Kaj Blennow

Summary

Country: Sweden

Publications

  1. ncbi Elevated CSF levels of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer's disease
    Hong Jiang
    Center for Advanced Therapeutic Strategies for Brain Disorders, Roskamp Institute, Sarasota, FL 34243, USA
    Mol Neurodegener 6:69. 2011
  2. ncbi BACE1 gene variants do not influence BACE1 activity, levels of APP or A? isoforms in CSF in Alzheimer's disease
    Annica Sjölander
    Institute of Neuroscience and Physiology, Department of Neurochemistry and Psychiatry, Sahlgrenska University Hospital, University of Gothenburg, Sweden
    Mol Neurodegener 5:37. 2010
  3. ncbi Effects of cerebrovascular disease on amyloid precursor protein metabolites in cerebrospinal fluid
    Per Selnes
    Department of Neurology, Akershus University Hospital, Norway
    Cerebrospinal Fluid Res 7:10. 2010
  4. ncbi Cerebrospinal fluid markers before and after shunting in patients with secondary and idiopathic normal pressure hydrocephalus
    Mats Tullberg
    Institute of Neuroscience and Physiology, The Sahlgrenska Academy at Goteborg University, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
    Cerebrospinal Fluid Res 5:9. 2008
  5. ncbi Neuroinflammation in Lyme neuroborreliosis affects amyloid metabolism
    Niklas Mattsson
    Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
    BMC Neurol 10:51. 2010
  6. ncbi Association of Nrf2-encoding NFE2L2 haplotypes with Parkinson's disease
    Malin von Otter
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Bla Straket 15, 413 45 Gothenburg, Sweden
    BMC Med Genet 11:36. 2010
  7. ncbi Normalisation of cerebrospinal fluid biomarkers parallels improvement of neurological symptoms following HAART in HIV dementia--case report
    Lars Magnus Andersson
    Department of Infectious Diseases, Sahlgrenska University Hospital, Goteborg, Sweden
    BMC Infect Dis 6:141. 2006
  8. ncbi Intrathecal levels of matrix metalloproteinases in systemic lupus erythematosus with central nervous system engagement
    Estelle Trysberg
    Department of Rheumatology and Inflammation Research, Goteborg University, Sahlgrenska University Hospital, Goteborg, Sweden
    Arthritis Res Ther 6:R551-6. 2004
  9. ncbi Use of theragnostic markers to select drugs for phase II/III trials for Alzheimer disease
    Henrik Zetterberg
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, S 431 80 Molndal, Sweden
    Alzheimers Res Ther 2:32. 2010
  10. ncbi A novel Abeta isoform pattern in CSF reflects gamma-secretase inhibition in Alzheimer disease
    Erik Portelius
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Molndal, SE 431 80, Sweden
    Alzheimers Res Ther 2:7. 2010

Collaborators

Detail Information

Publications198 found, 100 shown here

  1. ncbi Elevated CSF levels of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer's disease
    Hong Jiang
    Center for Advanced Therapeutic Strategies for Brain Disorders, Roskamp Institute, Sarasota, FL 34243, USA
    Mol Neurodegener 6:69. 2011
    ..These results suggest that TACE activity and soluble TNF receptors may be potential diagnostic candidate biomarkers in AD and MCI...
  2. ncbi BACE1 gene variants do not influence BACE1 activity, levels of APP or A? isoforms in CSF in Alzheimer's disease
    Annica Sjölander
    Institute of Neuroscience and Physiology, Department of Neurochemistry and Psychiatry, Sahlgrenska University Hospital, University of Gothenburg, Sweden
    Mol Neurodegener 5:37. 2010
    ..e., total-tau and phospho-tau181. Gene variants of BACE1 were neither associated with amyloid-related biomarkers, nor with markers for axonal degeneration in AD...
  3. ncbi Effects of cerebrovascular disease on amyloid precursor protein metabolites in cerebrospinal fluid
    Per Selnes
    Department of Neurology, Akershus University Hospital, Norway
    Cerebrospinal Fluid Res 7:10. 2010
    ..Through measurements of CSF APP metabolite levels in patients with a wide range of WML volumes, this study aimed to determine how SVD influences APP metabolism...
  4. ncbi Cerebrospinal fluid markers before and after shunting in patients with secondary and idiopathic normal pressure hydrocephalus
    Mats Tullberg
    Institute of Neuroscience and Physiology, The Sahlgrenska Academy at Goteborg University, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
    Cerebrospinal Fluid Res 5:9. 2008
    ..The aim of this study was to explore biochemical changes in the cerebrospinal fluid (CSF) induced by shunt surgery and the relationship between these changes and clinical improvement...
  5. ncbi Neuroinflammation in Lyme neuroborreliosis affects amyloid metabolism
    Niklas Mattsson
    Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
    BMC Neurol 10:51. 2010
    ..We have previously found altered cerebral amyloid metabolism in other neuroinflammatory conditions. To further elucidate this, we investigated amyloid metabolism in patients with Lyme neuroborreliosis (LNB)...
  6. ncbi Association of Nrf2-encoding NFE2L2 haplotypes with Parkinson's disease
    Malin von Otter
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Bla Straket 15, 413 45 Gothenburg, Sweden
    BMC Med Genet 11:36. 2010
    ..Here, we hypothesize that variation in NFE2L2 and KEAP1, the genes encoding the two major regulators of the phase II response, may affect the risk of Parkinson's disease...
