First-trimester ultrasound and biochemical markers of aneuploidy and the prediction of impending fetal deathK Spencer
Prenatal Screening Unit, Clinical Biochemistry Department, Harold Wood Hospital, Romford, Essex, UK
Ultrasound Obstet Gynecol 28:637-43. 2006
..To examine the clinical utility of the first-trimester markers of aneuploidy in their ability to predict future fetal loss...
- Second-trimester uterine artery Doppler pulsatility index and maternal serum PP13 as markers of pre-eclampsia
Kevin Spencer
Department of Clinical Biochemistry, Harold Wood Hospital, Romford, UK
Prenat Diagn 27:258-63. 2007
....
- A link between high serum levels of human chorionic gonadotrophin and chorionic expression of its mature functional receptor (LHCGR) in Down's syndrome pregnancies
Subhasis Banerjee
Harris Birthright Research Centre for Fetal Medicine, King s College Hospital Medical School, Denmark Hill, London SE5 9RS, UK
Reprod Biol Endocrinol 3:25. 2005
..However, the synthesis of high molecular weight mature LHCGR proteins was significantly reduced in DS compared to uncompromised pregnancies, suggesting a lack of utilization of circulating hCG in DS pregnancies...
- Second-trimester levels of pregnancy-associated plasma protein-A and free beta-hCG in pregnancies with trisomy 13
K Spencer
Prenatal Screening Unit, Department of Clinical Biochemistry, Harold Wood Hospital, Essex, UK
Prenat Diagn 25:358-61. 2005
....
- First-trimester maternal serum PP-13, PAPP-A and second-trimester uterine artery Doppler pulsatility index as markers of pre-eclampsia
K Spencer
Department of Clinical Biochemistry, Harold Wood Hospital, Romford, UK
Ultrasound Obstet Gynecol 29:128-34. 2007
..plasma protein-A (PAPP-A) at 11 + 0 to 13 + 6 weeks of gestation alone or in combination with second-trimester uterine artery pulsitility measured by Doppler velocimetry is useful in predicting those women who will develop pre-eclampsia..
- Temporal changes in maternal serum biochemical markers of trisomy 21 across the first and second trimester of pregnancy
K Spencer
Endocrine Unit, Clinical Biochemistry Department, Harold Wood Hospital Gubbins Lane Romford Essex RM3 0BE, UK
Ann Clin Biochem 39:567-76. 2002
..Many maternal serum markers show concentration changes in Down's syndrome pregnancies but the magnitude of the change in median marker levels varies with gestation. To date these changes have not been accurately specified...
- Uptake of prenatal screening for chromosomal anomalies: impact of test results in a previous pregnancy
Kevin Spencer
Prenatal Screening Unit, Clinical Biochemistry Dept, Harold Wood Hospital, Gubbins Lane, Romford, RM3 0BE, UK
Prenat Diagn 22:1229-32. 2002
..To assess whether the uptake of prenatal screening for trisomy 21 in a subsequent pregnancy is influenced by being classified in the 'increased risk' or 'not at increased risk' group in the first pregnancy...
- Aneuploidy screening in the first trimester
Kevin Spencer
Prenatal Screening Unit, Clinical Biochemistry Department, Harold Wood Hospital, Romford, UK
Am J Med Genet C Semin Med Genet 145:18-32. 2007
....
- A first trimester trisomy 13/trisomy 18 risk algorithm combining fetal nuchal translucency thickness, maternal serum free beta-hCG and PAPP-A
Kevin Spencer
Endocrine Unit, Clinical Biochemistry Department, Harold Wood Hospital, Gubbins Lane, Romford RM3 0BE, UK
Prenat Diagn 22:877-9. 2002
..3% false positive rate allow 95% of these chromosomal defects to be identified at 11-14 weeks. Such algorithms will enhance existing first trimester screening algorithms for trisomy 21...
- Between pregnancy biological variability of first trimester markers of Down syndrome and the implications for screening in subsequent pregnancies: an issue revisited
Kevin Spencer
Endocrine Unit, Clinical Biochemistry Department, Harold Wood Hospital, Gubbins Lane, Romford, Essex, RM3 0BE, UK
Prenat Diagn 22:874-6. 2002
..To assess the impact that between pregnancy biological variability has on the likelihood that women who are at increased risk in a first pregnancy being also at increased risk in a subsequent pregnancy...
- The influence of different sample collection types on the levels of markers used for Down's syndrome screening as measured by the Kryptor Immunosassay system
Kevin Spencer
Clinical Biochemistry Department, Harold Wood Hospital, Gubbins Lane, Romford RM3 0BE, UK
Ann Clin Biochem 40:166-8. 2003
..The need to leave whole blood samples some 10 min for coagulation and a further 5 min for centrifugation adds additional processing time...
- Prediction of pre-eclampsia by uterine artery Doppler ultrasonography and maternal serum pregnancy-associated plasma protein-A, free beta-human chorionic gonadotropin, activin A and inhibin A at 22 + 0 to 24 + 6 weeks' gestation
K Spencer
Prenatal Screening Unit, Clinical Biochemistry Department, Harold Wood Hospital, Romford, UK
Ultrasound Obstet Gynecol 27:658-63. 2006
....
