Ulf Andersson

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes
    U Andersson
    Department of Medicine, Rheumatology Unit, Karolinska Hospital, 17176 Stockholm, Sweden
    J Exp Med 192:565-70. 2000
  2. ncbi HMGB1 is a potent trigger of arthritis
    U Andersson
    Department of Medicine, Rheumatology Research Unit, Karolinska Institutet, Karolinska Hospital, Stockholm, Sweden
    J Intern Med 255:344-50. 2004
  3. ncbi HMGB1, a pro-inflammatory cytokine of clinical interest: introduction
    U G Andersson
    Department of Rheumatology, Astrid Lindgren Children s Hospital, Stockholm, Sweden
    J Intern Med 255:318-9. 2004
  4. ncbi HMGB1 in sepsis
    Ulf Andersson
    Department of Woman and Child Health, Karolinska Institutet, Astrid Lindgren Children s Hospital, Stockholm, Sweden
    Scand J Infect Dis 35:577-84. 2003
  5. ncbi HMGB1 as a DNA-binding cytokine
    Ulf Andersson
    Department of Medicine, Rheumatology Research Unit, Karolinska Hospital, Stockholm, Sweden
    J Leukoc Biol 72:1084-91. 2002
  6. ncbi The alarmin HMGB1 acts in synergy with endogenous and exogenous danger signals to promote inflammation
    Hulda Sigridur Hreggvidsdottir
    Department of Medicine, Rheumatology Research Unit, Karolinska Hospital, Karolinska Institutet, S 171 76 Stockholm, Sweden
    J Leukoc Biol 86:655-62. 2009
  7. ncbi High mobility group box protein 1 in complex with lipopolysaccharide or IL-1 promotes an increased inflammatory phenotype in synovial fibroblasts
    Heidi Wähämaa
    Department of Women s and Children s Health, Pediatric Rheumatology Research Unit Karolinska Institutet, Astrid Lindgren Children Hospital Karolinska University Hospital, Stockholm, 17176, Sweden
    Arthritis Res Ther 13:R136. 2011
  8. ncbi Systemic TNF blockade does not modulate synovial expression of the pro-inflammatory mediator HMGB1 in rheumatoid arthritis patients--a prospective clinical study
    Erik Sundberg
    Department of Woman and Child Health, Pediatric Rheumatology Research Unit, Karolinska Institutet Karolinska University Hospital, Stockholm, Sweden
    Arthritis Res Ther 10:R33. 2008
  9. ncbi Oxaliplatin retains HMGB1 intranuclearly and ameliorates collagen type II-induced arthritis
    Therese Ostberg
    Department of Woman and Child Health, Pediatric Rheumatology Research Unit, Karolinska Institutet Karolinska University Hospital, 171 176 Stockholm, Sweden
    Arthritis Res Ther 10:R1. 2008
  10. ncbi Effects of HMGB1 on in vitro responses of isolated muscle fibers and functional aspects in skeletal muscles of idiopathic inflammatory myopathies
    Cecilia Grundtman
    Rheumatology Unit, Department of Medicine, Karolinska University Hospital Solna, Stockholm, Sweden
    FASEB J 24:570-8. 2010

Collaborators

Detail Information

Publications35

  1. ncbi High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes
    U Andersson
    Department of Medicine, Rheumatology Unit, Karolinska Hospital, 17176 Stockholm, Sweden
    J Exp Med 192:565-70. 2000
    ..Together, these results indicate that, like other cytokine mediators of endotoxin lethality (e.g., TNF and IL-1), extracellular HMG-1 is a regulator of monocyte proinflammatory cytokine synthesis...
  2. ncbi HMGB1 is a potent trigger of arthritis
    U Andersson
    Department of Medicine, Rheumatology Research Unit, Karolinska Institutet, Karolinska Hospital, Stockholm, Sweden
    J Intern Med 255:344-50. 2004
    ..It is thus conceivable that therapeutic HMGB1 blockade may contribute to future treatment of human chronic arthritis...
  3. ncbi HMGB1, a pro-inflammatory cytokine of clinical interest: introduction
    U G Andersson
    Department of Rheumatology, Astrid Lindgren Children s Hospital, Stockholm, Sweden
    J Intern Med 255:318-9. 2004
    ..The manuscripts are the product of a recent meeting entitled the 'First HMGB1 Cytokine World Congress' sponsored by the Journal of Internal Medicine...
  4. ncbi HMGB1 in sepsis
    Ulf Andersson
    Department of Woman and Child Health, Karolinska Institutet, Astrid Lindgren Children s Hospital, Stockholm, Sweden
    Scand J Infect Dis 35:577-84. 2003
    ..Effectiveness of delayed treatment with HMGB1 blockade up to 24 h after induction of experimental sepsis offers a unique window of opportunities to allow rescue from lethal sepsis...