  7. ncbi Normalisation of cerebrospinal fluid biomarkers parallels improvement of neurological symptoms following HAART in HIV dementia--case report
    Lars Magnus Andersson
    Department of Infectious Diseases, Sahlgrenska University Hospital, Goteborg, Sweden
    BMC Infect Dis 6:141. 2006
    ....
  8. ncbi Intrathecal levels of matrix metalloproteinases in systemic lupus erythematosus with central nervous system engagement
    Estelle Trysberg
    Department of Rheumatology and Inflammation Research, Goteborg University, Sahlgrenska University Hospital, Goteborg, Sweden
    Arthritis Res Ther 6:R551-6. 2004
    ..0001), suggesting a potential MMP-9 activation pathway. Our findings suggest that proinflammatory cytokine induced MMP-9 production leads to brain damage in patients with CNS lupus...
  9. ncbi Use of theragnostic markers to select drugs for phase II/III trials for Alzheimer disease
    Henrik Zetterberg
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, S 431 80 Molndal, Sweden
    Alzheimers Res Ther 2:32. 2010
    ..Such biomarkers may be called 'theragnostic'. Here, we review the literature addressing the prospective value of these biomarkers...
  10. ncbi A novel Abeta isoform pattern in CSF reflects gamma-secretase inhibition in Alzheimer disease
    Erik Portelius
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Molndal, SE 431 80, Sweden
    Alzheimers Res Ther 2:7. 2010
    ..These Abeta isoforms may be novel sensitive biomarkers to monitor the biochemical effect in clinical trials. TRIAL REGISTRATION : Clinical Trials.gov NCT00244322...
  11. ncbi CSF biomarkers for mild cognitive impairment
    K Blennow
    Department of Clinical Neuroscience, Section of Experimental Neuroscience, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    J Intern Med 256:224-34. 2004
    ....
  12. ncbi No neurochemical evidence of brain injury after blast overpressure by repeated explosions or firing heavy weapons
    K Blennow
    Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    Acta Neurol Scand 123:245-51. 2011
    ..Psychiatric and neurological symptoms are common among soldiers exposed to blast without suffering a direct head injury. It is not known whether such symptoms are direct consequences of blast overpressure...
  13. ncbi Is it time for biomarker-based diagnostic criteria for prodromal Alzheimer's disease?
    Kaj Blennow
    Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, SE 431 80 Molndal, Sweden
    Alzheimers Res Ther 2:8. 2010
    ..More details are needed, however, on how these biomarkers can be standardized, to allow a general implementation in the clinical routine diagnostic work-up of patients with cognitive disturbances...
  14. ncbi CSF markers for incipient Alzheimer's disease
    Kaj Blennow
    Department of Clinical Neuroscience, Sahlgrenska Academy, Gothenburg University, Sweden
    Lancet Neurol 2:605-13. 2003
    ..The CSF biomarkers total tau protein, phosphorylated tau protein, and the 42 amino-acid residue form of amyloid-beta may, if put in the right clinical context, prove to have high enough diagnostic accuracy to meet this challenge...
  15. ncbi Longitudinal stability of CSF biomarkers in Alzheimer's disease
    Kaj Blennow
    Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Molndal, Sweden
    Neurosci Lett 419:18-22. 2007
    ....
  16. ncbi CSF markers for pathogenic processes in Alzheimer's disease: diagnostic implications and use in clinical neurochemistry
    Kaj Blennow
    Department of Clinical Neuroscience, University of Goteborg, SE 431 80 Molndal, Sweden
    Brain Res Bull 61:235-42. 2003
    ..These CSF markers may be useful as diagnostic aids, especially to discriminate early or incipient AD from age-associated memory impairment, depression, and some secondary dementias...
  17. ncbi CSF total tau, Abeta42 and phosphorylated tau protein as biomarkers for Alzheimer's disease
    K Blennow
    Department of Clinical Neuroscience, Unit of Neurochemistry, University of Goteborg, Sweden
    Mol Neurobiol 24:87-97. 2001
    ..Preliminary evidence strongly suggests that quantification of tau phosphorylated at specific sites in CSF improves early detection, differential diagnosis, and tracking of disease progression in AD...
  18. ncbi Cerebrospinal fluid biomarkers for Alzheimer's disease
    Kaj Blennow
    Clinical Neurochemistry Laboratory, The Sahlgrenska Academy at Goteborg University, Molndal, Sweden
    J Alzheimers Dis 18:413-7. 2009
    ..This paper reviews recent research advances on these CSF biomarkers for use in clinical diagnosis and in clinical trials in AD...
  19. ncbi Biomarkers in Alzheimer's disease drug development
    Kaj Blennow
    Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
    Nat Med 16:1218-22. 2010
    ....
  20. ncbi [CSF-analyses in clinical diagnosis of Creutzfeldt-Jakob disease. A literature review and three cases from routine clinical practice]
    K Blennow
    Institutionen för klinisk neurovetenskap, Sahlgrenska Universitetssjukhuset, Molndal
    Lakartidningen 98:2446-51. 2001
    ..We also present three cases from routine clinical practice, all with a marked increase in CSF-tau, which was the only positive objective sign in two of the cases...
  21. ncbi Cerebrospinal fluid protein biomarkers for Alzheimer's disease
    Kaj Blennow
    Department of Clinical Neuroscience, Section of Experimental Neuroscience, The Sahlgrenska Academy at Goteborg University, SE 43180 Göteborg, Sweden
    NeuroRx 1:213-25. 2004
    ....