- Increased total cell-free DNA in the serum of pregnant women carrying a fetus affected by trisomy 21
Kevin Spencer
Department of Clinical Biochemistry, Harold Wood Hospital, Gubbins Lane, Romford, Essex RM3 0BE, UK
Prenat Diagn 23:580-3. 2003
..Analysis of the levels of cell-free fetal and total DNA in serum of women carrying a male fetus affected by trisomy 21, and comparison of these levels with those in women carrying a normal male fetus...
- Ethnicity and the need for correction of biochemical and ultrasound markers of chromosomal anomalies in the first trimester: a study of Oriental, Asian and Afro-Caribbean populations
K Spencer
Prenatal Screening Unit, Clinical Biochemistry Department, Harold Wood Hospital, Essex, UK
Prenat Diagn 25:365-9. 2005
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- Factors affecting women's preference for type of prenatal screening test for chromosomal anomalies
K Spencer
Prenatal Screening Unit, Clinical Biochemistry Department, Harold Wood Hospital, Romford, Essex, UK
Ultrasound Obstet Gynecol 24:735-9. 2004
..To ascertain, by means of a questionnaire, women's preferences for four different approaches to prenatal screening for Down syndrome...
- First trimester maternal serum screening for Down's syndrome: an evaluation of the DPC Immulite 2000 free beta-hCG and pregnancy-associated plasma protein-A assays
Kevin Spencer
Prenatal Screening Unit, Clinical Biochemistry Department, Harold Wood Hospital, Gubbins Lane, Romford, Essex, UK
Ann Clin Biochem 42:30-40. 2005
..With the recent launch of these assays on the DPC Immulite 2000 platform, it is appropriate and timely to investigate their clinical and analytical performance on a high throughput immunoassay analyser...
- Prediction of pregnancy complications by first-trimester maternal serum PAPP-A and free beta-hCG and with second-trimester uterine artery Doppler
Kevin Spencer
Prenatal Screening Unit, Department of Clinical Biochemistry, Harold Wood Hospital, Essex, UK
Prenat Diagn 25:949-53. 2005
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- The impact of correcting for smoking status when screening for chromosomal anomalies using maternal serum biochemistry and fetal nuchal translucency thickness in the first trimester of pregnancy
Kevin Spencer
Clinical Biochemistry Department, Harold Wood Hospital, Gubbins Lane, Romford, Essex, UK
Prenat Diagn 24:169-73. 2004
....
- The influence of maternal insulin-dependent diabetes on fetal nuchal translucency thickness and first-trimester maternal serum biochemical markers of aneuploidy
Kevin Spencer
Prenatal Screening Unit, Clinical Biochemistry Department, Harold Wood Hospital, Romford, Essex, UK
Prenat Diagn 25:927-9. 2005
....
- Maternal weight correction of maternal serum PAPP-A and free beta-hCG MoM when screening for trisomy 21 in the first trimester of pregnancy
Kevin Spencer
Clinical Biochemistry Department, Harold Wood Hospital, Gubbins Lane, Romford, Essex, UK
Prenat Diagn 23:851-5. 2003
..To assess the suitability of either the log-linear or reciprocal-linear regression procedure for maternal weight correction of biochemical marker MoMs in the first trimester...
- Delta-NT or NT MoM: which is the most appropriate method for calculating accurate patient-specific risks for trisomy 21 in the first trimester?
K Spencer
Clinical Biochemistry Department, Harold Wood Hospital, Romford, UK
Ultrasound Obstet Gynecol 22:142-8. 2003
..To assess whether in screening for trisomy 21 by nuchal translucency (NT) the delta or the multiples of the median (MoM) approach is the most appropriate method for calculating accurate individual patient-specific risks...
- ADAM12 as a marker of trisomy 18 in the first and second trimester of pregnancy
Kevin Spencer
Prenatal Screening Unit, Clinical Biochemistry Department, Harold Wood Hospital, Romford, UK
J Matern Fetal Neonatal Med 20:645-50. 2007
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- Maternal serum ADAM12s as a marker of rare aneuploidies in the first or second trimester of pregnancy
Kevin Spencer
Prenatal Research Unit, Department of Clinical Biochemistry, King George Hospital, Barley Lane, Goodmayes, UK
Prenat Diagn 27:1233-7. 2007
..To assess whether the maternal serum ADAM12s concentrations are altered in the first and second trimester of pregnancies complicated by rare aneuploides...
- First-trimester ultrasound and biochemical markers of aneuploidy and the prediction of preterm or early preterm delivery
K Spencer
Prenatal Screening Unit, Clinical Biochemistry Department, Harold Wood Hospital, Romford, Essex, UK
Ultrasound Obstet Gynecol 31:147-52. 2008
..To examine the clinical utility of the first-trimester markers of aneuploidy in their ability to predict preterm delivery...
- Screening for chromosomal anomalies in the first trimester: does repeat maternal serum screening improve detection rates?
Kevin Spencer
Clinical Biochemistry Department, Harold Wood Hospital, Gubbins Lane, Romford, Essex RM3 0BE, UK
Prenat Diagn 22:903-6. 2002
..To evaluate whether repeat sampling and testing of free beta-hCG and PAPP-A during this period would result in an improved detection rate...