  5. ncbi HMGB1 as a DNA-binding cytokine
    Ulf Andersson
    Department of Medicine, Rheumatology Research Unit, Karolinska Hospital, Stockholm, Sweden
    J Leukoc Biol 72:1084-91. 2002
    ....
  6. ncbi The alarmin HMGB1 acts in synergy with endogenous and exogenous danger signals to promote inflammation
    Hulda Sigridur Hreggvidsdottir
    Department of Medicine, Rheumatology Research Unit, Karolinska Hospital, Karolinska Institutet, S 171 76 Stockholm, Sweden
    J Leukoc Biol 86:655-62. 2009
    ..HMGB1 thus acts broadly with many but not all immunostimulatory molecules to amplify their activity in a synergistic manner...
  7. ncbi High mobility group box protein 1 in complex with lipopolysaccharide or IL-1 promotes an increased inflammatory phenotype in synovial fibroblasts
    Heidi Wähämaa
    Department of Women s and Children s Health, Pediatric Rheumatology Research Unit Karolinska Institutet, Astrid Lindgren Children Hospital Karolinska University Hospital, Stockholm, 17176, Sweden
    Arthritis Res Ther 13:R136. 2011
    ..Furthermore, we examined the toll-like receptor (TLR) 4 and IL-1RI requirement for the cytokine-enhancing effects of the investigated HMGB1-ligand complexes...
  8. ncbi Systemic TNF blockade does not modulate synovial expression of the pro-inflammatory mediator HMGB1 in rheumatoid arthritis patients--a prospective clinical study
    Erik Sundberg
    Department of Woman and Child Health, Pediatric Rheumatology Research Unit, Karolinska Institutet Karolinska University Hospital, Stockholm, Sweden
    Arthritis Res Ther 10:R33. 2008
    ..It was, therefore, decided to investigate whether treatment based on TNF blockade in rheumatoid arthritis (RA) affects the expression of synovial HMGB1...
  9. ncbi Oxaliplatin retains HMGB1 intranuclearly and ameliorates collagen type II-induced arthritis
    Therese Ostberg
    Department of Woman and Child Health, Pediatric Rheumatology Research Unit, Karolinska Institutet Karolinska University Hospital, 171 176 Stockholm, Sweden
    Arthritis Res Ther 10:R1. 2008
    ..In the present study we asked whether nuclear sequestration of HMGB1 preventing HMGB1 release would be beneficial for synovitis treatment...
  10. ncbi Effects of HMGB1 on in vitro responses of isolated muscle fibers and functional aspects in skeletal muscles of idiopathic inflammatory myopathies
    Cecilia Grundtman
    Rheumatology Unit, Department of Medicine, Karolinska University Hospital Solna, Stockholm, Sweden
    FASEB J 24:570-8. 2010
    ..However, HMGB1-expressing fibers outnumbered fibers expressing MHC class I. Our data indicate that HMGB1 could be an early inducer of skeletal muscle dysfunction in IIMs...
  11. ncbi Pivotal advance: inhibition of HMGB1 nuclear translocation as a mechanism for the anti-rheumatic effects of gold sodium thiomalate
    Cecilia K Zetterström
    Department of Woman and Child Health, Pediatric Rheumatology Research Unit, Karolinska Institutet Karolinska University Hospital, Stockholm, Sweden
    J Leukoc Biol 83:31-8. 2008
    ..Together, these results suggest a new mechanism for the anti-rheumatic effects of gold salts in RA and the potential of drugs, which interfere with intracellular HMGB1 transport mechanisms, as novel agents to treat RA...
  12. ncbi Protective targeting of high mobility group box chromosomal protein 1 in a spontaneous arthritis model
    Therese Ostberg
    Astrid Lindgren Children s Hospital, Karolinska Hospital, and Karolinska Institutet, Stockholm, Sweden
    Arthritis Rheum 62:2963-72. 2010
    ..DNase II is needed for macrophage degradation of engulfed DNA. The aim of this study was to evaluate a potential pathogenic role of HMGB-1 in this novel murine model...
  13. ncbi Morphological characterization of intra-articular HMGB1 expression during the course of collagen-induced arthritis
    Karin Palmblad
    Department of Woman and Child Health, Karolinska Institutet, Astrid Lindgren Children s Hospital, SE 171 76 Stockholm, Sweden
    Arthritis Res Ther 9:R35. 2007
    ..In conclusion, these new findings implicate a role for HMGB1 in both inducing and perpetuating inflammatory events of significant importance in the destructive processes in chronic arthritis...
