O Hultgren

Summary

Country: Sweden

Publications

  1. ncbi Staphylococcus aureus-induced septic arthritis and septic death is decreased in IL-4-deficient mice: role of IL-4 as promoter for bacterial growth
    O Hultgren
    Department of Rheumatology, University of Goteborg, Sweden
    J Immunol 160:5082-7. 1998
  2. ncbi Serum interleukin-1 receptor antagonist is an early indicator of colitis onset in Galphai2-deficient mice
    O H Hultgren
    Department of Clinical Immunology, Goteborg University, Guldhedsgatan 10 A, S 413 46 Goteborg, Sweden
    World J Gastroenterol 12:621-4. 2006
  3. ncbi T-box transcription-factor-deficient mice display increased joint pathology and failure of infection control during staphylococcal arthritis
    Olof H Hultgren
    Department of Clinical Immunology, Göteborg University Gulhedsgatan 10A S 413 46 Göteborg, Sweden
    Microbes Infect 6:529-35. 2004
  4. ncbi Serum concentration of interleukin-18 is up-regulated in patients with ANCA-associated vasculitis
    O Hultgren
    Department of Clinical Immunology, Sahlgren s University Hospital, Goteborg, Sweden
    Autoimmunity 40:529-31. 2007
  5. ncbi Critical role of signaling through IL-1 receptor for development of arthritis and sepsis during Staphylococcus aureus infection
    Olof H Hultgren
    Department of Rheumatology, Goteborg University, Guldhedsgatan 10A, S 413 46 Goteborg, Sweden
    J Immunol 168:5207-12. 2002
  6. ncbi Leptin in septic arthritis: decreased levels during infection and amelioration of disease activity upon its administration
    O H Hultgren
    Department of Rheumatology, Goteborg University, Goteborg, Sweden
    Arthritis Res 3:389-94. 2001
  7. ncbi Role of IL-12 in Staphylococcus aureus-triggered arthritis and sepsis
    O H Hultgren
    Department of Rheumatology, University of Goteborg, Goteborg, Sweden
    Arthritis Res 3:41-7. 2001
  8. ncbi Outcome of Staphylococcus aureus-triggered sepsis and arthritis in IL-4-deficient mice depends on the genetic background of the host
    O Hultgren
    Department of Rheumatology University of Göteborg, Goteborg, Sweden
    Eur J Immunol 29:2400-5. 1999
  9. ncbi TNF/lymphotoxin-alpha double-mutant mice resist septic arthritis but display increased mortality in response to Staphylococcus aureus
    O Hultgren
    Department of Rheumatology, University of Goteborg, Sweden
    J Immunol 161:5937-42. 1998
  10. ncbi Is interleukin-18 useful for monitoring rheumatoid arthritis?
    M Bokarewa
    Department of Rheumatology, Goteborg University, Sweden
    Scand J Rheumatol 34:433-6. 2005