  22. ncbi [There is a strong evidence that professional boxing results in chronic brain damage. The more head punches during a boxer's career, the bigger is the risk]
    Kaj Blennow
    Institutionen för klinisk neurovetenskap, Sahlgrenska Universitetssjukhuset Mölndal, Sweden
    Lakartidningen 102:2468-70, 2472-5. 2005
    ..Focus is also set on the interesting similarities in neurochemical changes and pathogenic mechanisms between CTBI-B, acute traumatic brain injury (e.g. road traffic accidents) and Alzheimer's disease...
  23. ncbi Cerebrospinal fluid and plasma biomarkers in Alzheimer disease
    Kaj Blennow
    Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, SE 431 80 Molndal, Sweden
    Nat Rev Neurol 6:131-44. 2010
    ..Furthermore, we outline the roles of CSF biomarkers in drug discovery and clinical trials, and provide perspectives on AD biomarker discovery and the validation of such markers for use in the clinic...
  24. ncbi Alzheimer's disease
    Kaj Blennow
    Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, Sahlgren s University Hospital, Molndal, Sweden
    Lancet 368:387-403. 2006
    ..This seminar reviews the key aspects of the disease, including epidemiology, genetics, pathogenesis, diagnosis, and treatment, as well as recent developments and controversies...
  25. ncbi CSF biomarkers for Alzheimer's disease: use in early diagnosis and evaluation of drug treatment
    Kaj Blennow
    The Sahlgrenska Academy at Goteborg University, Department of Clinical Neuroscience, Section of Experimental Neuroscience, Sahlgrenska University Hospital, SE 431 80 Molndal, Sweden
    Expert Rev Mol Diagn 5:661-72. 2005
    ..Finally, the rationale for the use of CSF biomarkers to identify and monitor the biochemical effect of new drug candidates is reviewed...
  26. ncbi Association of the RAGE G82S polymorphism with Alzheimer's disease
    Jonny Daborg
    Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, 432, 405 30, Gothenburg, Sweden
    J Neural Transm 117:861-7. 2010
    ..4), and none of the AGER SNPs showed association with Abeta(42), T-tau, P-tau(181) or mini-mental state examination scores. The data speak for a weak, but significant effect of AGER on risk of AD...
  27. ncbi Association of complement factor H Y402H gene polymorphism with Alzheimer's disease
    Madeleine Zetterberg
    Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, Section of Ophthalmology, The Sahlgrenska Academy at Goteborg University, Molndal, Sweden
    Am J Med Genet B Neuropsychiatr Genet 147:720-6. 2008
    ..The CFH 1277C allele may predispose patients for co-morbidity in AD and AMD...
  28. ncbi Nrf2-encoding NFE2L2 haplotypes influence disease progression but not risk in Alzheimer's disease and age-related cataract
    Malin von Otter
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Bla Straket 15, the Sahlgrenska Academy at University of Gothenburg, S 413 45 Gothenburg, Sweden
    Mech Ageing Dev 131:105-10. 2010
    ..009). Our findings do not support NFE2L2 or KEAP1 as susceptibility genes for AD or cataract. However, common variants of the NFE2L2 gene may affect disease progression, potentially altering clinically recognized disease onset...
  29. ncbi The PPAR-alpha gene in Alzheimer's disease: lack of replication of earlier association
    Annica Sjölander
    Department of Clinical Neuroscience, Unit of Neurochemistry, The Sahlgrenska Academy at Goteborg University, Sweden
    Neurobiol Aging 30:666-8. 2009
    ..We found no significant differences in genotype or allele distributions between AD patients and controls. None of the PPAR-alpha gene variants influenced markers for AD...
  30. ncbi Measurement of alpha- and beta-secretase cleaved amyloid precursor protein in cerebrospinal fluid from Alzheimer patients
    Annika Olsson
    Institute of Clinical Neuroscience, Experimental Neuroscience Section, Goteborg University, Sahlgrenska University Hospital, Molndal, Sweden
    Exp Neurol 183:74-80. 2003
    ..Neither the levels of CSF-beta-sAPP nor CSF-Abeta(42) differed when comparing ApoE4 allele-positive with allele-negative individuals...
  31. ncbi Subcortical vascular dementia biomarker pattern in mild cognitive impairment
    Maria Bjerke
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
    Dement Geriatr Cogn Disord 28:348-56. 2009
    ..Mild cognitive impairment (MCI) is an etiologically unclear disorder. Cerebrospinal fluid (CSF) biomarkers are potentially useful for the differentiation between various MCI etiologies...
  32. ncbi Episodic memory and speed/attention deficits are associated with Alzheimer-typical CSF abnormalities in MCI
    Arto Nordlund
    Institute of Neuroscience and Physiology, Sahlgrenska Academy at Goteborg University, Molndal, Sweden
    J Int Neuropsychol Soc 14:582-90. 2008
    ..Mild cognitive impairment (MCI) is regarded as the prodromal stage of dementia disorders, such as Alzheimer's disease (AD)...
  33. ncbi TAU haplotype and the Saitohin Q7R gene polymorphism do not influence CSF Tau in Alzheimer's disease and are not associated with frontotemporal dementia or Parkinson's disease
    Annica Johansson
    Department of Clinical Neuroscience, Unit of Neurochemistry, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Neurodegener Dis 2:28-35. 2005
    ..A single nucleotide polymorphism in the STH gene has been suggested to be involved in sporadic AD and is in complete linkage disequilibrium with the TAU haplotype H1...
