Research Topics
| P ArhemSummaryAffiliation: Karolinska Institutet Country: Sweden Publications
| Collaborators
|
Detail Information
Publications
A truncated Kv1.1 protein in the brain of the megencephaly mouse: expression and interactionAnn Sophie Persson
Department of Molecular Medicine and Surgery, CMM, Karolinska Hospital, Karolinska Institutet, 171 76 Stockholm, Sweden
BMC Neurosci 6:65. 2005..However, high Kv1.1 mRNA levels in mceph/mceph brain indicated that it escaped this control mechanism. Therefore, we hypothesized that the truncated Kv1.1 would be expressed and dysregulate other Kv1 subunits in the mceph/mceph mice...- Vertical information flow in the brain: on neuronal micro events and consciousnessP Arhem
Nobel Institute for Neurophysiology, Karolinska Institute, Stockholm, Sweden
Biosystems 38:191-8. 1996..The findings highlight the importance of understanding the stochastic nature of channel gating... - Mechanisms of anesthesia: towards integrating network, cellular, and molecular level modelingPeter Arhem
Department of Neuroscience and the Nobel Institute for Neurophysiology, Karolinska Institutet, SE 171 77 Stockholm, Sweden
Neuropsychopharmacology 28:S40-7. 2003..Finally, the relation between the anesthesia problem and the classical consciousness problem is discussed, and some consequences of introducing the phenomenon of degeneracy into the picture are pointed out... - Spontaneous signalling in small central neurons: mechanisms and roles of spike-amplitude and spike-interval fluctuationsP Arhem
Nobel Institute for Neurophysiology, Karolinska Institutet, Stockholm, Sweden
Int J Neural Syst 7:369-76. 1996..These findings highlight the role of microfluctuations for the global macroactivity of the brain, and stress the importance of the study of channel kinetics for brain physiology... - NMDA and glycine regulate the affinity of the Mg2+-block site in NR1-1a/NR2A NMDA receptor channels expressed in Xenopus oocytesY Liu
Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
Life Sci 68:1817-26. 2001..This effect may have implications for the understanding the role of NMDA receptors both under physiological and pathophysiological conditions... - Channel density regulation of firing patterns in a cortical neuron modelP Arhem
Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, SE 17177 Stockholm, Sweden
Biophys J 90:4392-404. 2006.... - Localization of the extracellular end of the voltage sensor S4 in a potassium channelF Elinder
The Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, SE-171 77 Stockholm, Sweden
Biophys J 80:1802-9. 2001..We also present a three-dimensional model for all transmembrane segments. Knowledge of this structure is essential for the attempts to understand how voltage opens these channels... - Single residue (K332A) substitution in Kir6.2 abolishes the stimulatory effect of long-chain acyl-CoA esters: indications for a long-chain acyl-CoA ester binding motifR Branstrom
Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
Diabetologia 50:1670-7. 2007..LC-CoA esters have been shown to interact with Kir6.2, but the mechanism and binding site(s) have yet to be identified... - Voltage sensing in ion channels: a 50-year-old mystery resolved?Peter Arhem
Nobel Institute for Neurophysiology and Department of Neuroscience, Karolinska Institutet, SE 171 77, Stockholm, Sweden
Lancet 363:1221-3. 2004..Such a configuration may help to understand certain aspects of the action of lipid-soluble gating modifiers, such as local and general anaesthetics and antiarrythmic and antiepileptic agents... - Voltage-dependence of the human dopamine D2 receptorKristoffer Sahlholm
Department of Neuroscience, Karolinska Institutet, SE 117 77 Stockholm, Sweden
Synapse 62:476-80. 2008..Our results are likely to bear relevance to the function of the D2 receptor in gating synaptic input and in regulating plasticity... - A tyrosine substitution in the cavity wall of a k channel induces an inverted inactivationGöran Klement
The Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, SE 171 77 Stockholm, Sweden
Biophys J 94:3014-22. 2008..The experimental findings can be explained by a simple branched kinetic model with two inactivation pathways from the open state... - On the opening of voltage-gated ion channelsFredrik Elinder
Karolinska Institutet, Department of Neuroscience, The Nobel Institute for Neurophysiology, Stockholm, Sweden
Physiol Behav 92:1-7. 2007..This model opens up for understanding how lipophilic drugs and toxins directly affect the voltage sensor... - The human histamine H3 receptor couples to GIRK channels in Xenopus oocytesKristoffer Sahlholm
Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
Eur J Pharmacol 567:206-10. 2007.... - Truncation of the Shaker-like voltage-gated potassium channel, Kv1.1, causes megencephalySusanna Petersson
Neurogenetic Unit, Department of Molecular Medicine, CMM, L8 00, Karolinska Institutet, 171 76 Stockholm, Sweden
Eur J Neurosci 18:3231-40. 2003..However, in contrast to the commonly demonstrated epilepsy-induced neurodegeneration, we find that the mceph mutation leads to seizures with a concomitant increase in brain size, without overt neural atrophy... - Density dependent neurodynamicsGeir Halnes
Department of Biometry and Engineering, P O Box 7032 SLU, SE 75007 Uppsala, Sweden
Biosystems 89:126-34. 2007..Finally, we model a possible effect of anaesthesia by blocking specific inhibitory ion channels... - Computational modelling of the open-state Kv 1.5 ion channel block by bupivacaineVictor B Luzhkov
Department of Cell and Molecular Biology, Uppsala University, BMC, Box 596, SE-751 24 Uppsala, Sweden
Biochim Biophys Acta 1652:35-51. 2003..Surprisingly, no binding is predicted for the Gly-bend model. These results are discussed in light of electrophysiological data which show that the K(v)1.5 channel is unable to close when bupivacaine is bound... - Metal ion effects on ion channel gatingFredrik Elinder
Department of Neuroscience, The Nobel Institute for Neurophysiology, Karolinska Institutet, , SE-171 77 Stockholm, Sweden
Q Rev Biophys 36:373-427. 2003..With the exception of the ether-Ã -go-go-like channels, most channel types show remarkably similar ion-specific sensitivities... - Electrophysiology-based analysis of human histamine H(4) receptor pharmacology using GIRK channel coupling in Xenopus oocytesKristoffer Sahlholm
Department of Neuroscience, Karolinska Institutet, SE 117 77 Stockholm, Sweden
Eur J Pharmacol 591:52-8. 2008..GIRK channels represent a novel effector system for histamine H(4) receptor modulation, which may be of physiological relevance and prove useful in the development of compounds targeting this receptor...