Weight-based dosing of enoxaparin in obese patients with non-ST-segment elevation acute coronary syndromes: results from the CRUSADE initiativeSarah A Spinler
Department of Pharmacy Practice and Pharmacy Administration, Philadelphia College of Pharmacy, University of the Sciences in Philadelphia, Philadelphia, Pennsylvania 19104, USA
Pharmacotherapy 29:631-8. 2009
..To evaluate how enoxaparin is dosed in contemporary clinical practice as a function of patients' total body weight (TBW) and body mass index (BMI), and to determine any association between dose and major bleeding...
- Aspirin, clopidogrel, and warfarin: is the combination appropriate and effective or inappropriate and too dangerous?
A Janelle Hermosillo
Department of Pharmacy Practice and Pharmacy Administration, Philadelphia College of Pharmacy, University of the Sciences in Philadelphia, Philadelphia, PA 19104, USA
Ann Pharmacother 42:790-805. 2008
..To review the rationale, clinical practice guideline recommendations, and clinical trial data describing bleeding and clinical outcomes associated with the use of the combination of aspirin, a thienopyridine, and warfarin...
- Anticoagulation monitoring part 2: Unfractionated heparin and low-molecular-weight heparin
Sarah A Spinler
Cardiovascular Division, Department of Medicine, Philadelphia College of Pharmacy, University of Pennsylvania, Philadelphia, PA, USA
Ann Pharmacother 39:1275-85. 2005
..To review the availability, mechanisms, limitations, and clinical application of point-of-care (POC) devices used in monitoring anticoagulation with unfractionated heparin (UFH) and low-molecular-weight heparins (LMWHs)...
- Managing acute coronary syndrome: evidence-based approaches
Sarah A Spinler
University of Sciences in Philadelphia, Philadelphia College of Pharmacy, Pennsylvania 19104 4495, USA
Am J Health Syst Pharm 64:S14-24. 2007
....
- Percutaneous coronary intervention: assessing coronary vascular risk associated with bare-metal and drug-eluting stents
Sarah A Spinler
Department of Pharmacy Practice Pharmacy Administration, University of the Sciences in Philadelphia, 600 S 43rd St, Box GRI 108 T, Philadelphia, PA 19104, USA
Am J Manag Care 15:S42-7. 2009
..It is important that clinicians be aware of the indications for dual antiplatelet therapy and the appropriate durations of dual antiplatelet therapy in patients undergoing PCI...
- A benchmark for platelet count monitoring with low-molecular-weight heparin: expanding implementation of National Patient Safety Goals
Sarah A Spinler
Department of Pharmacy Practice and Pharmacy Administration, Philadelphia College of Pharmacy, University of Sciences in Philadelphia, 600 S 43rd St, Philadelphia, PA 19104, USA
Ann Pharmacother 43:1519-21. 2009
....
- Safety and tolerability of antiplatelet therapies for the secondary prevention of atherothrombotic disease
Sarah A Spinler
Philadelphia College of Pharmacy, University of the Sciences in Philadelphia, Philadelphia, Pennsylvania 19104 4495, USA
Pharmacotherapy 29:812-21. 2009
..Overall, aspirin, clopidogrel, aspirin plus clopidogrel, and aspirin plus extended-release dipyridamole have favorable risk-versus-benefit profiles when used as recommended in appropriate patient populations...
- Antithrombotic therapy for acute coronary syndromes
Sarah A Spinler
Philadelphia College of Pharmacy, University of the Sciences in Philadelphia, 600 South 43rd Street, Philadelphia, PA 19104, USA
J Am Pharm Assoc (2003) 44:S14-26; quiz S26-7. 2004
..To review the role of antithrombotic therapy for treatment of acute coronary syndromes (ACS) in the hospital setting...
- The role of apixaban for venous and arterial thromboembolic disease
Rathasen Prom
Department of Pharmacy Practice and Pharmacy Administration, Philadelphia College of Pharmacy, University of the Sciences, Philadelphia, PA, USA
Ann Pharmacother 45:1262-83. 2011
..To provide a comprehensive review of the pharmacology, pharmacokinetics, pharmacodynamics, clinical trial data, adverse effects, and drug interactions of apixaban...
- New concepts in heparin-induced thrombocytopenia: diagnosis and management
Sarah A Spinler
Philadelphia College of Pharmacy, University of the Sciences in Philadelphia, 600 S 43rd St, Philadelphia, PA 19104, USA
J Thromb Thrombolysis 21:17-21. 2006
..While several reports have described the treatment and prophylaxis of thrombosis in patients with HIT using fondaparinux, clinical trials should be conducted and reported before fondaparinux becomes a therapy of choice for HIT...