  34. ncbi Variability in the kinesin light chain 1 gene may influence risk of age-related cataract
    Malin E Andersson
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Mol Vis 13:993-6. 2007
    ..Here, we test the hypothesis that the rs8702 polymorphism in the kinesin light chain 1 gene (KLC1), previously linked to Alzheimer disease (AD), may play a role in cataractogenesis...
  35. ncbi Kinesin light chain 1 gene haplotypes in three conformational diseases
    Malin von Otter
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    Neuromolecular Med 12:229-36. 2010
    ..Altogether, these results do not convincingly support KLC1 as a major susceptibility gene in any of the studied diseases, although there is a small effect of KLC1 in relation to cataract...
  36. ncbi Characterization of tau in cerebrospinal fluid using mass spectrometry
    Erik Portelius
    Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, University of Goteborg, Sahlgrenska University Hospital, S 431 80 Molndal, Sweden
    J Proteome Res 7:2114-20. 2008
    ..Nineteen tryptic fragments of tau were detected, of which 16 are found in all tau isoforms while 3 represented unique tau isoforms. These results pave the way for clinical CSF studies on the tauopathies...
  37. ncbi Simultaneous measurement of beta-amyloid(1-42), total tau, and phosphorylated tau (Thr181) in cerebrospinal fluid by the xMAP technology
    Annika Olsson
    Institute of Clinical Neuroscience, Sahlgrenska University Hospital, Molndal, Sweden
    Clin Chem 51:336-45. 2005
    ....
  38. ncbi Reward-related genes and personality traits in alcohol-dependent individuals: a pilot case control study
    Sara Landgren
    Department of Pharmacology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    Neuropsychobiology 64:38-46. 2011
    ..In conclusion, this pilot study suggests that reward-related genes are associated with altered personality scores in type 1 alcohol dependence, which warrants future studies of these associations in larger study samples...
  39. ncbi Neurofilament protein in cerebrospinal fluid: a marker of white matter changes
    M Sjogren
    Institute of Clinical Neuroscience, Goteborg University, Goteborg, Sweden
    J Neurosci Res 66:510-6. 2001
    ..Because NFL is located mainly in large myelinated axons, increased CSF NFL in individuals with WMC probably reflects axonal degeneration...
  40. ncbi Amyloid and tau cerebrospinal fluid biomarkers in HIV infection
    Magnus Gisslen
    Department of Infectious Diseases, University of Gothenburg, Sahlgrenska University Hospital, SE 416 85 Gothenburg, Sweden
    BMC Neurol 9:63. 2009
    ..Because of the emerging intersections of HIV infection and Alzheimer's disease, we examined cerebrospinal fluid (CSF) biomarkers related of amyloid and tau metabolism in HIV-infected patients...
  41. ncbi No association of VEGF polymorphims with Alzheimer's disease
    Sara Landgren
    Department of Pharmacology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Medicinaregatan 13A, Gothenburg, Sweden
    Neuromolecular Med 12:224-8. 2010
    ..No significant associations with risk for AD or any of the studied biomarkers could be found in this study, thus not supporting VEGF as being a major risk gene for AD...
  42. ncbi No neurochemical evidence for brain injury caused by heading in soccer
    Henrik Zetterberg
    Institute of Neuroscience and Physiology, Department of Neurochemistry and Psychiatry, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Br J Sports Med 41:574-7. 2007
    ..The possible injurious effect to the brain of heading in soccer is a matter of discussion...
  43. ncbi Identification of novel N-terminal fragments of amyloid precursor protein in cerebrospinal fluid
    Erik Portelius
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, S 431 80 Molndal, Sweden
    Exp Neurol 223:351-8. 2010
    ....
  44. ncbi Cerebrospinal fluid microglial markers in Alzheimer's disease: elevated chitotriosidase activity but lack of diagnostic utility
    Niklas Mattsson
    Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, S 431 80 Molndal, Sweden
    Neuromolecular Med 13:151-9. 2011
    ..Microglial markers are unlikely to be useful for AD diagnosis, but might be useful for identification of distinct subgroups of patients, and for the development and implementation of drugs targeting microglial pathology...
  45. ncbi Association of nAChR gene haplotypes with heavy alcohol use and body mass
    Sara Landgren
    Institute of Neuroscience and Physiology, Department of Pharmacology, University of Gothenburg, Sweden
    Brain Res 1305:S72-9. 2009
    ....
  46. ncbi Converging pathways of chromogranin and amyloid metabolism in the brain
    Niklas Mattsson
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Gothenburg and Mölndal, Sweden
    J Alzheimers Dis 20:1039-49. 2010
    ..Cell medium from BACE1-inhibited cells had decreased CgB levels. These results suggest that a large part of AbetaPP in the human central nervous system is processed in the regulated secretory pathway of neurons...
  47. ncbi Ubiquitin carboxyl-terminal esterase L1 (UCHL1) S18Y polymorphism in patients with cataracts
    Thiemo Rudolph
    Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, Section of Ophthalmology, The Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden
    Ophthalmic Genet 32:75-9. 2011
    ..A protective role of the p.S18Y polymorphism of the UCHL1 gene has been shown in Parkinson`s disease. The current study aimed to examine possible effects on cataract formation...
  48. ncbi Is there a CSF biomarker profile related to depression in elderly women?