  14. ncbi Monoclonal anti-HMGB1 (high mobility group box chromosomal protein 1) antibody protection in two experimental arthritis models
    Hanna Schierbeck
    Department of Women s and Children s Health, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Mol Med 17:1039-44. 2011
    ....
  15. ncbi Immunomodulatory drugs regulate HMGB1 release from activated human monocytes
    Hanna Schierbeck
    Department of Women s and Children s Health, Pediatric Unit, Karolinska Institutet, Stockholm, Sweden
    Mol Med 16:343-51. 2010
    ..We conclude that dexamethasone, gold sodium thiomalate and chloroquine share a capacity to inhibit HMGB1 release from activated monocytes...
  16. ncbi Intraarticular glucocorticoid treatment reduces inflammation in synovial cell infiltrations more efficiently than in synovial blood vessels
    Erik af Klint
    Karolinska Institutet, Stockholm, Sweden
    Arthritis Rheum 52:3880-9. 2005
    ..These findings may reflect mechanisms controlling the transiency of clinical improvement frequently observed after IA GC injection...
  17. ncbi High mobility group box chromosomal protein 1 acts as a proliferation signal for activated T lymphocytes
    Erik Sundberg
    Department of Woman and Child Health, Pediatric Rheumatology Research Unit, Karolinska Institutet Karolinska University Hospital, L 8 04 CMM, S 17176 Stockholm, Sweden
    Immunobiology 214:303-9. 2009
    ..0 microg/ml. HMGB1 had no effect on proliferation in the absence of anti-CD3 stimulation or during T-cell activation obtained using high doses of anti-CD3 mAb. Our results demonstrate a direct HMGB1-mediated effect in adaptive immunity...
  18. ncbi HMGB1-secreting capacity of multiple cell lineages revealed by a novel HMGB1 ELISPOT assay
    Heidi Wähämaa
    Rheumatology Unit, Department of Medicine, Karolinska Institutet CMM L8 04, Karolinska sjukhuset, Stockholm, Sweden
    J Leukoc Biol 81:129-36. 2007
    ..We believe the ELISPOT method provides a novel tool to study pathways promoting or inhibiting HMGB1 secretion...
  19. ncbi Immunolocalization of interleukin-1 receptors in the sarcolemma and nuclei of skeletal muscle in patients with idiopathic inflammatory myopathies
    Cecilia Grundtman
    Rheumatology Research Unit, Karolinska University Hospital Solna and Karolinska Institutet, Stockholm, Sweden
    Arthritis Rheum 56:674-87. 2007
    ..The purpose of this study was to investigate the expression of IL-1 receptors and their ligands in muscle tissue from patients with myositis and from healthy controls...
  20. ncbi Mini-review: The nuclear protein HMGB1 as a proinflammatory mediator
    Helena Erlandsson Harris
    Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden
    Eur J Immunol 34:1503-12. 2004
    ....
  21. ncbi High mobility group box protein 1 (HMGB1)-partner molecule complexes enhance cytokine production by signaling through the partner molecule receptor
    Hulda Sigridur Hreggvidsdottir
    Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden
    Mol Med 18:224-30. 2012
    ..Elucidating HMGB1 receptor usage in processes where HMGB1 acts alone or in complex with other molecules is essential for the understanding of basic HMGB1 biology and for designing HMGB1-targeted therapies...
  22. ncbi The role of HMGB1 in the pathogenesis of rheumatic disease
    Ulf Andersson
    Department of Women s and Children s Health, Karolinska Institutet, Karolinska University Hospital at Solna, S 171 76 Stockholm, Sweden
    Biochim Biophys Acta 1799:141-8. 2010
    ..This review summarizes selected aspects of HMGB1 biology relevant for induction and propagation of some autoimmune conditions...
  23. ncbi HMGB1 as a mediator of necrosis-induced inflammation and a therapeutic target in arthritis
    Ulf Andersson
    Department of Woman and Child Health, Karolinska Institutet, Astrid Lindgren Children's Hospital, Stockholm, Sweden
    Rheum Dis Clin North Am 30:627-37, xi. 2004
    ..Anti-HMGB1 may be studied in future clinical trials of diseases of excessive production of HMGB1, such as severe sepsis and arthritis...
  24. ncbi Tumor necrosis factor, interleukin 11, and leukemia inhibitory factor produced by Langerhans cells in Langerhans cell histiocytosis
    Ulrika Andersson By
    Childhood Cancer Research Unit, Department of Woman and Child Health, Karolinska Institutet, Astrid Lindgren Children s Hospital, Stockholm, Sweden
    J Pediatr Hematol Oncol 26:706-11. 2004
    ....