- A re-evaluation of the influence of maternal insulin-dependent diabetes on fetal nuchal translucency thickness and first-trimester maternal serum biochemical markers of aneuploidy
K Spencer
Prenatal Screening Unit, Clinical Biochemistry Department, Barking Havering and Redbridge University Hospitals, King George Hospital, Goodmayes, UK
Prenat Diagn 30:937-40. 2010
....
- Early vaginal bleeding has no impact on markers used in first trimester aneuploidy screening
K Spencer
Prenatal Screening Unit, Clinical Biochemistry Department, King George Hospital, Goodmayes IG3 8YB, UK
Prenat Diagn 30:547-50. 2010
..To assess the impact of early vaginal bleeding on the levels of markers used in first trimester screening for aneuploidy...
- Maternal serum inhibin-A and activin-A levels in the first trimester of pregnancies developing pre-eclampsia
K Spencer
Prenatal Screening Unit, Clinical Biochemistry Department, King George Hospital, Goodmayes, London, UK
Ultrasound Obstet Gynecol 32:622-6. 2008
....
- First trimester aneuploidy screening in the presence of a vanishing twin: implications for maternal serum markers
K Spencer
Prenatal Screening Unit, Clinical Biochemistry Department, King George Hospital, Goodmayes, UK
Prenat Diagn 30:235-40. 2010
..To assess the impact of a vanishing twin on the levels of the biochemical markers used in the first trimester aneuploidy screening...
- Maternal serum screening marker levels in women with a previous aneuploidy pregnancy
Kevin Spencer
Clinical Biochemistry Department, Barking Havering and Redbridge University Hospitals NHS Trust, King George Hospital, Barley Lane, Goodmayes, IG3 8YB, UK
Prenat Diagn 29:1242-3. 2009
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- Is maternal renal disease a cause of elevated free beta-hCG in first trimester aneuploidy screening?
Kevin Spencer
Clinical Biochemistry Department, King George Hospital, Barley Lane, Goodmayes IG3 8YB, UK
Prenat Diagn 29:1045-9. 2009
..To asses whether supra elevated levels of maternal serum free beta hCG in the first trimester are associated with impaired renal function...
- First trimester intact hCG as an early marker of trisomy 21: a promise unrecognised?
Kevin Spencer
Prenatal Screening Unit, Department of Clinical Biochemistry, King George Hospital, Barley Lane, Goodmayes, Essex IG3 8YB, UK
Prenat Diagn 28:1156-9. 2008
..Here we further study the levels prior to and after 10 weeks of gestation to further establish whether or not the intact hCG is effective as a very early screening marker...
- Screening for trisomy 21 in twin pregnancies in the first trimester: an update of the impact of chorionicity on maternal serum markers
Kevin Spencer
Prenatal Screening Unit, Clinical Biochemistry Department, King George Hospital, Goodmayes, UK
Prenat Diagn 28:49-52. 2008
..To examine the distribution of first-trimester biochemical markers of aneuploidy in twin pregnancies, and to assess whether there are differences in the distributions between monochorionic and dichorionic twins...
- Low levels of maternal serum PAPP-A in the first trimester and the risk of pre-eclampsia
Kevin Spencer
Prenatal Screening Unit, Department of Clinical Biochemistry, King George Hospital, Goodmayes, Essex, UK
Prenat Diagn 28:7-10. 2008
..The objective of this study was to establish the relative risk for pre-eclampsia at various PAPP-A levels as an aid to counselling and follow up of pregnancies...
- Maternal serum ADAM12s as a potential marker of trisomy 21 prior to 10 weeks of gestation
Kevin Spencer
Prenatal Screening Unit, Clinical Biochemistry Department, King George Hospital, Goodmayes, Essex IG3 8YB, UK
Prenat Diagn 28:209-11. 2008
..Here we study the levels prior to 10 weeks of gestation to establish further the effectiveness or otherwise of ADAM12s as an early screening marker...
- First-trimester biochemical markers of aneuploidy and the prediction of small-for-gestational age fetuses
K Spencer
Prenatal Screening Unit, Clinical Biochemistry Department, Harold Wood Hospital, Romford, Essex, UK
Ultrasound Obstet Gynecol 31:15-9. 2008
..To examine the clinical utility of the first-trimester biochemical markers of aneuploidy in their ability to predict subsequent delivery of a small-for-gestational age (SGA) infant...
- ADAM12s in maternal serum as a potential marker of pre-eclampsia
Kevin Spencer
Prenatal Screening Unit, Clinical Biochemistry Department, King George Hospital, Goodmayes, Essex IG3 8YB, UK
Prenat Diagn 28:212-6. 2008
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- First-trimester ADAM12s as early markers of trisomy 21: a promise still unfulfilled?
Kevin Spencer
Prenatal Screening Unit, Department of Clinical Biochemistry, King George Hospital, Barley Lane, Goodmayes, Essex IG3 8YB, UK
Prenat Diagn 28:338-42. 2008
..Here we study the levels of ADAM12s prior to and after 10 weeks of gestation to establish further the effectiveness or otherwise of ADAM12s as an early screening marker...
