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Species | G SchulteSummaryAffiliation: Karolinska Institutet Country: Sweden Publications
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Publications
The Frizzled family of unconventional G-protein-coupled receptorsGunnar Schulte
Section of Receptor Biology and Signaling, Department of Physiology and Pharmacology, Karolinska Institutet, S 171 77 Stockholm, Sweden
Trends Pharmacol Sci 28:518-25. 2007..Here, we outline the current state of knowledge on FZDs and FZD signal transduction and pinpoint aspects of debate and future directions...- Novel aspects of G-protein-coupled receptor signalling--different ways to achieve specificityG Schulte
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
Acta Physiol (Oxf) 190:33-8. 2007.... - beta-Arrestins - scaffolds and signalling elements essential for WNT/Frizzled signalling pathways?Gunnar Schulte
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
Br J Pharmacol 159:1051-8. 2010.... - International Union of Basic and Clinical Pharmacology. LXXX. The class Frizzled receptorsGunnar Schulte
Section of Receptor Biology and Signaling, Dept of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
Pharmacol Rev 62:632-67. 2010.... - Peripheral adenosine A2A receptors are involved in carrageenan-induced mechanical hyperalgesia in miceL Li
Department of Physiology and Pharmacology, Karolinska Institutet, Nanna Svartz vag 2, S 171 77 Stockholm, Sweden
Neuroscience 170:923-8. 2010..The results indicate that activation of peripheral adenosine A(2A) receptors during inflammation is associated with mechanical hyperalgesia, and that this effect is more prominent in females than in males... - The human carotid body: expression of oxygen sensing and signaling genes of relevance for anesthesiaMalin Jonsson Fagerlund
Section for Anesthesiology and Intensive Care Medicine, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
Anesthesiology 113:1270-9. 2010.... - Modulation of glial cell functions by adenosine receptorsElisabetta Daré
Karolinska Institute, Department of Physiology and Pharmacology, Section of Molecular Pharmacology, Nanna Svartz vag 2, S 171 77 Stockholm, Sweden
Physiol Behav 92:15-20. 2007..Microglial cells appear to be important in regulating adenosine formation from ATP and adenosine can affect many microglial signaling pathways. Adenosine receptors on oligodendrocytes regulate white matter development... - Molecular reorganization of endocannabinoid signalling in Alzheimer's diseaseJan Mulder
European Neuroscience Institute at Aberdeen, School of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK
Brain 134:1041-60. 2011..Thus, enhanced endocannabinoid signalling, particularly around senile plaques, can exacerbate synaptic failure in Alzheimer's disease... - Inhibition of endocytosis blocks Wnt signalling to beta-catenin by promoting dishevelled degradationV Bryja
Department of Medical Biochemistry and Biophysics, Molecular Neurobiology, Karolinska Institutet, Stockholm, Sweden
Acta Physiol (Oxf) 190:55-61. 2007..Therefore, we investigated the effects of endocytosis inhibition on Frizzled4-green fluorescent protein (FZD(4)-GFP) localization, dishevelled levels and Wnt-3a signalling to beta-catenin... - Signalling from adenosine receptors to mitogen-activated protein kinasesGunnar Schulte
Department of Physiology and Pharmacology, Karolinska Institutet, S-171 77, Stockholm, Sweden
Cell Signal 15:813-27. 2003..Although each of the adenosine receptors can activate one or more of the MAPKs, the mechanisms appear to differ substantially, both between receptor subtypes in the same cell type and between the same receptor in different cell types... - Beta-arrestin and casein kinase 1/2 define distinct branches of non-canonical WNT signalling pathwaysVitezslav Bryja
Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Scheeles v ag 1, S 171 77 Stockholm, Sweden
EMBO Rep 9:1244-50. 2008..Thus, our results indicate that the balance between beta-arr and CK1/2 determines whether WNT/RAC-1 or other non-canonical WNT pathways are activated... - Recombinant WNTs differentially activate ?-catenin-dependent and -independent signalling in mouse microglia-like cellsM B C Kilander
Section Receptor Biology and Signalling, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
Acta Physiol (Oxf) 203:363-72. 2011.... - Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanismVitezslav Bryja
Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 171 77 Stockholm, Sweden
J Cell Sci 120:586-95. 2007.... - Wnt-3a utilizes a novel low dose and rapid pathway that does not require casein kinase 1-mediated phosphorylation of Dvl to activate beta-cateninVitezslav Bryja
Karolinska Institutet, Department Medical Biochemistry and Biophysics, Laboratory Molecular Neurobiology, S 171 77 Stockholm, Sweden