  25. ncbi HMGB1 is a therapeutic target for sterile inflammation and infection
    Ulf Andersson
    Department of Women s and Children s Health, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
    Annu Rev Immunol 29:139-62. 2011
    ..Experimental strategies that selectively target HMGB1 and TLR4 effectively reverse and prevent activation of innate immunity and significantly attenuate damage in diverse models of sterile and infection-induced threat...
  26. ncbi HMGB1: a multifunctional alarmin driving autoimmune and inflammatory disease
    Helena Erlandsson Harris
    Rheumatology Unit, Department of Medicine, Center for Molecular Medicine, Karolinska Institutet, 17177 Stockholm, Sweden
    Nat Rev Rheumatol 8:195-202. 2012
    ..Together, these findings indicate that HMGB1 might be an important mediator and biomarker in rheumatic diseases as well as a target of new therapy...
  27. ncbi Down-regulation of the aberrant expression of the inflammation mediator high mobility group box chromosomal protein 1 in muscle tissue of patients with polymyositis and dermatomyositis treated with corticosteroids
    Ann Kristin Ulfgren
    Rheumatology Research Unit, CMM L8 04, Karolinska Hospital, Karolinska Institutet, 171 76 Stockholm, Sweden
    Arthritis Rheum 50:1586-94. 2004
    ..The present study was therefore undertaken to investigate how HMGB-1 is expressed in muscle tissue of patients with myositis and, if so, whether such expression is modulated by prednisolone therapy...
  28. ncbi Reflex principles of immunological homeostasis
    Ulf Andersson
    Department of Women s and Children s Health, Karolinska University Hospital, Karolinska Institutet, S 171 76 Stockholm, Sweden
    Annu Rev Immunol 30:313-35. 2012
    ....
  29. ncbi Pro-inflammatory cytokines produced by growth plate chondrocytes may act locally to modulate longitudinal bone growth
    Paola Fernandez-Vojvodich
    Pediatric Endocrinology, Department of Women s and Children s Health, Karolinska Institutet, Stockholm, Sweden
    Horm Res Paediatr 77:180-7. 2012
    ....
  30. ncbi High mobility group box chromosomal protein 1 (HMGB1) is an antibacterial factor produced by the human adenoid
    Cecilia K Zetterström
    Pediatric Endocrinology Unit, Department of Woman and Child Health, Astrid Lindgren Children s Hospital, Karolinska Hospital, Stockholm, Sweden
    Pediatr Res 52:148-54. 2002
    ..We conclude that HMGB1, produced and stored intracellularly in the adenoid gland, contributes to the local antibacterial barrier defense system in the upper respiratory tract...
  31. ncbi High mobility group box chromosomal protein 1 as a nuclear protein, cytokine, and potential therapeutic target in arthritis
    Luis Ulloa
    Arthritis Rheum 48:876-81. 2003
  32. ncbi Structural basis for the proinflammatory cytokine activity of high mobility group box 1
    Jianhua Li
    Laboratory of Biomedical Science, North Shore-Long Island Jewish Research Institute, 350 Community Drive, Manhasset, NY 11030, USA
    Mol Med 9:37-45. 2003
    ..These results indicate that a proinflammatory domain of HMGB1 maps to the highly conserved DNA-binding B box, making this primary sequence a suitable target in the design of therapeutics...
  33. ncbi High mobility group box chromosomal protein 1, a DNA binding cytokine, induces arthritis
    Rille Pullerits
    Department of Rheumatology and Inflammation Research, Sahlgrenska University Hospital, University of Goteborg, Gothenburg, Sweden
    Arthritis Rheum 48:1693-700. 2003
    ..To examine the potential role of high mobility group box chromosomal protein 1 (HMGB-1) in the pathogenesis of arthritis...
  34. ncbi Reversing established sepsis with antagonists of endogenous high-mobility group box 1
    Huan Yang
    Laboratory of Biomedical Science, North Shore-Long Island Jewish Research Institute, 350 Community Drive, Manhasset, NY 11030, USA
    Proc Natl Acad Sci U S A 101:296-301. 2004
    ..These observations demonstrate that specific inhibition of endogenous HMGB1 therapeutically reverses lethality of established sepsis indicating that HMGB1 inhibitors can be administered in a clinically relevant time frame...
  35. ncbi Microscopic measurement of inflammation in synovial tissue: inter-observer agreement for manual quantitative, semiquantitative and computerised digital image analysis
    Terence Rooney
    Department of Rheumatology, St Vincent s University Hospital, Dublin 4, Ireland
    Ann Rheum Dis 66:1656-60. 2007
    ..To evaluate inter-observer agreement for microscopic measurement of inflammation in synovial tissue using manual quantitative, semiquantitative and computerised digital image analysis...