- Maternal serum ADAM12s in the late first trimester of pregnancies with Trisomy 21
Kevin Spencer
Prenatal Screening Unit, Clinical Biochemistry Department, King George Hospital, Goodmayes, Essex IG3 8YB, UK
Prenat Diagn 28:422-4. 2008
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- First and second trimester markers of fetal aneuploidy in pregnant women with HIV infection
Kevin Spencer
Prenatal Screening Unit, Department of Clinical Biochemistry, King George Hospital, Barley Lane, Goodmayes, UK
Fetal Diagn Ther 29:135-8. 2011
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- The effect of temporal variation in biochemical markers of trisomy 21 across the first and second trimesters of pregnancy on the estimation of individual patient-specific risks and detection rates for Down's syndrome
K Spencer
Endocrine Unit, Clinical Biochemistry Department, Harold Wood Hospital, Romford RM3 0BE, UK
Ann Clin Biochem 40:219-31. 2003
..In this paper, we assess the impact of this temporal shift on the estimation of patient-specific risks and the detection rates (DRs) for Down's syndrome pregnancies...
- Uterine artery Doppler and mid-trimester maternal plasma homocysteine in subsequent pre-eclampsia
C K H Yu
Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, Medical School, London, UK
J Matern Fetal Neonatal Med 16:134-9. 2004
..9-27.9 micromol/l, p = 0.13). CONCLUSION: Mid-trimester maternal plasma homocysteine concentration is not elevated in women who developed pre-eclampsia even in those at high risk defined by abnormal uterine artery Doppler velocimetry...
- Screening for triploidy by fetal nuchal translucency and maternal serum free beta-hCG and PAPP-A at 10-14 weeks of gestation
K Spencer
Endocrine Unit, Clinical Biochemistry Department, Harold Wood Hospital, Essex, UK
Prenat Diagn 20:495-9. 2000
..We conclude that a large proportion of triploidy cases of both phenotypes could be identified in the first trimester using NT, maternal serum free beta-hCG and PAPP-A with a combination of trisomy 21 risk and an atypicality approach...
- Screening for trisomy 13 by fetal nuchal translucency and maternal serum free beta-hCG and PAPP-A at 10-14 weeks of gestation
K Spencer
Endocrine Unit, Clinical Biochemistry Department, Harold Wood Hospital, Essex, UK
Prenat Diagn 20:411-6. 2000
..We conclude that specific trisomy 13 risks should be part of developing risk algorithms combining maternal serum biochemistry and nuchal translucency for use in first trimester screening alongside those for trisomy 21 and trisomy 18...
- The influence of ethnic origin on first trimester biochemical markers of chromosomal abnormalities
K Spencer
Endocrine Unit, Clinical Biochemistry Department, Harold Wood Hospital, Gubbins Lane, Romford, Essex RM3 0BE, UK
Prenat Diagn 20:491-4. 2000
..The impact of ethnic origin seems to be greater than that observed with second trimester biochemical markers and larger studies are required in order to develop robust algorithms for correcting for ethnic origin in the first trimester...
- ADAM-12 stability in first trimester maternal serum
N J Cowans
Clinical Biochemistry Department, Prenatal Research Unit, King George Hospital, Goodmayes IG3 8YB, UK
Prenat Diagn 30:555-60. 2010
..In this study, we examine the stability of ADAM-12 with time and at different temperatures...
- First-trimester markers for the prediction of pre-eclampsia in women with a-priori high risk
A Khalil
Department of Obstetrics and Gynaecology, University College London Hospitals, Institute for Women s Health, London, UK
Ultrasound Obstet Gynecol 35:671-9. 2010
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- Maternal serum levels of dimeric inhibin A in pregnancies affected by trisomy 21 in the first trimester
K Spencer
Endocrine Unit, Clinical Biochemistry Department, Harold Wood Hospital, Gubbins Lane, Romford, Essex RM3 0BE, UK
Prenat Diagn 21:441-4. 2001
..These findings suggest that first trimester biochemical screening for trisomy 21, which is currently optimised using maternal serum free beta-hCG and PAPP-A and fetal nuchal translucency, will not benefit from the inclusion of inhibin A...
- The influence of parity and gravidity on first trimester markers of chromosomal abnormality
K Spencer
Endocrine Unit, Clinical Biochemistry Department, Harold Wood Hospital, Gubbins Lane, Romford, Essex RM3 0BE, UK
Prenat Diagn 20:792-4. 2000
..None of these small changes with increasing gravidity or parity are statistically significant and hence correction for these variables is not necessary when considering first trimester screening for chromosomal abnormalities...
- Maternal serum activin A and inhibin A in trisomy 18 pregnancies at 10-14 weeks
K Spencer
Endocrine Unit, Clinical Biochemistry Department, Harold Wood Hospital, Gubbins Lane, Romford, Essex RM3 0BE, UK
Prenat Diagn 21:571-4. 2001
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- Second trimester levels of pregnancy associated plasma protein-A in cases of trisomy 18
K Spencer
Endocrine Unit, Department of Clinical Biochemistry, Harold Wood Hospital, Romford, Essex, U K
Prenat Diagn 19:1127-34. 1999
..This approach is unlikely to be better than the excellent detection rates achievable with free beta-hCG, PAPP-A and nuchal translucency in the first trimester...
