Research Topics
Genomes and Genes | Oliver SoehnleinSummaryAffiliation: Karolinska Institutet Country: Sweden Publications
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Publications
Neutrophil primary granule proteins HBP and HNP1-3 boost bacterial phagocytosis by human and murine macrophagesOliver Soehnlein
Department of Physiology and Pharmacology and Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
J Clin Invest 118:3491-502. 2008..Thus, we attribute what may be a novel role for PMN granule proteins in regulating the immune response to bacterial infections...- Neutrophil secretion products pave the way for inflammatory monocytesOliver Soehnlein
Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden
Blood 112:1461-71. 2008..This cellular cross-talk functionally results in enhanced cytokine levels and increased bacterial clearance, thus boosting the early immune response... - Neutrophil degranulation mediates severe lung damage triggered by streptococcal M1 proteinO Soehnlein
Dept of Physiology and Pharmacology, Karolinska Institute, 17177 Stockholm, Sweden
Eur Respir J 32:405-12. 2008..Interestingly, the lung damage was restored by injecting neutrophil secretion. The present data suggest that neutrophil granule proteins are directly responsible for lung damage induced by the streptococcal M1 protein... - Neutrophil-derived azurocidin alarms the immune systemOliver Soehnlein
Universitätsklinik Aachen, Pauwelsstrasse 30, Aachen, Germany
J Leukoc Biol 85:344-51. 2009..In addition, azurocidin activates endothelial cells leading to vascular leakage and edema formation. For these reasons, targeting azurocidin release and its actions may have therapeutic potential in inflammatory disease conditions... - Neutrophil secretion products regulate anti-bacterial activity in monocytes and macrophagesO Soehnlein
Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden
Clin Exp Immunol 151:139-45. 2008..Both mechanisms attribute novel microbicidal properties to PMN granule proteins, suggesting their potential use in anti-microbial therapy... - Distinct infiltration of neutrophils in lesion shoulders in ApoE-/- micePierre Rotzius
Departments of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
Am J Pathol 177:493-500. 2010..These data demonstrate neutrophilic granulocytes as a major cellular component of atherosclerotic lesions in ApoE(-/-) mice and call for further study on the roles of these cells in atherogenesis... - Neutrophil granule proteins tune monocytic cell functionOliver Soehnlein
Institute of Molecular Cardiovascular Research, University Hospital, RWTH Aachen University, Aachen, Germany
Trends Immunol 30:538-46. 2009..Efforts in this field might lead to the development of drugs for specific modulation of innate immune functions... - Leukotriene B4-induced changes in vascular permeability are mediated by neutrophil release of heparin-binding protein (HBP/CAP37/azurocidin)Antonio Di Gennaro
Department of Medical Biochemistry and Biophysics, Division of Chemistry 2, Karolinska Institutet, S 171 77 Stockholm, Sweden
FASEB J 23:1750-7. 2009..This lipid-protein axis could offer novel opportunities for pharmacological intervention in key steps of the vascular response to inflammation... - Neutrophil-derived heparin-binding protein (HBP/CAP37) deposited on endothelium enhances monocyte arrest under flow conditionsOliver Soehnlein
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
J Immunol 174:6399-405. 2005..Thus, secretion of a neutrophil granule protein, accumulating on the EC surface and promoting arrest of monocytes, could contribute to the recruitment of monocytes at inflammatory loci... - ApoE(-/-)/lysozyme M(EGFP/EGFP) mice as a versatile model to study monocyte and neutrophil trafficking in atherosclerosisPierre Rotzius
Department of Physiology and Pharmacology, Karolinska Institute, S 171 77 Stockholm, Sweden
Atherosclerosis 202:111-8. 2009..Therefore, we generated ApoE(-/-)/Lysozyme M(EGFP/EGFP) mice and investigated whether targeted cell types could be visualized by in vivo microscopy and whether absence of lysozyme M will influence atherosclerosis... - Regulated release and functional modulation of junctional adhesion molecule A by disintegrin metalloproteinasesRory R Koenen
MedicalFaculty, Institute for Molecular Cardiovascular Research, RWTH Aachen University, Aachen, Germany
Blood 113:4799-809. 2009.... - Immune cell recruitment to inflammatory loci is impaired in mice deficient in basement membrane protein laminin alpha4Ellinor Kenne
Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden
J Leukoc Biol 88:523-8. 2010..Collectively, our data suggest a reduced ability of immune cells to penetrate the vessel wall in mice deficient in laminin alpha4... - Platelet microparticles enhance the vasoregenerative potential of angiogenic early outgrowth cells after vascular injurySebastian F Mause
Medical Faculty, Institute for Molecular Cardiovascular Research, RWTH Aachen University, Aachen, Germany
Circulation 122:495-506. 2010..Vascular pathologies comprise platelet activation and concomitant generation of platelet microparticles (PMPs). We hypothesized that PMPs may interact with EOCs in the context of vascular injury and modulate their regenerative potential... - Double-Edged Role of the CXCL12/CXCR4 Axis in Experimental Myocardial InfarctionElisa A Liehn
Institute for Molecular Cardiovascular Research, RWTH Aachen University, Aachen, Germany Department of Cardiology, RWTH Aachen University, Aachen, Germany
J Am Coll Cardiol 58:2415-23. 2011..Here we assess the intrinsic functions of the chemokine receptor CXCR4 in remodeling after myocardial infarction (MI) using Cxcr4 heterozygous (Cxcr4(+/-)) mice... - Direct and alternative antimicrobial mechanisms of neutrophil-derived granule proteinsOliver Soehnlein
