I E Lundberg

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi Predictors of the first cardiovascular event in patients with systemic lupus erythematosus - a prospective cohort study
    Johanna Gustafsson
    Rheumatology Unit, Department of Medicine Karolinska University Hospital, Solna, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Arthritis Res Ther 11:R186. 2009
  2. ncbi Molecular effects of exercise in patients with inflammatory rheumatic disease
    Ingrid E Lundberg
    Rheumatology Unit, Department of Medicine at Karolinska University Hospital, Solna
    Nat Clin Pract Rheumatol 4:597-604. 2008
  3. ncbi Developments in the scientific and clinical understanding of inflammatory myopathies
    Ingrid E Lundberg
    Rheumatology Unit, Department of Medicine, Karolinska University Hospital Solna, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Arthritis Res Ther 10:220. 2008
  4. ncbi Technology insight: tools for research, diagnosis and clinical assessment of treatment in idiopathic inflammatory myopathies
    Ingrid E Lundberg
    Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Nat Clin Pract Rheumatol 3:282-90. 2007
  5. ncbi The type I interferon system in idiopathic inflammatory myopathies
    Ingrid E Lundberg
    Rheumatology Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden
    Autoimmunity 43:239-43. 2010
  6. ncbi The heart in dermatomyositis and polymyositis
    I E Lundberg
    Rheumatology Unit, Department of Medicine, Karolinska Institutet at Karolinska University Hospital, Solna Stockholm, Sweden
    Rheumatology (Oxford) 45:iv18-21. 2006
  7. ncbi Higher proportion of fast-twitch (type II) muscle fibres in idiopathic inflammatory myopathies - evident in chronic but not in untreated newly diagnosed patients
    I Loell
    Rheumatology Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Sweden
    Clin Physiol Funct Imaging 31:18-25. 2011
  8. ncbi A high incidence of disease flares in an open pilot study of infliximab in patients with refractory inflammatory myopathies
    M Dastmalchi
    Rheumatology, Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Solna, SE 171 76 Stockholm, Sweden
    Ann Rheum Dis 67:1670-7. 2008
  9. ncbi Skeletal muscle fibers express major histocompatibility complex class II antigens independently of inflammatory infiltrates in inflammatory myopathies
    P Englund
    Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden
    Am J Pathol 159:1263-73. 2001
  10. ncbi Can muscle regeneration fail in chronic inflammation: a weakness in inflammatory myopathies?
    I Loell
    Department of Medicine, Karolinska University Hospital, Solna, Stockholm, Sweden
    J Intern Med 269:243-57. 2011

Detail Information

Publications67

  1. ncbi Predictors of the first cardiovascular event in patients with systemic lupus erythematosus - a prospective cohort study
    Johanna Gustafsson
    Rheumatology Unit, Department of Medicine Karolinska University Hospital, Solna, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Arthritis Res Ther 11:R186. 2009
    ..e. clinically important cardiovascular events (CVE). We investigated the impact of traditional and lupus associated risk factors for the first ever CVE in a longitudinal cohort of SLE patients...
  2. ncbi Molecular effects of exercise in patients with inflammatory rheumatic disease
    Ingrid E Lundberg
    Rheumatology Unit, Department of Medicine at Karolinska University Hospital, Solna
    Nat Clin Pract Rheumatol 4:597-604. 2008
    ..Further studies of the systemic and local responses underlying exercise-associated improvement in muscle performance, soft tissue integrity and health outcomes are warranted...
  3. ncbi Developments in the scientific and clinical understanding of inflammatory myopathies
    Ingrid E Lundberg
    Rheumatology Unit, Department of Medicine, Karolinska University Hospital Solna, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Arthritis Res Ther 10:220. 2008
    ..Furthermore, nonimmunological pathways have been identified, suggesting that factors other than direct T cell-mediated muscle fibre necrosis could have a role in the development of muscle weakness...
  4. ncbi Technology insight: tools for research, diagnosis and clinical assessment of treatment in idiopathic inflammatory myopathies
    Ingrid E Lundberg
    Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Nat Clin Pract Rheumatol 3:282-90. 2007
    ..This Review focuses on advances in diagnostic and outcome tools and their roles in clinical practice and clinical research in patients with polymyositis and dermatomyositis...
