Caroline Jochems

Summary

Country: Sweden

Publications

  1. ncbi Combined treatment with dexamethasone and raloxifene totally abrogates osteoporosis and joint destruction in experimental postmenopausal arthritis
    Ulrika Islander
    Centre for Bone and Arthritis Research, The Sahlgrenska Academy, University of Gothenburg, Box 480, 405 30 Gothenburg, Sweden
    Arthritis Res Ther 13:R96. 2011
  2. ncbi Effects of oestradiol and raloxifene on the induction and effector phases of experimental postmenopausal arthritis and secondary osteoporosis
    C Jochems
    Department of Rheumatology and Inflammation Research, The Sahlgrenska Academy at Goteborg University, Karolinska Institute, Stockholm, Sweden
    Clin Exp Immunol 165:121-9. 2011
  3. ncbi Role of endogenous and exogenous female sex hormones in arthritis and osteoporosis development in B10.Q-ncf1*/* mice with collagen-induced chronic arthritis
    Caroline Jochems
    Department of Rheumatology and Inflammation Research, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    BMC Musculoskelet Disord 11:284. 2010
  4. ncbi Osteoporosis in experimental postmenopausal polyarthritis: the relative contributions of estrogen deficiency and inflammation
    Caroline Jochems
    Department of Rheumatology and Inflammation Research at the Sahlgrenska Academy, Goteborg, Sweden
    Arthritis Res Ther 7:R837-43. 2005
  5. ncbi Long-term anti-arthritic and anti-osteoporotic effects of raloxifene in established experimental postmenopausal polyarthritis
    C Jochems
    Department of Rheumatology and Inflammation Research, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Clin Exp Immunol 152:593-7. 2008
  6. ncbi Role of raloxifene as a potent inhibitor of experimental postmenopausal polyarthritis and osteoporosis
    Caroline Jochems
    Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Arthritis Rheum 56:3261-70. 2007
  7. ncbi In vivo activation of gene transcription via oestrogen response elements by a raloxifene analogue
    Cecilia Engdahl
    Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Guldhedsgatan 10A, 413 46 Gothenburg, Sweden
    J Endocrinol 203:349-56. 2009
  8. ncbi Estrogens in rheumatoid arthritis; the immune system and bone
    Ulrika Islander
    Center for Bone and Arthritis Research CBAR, Department of Rheumatology and Inflammation Research, The Sahlgrenska Academy, University of Gothenburg, Sweden
    Mol Cell Endocrinol 335:14-29. 2011
  9. ncbi Estren promotes androgen phenotypes in primary lymphoid organs and submandibular glands
    Ulrika Islander
    Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, Goteborg University, Sweden
    BMC Immunol 6:16. 2005
  10. ncbi Amelioration of collagen-induced arthritis and immune-associated bone loss through signaling via estrogen receptor alpha, and not estrogen receptor beta or G protein-coupled receptor 30
    Cecilia Engdahl
    Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
    Arthritis Rheum 62:524-33. 2010

Detail Information

Publications10

  1. ncbi Combined treatment with dexamethasone and raloxifene totally abrogates osteoporosis and joint destruction in experimental postmenopausal arthritis
    Ulrika Islander
    Centre for Bone and Arthritis Research, The Sahlgrenska Academy, University of Gothenburg, Box 480, 405 30 Gothenburg, Sweden
    Arthritis Res Ther 13:R96. 2011
    ....
  2. ncbi Effects of oestradiol and raloxifene on the induction and effector phases of experimental postmenopausal arthritis and secondary osteoporosis
    C Jochems
    Department of Rheumatology and Inflammation Research, The Sahlgrenska Academy at Goteborg University, Karolinska Institute, Stockholm, Sweden
    Clin Exp Immunol 165:121-9. 2011
    ..CII-immunization increased the oestradiol-induced ERE activation in spleen, and raloxifene activated the ERE at about 25% the intensity of oestradiol. Further experiments are needed to elucidate the exact mechanisms behind this finding...
  3. ncbi Role of endogenous and exogenous female sex hormones in arthritis and osteoporosis development in B10.Q-ncf1*/* mice with collagen-induced chronic arthritis
    Caroline Jochems
    Department of Rheumatology and Inflammation Research, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    BMC Musculoskelet Disord 11:284. 2010
    ..We also examined whether treatment would prevent the development of inflammation-triggered generalized osteoporosis...
  4. ncbi Osteoporosis in experimental postmenopausal polyarthritis: the relative contributions of estrogen deficiency and inflammation
    Caroline Jochems
    Department of Rheumatology and Inflammation Research at the Sahlgrenska Academy, Goteborg, Sweden
    Arthritis Res Ther 7:R837-43. 2005
    ..Markers of bone remodeling and bone marrow lymphocyte phenotypes indicate different mechanisms for the development of osteoporosis caused by ovariectomy and arthritis in this model...
  5. ncbi Long-term anti-arthritic and anti-osteoporotic effects of raloxifene in established experimental postmenopausal polyarthritis
    C Jochems
    Department of Rheumatology and Inflammation Research, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Clin Exp Immunol 152:593-7. 2008
    ..The serum levels of antibodies to collagen were not affected by raloxifene-treatment. Long-term treatment with raloxifene has both anti-arthritic and anti-osteoporotic effects in established experimental postmenopausal polyarthritis...
  6. ncbi Role of raloxifene as a potent inhibitor of experimental postmenopausal polyarthritis and osteoporosis
    Caroline Jochems
    Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Arthritis Rheum 56:3261-70. 2007
    ..We therefore used a mouse model of human RA to test the hypothesis that a selective estrogen receptor modulator (SERM), the raloxifene analog LY117018, could be beneficial in the treatment of both arthritis and osteoporosis...
  7. ncbi In vivo activation of gene transcription via oestrogen response elements by a raloxifene analogue
    Cecilia Engdahl
    Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Guldhedsgatan 10A, 413 46 Gothenburg, Sweden
    J Endocrinol 203:349-56. 2009
    ..In summary, the raloxifene analogue LY117018 can activate the classical oestrogen pathway in bone, uterus and thymus in vivo, and this activation is associated with BMD and uterus weight, but not thymus weight...
  8. ncbi Estrogens in rheumatoid arthritis; the immune system and bone
    Ulrika Islander
    Center for Bone and Arthritis Research CBAR, Department of Rheumatology and Inflammation Research, The Sahlgrenska Academy, University of Gothenburg, Sweden
    Mol Cell Endocrinol 335:14-29. 2011
    ..This review will focus on the influence of female sex hormones in the pathogenesis and progression of RA...
  9. ncbi Estren promotes androgen phenotypes in primary lymphoid organs and submandibular glands
    Ulrika Islander
    Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, Goteborg University, Sweden
    BMC Immunol 6:16. 2005
    ..Estrogen receptors (ERs) were blocked by treatment of mice with the ER-antagonist ICI 182,780; also, knock-out mice lacking one or both ERs were used...
  10. ncbi Amelioration of collagen-induced arthritis and immune-associated bone loss through signaling via estrogen receptor alpha, and not estrogen receptor beta or G protein-coupled receptor 30
    Cecilia Engdahl
    Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
    Arthritis Rheum 62:524-33. 2010
    ..The purpose of this study was to elucidate the ER specificity for the ameliorating effects of estrogen on arthritis and bone loss in a model of postmenopausal rheumatoid arthritis (RA)...