Cell Signal 19:610-6. 2007..Thus, our results show that Wnt-3a rapidly induce a partial activation of beta-catenin in the absence of PS-Dvl at low doses, while at high doses induce a full activation of beta-catenin in a PS-Dvl-dependent manner... - Purified Wnt-5a increases differentiation of midbrain dopaminergic cells and dishevelled phosphorylationGunnar Schulte
Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 171 77 Stockholm, Sweden
J Neurochem 92:1550-3. 2005..Furthermore, we identify dishevelled as a key player in transducing both Wnt canonical and non-canonical signals in dopaminergic cells... - Evidence for functional adenosine A3 receptors in microglia cellsChristian Hammarberg
Karolinska Institutet, Department of Physiology and Pharmacology, Section of Molecular Pharmacology, Stockholm, Sweden
J Neurochem 86:1051-4. 2003..The involvement of the A3R in Cl-IB-MECA-induced ERK1/2 phosphorylation was confirmed by demonstrating that those effects are absent in primary mouse microglia cells isolated from mice lacking the gene for the A3R... - Adenosine A(2A) receptor dynamics studied with the novel fluorescent agonist Alexa488-APECFrank Brand
Karolinska Institutet, Department of Physiology and Pharmacology, Sect Receptor Biology and Signaling, S 171 77 Stockholm, Sweden
Eur J Pharmacol 590:36-42. 2008..The basic characterization of Alexa488-APEC described here showed that it provides a useful tool for tracing adenosine A(2A) receptors in vitro... - Vang-like protein 2 and Rac1 interact to regulate adherens junctionsMaria Lindqvist
Neonatal Unit, Department of Woman and Child Health, SE 171 76, Stockholm, Sweden
J Cell Sci 123:472-83. 2010..We propose that Vangl2 affects cell adhesion and the cytoskeleton by recruiting Rac1 and targeting its activity in the cell to adherens junctions... - A Nordic meeting on G-protein-coupled receptors: from molecular aspects to novel therapyGunnar Schulte
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
Acta Physiol (Oxf) 190:1. 2007 - Beta-arrestin is a necessary component of Wnt/beta-catenin signaling in vitro and in vivoVitezslav Bryja
Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 171 77 Stockholm, Sweden
Proc Natl Acad Sci U S A 104:6690-5. 2007.... - Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptorPaul Berghuis
Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Scheeles väg 1 A1, Karolinska Institutet, S 17177 Stockholm, Sweden
Proc Natl Acad Sci U S A 102:19115-20. 2005..Moreover, eCBs use TrkB receptor-dependent signaling pathways to regulate subtype-selective interneuron migration and specification... - Brain-derived neurotrophic factor controls functional differentiation and microcircuit formation of selectively isolated fast-spiking GABAergic interneuronsPaul Berghuis
Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Scheeles väg 1 A1, Karolinska Institutet, S 17177 Stockholm, Sweden
Eur J Neurosci 20:1290-306. 2004..Our results show that BDNF, along with membrane depolarization, is critical for FS cells to establish inhibitory circuitries during corticogenesis... - Endocannabinoid-independent retrograde signaling at inhibitory synapses in layer 2/3 of neocortex: involvement of vesicular glutamate transporter 3Tibor Harkany
Unit of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-17177 Stockholm, Sweden
J Neurosci 24:4978-88. 2004.... - The G(s)-coupled adenosine A(2B) receptor recruits divergent pathways to regulate ERK1/2 and p38Gunnar Schulte
Department of Physiology and Pharmacology, Karolinska Institutet, S 171 77 Stockholm, Sweden
Exp Cell Res 290:168-76. 2003..ERK1/2 activation was dependent on PI3K but not on PKA. p38 activation by NECA was instead independent of PI3K but required cAMP and PKA. The potent activation of both MAPKs suggests a physiological role... - Signaling pathway from the human adenosine A(3) receptor expressed in Chinese hamster ovary cells to the extracellular signal-regulated kinase 1/2Gunnar Schulte
Section of Molecular Neuropharmacology, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
Mol Pharmacol 62:1137-46. 2002..In conclusion, the adenosine A(3) receptor recruits a pathway that involves betagamma release from G(i/o), PI3K, Ras, and MEK to induce ERK1/2 phosphorylation and activation, whereas signaling is independent of Ca(2+), PKC, and c-Src... - Diverse inhibitors of intracellular signalling act as adenosine receptor antagonistsGunnar Schulte
Section of Molecular Neuropharmacology, Department of Physiology and Pharmacology, Karolinska Institutet, S 171 77 Stockholm, Sweden
Cell Signal 14:109-13. 2002.... - Adenosine A 2B receptors modulate cAMP levels and induce CREB but not ERK1/2 and p38 phosphorylation in rat skeletal muscle cellsJan Lynge
Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sports Sciences, August Krogh Institute, Copenhagen University, Universitetsparken 13, Copenhagen Ø, DK 2100, Denmark
Biochem Biophys Res Commun 307:180-7. 2003....