  5. ncbi The type I interferon system in idiopathic inflammatory myopathies
    Ingrid E Lundberg
    Rheumatology Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden
    Autoimmunity 43:239-43. 2010
    ..Accumulating data indicate a role of the type I interferon in myositis, particularly in juvenile and adult DM and in anti-Jo-1 or anti-SSA positive PM...
  6. ncbi The heart in dermatomyositis and polymyositis
    I E Lundberg
    Rheumatology Unit, Department of Medicine, Karolinska Institutet at Karolinska University Hospital, Solna Stockholm, Sweden
    Rheumatology (Oxford) 45:iv18-21. 2006
    ..The underlying pathophysiological mechanisms that may cause cardiac manifestations involve myocarditis and coronary artery disease as well as involvement of the small vessels of the myocardium...
  7. ncbi Higher proportion of fast-twitch (type II) muscle fibres in idiopathic inflammatory myopathies - evident in chronic but not in untreated newly diagnosed patients
    I Loell
    Rheumatology Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Sweden
    Clin Physiol Funct Imaging 31:18-25. 2011
    ..Biopsies from chronic patients display a low proportion type I and a high proportion of type II muscle fibres. This raised a suspicion that the low proportion of type I fibres might play a role in the muscle fatigue...
  8. ncbi A high incidence of disease flares in an open pilot study of infliximab in patients with refractory inflammatory myopathies
    M Dastmalchi
    Rheumatology, Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Solna, SE 171 76 Stockholm, Sweden
    Ann Rheum Dis 67:1670-7. 2008
    ..To investigate the effect of the tumour necrosis factor (TNF) blocking agent infliximab in patients with treatment-resistant inflammatory myopathies...
  9. ncbi Skeletal muscle fibers express major histocompatibility complex class II antigens independently of inflammatory infiltrates in inflammatory myopathies
    P Englund
    Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden
    Am J Pathol 159:1263-73. 2001
    ..Our results indicate that MHC class II and MHC class I molecules may be involved in initiating and maintaining the pathological condition in myositis rather than only being a consequence of a preceding local inflammation...
  10. ncbi Can muscle regeneration fail in chronic inflammation: a weakness in inflammatory myopathies?
    I Loell
    Department of Medicine, Karolinska University Hospital, Solna, Stockholm, Sweden
    J Intern Med 269:243-57. 2011
    ..This would also be relevant for other chronic inflammatory diseases...
  11. ncbi Effects of immunosuppressive treatment on microsomal prostaglandin E synthase 1 and cyclooxygenases expression in muscle tissue of patients with polymyositis or dermatomyositis
    M Korotkova
    Department of Medicine, Rheumatology Unit, Karolinska Institutet Karolinska University Hospital, Solna, Stockholm, Sweden
    Ann Rheum Dis 67:1596-602. 2008
    ..To investigate the expression of microsomal prostaglandin E (PGE) synthase 1 (mPGES-1) and cyclooxygenase (COX) in muscle biopsies from patients with polymyositis or dermatomyositis before and after conventional immunosuppressive treatment...
  12. ncbi Percutaneous conchotome muscle biopsy. A useful diagnostic and assessment tool
    C Dorph
    Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    J Rheumatol 28:1591-9. 2001
    ..To evaluate the diagnostic yield, performance simplicity, and safety of the percutaneous conchotome muscle biopsy technique for clinical and research purposes in an outpatient rheumatology clinic...
  13. ncbi Signs of inflammation in both symptomatic and asymptomatic muscles from patients with polymyositis and dermatomyositis
    C Dorph
    Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Solna, Sweden
    Ann Rheum Dis 65:1565-71. 2006
    ..To determine whether muscle weakness is correlated with inflammation, expression of interleukin 1alpha (IL1alpha) and major histocompatibility complex (MHC) class I and II antigens on muscle fibres...
  14. ncbi Interleukin-1alpha expression in capillaries and major histocompatibility complex class I expression in type II muscle fibers from polymyositis and dermatomyositis patients: important pathogenic features independent of inflammatory cell clusters in muscle
    Pernilla Englund
    Karolinska Institutet, Stockholm, Sweden
    Arthritis Rheum 46:1044-55. 2002
    ..To address the hypothesis that endothelial cells and/or muscle fibers are primary targets in the disease process by analysis of muscle tissue from patients with polymyositis (PM) and dermatomyositis (DM)...