- Maternal serum free beta-hCG and PAPP-A in fetal sex chromosome defects in the first trimester
K Spencer
Endocrine Unit, Clinical Biochemistry Department, Harold Wood Hospital, Gubbins Lane, Romford, Essex RM3 0BE, UK
Prenat Diagn 20:390-4. 2000
..Using a previously derived multivariate risk algorithm for trisomy 21, incorporating NT, PAPP-A, free beta-hCG and maternal age, 96% of the Turner's cases and 62% of the other sex chromosomal anomalies would have been identified...
- First-trimester placental growth factor as a marker for hypertensive disorders and SGA
N J Cowans
Prenatal Research Unit, Clinical Biochemistry Department, King George Hospital, Goodmayes IG3 8YB, UK
Prenat Diagn 30:565-70. 2010
..The objective of this study was to examine first-trimester maternal serum placental growth factor (PlGF) levels in pregnancies which later develop hypertensive and growth complications...
- First trimester maternal serum placental growth factor in trisomy 21 pregnancies
N J Cowans
Prenatal Research Unit, Clinical Biochemistry Department, King George Hospital, Goodmayes, UK
Prenat Diagn 30:449-53. 2010
..To examine placental growth factor (PlGF) levels in first trimester maternal serum in trisomy 21 pregnancies and to investigate the potential value of PlGF in a first trimester screening test...
- First and second-trimester biochemical markers of chromosomal anomalies and their relationship to maternal haemoglobin levels
N J Cowans
Prenatal Screening Unit, Clinical Biochemistry Department, Harold Wood Hospital, Gubbins Lane, Romford, Essex, UK
Prenat Diagn 25:693-9. 2005
..Biochemical marker levels do not need to be corrected for haemoglobin concentrations when used in screening for Down syndrome...
- First-trimester screening for trisomy 21 by free beta-human chorionic gonadotropin and pregnancy-associated plasma protein-A: impact of maternal and pregnancy characteristics
K O Kagan
Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, UK
Ultrasound Obstet Gynecol 31:493-502. 2008
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- One-stop clinic for assessment of risk for trisomy 21 at 11-14 weeks: a prospective study of 15 030 pregnancies
R Bindra
Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, UK
Ultrasound Obstet Gynecol 20:219-25. 2002
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- First trimester maternal serum AFP and total hCG in aneuploidies other than trisomy 21
K Spencer
Endocrine Unit, Clinical Biochemistry Department, Harold Wood Hospital, Gubbins Lane, Romford, Essex RM3 0BE, UK
Prenat Diagn 20:635-9. 2000
..AFP and total hCG are not likely to replace the markers free beta-hCG and PAPP-A in first trimester screening for chromosomal anomalies...
- Is maternal serum total hCG a marker of trisomy 21 in the first trimester of pregnancy?
K Spencer
Endocrine Unit, Clinical Biochemistry Department, Harold Wood Hospital, Gubbins Lane, Romford, Essex, RM3 0BE, UK
Prenat Diagn 20:311-7. 2000
..This observation explains much of the confusion around total hCG in the first trimester and shows the importance of selecting analyte pairs and population parameters appropriate to the time in gestation when screening is performed...
- PP13 stability in first trimester maternal serum and whole blood
N J Cowans
Prenatal Research Unit, Clinical Biochemistry Department, King George Hospital, Goodmayes IG3 8YB, UK
Prenat Diagn 30:582-5. 2010
..Maternal serum placental protein 13 (PP13) has been proposed as a marker for prenatal screening of pre-eclampsia (PE) and other adverse pregnancy outcomes. This study aims to examine the stability of PP13 at different routine temperatures...
- Detection of maternal serum hCG glycoform variants in the second trimester of pregnancies affected by Down syndrome using a lectin immunoassay
J A Talbot
Clinical Biochemistry Department, Clinical Sciences Building, Hope Hospital, Eccles Old Road, Salford, UK
Prenat Diagn 23:1-5. 2003
..CONCLUSION: Maternal serum GlyhCG, as measured by the sialic acid-binding lectin immunoassay is unlikely to be of additional value when screening for Down syndrome in the second trimester...
- The influence of fetal sex in screening for trisomy 21 by fetal nuchal translucency, maternal serum free beta-hCG and PAPP-A at 10-14 weeks of gestation
K Spencer
Endocrine Unit, Clinical Biochemistry Department, Harold Wood Hospital, Gubbins Lane, Romford, Essex, RM3 0BE, UK
Prenat Diagn 20:673-5. 2000
..Correction of risk algorithms for fetal sex, however, is probably not feasible, since ultrasound detection of fetal sex is only 70-90% accurate in the 10-14 week period...
- Maternal serum levels of total activin-A in first-trimester trisomy 21 pregnancies
K Spencer
Endocrine Unit, Clinical Biochemistry Department, Harold Wood Hospital, Gubbins Lane, Romford, Essex RM3 0BE, UK
Prenat Diagn 21:270-3. 2001
..6071) and free beta-hCG (0.4255). The low median difference and the high overlap in values between trisomic and unaffected pregnancies make total activin-A of little practical use in first-trimester screening for trisomy 21...