    Pia Gudmundsson
    Institute of Neuroscience and Physiology, Section for Psychiatry and Neurochemistry, Sahlgrenska Academy at University of Gothenburg, Sweden
    Psychiatry Res 176:174-8. 2010
    ..This contrasts with the well-characterized pattern of low Abeta42, higher CSF/serum albumin ratio, and higher NFL in Alzheimer's disease...
  49. ncbi Kinesin gene variability may affect tau phosphorylation in early Alzheimer's disease
    Malin E Andersson
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Int J Mol Med 20:233-9. 2007
    ..018). These findings support earlier indications that genetic variability in the KNS2 gene may play a role during early stages of AD pathogenesis...
  50. ncbi The relationship between cerebrospinal fluid biomarkers and depression in elderly women
    Pia Gudmundsson
    Institute of Neuroscience and Physiology, Section for Psychiatry and Neurochemistry, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Am J Geriatr Psychiatry 15:832-8. 2007
    ..However, studies focusing on the relationship between these CSF biomarkers and geriatric depression are lacking...
  51. ncbi High education may offer protection against tauopathy in patients with mild cognitive impairment
    Sindre Rolstad
    Institute of Neuroscience and Physiology, Section for Neurochemistry and Psychiatry, The Sahlgrenska Academy at Goteborg University, Molndal, Sweden
    J Alzheimers Dis 21:221-8. 2010
    ..Also, educational level predicted a significant proportion of the total variance in t-tau concentrations. Our results suggest that higher education may offer protection against tauopathy...
  52. ncbi Genetic variation of the ghrelin signaling system in females with severe alcohol dependence
    Sara Landgren
    Department of Pharmacology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    Alcohol Clin Exp Res 34:1519-24. 2010
    ....
  53. ncbi Apolipoprotein E polymorphisms in patients with primary open-angle glaucoma
    Madeleine Zetterberg
    Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation, Section of Ophthalmology, The Sahlgrenska Academy at Goteborg University, Molndal, Sweden
    Am J Ophthalmol 143:1059-60. 2007
    ..To investigate apolipoprotein E (APOE) polymorphisms, which are known to influence the risk of Alzheimer disease (AD), in patients with primary open-angle glaucoma (POAG)...
  54. ncbi Neurogranin in cerebrospinal fluid as a marker of synaptic degeneration in Alzheimer's disease
    Annika Thorsell
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
    Brain Res 1362:13-22. 2010
    ..These results together suggest that cerebrospinal fluid neurogranin might be valuable together with the established AD biomarkers in the early diagnosis of AD and warrants further studies to determine the diagnostic value of neurogranin...
  55. ncbi CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment
    Niklas Mattsson
    Institute of Neuroscience and Physiology, Department of Neurochemistry and Psychiatry, the Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
    JAMA 302:385-93. 2009
    ....
  56. ncbi SILAC zebrafish for quantitative analysis of protein turnover and tissue regeneration
    Ann Westman-Brinkmalm
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Sweden
    J Proteomics 75:425-34. 2011
    ..This newly developed SILAC zebrafish model constitutes a novel tool to analyze tissue regeneration in an animal model amenable to genetic and pharmacologic manipulation...
  57. ncbi Variants of CYP46A1 may interact with age and APOE to influence CSF Abeta42 levels in Alzheimer's disease
    Annica Johansson
    Department of Clinical Neuroscience, Sahlgrenska University Hospital, Goteborg University, Goteborg, Sweden
    Hum Genet 114:581-7. 2004
    ..Our results provide an important independent replication of previous findings, supporting the existence of CYP46A1 sequence variants that contribute to variability in beta-amyloid metabolism...
  58. ncbi Neurochemical aftermath of amateur boxing
    Henrik Zetterberg
    Department of Experimental Neuroscience, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Arch Neurol 63:1277-80. 2006
    ..Little solid information is available on the possible risks for neuronal injury in amateur boxing...
  59. ncbi Amyloid-??? is associated with cognitive impairment in healthy elderly and subjective cognitive impairment
    Sindre Rolstad
    Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden
    J Alzheimers Dis 26:135-42. 2011
    ..A??? is associated with cognitive functions from a potentially early to a later disease phase, and T-tau is more indicative of performance in a later disease phase...
  60. ncbi Methylenetetrahydrofolate reductase genetic polymorphisms in patients with primary open-angle glaucoma
    Madeleine Zetterberg
    Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation, Section of Ophthalmology, The Sahlgrenska Academy at Goteborg University, Molndal, Sweden
    Ophthalmic Genet 28:47-50. 2007
    ..The purpose of the present study was to determine if hyperhomocysteinemia-associated polymorphisms of the methylenetetrahydrofolate reductase gene (MTHFR) are overrepresented in primary open-angle glaucoma...
  61. ncbi Genetic association of CDC2 with cerebrospinal fluid tau in Alzheimer's disease
    Annica Johansson
    Department of Clinical Neuroscience, Unit of Neurochemistry, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Dement Geriatr Cogn Disord 20:367-74. 2005
    ..006, OR = 1.57, 95% CI 1.13-2.17). Our results provide further evidence for an involvement of cdc2 in the pathogenesis of AD...
  62. ncbi Cerebrospinal fluid alpha-synuclein in neurodegenerative disorders-a marker of synapse loss?
    Annika Ohrfelt
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
    Neurosci Lett 450:332-5. 2009
    ..The lower alpha-syn levels in AD, as well as the association of alpha-syn reduction with AD severity, approximated by MMSE, suggests that it may be a general marker of synapse loss, a hypothesis that warrants further investigation...