  15. ncbi Immunolocalization of interleukin-1 receptors in the sarcolemma and nuclei of skeletal muscle in patients with idiopathic inflammatory myopathies
    Cecilia Grundtman
    Rheumatology Research Unit, Karolinska University Hospital Solna and Karolinska Institutet, Stockholm, Sweden
    Arthritis Rheum 56:674-87. 2007
    ..The purpose of this study was to investigate the expression of IL-1 receptors and their ligands in muscle tissue from patients with myositis and from healthy controls...
  16. ncbi Restricted T cell receptor BV gene usage in the lungs and muscles of patients with idiopathic inflammatory myopathies
    Pernilla Englund
    Karolinska University Hospital at Solna, and Karolinska Institutet, Stockholm, Sweden
    Arthritis Rheum 56:372-83. 2007
    ..To investigate T cell receptor (TCR) expression in 3 different compartments that could be involved in patients with myositis: muscle, lung, and peripheral blood...
  17. ncbi Longitudinal study of interleukin-10, tumor necrosis factor-alpha, anti-U1-snRNP antibody levels and disease activity in patients with mixed connective tissue disease
    A B Hassan
    Department of Rheumatology, Karolinska Institutet, Stockholm, Sweden
    Scand J Rheumatol 30:282-9. 2001
    ..To investigate the levels and relationship between IL-10, TNF-alpha, anti-U1snRNP antibodies and disease activity in longitudinally collected serum samples from patients with mixed connective tissue disease (MCTD)...
  18. ncbi Immune mechanisms in the pathogenesis of idiopathic inflammatory myopathies
    Cecilia Grundtman
    Rheumatology Unit, Department of Medicine, Karolinska University Hospital Solna, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Arthritis Res Ther 9:208. 2007
    ..In this review we summarize the latest findings concerning the role of T lymphocytes, B lymphocytes, dendritic cells, and other antigen-presenting cells in the pathophysiology of IIMs...
  19. ncbi Limited effects of high-dose intravenous immunoglobulin (IVIG) treatment on molecular expression in muscle tissue of patients with inflammatory myopathies
    Sevim Barbasso Helmers
    Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden
    Ann Rheum Dis 66:1276-83. 2007
    ....
  20. ncbi Genetically determined imbalance between serum levels of tumour necrosis factor (TNF) and interleukin (IL)-10 is associated with anti-Jo-1 and anti-Ro52 autoantibodies in patients with poly- and dermatomyositis
    Adla B Hassan
    Department of Medicine, Rheumatology Unit, CMM L8 O4, Karolinska University Hospital, Solna, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    J Autoimmun 27:62-8. 2006
    ..negative, p=0.041). Our data suggest that a genetically programmed cytokine imbalance exists in patients with poly- or dermatomyositis and that this imbalance is related to the presence of disease-associated autoantibodies...
  21. ncbi Impaired myofibrillar function in the soleus muscle of mice with collagen-induced arthritis
    Takashi Yamada
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Arthritis Rheum 60:3280-9. 2009
    ..This study was undertaken to investigate muscle contractility and the myoplasmic free Ca2+ concentration ([Ca2+](i)) in the soleus, a major postural muscle, in mice with collagen-induced arthritis (CIA)...
  22. ncbi T cell infiltrates in the muscles of patients with dermatomyositis and polymyositis are dominated by CD28null T cells
    Andreas E R Fasth
    Rheumatology Unit, Center for Molecular Medicine L8 04, Karolinska University Hospital, Stockholm S 171 76, Sweden
    J Immunol 183:4792-9. 2009
    ..Our observations imply that CD28(null) T cells represent clinically important effector cells in dermatomyositis and polymyositis, and that HCMV might play a role in propagating disease in a subset of patients...
  23. ncbi Vascular endothelial growth factor is highly expressed in muscle tissue of patients with polymyositis and patients with dermatomyositis
    Cecilia Grundtman
    Rheumatology Research Unit, Karolinska University Hospital Solna and Karolinska Institutet, Stockholm, Sweden
    Arthritis Rheum 58:3224-38. 2008
    ..To investigate the expression of vascular endothelial growth factor (VEGF) in muscle biopsy specimens and serum from patients with polymyositis and patients with dermatomyositis compared with that in healthy control subjects...