- First-trimester ADAM12 and PAPP-A as markers for intrauterine fetal growth restriction through their roles in the insulin-like growth factor system
Nicholas J Cowans
Prenatal Screening Unit, Clinical Biochemistry Department, Harold Wood Hospital, Romford, RM3 0BE, UK
Prenat Diagn 27:264-71. 2007
..We therefore wish to examine if the levels of either of these proteases are related to various growth related adverse pregnancy outcomes...
- Maternal serum hyperglycosylated human chorionic gonadotrophin (HhCG) in the first trimester of pregnancies affected by Down syndrome, using a sialic acid-specific lectin immunoassay
K Spencer
Endocrine Unit, Clinical Biochemistry Department, Harold Wood Hospital, Romford, UK
Prenat Diagn 22:656-62. 2002
..Maternal serum HhCG is unlikely to be of additional value when screening for Down syndrome in the first trimester...
- Integrated ultrasound and biochemical screening for trisomy 21 using fetal nuchal translucency, absent fetal nasal bone, free beta-hCG and PAPP-A at 11 to 14 weeks
Simona Cicero
Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, Denmark Hill, London, UK
Prenat Diagn 23:306-10. 2003
..For a false-positive rate of 0.5%, the detection rate was 90.5%. CONCLUSIONS: An integrated sonographic and biochemical test at 11 to 14 weeks can potentially identify about 90% of trisomy 21 fetuses for a false-positive rate of 0.5%...
- Age related detection and false positive rates when screening for Down's syndrome in the first trimester using fetal nuchal translucency and maternal serum free betahCG and PAPP-A
K Spencer
Clinical Biochemistry Department, Harold Wood Hospital, Romford, UK
BJOG 108:1043-6. 2001
..This information may be useful in counselling women with an increased risk result in first trimester screening...
- Second-trimester prenatal screening for Down syndrome and the relationship of maternal serum biochemical markers to pregnancy complications with adverse outcome
K Spencer
Endocrine Unit, Clinical Biochemistry Department, Harold Wood Hospital, Gubbins Lane, Romford, Essex, RM3 0BE, UK
Prenat Diagn 20:652-6. 2000
..0 MoM, suggesting increased risk of preterm delivery or impending fetal death, the clinical utility of such significant differences is probably poor...
- Screening for trisomy 21 in twin pregnancies in the first trimester: does chorionicity impact on maternal serum free beta-hCG or PAPP-A levels?
K Spencer
Endocrine Unit, Clinical Biochemistry Department, Harold Wood Hospital, Gubbins Lane, Romford RM3 0BE, UK
Prenat Diagn 21:715-7. 2001
..03 vs 1.00). It is concluded that the existing pseudo risk twin correction algorithm is appropriate for both monochorionic and dichorionic twins in providing accurate first trimester risks for trisomy 21...
- Maternal serum biochemistry at 11-13(+6) weeks in relation to the presence or absence of the fetal nasal bone on ultrasonography in chromosomally abnormal fetuses: an updated analysis of integrated ultrasound and biochemical screening
Simona Cicero
Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, Denmark Hill, London, UK
Prenat Diagn 25:977-83. 2005
..An integrated sonographic and biochemical test at 11-13(+6) weeks can potentially identify about 88% of trisomy 21 fetuses for a false-positive rate of 0.5%...
- Screening for chromosomal abnormalities in the first trimester using ultrasound and maternal serum biochemistry in a one-stop clinic: a review of three years prospective experience
Kevin Spencer
Department of Clinical Biochemistry, Harold Wood Hospital, Essex, UK
BJOG 110:281-6. 2003
..The detection rates are far better than can be achieved by second trimester serum screening...
- The use of nuchal translucency measurement and second trimester biochemical markers in screening for Down's syndrome
G D Michailidis
Department of Obstetrics and Gynaecology, Royal Free Hospital, London, UK
BJOG 108:1047-52. 2001
....
- Between pregnancy biological variability of first trimester markers of Down syndrome: implications for screening in subsequent pregnancies
K Spencer
Endocrine Unit, Clinical Biochemistry Department, Harold Wood Hospital, Gubbins Lane, Romford, Essex RM3 0BE, UK
Prenat Diagn 21:445-7. 2001
..5-2 times more likely to repeat this event in their next pregnancy. This observation may be useful in counselling women in the first trimester screening of a subsequent pregnancy...
- First-trimester combined screening for trisomy 21 in a predominantly Chinese population
T Y Leung
Department of Obstetrics and Gynecology, The Chinese University of Hong Kong, Hong Kong, China SAR, and Prenatal Screening Unit, Clinical Biochemistry Department, Harold Wood Hospital, Essex, UK
Ultrasound Obstet Gynecol 29:14-7. 2007
....
- Multicenter study of first-trimester screening for trisomy 21 in 75 821 pregnancies: results and estimation of the potential impact of individual risk-orientated two-stage first-trimester screening
K H Nicolaides
Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, UK
Ultrasound Obstet Gynecol 25:221-6. 2005
..In addition, the potential impact of a new individual risk-orientated two-stage approach to first-trimester screening was examined...
- Screening for trisomy 21 in twin pregnancies in the first trimester using free beta-hCG and PAPP-A, combined with fetal nuchal translucency thickness
K Spencer
Endocrine Unit, Clinical Biochemistry Department, Harold Wood Hospital, Gubbins Lane, Romford, Essex RM3 0BE, UK
Prenat Diagn 20:91-5. 2000
..Twin screening using both modalities should be considered when introducing first trimester screening...