  63. ncbi Gene-gene interaction between fetal MTHFR 677C>T and transcobalamin 776C>G polymorphisms in human spontaneous abortion
    Henrik Zetterberg
    Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Goteborg University, S 413 45 Goteborg, Sweden
    Hum Reprod 18:1948-50. 2003
    ..It was hypothesized that there may be a significant interaction between MTHFR and TC genotypes which affects the pathogenesis of spontaneous abortion...
  64. ncbi Reduced levels of amyloid-beta-binding proteins in cerebrospinal fluid from Alzheimer's disease patients
    Sara F Hansson
    Neurochemical Laboratory, Department of Neuroscience and Physiology, Section of Psychiatry and Neurochemistry, The Sahlgrenska Academy at Goteborg University, Sahlgrenska University Hospital Molndal, Molndal, Sweden
    J Alzheimers Dis 16:389-97. 2009
    ..015). Positive correlations between Abeta(1-42) and beta-trace, CysC and TTR, respectively, were seen only in the AD group, suggesting that deficient Abeta-binding capacity in CSF may contribute to the amyloidogenic process in AD...
  65. ncbi Identification of novel APP/Abeta isoforms in human cerebrospinal fluid
    Erik Portelius
    Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, University of Goteborg, Sahlgrenska University Hospital, Molndal, Sweden
    Neurodegener Dis 6:87-94. 2009
    ..A lot of research has focused on Abeta production and the neurotoxic 42-amino-acid form of Abeta (Abeta1-42), while less is known about the nonamyloidogenic pathway and how Abeta is degraded...
  66. ncbi No association of LOXL1 gene polymorphisms with Alzheimer's disease
    Alexandra Abramsson
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    Neuromolecular Med 13:160-6. 2011
    ..No evidence for associations of these polymorphisms with risk for AD or any of the studied CSF biomarkers measured was found. These results do not support LOXL1 as being a major risk gene for AD...
  67. ncbi Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y polymorphism in Alzheimer's disease
    Madeleine Zetterberg
    Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation, Section of Ophthalmology, The Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden
    Mol Neurodegener 5:11. 2010
    ..82 ([95% CI 0.55-1.24], P = 0.35) was obtained for a positive UCHL1 allele A carrier status. The present study thus do not support a protective effect of the UCHL1 S18Y polymorphism against AD...
  68. ncbi Converging molecular pathways in human neural development and degeneration
    Niklas Mattsson
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at University of Gothenburg, Göteborg Mölndal, Sweden
    Neurosci Res 66:330-2. 2010
    ..Tau phosphorylation in Alzheimer's disease may be a physiological response to Alzheimer-associated synaptotoxicity...
  69. ncbi Characterization of amyloid beta peptides in cerebrospinal fluid by an automated immunoprecipitation procedure followed by mass spectrometry
    Erik Portelius
    Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, University of Goteborg, Sahlgrenska University Hospital, S 431 80 Molndal, Sweden
    J Proteome Res 6:4433-9. 2007
    ..Finally, we report the finding of two novel Abeta peptides (Abeta2-17 and Abeta3-17)...
  70. ncbi Proteomics/peptidomics tools to find CSF biomarkers for neurodegenerative diseases
    Ann Westman-Brinkmalm
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neuochemistry, The Sahlgrenska Academy at Goteborg University, Sweden
    Front Biosci 14:1793-806. 2009
    ..In this review we discuss our experience in the field of neuroproteomics/peptidomics, with special focus on biomarker discovery studies that have been performed on CSF samples from well-defined patient and control populations...
  71. ncbi Advances in the detection of Alzheimer's disease-use of cerebrospinal fluid biomarkers
    Magnus Sjogren
    Institute of Clinical Neuroscience, Goteborg University, SE 431 80, Goteborg, Sweden
    Clin Chim Acta 332:1-10. 2003
    ..It increases if P-tau is added. An increasing number of studies suggest that supplementary use of these CSF markers, preferably in combination, adds to the accuracy of an AD diagnosis...
  72. ncbi Neurochemical measures co-vary with personality traits: forensic psychiatric findings replicated in a general population sample
    Thomas Nilsson
    Institute of Neuroscience and Physiology, University of Gothenburg, Sweden
    Psychiatry Res 178:525-30. 2010
    ....
  73. ncbi Elevated cerebrospinal fluid BACE1 activity in incipient Alzheimer disease
    Henrik Zetterberg
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at Goteborg University, Molndal, Sweden
    Arch Neurol 65:1102-7. 2008
    ....
  74. ncbi Methylenetetrahydrofolate reductase genetic polymorphisms in patients with cataract
    Madeleine Zetterberg
    Institute of Clinical Neuroscience, Section of Ophthalmology, Sahlgrenska University Hospital, Goteborg University, Molndal, Sweden
    Am J Ophthalmol 140:932-4. 2005
    ..The level of homocysteine can be lowered by dietary intake of folate. A protective effect of folate supplementation has been reported against cataract. Here we investigate MTHFR polymorphisms in human cataract...
  75. ncbi Effects of gamma-secretase inhibition on the amyloid beta isoform pattern in a mouse model of Alzheimer's disease
    Erik Portelius
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, SE 431 80 Molndal, Sweden
    Neurodegener Dis 6:258-62. 2009
    ..g. Abeta1-15 and Abeta1-16), and that the levels of these shorter isoforms are elevated in media from cells that have been treated with gamma-secretase inhibitors...