  24. ncbi Sera from anti-Jo-1-positive patients with polymyositis and interstitial lung disease induce expression of intercellular adhesion molecule 1 in human lung endothelial cells
    Sevim Barbasso Helmers
    Karolinska University Hospital Solna, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden
    Arthritis Rheum 60:2524-30. 2009
    ..To investigate whether sera or purified IgG from patients with polymyositis (PM) and patients with dermatomyositis (DM), with or without interstitial lung disease (ILD), can activate endothelial cells (ECs)...
  25. ncbi Expanded T cell receptor V?-restricted T cells from patients with sporadic inclusion body myositis are proinflammatory and cytotoxic CD28null T cells
    Jayesh M Pandya
    Rheumatology Unit, Karolinska University Hospital, Stockholm, Sweden
    Arthritis Rheum 62:3457-66. 2010
    ..This study was undertaken to investigate the phenotype and functionality of T cells, specifically a subset of proinflammatory, cytotoxic, and apoptosis-resistant T cells defined as CD28(null) T cells, in the pathogenesis of sporadic IBM...
  26. ncbi Citrullination is an inflammation-dependent process
    D Makrygiannakis
    Department of Medicine, Rheumatology Unit, CMM, L8-04, Karolinska University Hospital, Solna, S-17176 Stockholm, Sweden
    Ann Rheum Dis 65:1219-22. 2006
    ..CONCLUSION: Citrullination is present in a wide range of inflammatory tissues, suggesting that this process is inflammation dependent rather than disease dependent...
  27. ncbi Interstitial lung disease in polymyositis and dermatomyositis
    Maryam Fathi
    Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
    Curr Opin Rheumatol 17:701-6. 2005
    ....
  28. ncbi Effect of physical training on the proportion of slow-twitch type I muscle fibers, a novel nonimmune-mediated mechanism for muscle impairment in polymyositis or dermatomyositis
    Maryam Dastmalchi
    Karolinska University Hospital, Solna, Karolinska Instituet, Stockholm, Sweden
    Arthritis Rheum 57:1303-10. 2007
    ..To compare muscle fiber type composition and muscle fiber area in patients with chronic polymyositis or dermatomyositis and healthy controls, and to determine whether physical training for 12 weeks could alter these muscle characteristics...
  29. ncbi Effects of HMGB1 on in vitro responses of isolated muscle fibers and functional aspects in skeletal muscles of idiopathic inflammatory myopathies
    Cecilia Grundtman
    Rheumatology Unit, Department of Medicine, Karolinska University Hospital Solna, Stockholm, Sweden
    FASEB J 24:570-8. 2010
    ..However, HMGB1-expressing fibers outnumbered fibers expressing MHC class I. Our data indicate that HMGB1 could be an early inducer of skeletal muscle dysfunction in IIMs...
  30. ncbi Pulmonary complications of polymyositis and dermatomyositis
    Maryam Fathi
    Department of Medicine, Division of Respiratory Medicine and Allergy, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden
    Semin Respir Crit Care Med 28:451-8. 2007
    ..Therefore, all patients with polymyositis or dermatomyositis should be investigated with chest radiography, high-resolution computed tomography, and lung function tests...
  31. ncbi Leukocytes, cytokines, growth factors and hormones in human skeletal muscle and blood after uphill or downhill running
    Christer Malm
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    J Physiol 556:983-1000. 2004
    ..It is suggested that exercise can induce DOMS by activating inflammatory factors present in the epimysium before exercise. Repeated physical training may alter the content of inflammatory factors in the epimysium and thus reduce DOMS...
  32. ncbi Disease-specific quality indicators, outcome measures and guidelines in polymyositis and dermatomyositis
    H Alexanderson
    Department of Physical Therapy, Rheumatology Unit and Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Solna, Stockholm, Sweden
    Clin Exp Rheumatol 25:153-8. 2007
    ..A close collaboration between physicians, physical and occupational therapists and specialized nurses is of great value in care and disease assessment of patients with polymyositis and dermatomyositis...
  33. ncbi The physiology of inflammatory myopathies: an overview
    I E Lundberg
    Rheumatology Unit, Department of Medicine, Karolinska Institutet, and Rheumatology Clinic, Karolinska Hospital, Stockholm, Sweden
    Acta Physiol Scand 171:207-13. 2001
    ..The underlying mechanisms responsible for these biochemical abnormalities have not been defined but could be related to a disturbed tissue oxygenation...
