Research Topics
Species | Erik SundbergSummaryAffiliation: Karolinska Institutet Country: Sweden Publications
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Publications
Systemic TNF blockade does not modulate synovial expression of the pro-inflammatory mediator HMGB1 in rheumatoid arthritis patients--a prospective clinical studyErik Sundberg
Department of Woman and Child Health, Pediatric Rheumatology Research Unit, Karolinska Institutet Karolinska University Hospital, Stockholm, Sweden
Arthritis Res Ther 10:R33. 2008..It was, therefore, decided to investigate whether treatment based on TNF blockade in rheumatoid arthritis (RA) affects the expression of synovial HMGB1...
High mobility group box chromosomal protein 1 acts as a proliferation signal for activated T lymphocytesErik Sundberg
Department of Woman and Child Health, Pediatric Rheumatology Research Unit, Karolinska Institutet Karolinska University Hospital, L 8 04 CMM, S 17176 Stockholm, Sweden
Immunobiology 214:303-9. 2009..0 microg/ml. HMGB1 had no effect on proliferation in the absence of anti-CD3 stimulation or during T-cell activation obtained using high doses of anti-CD3 mAb. Our results demonstrate a direct HMGB1-mediated effect in adaptive immunity...
Morphological characterization of intra-articular HMGB1 expression during the course of collagen-induced arthritisKarin Palmblad
Department of Woman and Child Health, Karolinska Institutet, Astrid Lindgren Children s Hospital, SE 171 76 Stockholm, Sweden
Arthritis Res Ther 9:R35. 2007..In conclusion, these new findings implicate a role for HMGB1 in both inducing and perpetuating inflammatory events of significant importance in the destructive processes in chronic arthritis...