  76. ncbi Influence of the apolipoprotein E epsilon4 allele on human embryonic development
    Henrik Zetterberg
    Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Goteborg University, 41345 Gothenburg, Sweden
    Neurosci Lett 324:189-92. 2002
    ..005), suggesting that epsilon4 may have protective effects during embryogenesis. These protective effects might counterbalance the deleterious age-related effects of the epsilon4 allele in natural selection...
  77. ncbi An Alzheimer's disease-specific beta-amyloid fragment signature in cerebrospinal fluid
    Erik Portelius
    Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, University of Goteborg, Sahlgrenska University Hospital, Molndal, Sweden
    Neurosci Lett 409:215-9. 2006
    ..Here, we provide direct evidence that an Abeta fragment signature consisting of Abeta1-16, Abeta1-33, Abeta1-39, and Abeta1-42 in CSF distinguishes sporadic AD patients from non-demented controls with an overall accuracy of 86%...
  78. ncbi Cerebrospinal fluid concentrations of peptides derived from chromogranin B and secretogranin II are decreased in multiple sclerosis
    Niklas Mattsson
    Department of Neurochemistry and Psychiatry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at Goteborg University, Molndal, Sweden
    J Neurochem 103:1932-9. 2007
    ..Further studies will investigate the involvement of these peptides in MS pathogenesis...
  79. ncbi CSF biomarkers in the evaluation of idiopathic normal pressure hydrocephalus
    A Agren-Wilsson
    Department of Clinical Neuroscience, Umea University, Umea, Sweden
    Acta Neurol Scand 116:333-9. 2007
    ..CONCLUSIONS - The most striking finding was the power of the combined pattern of NFL, P-tau, and Abeta42 in distinguishing between the clinical diagnoses of INPH, SAE, and neurologically healthy elderly...
  80. ncbi Mass spectrometric characterization of brain amyloid beta isoform signatures in familial and sporadic Alzheimer's disease
    Erik Portelius
    Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
    Acta Neuropathol 120:185-93. 2010
    ..No prominent differences in Abeta isoform patterns between FAD and SAD patients were seen, underscoring the similarity in the amyloid pathology of these two disease entities...
  81. ncbi Cerebrospinal fluid markers for prediction of Alzheimer's disease
    Henrik Zetterberg
    Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Goteborg University, S 413 45 Gothenburg, Sweden
    Neurosci Lett 352:67-9. 2003
    ..The usefulness of these markers is further emphasized by the finding of a positive predictive value of 94% and a negative predictive value of 81%...
  82. ncbi Cerebrospinal fluid beta-amyloid 1-42 concentration may predict cognitive decline in older women
    Deborah R Gustafson
    The Institute of Neuroscience and Physiology, Section for Psychiatry and Neurochemistry, Neuropsychiatric Epidemiology Unit, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    J Neurol Neurosurg Psychiatry 78:461-4. 2007
    ..It is not known, however, whether these biomarkers may be risk indicators for cognitive decline in otherwise healthy older people...
  83. ncbi Neurochemical dissection of synaptic pathology in Alzheimer's disease
    P Davidsson
    Department of Clinical Neuroscience, Sahlgrenska University Hospital, Molndal, Sweden
    Int Psychogeriatr 10:11-23. 1998
    ..The finding that all synaptic proteins were reduced in AD suggests a degeneration and loss of whole synaptic elements that are more pronounced in EAD than in LAD...
  84. ncbi One-carbon metabolism and other biochemical correlates of cognitive impairment as visualized by principal component analysis
    J Gottfries
    Psychiatry Section, The Institute of Clinical Neuroscience, , , , Sweden
    J Geriatr Psychiatry Neurol 14:109-14. 2001
    ..There was poor discrimination between DAT and VAD...
  85. ncbi The cerebrospinal fluid levels of tau, growth-associated protein-43 and soluble amyloid precursor protein correlate in Alzheimer's disease, reflecting a common pathophysiological process
    M Sjogren
    Institute of Clinical Neuroscience, Goteborg University, Sahlgrenska University Hospital, Molndal, Sweden
    Dement Geriatr Cogn Disord 12:257-64. 2001
    ..The correlations found may reflect a common pathophysiologic process such as axonal degeneration...
  86. ncbi Monitoring of brain interstitial total tau and beta amyloid proteins by microdialysis in patients with traumatic brain injury
    Niklas Marklund
    Department of Neuroscience, Neurosurgery, Uppsala University Hospital, Uppsala, Gothenburg, Sweden
    J Neurosurg 110:1227-37. 2009
    ....
  87. ncbi Initial CSF total tau correlates with 1-year outcome in patients with traumatic brain injury
    M Ost
    Department of Anesthesiology and Intensive Care Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
    Neurology 67:1600-4. 2006
    ..We investigated if tau, microtubular binding protein, in serum and ventricular CSF (vCSF) in patients with severe traumatic brain injury (TBI) during the initial posttraumatic days correlated to 1-year outcome...
  88. ncbi A quantitative and immunohistochemical study on apolipoprotein E in brain tissue in Alzheimer's disease
    C Hesse
    Department of Clinical Neuroscience, Unit of Neurochemistry, University of Goteborg, Sahlgren s University Hospital, Molndal, Sweden
    Dement Geriatr Cogn Disord 10:452-9. 1999
    ..One may speculate whether the decrease in ApoE may suggest a disturbance in the ApoE system in AD that is unrelated to ApoE isoforms, beta-amyloid deposition and NFT formation. Copyrightz1999S.KargerAG,Basel..
