Lars Gunnar Larsson

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi The Yin and Yang functions of the Myc oncoprotein in cancer development and as targets for therapy
    Lars Gunnar Larsson
    Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institutet, Box 280, 171 77 Stockholm, Sweden
    Exp Cell Res 316:1429-37. 2010
  2. ncbi Oncogene- and tumor suppressor gene-mediated suppression of cellular senescence
    Lars Gunnar Larsson
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Box 280, SE 171 77 Stockholm, Sweden
    Semin Cancer Biol 21:367-76. 2011
  3. ncbi Tipping the balance: Cdk2 enables Myc to suppress senescence
    Per Hydbring
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
    Cancer Res 70:6687-91. 2010
  4. ncbi Cdk2: a key regulator of the senescence control function of Myc
    Per Hydbring
    Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institutet, 171 77 Stockholm, Sweden
    Aging (Albany NY) 2:244-50. 2010
  5. ncbi Myc is required for activation of the ATM-dependent checkpoints in response to DNA damage
    Lina Guerra
    Department of Cell Biology, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 5:e8924. 2010
  6. ncbi Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation
    Per Hydbring
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 107:58-63. 2010
  7. ncbi Inhibition of the intrinsic but not the extrinsic apoptosis pathway accelerates and drives MYC-driven tumorigenesis towards acute myeloid leukemia
    Kari Högstrand
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    PLoS ONE 7:e31366. 2012

Collaborators

  • Bo Stenerlow
  • Birgitta Sander
  • Per Hydbring
  • Kari Högstrand
  • Alf Grandien
  • Lina Guerra
  • Susanna Tronnersjö
  • Marie Henriksson
  • Eduar Hejll
  • Bjorn Rozell
  • Teresa Frisan
  • Fuad Bahram
  • Yingtao Su
  • Siqin Wu
  • Christine Josenhans
  • Jörg Vervoorts
  • Ami Albihn
  • Monica Thelestam
  • James G Fox
  • Natalie von der Lehr
  • David B Schauer
  • Richard Lilischkis
  • Riccardo Guidi
  • Qinzi Yan
  • Bernhard Luscher
  • Hamid Reza Sharifi
  • Nadine Hein
  • Torsten Sterzenbach

Detail Information

Publications7

  1. ncbi The Yin and Yang functions of the Myc oncoprotein in cancer development and as targets for therapy
    Lars Gunnar Larsson
    Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institutet, Box 280, 171 77 Stockholm, Sweden
    Exp Cell Res 316:1429-37. 2010
    ....
  2. ncbi Oncogene- and tumor suppressor gene-mediated suppression of cellular senescence
    Lars Gunnar Larsson
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Box 280, SE 171 77 Stockholm, Sweden
    Semin Cancer Biol 21:367-76. 2011
    ..This can hopefully form the basis for a "pro-senescence therapy" strategy to combat cancer in the future...
  3. ncbi Tipping the balance: Cdk2 enables Myc to suppress senescence
    Per Hydbring
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
    Cancer Res 70:6687-91. 2010
    ....
  4. ncbi Cdk2: a key regulator of the senescence control function of Myc
    Per Hydbring
    Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institutet, 171 77 Stockholm, Sweden
    Aging (Albany NY) 2:244-50. 2010
    ..Importantly, selective pharmacological inhibition of Cdk2 forced Myc/Ras expressing cells into cellular senescence, highlighting this kinase as a potential therapeutic target for treatment of tumors driven by Myc or Ras...
  5. ncbi Myc is required for activation of the ATM-dependent checkpoints in response to DNA damage
    Lina Guerra
    Department of Cell Biology, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 5:e8924. 2010
    ..In response to genotoxic agents, cells overexpressing MYC undergo apoptosis. However, the MYC-regulated effectors acting upstream of the mitochondrial apoptotic pathway are still unknown...
  6. ncbi Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation
    Per Hydbring
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 107:58-63. 2010
    ..Finally, our findings highlight that pharmacological inhibition of Cdk2 activity is a potential therapeutical principle for cancer therapy, in particular for tumors with activated Myc or Ras...
  7. ncbi Inhibition of the intrinsic but not the extrinsic apoptosis pathway accelerates and drives MYC-driven tumorigenesis towards acute myeloid leukemia
    Kari Högstrand
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    PLoS ONE 7:e31366. 2012
    ..In conclusion, our findings provide direct evidence that BCL-X(L) and BCL-2 but not FLIP(L) acts in synergy with MYC to drive AML development...