Lm Villar

Summary

Country: Spain

Publications

  1. ncbi Immunological markers of optimal response to natalizumab in multiple sclerosis
    Luisa M Villar
    Department of Immunology, Hospital Ramon y Cajal, Carretera de Colmenar Km 9 100, 28034 Madrid, Spain
    Arch Neurol 69:191-7. 2012
  2. ncbi Immunological mechanisms that associate with oligoclonal IgM band synthesis in multiple sclerosis
    Luisa M Villar
    Department of Immunology, Hospital Ramon y Cajal, Madrid, Spain
    Clin Immunol 137:51-9. 2010
  3. ncbi Current concepts in immunology
    Luisa M Villar
    Department of Immunology, , Madrid, Spain
    Expert Rev Clin Immunol 4:559-64. 2008
  4. ncbi CSF oligoclonal band patterns reveal disease heterogeneity in multiple sclerosis
    Luisa M Villar
    Departments of Neurology and Immunology, Ramon y Cajal Hospital, Madrid, Spain
    J Neuroimmunol 211:101-4. 2009
  5. ncbi Influence of oligoclonal IgM specificity in multiple sclerosis disease course
    Lm Villar
    Department of Neurology and Immunology, Hospital Ramon y Cajal, Madrid, Spain
    Mult Scler 14:183-7. 2008
  6. ncbi Early differential diagnosis of multiple sclerosis using a new oligoclonal band test
    Luisa M Villar
    Department of Immunology, Hospital Ramon y Cajal, Madrid, Spain
    Arch Neurol 62:574-7. 2005
  7. ncbi Intrathecal synthesis of oligoclonal IgM against myelin lipids predicts an aggressive disease course in MS
    Luisa M Villar
    Departments of Immunology and Neurology, Hospital Ramon y Cajal, Madrid, Spain
    J Clin Invest 115:187-94. 2005
  8. ncbi Intrathecal IgM synthesis is a prognostic factor in multiple sclerosis
    Luisa M Villar
    Department of Immunology, Hospital Ramon y Cajal, Madrid, Spain
    Ann Neurol 53:222-6. 2003
  9. ncbi Accuracy of CSF and MRI criteria for dissemination in space in the diagnosis of multiple sclerosis
    Luisa M Villar
    Department of Immunology, Ramon y Cajal Hospital, Madrid, Spain
    J Neurol Sci 266:34-7. 2008

Detail Information

Publications10

  1. ncbi Immunological markers of optimal response to natalizumab in multiple sclerosis
    Luisa M Villar
    Department of Immunology, Hospital Ramon y Cajal, Carretera de Colmenar Km 9 100, 28034 Madrid, Spain
    Arch Neurol 69:191-7. 2012
    ..It shows high efficacy in modifying the natural history of MS and induces freedom of disease activity in about 40% of treated patients with MS...
  2. ncbi Immunological mechanisms that associate with oligoclonal IgM band synthesis in multiple sclerosis
    Luisa M Villar
    Department of Immunology, Hospital Ramon y Cajal, Madrid, Spain
    Clin Immunol 137:51-9. 2010
    ..These results help to elucidate the B lymphocytes responsible for intrathecal IgM secretion in MS and the origin of this abnormal B-cell response in patients with aggressive MS...
  3. ncbi Current concepts in immunology
    Luisa M Villar
    Department of Immunology, , Madrid, Spain
    Expert Rev Clin Immunol 4:559-64. 2008
    ..Some of the most interesting plenary presentations given at this meeting are summarized...
  4. ncbi CSF oligoclonal band patterns reveal disease heterogeneity in multiple sclerosis
    Luisa M Villar
    Departments of Neurology and Immunology, Ramon y Cajal Hospital, Madrid, Spain
    J Neuroimmunol 211:101-4. 2009
    ..0001). Moreover, no PPMS patient presented LS-OCMB, while 31% of RRMS and 60% of SPMS groups showed these antibodies (p<0.0001). This suggests heterogeneous autoimmune mechanisms in MS...
  5. ncbi Influence of oligoclonal IgM specificity in multiple sclerosis disease course
    Lm Villar
    Department of Neurology and Immunology, Hospital Ramon y Cajal, Madrid, Spain
    Mult Scler 14:183-7. 2008
    ..02) than M+L- group. These data corroborate that anti-lipid OCMB associate with an aggressive MS course and show that OCMB that do not recognize myelin lipids represent a transient immune response related to a more benign disease course...
  6. ncbi Early differential diagnosis of multiple sclerosis using a new oligoclonal band test
    Luisa M Villar
    Department of Immunology, Hospital Ramon y Cajal, Madrid, Spain
    Arch Neurol 62:574-7. 2005
    ..Recently, we developed a new oligoclonal IgG band (OCGB) test for ITGS detection that is more sensitive and easier to interpret than previously described methods...
  7. ncbi Intrathecal synthesis of oligoclonal IgM against myelin lipids predicts an aggressive disease course in MS
    Luisa M Villar
    Departments of Immunology and Neurology, Hospital Ramon y Cajal, Madrid, Spain
    J Clin Invest 115:187-94. 2005
    ..The presence of intrathecal anti-myelin lipid IgM antibodies is therefore a very accurate predictor of aggressive evolution in MS...
  8. ncbi Intrathecal IgM synthesis is a prognostic factor in multiple sclerosis
    Luisa M Villar
    Department of Immunology, Hospital Ramon y Cajal, Madrid, Spain
    Ann Neurol 53:222-6. 2003
    ..At the end of the study, the mean EDSS score was 4.64 in patients with ITMS and 1.31 in those without. The presence of oligoclonal IgM bands in cerebrospinal fluid is an unfavorable prognostic marker in MS...
  9. ncbi Accuracy of CSF and MRI criteria for dissemination in space in the diagnosis of multiple sclerosis
    Luisa M Villar
    Department of Immunology, Ramon y Cajal Hospital, Madrid, Spain
    J Neurol Sci 266:34-7. 2008
    ..The presence of oligoclonal IgG bands plus two T2 lesions accurately predicts CIS conversion to MS. MRI-BC criteria have a high specificity but less sensitivity and accuracy. These results reinforce the role of CSF study in MS diagnosis...