  89. ncbi Combination of hippocampal volume and cerebrospinal fluid biomarkers improves predictive value in mild cognitive impairment
    C Eckerström
    Institute of Neuroscience and Physiology, Linguistics and Theory of Science, University of Gothenburg, Molndal, Sweden
    Dement Geriatr Cogn Disord 29:294-300. 2010
    ..Recent findings suggest that hippocampal volumetry and CSF biomarkers can be used to predict which MCI patients have an underlying neurodegenerative disorder...
  90. ncbi A population study on blood-brain barrier function in 85-year-olds: relation to Alzheimer's disease and vascular dementia
    I Skoog
    Department of Psychiatry, Sahlgrenska University Hospital, Goteborg, Sweden
    Neurology 50:966-71. 1998
    ..6 +/- 2.1; p = 0.029) than other individuals. A relative BBB dysfunction is associated with both AD and VAD among very elderly individuals. This finding is possibly found early in the disease before the onset of clinical dementia...
  91. ncbi No association between the alpha2-macroglobulin (A2M) deletion and Alzheimer's disease, and no change in A2M mRNA, protein, or protein expression
    K Blennow
    Department of Clinical Neuroscience, University of Goteborg, Sahlgren s University Hospital, Molndal, Sweden
    J Neural Transm 107:1065-79. 2000
    ..The lack of an association between the A2M-2 allele and AD in the present study, and the lack of abnormalities in the A2M mRNA or protein suggest that the A2M-2 allele is not associated with AD...
  92. ncbi Evolution of Abeta42 and Abeta40 levels and Abeta42/Abeta40 ratio in plasma during progression of Alzheimer's disease: a multicenter assessment
    K Blennow
    Sahlgrenska University Hospital, Goteborg University, Sweden
    J Nutr Health Aging 13:205-8. 2009
    ..To better understand the seemingly contradictory plasma beta-amyloid (Abeta) results in Alzheimer's disease (AD) patients by using a newly developed plasma Abeta assay, the INNO-BIA plasma Abeta forms, in a multicenter study...
  93. ncbi Identification of CSF biomarkers for frontotemporal dementia using SELDI-TOF
    Ulla Ruetschi
    Institute of Laboratory Medicine, Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Goteborg University, Sweden
    Exp Neurol 196:273-81. 2005
    ..With use of these potential biomarkers, FTD can be distinguished from control subjects with high accuracy in this pilot study...
  94. ncbi Intra-individual stability of CSF biomarkers for Alzheimer's disease over two years
    Henrik Zetterberg
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at Goteborg University, Molndal, Sweden
    J Alzheimers Dis 12:255-60. 2007
    ..Thus, even minor biochemical changes induced by treatment against AD should be detectable using these biomarkers, which bodes well for their usefulness as surrogate markers for drug efficacy in clinical trials...
  95. ncbi Apolipoprotein E polymorphism and gender difference in outcome after severe traumatic brain injury
    M Ost
    Department of Anesthesiology and Intensive Care Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
    Acta Anaesthesiol Scand 52:1364-9. 2008
    ..Studies have demonstrated a connection between apolipoprotein E (APOE) genotype and outcome after TBI, but few are prospective and none is from northern Europe. APOE has three alleles: epsilon2, epsilon3 and epsilon4...
  96. ncbi CSF levels of tau, beta-amyloid(1-42) and GAP-43 in frontotemporal dementia, other types of dementia and normal aging
    M Sjogren
    Institute of Clinical Neuroscience, Göbteborg University, Sahlgrenska University Hospital, Molndal, Sweden
    J Neural Transm 107:563-79. 2000
    ..In SWD, decreased levels of CSF-beta-amyloid(1-42) suggest concomitant involvement of vascular and amyloid protein mechanisms...
  97. ncbi Transient increase in total tau but not phospho-tau in human cerebrospinal fluid after acute stroke
    C Hesse
    Institute of Clinical Neuroscience, Unit of Neurochemistry, , , SE-431 80, , Sweden
    Neurosci Lett 297:187-90. 2001
    ....
  98. ncbi Proteome analysis of cerebrospinal fluid proteins in Alzheimer patients
    Pia Davidsson
    Department of Clinical Neuroscience, Experimental Neuroscience Section, , , SE-431 80, Sweden
    Neuroreport 13:611-5. 2002
    ..The most prominently altered proteins were the apolipoproteins, especially proapolipoprotein...
  99. ncbi Clusterin in cerebrospinal fluid: analysis of carbohydrates and quantification of native and glycosylated forms
    A M Nilselid
    Institute of Clinical Neuroscience, The Sahlgrenska Academy at Goteborg University, Sahlgrenska University Hospital, SE 431 80 Molndal, Sweden
    Neurochem Int 48:718-28. 2006
    ..However, the individual clusterin levels overlap between the two groups, and thus cerebrospinal fluid clusterin measurement is not suitable as a biochemical marker in the diagnosis of Alzheimer's disease...
  100. ncbi Measurement of apolipoprotein E (apoE) in cerebrospinal fluid
    C Hesse
    Institute of Clinical Neuroscience, Unit of Neurochemistry, University of Goteborg, Sahlgren s University Hospital Mölndal, Sweden
    Neurochem Res 25:511-7. 2000
    ..Differences in the amount of patients and controls possessing the ApoE4 allele included might also increase the variance between different studies...