Acad Sci U S A 106:6802-7. 2009..The model provides a mechanistic framework for understanding top-down control of working memory and specifies two different contributions of prefrontal and parietal cortex to working memory capacity... - Fronto-parietal connection asymmetry regulates working memory distractibilityFredrik Edin
School of Computer Science and Communication, Kungliga Tekniska Högskolan, SE 100 44 Stockholm, Sweden
J Integr Neurosci 6:567-96. 2007..Our results therefore suggest that the previously demonstrated improvement of vsWM performance during development could be due to a shift in the control of the effective balance between the SFS-IPS networks... - DGAT1 participates in the effect of HNF4A on hepatic secretion of triglyceride-rich lipoproteinsSergey Krapivner
Cardiovascular Genetics Group, Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden
Arterioscler Thromb Vasc Biol 30:962-7. 2010..In this study, we searched for the critical protein that mediates this effect using different human model systems... - Electrotonic signals along intracellular membranes may interconnect dendritic spines and nucleusIsaac Shemer
Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
PLoS Comput Biol 4:e1000036. 2008..This study considers a novel computational role for dendritic spines, and sheds new light on how spines and ER may jointly create an additional level of processing within the single neuron... - Human C-reactive protein slows atherosclerosis development in a mouse model with human-like hypercholesterolemiaAlexander Kovacs
Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, 171 76 Stockholm, Sweden
Proc Natl Acad Sci U S A 104:13768-73. 2007..Our results show that hCRP is not proatherogenic but instead slows atherogenesis, possibly through proteasome-mediated protein degradation... - Systems biology of innate immunityJesper Tegner
Unit of Computational Medicine, King Gustaf V Research Institute, Department of Medicine, Karolinska Institute, SE 171 76 Stockholm, Sweden
Cell Immunol 244:105-9. 2006..We believe that our system biological approach could be useful for identifying other complex networks mediating immunological responses... - Thematic review series: systems biology approaches to metabolic and cardiovascular disorders. Multi-organ whole-genome measurements and reverse engineering to uncover gene networks underlying complex traitsJesper Tegner
The CoCenter for Molecular Medicine, King Gustaf V Research Institute, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Solna, SE 171 76 Stockholm, Sweden
J Lipid Res 48:267-77. 2007..We also address how gene networks will probably play a key role in the development of early diagnostics and treatments for complex disorders in the coming era of individualized medicine...