Detail Information

Publications14

  1. ncbi Staphylococcus aureus-induced septic arthritis and septic death is decreased in IL-4-deficient mice: role of IL-4 as promoter for bacterial growth
    O Hultgren
    Department of Rheumatology, University of Goteborg, Sweden
    J Immunol 160:5082-7. 1998
    ..Our results suggest that IL-4 and IL-4-dependent Th2 responses promote septic arthritis and sepsis-related mortality by inhibition of bacterial clearance during S. aureus infection...
  2. ncbi Serum interleukin-1 receptor antagonist is an early indicator of colitis onset in Galphai2-deficient mice
    O H Hultgren
    Department of Clinical Immunology, Goteborg University, Guldhedsgatan 10 A, S 413 46 Goteborg, Sweden
    World J Gastroenterol 12:621-4. 2006
    ..To study the serum concentration of IL-1beta, IL-1 receptor antagonist (IL-1Ra) and IL-18 in Galphai2-deficient mice at the age of 6 (healthy), 12 (pre-colitic) and 24 wk (colitic) and in healthy control mice...
  3. ncbi T-box transcription-factor-deficient mice display increased joint pathology and failure of infection control during staphylococcal arthritis
    Olof H Hultgren
    Department of Clinical Immunology, Göteborg University Gulhedsgatan 10A S 413 46 Göteborg, Sweden
    Microbes Infect 6:529-35. 2004
    ..aureus infection, protecting against bacterial accumulation, cachexia and septic death. Furthermore T-bet downregulates joint inflammation in the early phase of disease...
  4. ncbi Serum concentration of interleukin-18 is up-regulated in patients with ANCA-associated vasculitis
    O Hultgren
    Department of Clinical Immunology, Sahlgren s University Hospital, Goteborg, Sweden
    Autoimmunity 40:529-31. 2007
    ..As expected the hemodialysis patients also showed significantly increased circulating IL-18 concentrations as compared to control subjects...
  5. ncbi Critical role of signaling through IL-1 receptor for development of arthritis and sepsis during Staphylococcus aureus infection
    Olof H Hultgren
    Department of Rheumatology, Goteborg University, Guldhedsgatan 10A, S 413 46 Goteborg, Sweden
    J Immunol 168:5207-12. 2002
    ..In conclusion, IL-1R signaling plays a crucial role in host protection during systemic S. aureus infection as seen by the fatal outcome of S. aureus sepsis and arthritis in IL-1R-deficient mice...
  6. ncbi Leptin in septic arthritis: decreased levels during infection and amelioration of disease activity upon its administration
    O H Hultgren
    Department of Rheumatology, Goteborg University, Goteborg, Sweden
    Arthritis Res 3:389-94. 2001
    ..aureus-induced arthritis and the inflammatory response, as measured by serum IL-6 levels, without affecting the survival of bacteria in vivo...
  7. ncbi Role of IL-12 in Staphylococcus aureus-triggered arthritis and sepsis
    O H Hultgren
    Department of Rheumatology, University of Goteborg, Goteborg, Sweden
    Arthritis Res 3:41-7. 2001
    ..Although IL-12-deficient mice were exposed to higher staphylococcal load, they demonstrated no increased severity of arthritis as compared with control animals...
  8. ncbi Outcome of Staphylococcus aureus-triggered sepsis and arthritis in IL-4-deficient mice depends on the genetic background of the host
    O Hultgren
    Department of Rheumatology University of Göteborg, Goteborg, Sweden
    Eur J Immunol 29:2400-5. 1999
    ..Altogether, our results show the dual role of IL-4 in S. aureus sepsis and arthritis, depending on the genetic background of the host...
  9. ncbi TNF/lymphotoxin-alpha double-mutant mice resist septic arthritis but display increased mortality in response to Staphylococcus aureus
    O Hultgren
    Department of Rheumatology, University of Goteborg, Sweden
    J Immunol 161:5937-42. 1998
    ..Our results show the importance of TNF/LT alpha in defense against systemic S. aureus infections and point out the detrimental role of these cytokines as mediators of inflammatory response in S. aureus arthritis...
  10. ncbi Is interleukin-18 useful for monitoring rheumatoid arthritis?
    M Bokarewa
    Department of Rheumatology, Goteborg University, Sweden
    Scand J Rheumatol 34:433-6. 2005
    ..Its similarities to IL-1beta and ability to induce tumour necrosis factor-alpha (TNF-alpha) make it potentially important in the pathogenesis of rheumatoid arthritis (RA)...
  11. ncbi Leptin consumption in the inflamed joints of patients with rheumatoid arthritis
    M Bokarewa
    Department of Rheumatology and Inflammation Research, Sahlgrenska University Hospital, Goteborg, Sweden
    Ann Rheum Dis 62:952-6. 2003
    ..Leptin has been shown to participate in bone remodelling and leptin substitution reported to have a protective effect in experimental septic arthritis...
  12. ncbi Current status of pathogenetic mechanisms in staphylococcal arthritis
    Andrej Tarkowski
    Department of Rheumatology and Inflammation Research, University of Goteborg, Guldhedsgatan 10, 413 46 Goteborg, Sweden
    FEMS Microbiol Lett 217:125-32. 2002
    ..This review deals with the intricate host-bacterium interactions that occur during experimental septic arthritis, and outlines potential preventive and treatment modalities...
  13. ncbi Enhanced pro-inflammatory cytokine production in Galphai2-deficient mice on colitis prone and colitis resistant 129Sv genetic backgrounds
    Malin Bjursten
    Department of Clinical Immunology, Goteborg University, S 413 46, Gothenburg, Sweden
    Cell Immunol 228:77-80. 2004
    ....
  14. ncbi IL-1 receptor-associated kinase 1 mediates protection against Staphylococcus aureus infection
    Margareta Verdrengh
    Department of Rheumatology and Inflammation Research, Goteborg University, Guldhedsgatan 10 A, S 413 46 Goteborg, Sweden
    Microbes Infect 6:1268-72. 2004
    ..aureus, IRAK-1-/- mice are resistant to this low dose of S. aureus. Thus IRAK-1 plays an important role in the host response to staphylococcal sepsis...