  34. ncbi Cardiac involvement in autoimmune myositis and mixed connective tissue disease
    I E Lundberg
    Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Solna Karolinska Institutet, Stockholm, Sweden
    Lupus 14:708-12. 2005
    ....
  35. ncbi Serial analysis of Ro/SSA and La/SSB antibody levels and correlation with clinical disease activity in patients with systemic lupus erythematosus
    Adla B Hassan
    Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Scand J Rheumatol 31:133-9. 2002
    ..To investigate the temporal correlation between anti-Ro/SSA and anti-La/SSB antibody levels and compare them with variation in clinical disease activity in patients with systemic lupus erythematosus (SLE)...
  36. ncbi Interstitial lung disease in polymyositis and dermatomyositis: longitudinal evaluation by pulmonary function and radiology
    Maryam Fathi
    Karolinska University Hospital, Solna, Sweden
    Arthritis Rheum 59:677-85. 2008
    ..To estimate predictors and long-term outcome of interstitial lung disease (ILD) in patients with polymyositis (PM) and dermatomyositis (DM)...
  37. ncbi Down-regulation of the aberrant expression of the inflammation mediator high mobility group box chromosomal protein 1 in muscle tissue of patients with polymyositis and dermatomyositis treated with corticosteroids
    Ann Kristin Ulfgren
    Rheumatology Research Unit, CMM L8 04, Karolinska Hospital, Karolinska Institutet, 171 76 Stockholm, Sweden
    Arthritis Rheum 50:1586-94. 2004
    ..The present study was therefore undertaken to investigate how HMGB-1 is expressed in muscle tissue of patients with myositis and, if so, whether such expression is modulated by prednisolone therapy...
  38. ncbi Idiopathic inflammatory myopathies - myositis
    Christina Dorph
    Rheumatology Unit, Karolinska Hospital, SE 171 76, Stockholm, Sweden
    Best Pract Res Clin Rheumatol 16:817-32. 2002
    ..Whether there is an association between myositis and malignancies has been a subject of controversy for many years and recent epidemiological data have brought some clarification on this issue...
  39. ncbi Sporadic inclusion body myositis: pilot study on the effects of a home exercise program on muscle function, histopathology and inflammatory reaction
    Snjolaug Arnardottir
    Department of Clinical Neuroscience Division of Neurology, Karolinska Hospital, SE 171 76 Stockholm, Sweden
    J Rehabil Med 35:31-5. 2003
    ..To evaluate the safety and effect of a home training program on muscle function in 7 patients with sporadic inclusion body myositis...
  40. ncbi CBA/J mice infected with Trypanosoma cruzi: an experimental model for inflammatory myopathies
    John Andersson
    Microbiology and Tumorbiology Center, Karolinska Institutet, Stockholm, Sweden
    Muscle Nerve 27:442-8. 2003
    ..The murine model described in this article may be useful in studying certain aspects of idiopathic inflammatory myopathies such as the role of T-cells in chronic muscle inflammation and chronic myocytotoxicity...
  41. ncbi Upregulation of MHC class I in transgenic mice results in reduced force-generating capacity in slow-twitch muscle
    Stina Salomonsson
    Department of Medicine, Rheumatology Unit, Karolinska University Hospital Solna, CMM L8 04, Karolinska Institute, S 171 76 Stockholm, Sweden
    Muscle Nerve 39:674-82. 2009
    ..These observations may have important implications for our understanding of the pathophysiological processes of muscle weakness seen in inflammatory myopathies. Muscle Nerve, 2008...
  42. ncbi Aerobic capacity correlates to self-assessed physical function but not to overall disease activity or organ damage in women with systemic lupus erythematosus with low-to-moderate disease activity and organ damage
    C Bostrom
    Division of Physiotherapy, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden
    Lupus 17:100-4. 2008
    ..However, with no correlation between aerobic capacity and overall disease activity and organ damage, low physical activity may contribute to the low aerobic capacity in our sample...
  43. ncbi Elevated triglycerides and low levels of high-density lipoprotein as markers of disease activity in association with up-regulation of the tumor necrosis factor alpha/tumor necrosis factor receptor system in systemic lupus erythematosus
    Elisabet Svenungsson
    Department of Medicine, Karolinska Institute, Stockholm, Sweden
    Arthritis Rheum 48:2533-40. 2003
    ....
