Research Topics
Species | F PiehlSummaryAffiliation: Karolinska Institutet Country: Sweden Publications
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Publications
Swedish natalizumab (Tysabri) multiple sclerosis surveillance studyFredrik Piehl
Department of Clinical Neuroscience, Karolinska Institutet, 171 76, Stockholm, Sweden
Neurol Sci 31:289-93. 2011..Our results demonstrate good general tolerability and sustained efficacy of natalizumab for patients with severe MS, though the risk of PML remains a concern...- Inflammation and susceptibility to neurodegeneration: the use of unbiased genetics to decipher critical regulatory pathwaysF Piehl
Department of Clinical Neuroscience, Neuroimmunology Unit, Karolinska Institutet, CMM, L8 4, Karolinska Hospital, S 17176, Stockholm, Sweden
Neuroscience 158:1143-50. 2009..Ultimately, a better knowledge about the interplay between the nervous system and the local and systemic immune system can define new ways of intervention in neurodegenerative processes... - Non-MHC gene regulation of nerve root injury induced spinal cord inflammation and neuron deathF Piehl
Department of Medicine, Karolinska Institute, Karolinska Hospital, Stockholm, Sweden
J Neuroimmunol 101:87-97. 1999..Thus, non-MHC gene(s) regulate the inflammation and neuron death after nerve trauma by mechanisms not involving antigen-specific immune responses... - Regulatory effects of trophic factors on expression and distribution of CGRP and GAP-43 in rat motoneuronsF Piehl
Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
J Neurosci Res 51:1-14. 1998..The effect of a CGRP antagonist on GAP-43 in muscle indicates a role for CGRP in sprouting-related processes... - Reduction of both pro- and anti-inflammatory cytokines after 6 months of interferon beta-1a treatment of multiple sclerosisM Khademi
Department of Medicine, Karolinska Institute, Karolinska Hospital, Stockholm, Sweden
J Neuroimmunol 103:202-10. 2000.... - Genetic regulation of nerve avulsion-induced spinal cord inflammationT Olsson
Neuroimmunology Unit, Department of Medicine, Karolinska Institute, CMM L08 04, Karolinska Hospital, S 171 76 Stockholm, Sweden
Ann N Y Acad Sci 917:186-96. 2000.... - Changes in the mRNA expression pattern, with special reference to calcitonin gene-related peptide, after axonal injuries in rat motoneurons depends on age and type of injuryF Piehl
Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
Exp Brain Res 119:191-204. 1998..Of the substances studied here, upregulation of alpha-CGRP and p75 mRNAs best correlated with a possibility of axon regeneration... - Genetics of rat neuroinflammationT Olsson
Neuroimmunology Unit, Department of Medicine, Karolinska Institute, Center for Molecular Medicine L8 04, Karolinska Hospital, 171 76, Stockholm, Sweden
J Neuroimmunol 107:191-200. 2000..The genetic dissection of these influences may unravel pathways controlling CNS vulnerability... - Neuroinflammation in the rat--CNS cells and their role in the regulation of immune reactionsF Piehl
Department of Medicine, Neuroimmunology Unit, Karolinska Hospital, Stockholm, Sweden
Immunol Rev 184:212-25. 2001.... - Decreased expression of VEGF-A in rat experimental autoimmune encephalomyelitis and in cerebrospinal fluid mononuclear cells from patients with multiple sclerosisE Tham
Department of Molecular Medicine and Surgery, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
Scand J Immunol 64:609-22. 2006..These results demonstrate a complex regulation of VEGF-A during neuroinflammation and suggest that VEGF-B is not involved in the pathogenesis of MS... - High levels of 15-oxygenated steroids in circulation of patients with multiple sclerosis: fact or fiction?I Bjorkhem
Department of Laboratory Medicine, Division of Clinical Chemistry, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden
J Lipid Res 52:170-4. 2011..We conclude that if present there are trace amounts only of the above 15-oxygenated steroids in human circulation and that the role of such oxysterols as pathogenetic factors and biomarkers must be reconsidered... - Expression of MHC class I heavy chain and beta2-microglobulin in rat brainstem motoneurons and nigral dopaminergic neuronsH Linda
Department of Neurology, Karolinska Institutet, Huddinge Hospital, Stockholm, Sweden
J Neuroimmunol 101:76-86. 1999..We find it striking that these particular neurons are those which are vulnerable to neurodegeneration in diseases such as Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS)... - A comparative study of the expression patterns for vegf, vegf-b/vrf and vegf-c in the developing and adult mouseJ Lagercrantz
Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden
Biochim Biophys Acta 1398:157-63. 1998..There are at present at least three specific effectors of vascular proliferation with clear differences in their expression... - Differential expression of neurotrophic factors and inflammatory cytokines by myelin basic protein-specific and other recruited T cells infiltrating the central nervous system during experimental autoimmune encephalomyelitisS Muhallab
Neuroimmunology Unit, Department of Medicine, Center for Molecular Medicine L8 04, Karolinska Hospital, 17176 Stockholm, Sweden
Scand J Immunol 55:264-73. 2002.... - Neurodegeneration and glial activation patterns after mechanical nerve injury are differentially regulated by non-MHC genes in congenic inbred rat strainsC Lundberg
Department of Medicine, Neuroimmunology Unit, Karolinska Hospital, S171 76 Stockholm, Sweden
J Comp Neurol 431:75-87. 2001.... - Expression of insulin-like growth factors and corresponding binding proteins (IGFBP 1-6) in rat spinal cord and peripheral nerve after axonal injuriesH Hammarberg
Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
J Comp Neurol 400:57-72. 1998..The robust upregulation of IGFBP-6 mRNA in lesioned motoneurons suggests that this binding protein may be of special relevance for the severed cells... - The effects of natalizumab on inflammatory mediators in multiple sclerosis: prospects for treatment-sensitive biomarkersM Khademi
Neuroimmunology Unit, CMM, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
Eur J Neurol 16:528-36. 2009.... - Increased brain-derived neurotrophic factor expression in white blood cells of relapsing-remitting multiple sclerosis patientsA Gielen
Department of Medicine, Karolinska Institute, Karolinska Hospital, Stockholm, Sweden
Scand J Immunol 57:493-7. 2003..These results provide additional evidence that a potentially neuroprotective facet of autoimmune inflammation is present in MS... - Induction of VEGF and VEGF receptors in the spinal cord after mechanical spinal injury and prostaglandin administrationM Skold
Department of Neuroscience, Nobels vag 12a, Karolinska Institutet, S 171 77 Stockholm, Sweden
Eur J Neurosci 12:3675-86. 2000.... - Sequence and expression of the mouse homologue to human phospholipase C beta3 neighboring geneJ Lagercrantz
Department of Molecular Medicine, Clinical Genetics Unit, Karolinska Hospital, Stockholm, Sweden
Biochem Biophys Res Commun 223:335-40. 1996..In late stage embryos, png was highly expressed in skeletal muscle, retina and neocortex. In the adult animal, expression was restricted to testis and thymus... - Differential subcellular localization of SNAP-25a and SNAP-25b RNA transcripts in spinal motoneurons and plasticity in expression after nerve injuryG Jacobsson
Berzelius Laboratory, Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
Brain Res Mol Brain Res 37:49-62. 1996..This study shows that, in spinal motoneurons, SNAP-25a and SNAP-25b RNA transcripts have different subcellular localization and that levels of SNAP-25 RNA transcripts are down-regulated after axonal injury... - Mapping of the human Ca2+ channel beta 4 subunit to 2q22-23 and its expression in developing mouseR Betz
Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden
Mamm Genome 9:310-1. 1998 - Properties of motoneurons underlying their regenerative capacity after axon lesions in the ventral funiculus or at the surface of the spinal cordS Cullheim
Department of Neuroscience, Retzius väg 8 B3 3, Karolinska Institutet, SE 171 77, Stockholm, Sweden
Brain Res Brain Res Rev 40:309-16. 2002..These results should be considered in the design of combined pharmacological and surgical approaches to lesions of motor axons at or close to the CNS-PNS interface... - Characterization of the human synaptogyrin gene familyD Kedra
Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden
Hum Genet 103:131-41. 1998..The C-terminal polypeptide ends are variable in length, display a low degree of sequence similarity between family members, and are therefore likely to convey the functional specificity of each protein... - Expression of the VEGF-related factor gene in pre- and postnatal mouseJ Lagercrantz
Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden
Biochem Biophys Res Commun 220:147-52. 1996..At 17 days post coitum expression is almost exclusively seen in heart, brown fat and spinal cord. This pattern of expression could be consistent with a role of vrf as a growth factor in these tissues...