Institute of Molecular Cardiovascular Research IMCAR, University Hospital, RWTH Aachen University, Aachen, Germany
J Mol Med (Berl) 87:1157-64. 2009..Understanding mechanisms by which PMN granule proteins stimulate antimicrobial mechanisms in macrophages may open novel strategies in fighting bacterial infections... - Hyperlipidemia-triggered neutrophilia promotes early atherosclerosisMaik Drechsler
Institute for Molecular Cardiovascular Research, Pauwelsstrasse 30, 52074 Aachen, Germany
Circulation 122:1837-45. 2010..Here, we investigate the effect of hypercholesterolemia on peripheral neutrophil counts, neutrophil recruitment to atherosclerotic lesions, and the importance of neutrophils in atherosclerotic lesion formation in Apoe(-/-) mice... - Mechanisms underlying neutrophil-mediated monocyte recruitmentOliver Soehnlein
Institute for Molecular Cardiovascular Research IMCAR, RWTH University Aachen, Aachen, Germany
Blood 114:4613-23. 2009..As targeting PMNs without causing serious side effects seems futile, it may be more promising to aim at interfering with subsequent PMN-driven proinflammatory events... - Nonhematopoietic cells control the outcome of infection with Listeria monocytogenes in a nucleotide oligomerization domain 1-dependent mannerAhmed Mosa
Department of Microbiology, Karolinska Institute, Stockholm, Sweden
Infect Immun 77:2908-18. 2009..monocytogenes growth were hampered in NOD1(-/-) BMM. Thus, NOD1 confers nonhematopoietic cell-mediated resistance to infection with L. monocytogenes and controls intracellular bacterial growth in different cell populations in vitro... - Anesthesia aggravates lung damage and precipitates hypotension in endotoxemic sheepOliver Soehnlein
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
Shock 34:412-9. 2010..Our data suggest that isoflurane in conjunction with mechanical ventilation blunts cardiovascular compensatory mechanisms in sepsis and enhances leukocyte activation, which may contribute to lung edema formation and tissue damage... - Myeloid cells in atherosclerosis: initiators and decision shapersOliver Soehnlein
Institute for Molecular Cardiovascular Research, RWTH University Aachen, Pauwelsstr 30, 52074, Aachen, Germany
Semin Immunopathol 31:35-47. 2009..To stimulate further investigations about the contribution of these myeloid cells, we highlight the current mechanistic understanding by which these cells tune atherosclerosis... - Phagocyte partnership during the onset and resolution of inflammationOliver Soehnlein
Department of Physiology and Pharmacology, Karolinska Institutet, S 171 77 Stockholm, Sweden
Nat Rev Immunol 10:427-39. 2010..Finally, we highlight the potential therapeutic relevance of these interactions... - A new monocyte chemotactic protein-1/chemokine CC motif ligand-2 competitor limiting neointima formation and myocardial ischemia/reperfusion injury in miceElisa A Liehn
Institute for Molecular Cardiovascular Research IMCAR, RWTH Aachen University, Aachen, Germany
J Am Coll Cardiol 56:1847-57. 2010.... - Disruption of platelet-derived chemokine heteromers prevents neutrophil extravasation in acute lung injuryJochen Grommes
Institute for Molecular Cardiovascular Research, Rheinisch Westfalische Technische Hochschule, Aachen, Germany
Am J Respir Crit Care Med 185:628-36. 2012..Platelets are activated during ALI, but insights into their mechanistic contribution to neutrophil accumulation in the lung are elusive... - Protective role of CXC receptor 4/CXC ligand 12 unveils the importance of neutrophils in atherosclerosisAlma Zernecke
Institute for Molecular Cardiovascular Research, Rheinisch Westfalische Technische Hochschule, Aachen University, Germany
Circ Res 102:209-17. 2008..Disrupting Cxcl12/Cxcr4 thus promotes lesion formation through deranged neutrophil homeostasis, indicating that Cxcl12/Cxcr4 controls the important contribution of neutrophils to atherogenesis in mice... - A novel class of potent nonglycosidic and nonpeptidic pan-selectin inhibitorsHolger K Ulbrich
Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Johannes Gutenberg University, Staudingerweg 5, DE 55099 Mainz, Germany
J Med Chem 49:5988-99. 2006..The assays used are predictive for the in vivo efficacy of test compounds as shown for 2a in a proteose peptone induced peritonitis model of acute inflammation in mice... - ACE inhibition lowers angiotensin-II-induced monocyte adhesion to HUVEC by reduction of p65 translocation and AT 1 expressionOliver Soehnlein
Medical Clinic II, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
J Vasc Res 42:399-407. 2005..Thus, modulation of the local AngII system by ramiprilat may at least in part contribute to the benefits of ACE inhibition in the treatment of atherosclerotic diseases... - ACE inhibition lowers angiotensin II-induced chemokine expression by reduction of NF-kappaB activity and AT1 receptor expressionAlexander Schmeisser
Medical Clinic II, University of Technology, Dresden, Germany
Biochem Biophys Res Commun 325:532-40. 2004..Therefore, our study concentrates on the effect of the ACE-inhibitor ramiprilat on chemokine release, AngII receptor (ATR) expression, and NF-kappaB activity in monocytes stimulated with AngII... - Atorvastatin induces tissue transglutaminase in human endothelial cellsOliver Soehnlein
Medical Clinic II, Friedrich Alexander University of Erlangen Nuremberg, Ulmenweg 18, 91054 Erlangen, Germany
Biochem Biophys Res Commun 322:105-9. 2004..By inducing the expression of tTgase, statins may promote tTgase-mediated stabilisation of the basement membrane. This effect of atorvastatin may contribute to the beneficial role of statins on endothelial function...