  44. ncbi Cardiovascular disease in patients with inflammatory rheumatic disease is associated with up-regulation of markers of inflammation in cardiac microvessels and cardiomyocytes
    Cecilia Grundtman
    Karolinska University Sola, Karolinska Institutet, Stockholm, Sweden
    Arthritis Rheum 62:667-73. 2010
    ....
  45. ncbi Possible pathogenic mechanisms in inflammatory myopathies
    Ingrid E Lundberg
    Rheumatology Unit, Department of Medicine, Karolinska Institutet, Karolinska Hospital, SE 171 76, Stockholm, Sweden
    Rheum Dis Clin North Am 28:799-822. 2002
    ....
  46. ncbi Development of the myositis activities profile--validity and reliability of a self-administered questionnaire to assess activity limitations in patients with polymyositis/dermatomyositis
    Helene Alexanderson
    Physical Therapy Unit and Department of Rheumatology, Karolinska Hospital, Stockholm, Sweden
    J Rheumatol 29:2386-92. 2002
    ..To develop a disease-specific questionnaire for assessing limitations in activities of daily life, the Myositis Activities Profile (MAP), and to investigate its validity and reliability...
  47. ncbi Cytokines in idiopathic inflammatory myopathies
    Stina Salomonsson
    Karolinska University Hospital, Karolinska Institutet, Rheumatology Unit, Department of Medicine, Solna, Stockholm, Sweden
    Autoimmunity 39:177-90. 2006
    ....
  48. ncbi Exercise as an anti-inflammatory intervention to combat inflammatory diseases of muscle
    Gustavo A Nader
    Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden
    Curr Opin Rheumatol 21:599-603. 2009
    ..The purpose of this review was to give an update on the effects of physical exercise in patients with chronic inflammatory disorders with a focus on the potential anti-inflammatory effects, particularly in inflammatory myopathies...
  49. ncbi Lipid peroxidation is enhanced in patients with systemic lupus erythematosus and is associated with arterial and renal disease manifestations
    Johan Frostegard
    Center for Infectious Medicine and Center for Metabolism and Endocrinology, Department of Medicine, Karolinska University Hospital, Huddinge, S 141 86 Stockholm, Sweden
    Arthritis Rheum 52:192-200. 2005
    ..Autoantibodies to OxLDL are common in SLE and cross-react with anticardiolipin antibodies (aCL). We therefore hypothesized that lipid peroxidation is enhanced in patients with SLE in general...
  50. ncbi The role of exercise in the rehabilitation of idiopathic inflammatory myopathies
    Helene Alexanderson
    Department of Physical Therapy, Rheumatology Unit, Karolinska University Hospital, Solna, Stockholm, Sweden
    Curr Opin Rheumatol 17:164-71. 2005
    ..The objective of this review is to provide an update on exercise and clinical assessment in the idiopathic inflammatory myopathies...
  51. ncbi Functional index-2: Validity and reliability of a disease-specific measure of impairment in patients with polymyositis and dermatomyositis
    Helene Alexanderson
    Physical Therapy Department, Rheumatology Unit D2 07, Karolinska Institutet and Karolinska University Hospital, Solna, SE 171 76 Stockholm, Sweden
    Arthritis Rheum 55:114-22. 2006
    ..To revise the content of the Functional Index in myositis (FI) and to evaluate measurement properties of a revised FI...
  52. ncbi Corticosteroids--from an idea to clinical use
    Ingrid E Lundberg
    Rheumatology Unit, Department of Medicine at Karolinska Hospital, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Best Pract Res Clin Rheumatol 18:7-19. 2004
    ..Perhaps the results in the first comparative studies would have been different if individual response criteria had been used. This is discussed in this chapter...
  53. ncbi Benefits of intensive resistance training in patients with chronic polymyositis or dermatomyositis
    Helene Alexanderson
    Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
    Arthritis Rheum 57:768-77. 2007
    ..To investigate the benefits and safety of an intensive muscular training program in patients with chronic polymyositis (PM) and dermatomyositis (DM)...
  54. ncbi Interstitial lung disease, a common manifestation of newly diagnosed polymyositis and dermatomyositis
    M Fathi
    Division of Respiratory Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Ann Rheum Dis 63:297-301. 2004
    ..To estimate the prevalence and predictors of interstitial lung disease in newly diagnosed polymyositis and dermatomyositis...