- Screening for trisomy 21 in twins using first trimester ultrasound and maternal serum biochemistry in a one-stop clinic: a review of three years experience
Kevin Spencer
Department of Clinical Biochemistry, Harold Wood Hospital, Essex, Romford, UK
BJOG 110:276-80. 2003
....
- Prospective first-trimester screening for trisomy 21 in 30,564 pregnancies
Kyriaki Avgidou
Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, UK
Am J Obstet Gynecol 192:1761-7. 2005
..4% of those with trisomy 21 and in 88.8% of those with other chromosomal defects. CONCLUSION: The most effective method of screening for chromosomal defects is by first-trimester fetal NT and maternal serum biochemistry...
- Screening for trisomy 21 by fetal tricuspid regurgitation, nuchal translucency and maternal serum free beta-hCG and PAPP-A at 11 + 0 to 13 + 6 weeks
O Falcon
Harris Birthright Research Centre for Fetal Medicine, King's College Hospital Medical School, London, UK
Ultrasound Obstet Gynecol 27:151-5. 2006
..An integrated sonographic and biochemical test at 11 + 0 to 13 + 6 weeks can potentially identify about 90% of trisomy 21 fetuses for a false-positive rate of 2-3%...
- First-trimester maternal serum activin A in pre-eclampsia and fetal growth restriction
C Y T Ong
Harris Birthright Research Centre for Fetal Medicine, King's College Hospital Medical School, Denmark Hill, London, UK
J Matern Fetal Neonatal Med 15:176-80. 2004
..92. CONCLUSION: Maternal serum activin A concentration at 12 weeks of gestation in pregnancies which subsequently develop hypertensive disease is increased, whereas in those complicated by fetal growth restriction it is normal...
- Accuracy of Down syndrome risks produced in a first-trimester screening programme incorporating fetal nuchal translucency thickness and maternal serum biochemistry
Kevin Spencer
Endocrine Unit, Department of Clinical Biochemistry, Harold Wood Hospital, Gubbins Lane, Romford, Essex, RM3 0BE, UK
Prenat Diagn 22:244-6. 2002
..9995). It is concluded that risks produced by the Fetal Medicine Foundation combined risk algorithm agree very closely with Down syndrome prevalence and can be used with confidence when counselling women of their risk...
- Is there an association between maternal ABO and rhesus blood groups and the first-trimester serum markers free beta-hCG and PAPP-A used for the detection of fetal aneuploidy?
Nicholas J Cowans
Prenatal Screening Unit, Department of Clinical Biochemistry, Harold Wood Hospital, Romford, Essex RM3 0BE
Prenat Diagn 27:64-7. 2007
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- First-trimester maternal placental protein 13 levels in pregnancies resulting in adverse outcomes
Nicholas J Cowans
Prenatal Screening Unit, Department of Clinical Biochemistry, King George Hospital, Barley Lane, Goodmayes, Essex IG3 8YB, UK
Prenat Diagn 28:121-5. 2008
..5 and < 2.5 kg) birth weight (LBW), macrosomia (the > 90th centile), large birth weight (>4.5 kg), preterm (35-36 weeks) and very early (<34 weeks) delivery (PTD), and intrauterine fetal demise (IUFD)...
- The influence of fetal sex in screening for Down syndrome in the second trimester using AFP and free beta-hCG
K Spencer
Endocrine Unit, Clinical Biochemistry Department, Harold Wood Hospital, Gubbins Lane, Romford, Essex RM3 0BE, UK
Prenat Diagn 20:648-51. 2000
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- First trimester maternal serum placenta growth factor (PIGF)concentrations in pregnancies with fetal trisomy 21 or trisomy 18
K Spencer
Endocrine Unit, Clinical Biochemistry Department, Harold Wood Hospital, Gubbins Lane, Romford, Essex RM3 0BE, UK
Prenat Diagn 21:718-22. 2001
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- The effect of Rhesus status on first-trimester pregnancy screening markers free beta human chorionic gonadotropin, pregnancy-associated plasma protein-A and nuchal translucency
Nicholas J Cowans
Department of Clinical Biochemistry, King George Hospital, Essex, UK
Prenat Diagn 29:505-7. 2009
..To examine whether maternal Rhesus status has any effect on the levels of first-trimester markers free beta-human chorionic gonadotropin (beta-hCG), pregnancy-associated plasma protein-A (PAPP-A) and nuchal translucency (NT)...
- The impact of fetal gender on first trimester nuchal translucency and maternal serum free beta-hCG and PAPP-A MoM in normal and trisomy 21 pregnancies
Nicholas J Cowans
Prenatal Screening Unit, Clinical Biochemistry Department, King George Hospital, Barley Lane, Goodmayes, IG3 8YB, UK
Prenat Diagn 29:578-81. 2009
..To investigate if fetal sex has an impact on 1st trimester combined screening for aenuploidy...
- First trimester sex hormone-binding globulin and subsequent development of preeclampsia or other adverse pregnancy outcomes
Kevin Spencer
Harris Birthright Research Centre for Fetal Medicine, King s College Hospital Medical School, Denmark Hill, London, UK
Hypertens Pregnancy 24:303-11. 2005
..To investigate whether first trimester maternal serum sex hormone-binding globulin (SHBG) concentrations are altered in women who subsequently develop preeclampsia or other pregnancy complications...