- Anticoagulation monitoring part 1: warfarin and parenteral direct thrombin inhibitors
Sarah A Spinler
Cardiovascular Division, Department of Medicine, Philadelphia College of Pharmacy, University of Pennsylvania, Philadelphia, PA 19104 4495, USA
Ann Pharmacother 39:1049-55. 2005
..To review the availability, mechanisms, limitations, and clinical application of point-of-care (POC) devices used in the management of warfarin and parenteral direct thrombin inhibitors...
- Overview of heparin-induced thrombocytopenia
Sarah A Spinler
Department of Pharmacy Practice and Pharmacy Administration, Philadelphia College of Pharmacy, University of the Sciences, Philadelphia, 600 S 43rd Street, Philadelphia, PA 19104, USA
Am J Health Syst Pharm 60:S5-11. 2003
..The appropriate use of DTIs in HIT reduces the risk of thrombotic events and severe consequences associated with this serious drug reaction...
- Review of prasugrel for the secondary prevention of atherothrombosis
Sarah A Spinler
University of the Sciences in Philadelphia, Department of Pharmacy Practice and Pharmacy Administration, 600 S 43rd St, Philadelphia, PA 19104, USA
J Manag Care Pharm 15:383-95. 2009
....
- History of depression as a predictor of adverse outcomes in patients hospitalized for decompensated heart failure
Simon de Denus
Philadelphia College of Pharmacy, University of the Sciences in Philadelphia, Philadelphia, Pennsylvania 19104, USA
Pharmacotherapy 24:1306-10. 2004
..Our results require confirmation in larger trials...
- Oral antiplatelet therapy after acute coronary syndrome and percutaneous coronary intervention: balancing efficacy and bleeding risk
Sarah A Spinler
Philadelphia College of Pharmacy, University of the Sciencesin Philadelphia, 600 South 43rd Street, Philadelphia, PA 19104, USA
Am J Health Syst Pharm 67:S7-17. 2010
..The benefits and risk of bleeding associated with oral antiplatelet agents used for acute coronary syndrome (ACS) or in patients who have undergone percutaneous coronary intervention (PCI) are discussed...
- Statins and liver toxicity: a meta-analysis
Simon de Denus
Philadelphia College of Pharmacy, University of the Sciences in Philadelphia, PA 19103-4495, USA
Pharmacotherapy 24:584-91. 2004
..Additional data are required to determine whether other statins have a similar safety profile...
- Relationship between renal function and outcomes in high-risk patients with non-ST-segment elevation acute coronary syndromes: results from SYNERGY
Sarah A Spinler
Department of Pharmacy Practice and Pharmacy Administration, Philadelphia College of Pharmacy, University of the Sciences in Philadelphia, Philadelphia, PA, USA
Int J Cardiol 144:36-41. 2010
..We evaluated the effect of renal function on efficacy and outcomes in high-risk patients with NSTE ACS in the SYNERGY trial...
- Dabigatran etexilate: an oral direct thrombin inhibitor for prophylaxis and treatment of thromboembolic diseases
Brooke E Baetz
Department of Pharmacy Practice and Pharmacy Administration, University of the Sciences in Philadelphia, PA 19104, USA
Pharmacotherapy 28:1354-73. 2008
..Results of short-term efficacy and safety appear promising. Further research is needed regarding long-term safety and efficacy for other anticoagulation indications...
- Duration of clopidogrel therapy after placement of drug-eluting intracoronary stent
Sarah A Spinler
Philadelphia College of Pharmacy, University of the Sciences in Philadelphia, PA 19104, USA
Am J Health Syst Pharm 64:1432-4. 2007
- ST-segment-elevation myocardial infarction: guidelines and the challenge of real-world patient care
Sarah A Spinler
Department of Pharmacy Practice and Pharmacy Administration, Philadelphia College of Pharmacy, University of the Sciences in Philadelphia, Philadelphia, Pennsylvania 19104, USA
Pharmacotherapy 26:115S-122S. 2006
..This approach may shorten the time to effective reperfusion and improve outcomes. Ongoing studies will help in determining the role this facilitated-PCI strategy may play in effective management of STEMI...
- Safety and efficacy of unfractionated heparin versus enoxaparin in patients who are obese and patients with severe renal impairment: analysis from the ESSENCE and TIMI 11B studies
Sarah A Spinler
Philadelphia College of Pharmacy, University of the Sciences in Philadelphia, PA 19104, USA
Am Heart J 146:33-41. 2003
..However, no data are available about the safety and efficacy in patients who are obese and patients with severe renal impairment...
- Efficacy of statins in preventing progression of aortic stenosis
Daniel W Quinn
Philadelphia College of Pharmacy, University of the Sciences, Philadelphia, PA 19104, USA
Am J Health Syst Pharm 62:979-81. 2005
- Managing heparin-induced thrombocytopenia: preventing life- and limb-threatening thrombosis. Introduction
Sarah A Spinler
Department of Pharmacy Practice and Pharmacy Administration, Philadelphia College of Pharmacy, University of the Sciences, Philadelphia (USP, PA, USA
Am J Health Syst Pharm 60:S2-4. 2003