  55. ncbi Women in academic rheumatology
    Ingrid E Lundberg
    Karolinska University Hospital, Solna, Stockholm, Sweden
    Arthritis Rheum 52:697-706. 2005
  56. ncbi Inflammatory muscle disease: clinical presentation and assessment of patients
    Helene Alexanderson
    Department of Physical Therapy, Rheumatology Unit D2 07, Karolinska University Hospital, Solna SE 171 76, Stockholm, Sweden
    Curr Rheumatol Rep 9:273-9. 2007
    ....
  57. ncbi MICA4/HLA-DRB1*04/TNF1 haplotype is associated with mixed connective tissue disease in Swedish patients
    Adla B Hassan
    Rheumatology Unit, Department of Medicine, Karolinska Institutet, Karolinska Hospital S 171 76, Stockholm, Sweden
    Hum Immunol 64:290-6. 2003
    ..1 genotype. Mixed connective tissue disease was also associated with shared epitope genes, which in RA has been associated with a more severe disease. Whether these genotypes affect the clinical phenotype of MCTD needs to be determined...
  58. ncbi The prognosis of mixed connective tissue disease
    Ingrid E Lundberg
    Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Solna, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Rheum Dis Clin North Am 31:535-47, vii-viii. 2005
    ..Pulmonary hypertension is associated with proliferative vascular abnormalities that involve small pulmonary vessels, rather than interstitial lung disease...
  59. ncbi [Exercise is beneficial for patients with myositis. Both pharmaceuticals and physical activity should be included in the therapy of chronic rheumatic muscle inflammation]
    Ingrid E Lundberg
    Neurologkliniken, Karolinska sjukhuset, Stockholm
    Lakartidningen 100:2754-9. 2003
  60. ncbi New possibilities to achieve increased understanding of disease mechanisms in idiopathic inflammatory myopathies
    Ingrid E Lundberg
    Curr Opin Rheumatol 14:639-42. 2002
    ....
  61. ncbi Creatine supplements in patients with idiopathic inflammatory myopathies who are clinically weak after conventional pharmacologic treatment: Six-month, double-blind, randomized, placebo-controlled trial
    Yuen Li Chung
    King s College London School of Medicine, and the MRC Clinical Science Centre, Hammersmith Hospital, Imperial College School of Medicine, London, UK
    Arthritis Rheum 57:694-702. 2007
    ....
  62. ncbi Pathogenesis of idiopathic inflammatory myopathies
    Cecilia Grundtman
    Curr Rheumatol Rep 8:188-95. 2006
    ..These newly identified molecular pathways could play a major role in the pathogenesis of myositis and could be important targets in the development of new therapies...
  63. ncbi Clinical symptoms in patients with myositis-an acquired metabolic myopathy?
    Ingrid E Lundberg
    Curr Opin Rheumatol 15:675-8. 2003
  64. ncbi A possible mechanism for endogenous activation of the type I interferon system in myositis patients with anti-Jo-1 or anti-Ro 52/anti-Ro 60 autoantibodies
    Maija Leena Eloranta
    Uppsala University, Uppsala, Sweden
    Arthritis Rheum 56:3112-24. 2007
    ..To investigate type I interferon (IFN) system activation and its correlation with autoantibodies and organ manifestations in polymyositis (PM), dermatomyositis (DM), and inclusion body myositis...
  65. ncbi International consensus on a proposed score system for muscle biopsy evaluation in patients with juvenile dermatomyositis: a tool for potential use in clinical trials
    Lucy R Wedderburn
    University College London, London, UK
    Arthritis Rheum 57:1192-201. 2007
    ..To devise and test a system with which to evaluate abnormalities on muscle biopsy samples obtained from children diagnosed with juvenile dermatomyositis (DM)...
  66. ncbi 119th ENMC international workshop: trial design in adult idiopathic inflammatory myopathies, with the exception of inclusion body myositis, 10-12 October 2003, Naarden, The Netherlands
    Jessica E Hoogendijk
    Department of Neurology, University Medical Center, Heidelberg laan 100, Utrecht, CX 3584, The Netherlands
    Neuromuscul Disord 14:337-45. 2004
  67. ncbi Association of the proinflammatory haplotype (MICA5.1/TNF2/TNFa2/DRB1*03) with polymyositis and dermatomyositis
    Adla B Hassan
    Arthritis Rheum 50:1013-5. 2004