- Dose dependency between cigarette consumption and reduced maternal serum PAPP-A levels at 11-13+6 weeks of gestation
K O Kagan
Harris Birthright Research Centre for Fetal Medicine, King s College Hospital Medical School, London, UK
Prenat Diagn 27:849-53. 2007
..To examine whether in smokers there is a significant dose dependency between the number of cigarettes per day and levels of free ss-hCG and pregnancy-associated plasma protein A (PAPP-A) at 11-13(+6) weeks of gestation...
- Second-trimester sex hormone-binding globulin and subsequent development of pre-eclampsia
C K H Yu
Harris Birthright Research Centre for Fetal Medicine, King's College Hospital Medical School, London, UK
J Matern Fetal Neonatal Med 16:158-62. 2004
..median 336, range 142-674 nmol/l, p = 0.09). CONCLUSION: Maternal plasma SHBG concentrations are reduced in women who subsequently develop pre-eclampsia...
- PAPP-A and free ss-hCG stability in first trimester serum using PerkinElmer AutoDELFIA and DELFIA Xpress systems
Nicholas J Cowans
Prenatal Research Unit, Clinical Biochemistry Department, King George Hospital, Goodmayes, UK
Prenat Diagn 30:127-32. 2010
..In this study we aim to investigate the stability of free-beta-hCG and PAPP-A over time in serum and whole blood in typical routine temperatures...
- On being at higher risk: a qualitative study of prenatal screening for chromosomal anomalies
Bob Heyman
City University, London, UK
Soc Sci Med 62:2360-72. 2006
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- Age-standardisation when target setting and auditing performance of Down syndrome screening programmes
Howard Cuckle
Reproductive Epidemiology, University of Leeds, UK
Prenat Diagn 24:851-6. 2004
..To describe and illustrate a method of setting Down syndrome screening targets and auditing performance that allows for differences in the maternal age distribution...
- Women as moral pioneers? Experiences of first trimester antenatal screening
Clare Williams
School of Nursing and Midwifery, King s College London, Rm 5 4, Waterloo Bridge Wing, 150 Stamford Street, London SE1 9NN, UK
Soc Sci Med 61:1983-92. 2005
..It seems that whatever other implications they may have, first trimester screening technologies will continue the tradition of pregnant women acting as 'moral pioneers' in increasingly complex settings...
- Predicting complications of pregnancy with first-trimester maternal serum free-betahCG, PAPP-A and inhibin-A
Natasa Tul
Perinatology Unit, Department of Obstetrics and Gynecology, University Medical Centre Ljubljana, Slovenia
Prenat Diagn 23:990-6. 2003
..To find whether fbetahCG, PAPP-A and inhibin-A levels in maternal serum or fetal nuchal translucency (NT) thickness at the first-trimester screening for trisomy 21 (T21) might detect women at high risk for adverse pregnancy outcomes...
- Maternal serum level of placental growth factor in diabetic pregnancies
Charas Y T Ong
Obstetrics and Gynaecology Department, University of Hong Kong, Queen Mary Hospital, Hong Kong
J Reprod Med 49:477-80. 2004
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- Higher median levels of free beta-hCG and PAPP-A in the first trimester of pregnancy in a Chinese ethnic group. Implication for first trimester combined screening for Down's syndrome in the Chinese population
Tak Yeung Leung
Department of Obstetrics and Gynaecology, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong
Fetal Diagn Ther 21:140-3. 2006
..Adjustment for ethnicity may be necessary for these biochemical markers in a first trimester screening program...
- Physiological distribution of placental growth factor and soluble Flt-1 in early pregnancy
George Makrydimas
Department of Obstetrics and Gynecology, Ioannina University Hospital, 45500 Ioannina, Greece
Prenat Diagn 28:175-9. 2008
..To examine the distribution of placental growth factor (PlGF), vascular endothelial growth factor (VEGF) and soluble VEGF receptor-1 (sFlt-1) in maternal and embryonic fluid compartments in early pregnancy...
- Point-of-care screening for chromosomal anomalies in the first trimester of pregnancy
Kevin Spencer
Clin Chem 48:403-4. 2002
- ADAM 12 as a second-trimester maternal serum marker in screening for Down syndrome
Michael Christiansen
Department of Clinical Biochemistry, Statens Serum Institut, Copenhagen, Denmark
Prenat Diagn 27:611-5. 2007
..The maternal serum concentration of ADAM 12 is a potential first-trimester maternal serum marker of Down syndrome (DS). Here we examine the potential of ADAM 12 as a second-trimester maternal serum marker of DS...
- ADAM12-s in coelomic fluid and maternal serum in early pregnancy
George Makrydimas
Department of Obstetrics and Gynaecology, Ioannina University Hospital, 45500 Ioannina, Greece
Prenat Diagn 26:1197-200. 2006
..255, p = 0.401) or maternal serum ADAM12-s (r = 0.302, p = 0.316). CONCLUSION: The distribution of ADAM12-s in maternal serum and the early embryonic fluid compartments is consistent with its syncytiotrophoblastic origin...
