Research Topics
Genomes and Genes | Gorka LarrinagaSummaryAffiliation: University of the Basque Country Country: Spain Publications
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Publications
Expression and activity profiles of DPP IV/CD26 and NEP/CD10 glycoproteins in the human renal cancer are tumor-type dependentAdolfo Varona
Department of Physiology, Faculty of Medicine and Dentistry, University of Basque Country, Barrio Sarriena s n, 48940 Leioa, Spain
BMC Cancer 10:193. 2010..In the present study, the activity and protein and mRNA expression of these glycoproteins were analysed in a subset of clear-cell (CCRCC) and chromophobe (ChRCC) renal cell carcinomas, and in renal oncocytomas (RO)...- Increased prolyl endopeptidase activity in human neoplasiaGorka Larrinaga
Department of Physiology, School of Medicine and Dentistry, Leioa, Bizkaia, Spain
Regul Pept 163:102-6. 2010..Both cytosolic and membrane-bound PEP activity were also increased in colorectal adenomatous polyps. These data suggest the involvement of PEP in some mechanisms that underlie neoplastic processes... - Angiotensin-converting enzymes (ACE and ACE2) are downregulated in renal tumorsGorka Larrinaga
Department of Physiology, Faculty of Medicine and Dentistry, University of the Basque Country, Bilbao, Biscay, Spain
Regul Pept 165:218-23. 2010..These findings suggest a metabolic imbalance in iRAS and a role of this system in renal neoplastic diseases, and point to ACE and ACE2 as potential prognostic/diagnostic markers... - Expression of cannabinoid receptors in human kidneyGorka Larrinaga
Department of Physiology, Faculty of Medicine and Dentistry, University of the Basque Country UPV EHU, Leioa, Bizkaia, Spain
Histol Histopathol 25:1133-8. 2010..Conversely, the CB2 cannabinoid receptor protein was consistently negative in all cases. Our data suggest a possible implication of the endocannabinoid system in the physiology and development of the human kidney... - Cystinyl aminopeptidase activity is decreased in renal cell carcinomasGorka Larrinaga
Department of Nursing I, University of the Basque Country, Leioa, Bizkaia, Spain
Regul Pept 144:56-61. 2007..These data may open additional possibilities in the study of renal cell carcinoma with regard to the prognosis of patients... - Altered levels of acid, basic, and neutral peptidase activity and expression in human clear cell renal cell carcinomaAdolfo Varona
Dept of Physiology, Faculty of Medicine and Dentistry, Hospital de Basurto, University of the Basque Country, E 48080 Bilbao, Bizkaia, Spain
Am J Physiol Renal Physiol 292:F780-8. 2007..3-fold). This peptidase activity profile in the neoplastic kidney suggests a specific role for the studied convertases and the possible involvement of an intracrine renin-angiotensin system in the pathogenesis of CCRCC... - Activity of soluble aminopeptidase A and dipeptidyl peptidase IV and membrane-bound aminopeptidase B and pyroglutamyl peptidase I in adenoid hyperplasia, tonsillar hyperplasia and chronic tonsillitisGorka Larrinaga
Department of Physiology, School of Medicine, University of the Basque Country, Spain
Int J Pediatr Otorhinolaryngol 75:1399-403. 2011..To analyze soluble and membrane-bound peptidase activities in the tonsils and adenoids removed from patients with adenoid hyperplasia, tonsillar hyperplasia and chronic tonsillitis... - Acid, basic, and neutral peptidases present different profiles in chromophobe renal cell carcinoma and in oncocytomaLorena Blanco
Dept of Physiology, Faculty of Medicine and Dentistry, Univ of the Basque Country, P O Box 699, E 48080 Bilbao, Bizkaia, Spain
Am J Physiol Renal Physiol 294:F850-8. 2008..These results may suggest an involvement of several peptidases in the pathophysiology of renal cancer, since they presented different patterns of activity and expression in tumors with different behaviors... - Changes in cell-surface peptidase activity in papillary renal cell carcinomaLorena Blanco
Department of Physiology, Faculty of Medicine and Dentistry, University of the Basque Country, Barrio Sarriena, Leioa, Spain
Anticancer Res 30:1137-41. 2010..Peptidases are proteolytic enzymes known to be involved in oncological processes, although their precise role in renal cancer is poorly understood... - Cannabinoid CB? receptor is downregulated in clear cell renal cell carcinomaGorka Larrinaga
Department of Physiology, Faculty of Medicine and Dentistry, University of the Basque Country, Universidad del Pais Vasco Euskal Herriko Unibertsitatea UPV EHU, Leioa, Bizkaia, Spain
J Histochem Cytochem 58:1129-34. 2010..The obtained data suggest a possible implication of the endocannabinoid system in renal carcinogenesis. A posttranscriptional downregulation of CB? and the absence of expression of CB? characterize CCRCC... - Increased APN/CD13 and acid aminopeptidase activities in head and neck squamous cell carcinomaItxaro Perez
Department of Physiology, School of Medicine and Dentistry, University of the Basque Country, Bilbao, Spain
Head Neck 31:1335-40. 2009..However, very little is known about involvement of peptidases in this neoplasm... - Subcellular distribution of membrane-bound aminopeptidases in the human and rat brainGorka Larrinaga
Department of Nursing I, University of the Basque Country, Bilbao, Bizkaia, Spain
Neurosci Lett 383:136-40. 2005..Moreover, these peptidases may play specific roles depending on their activity levels at the different subcellular structures where they are localized... - Altered dipeptidyl peptidase IV and prolyl endopeptidase activities in chronic tonsillitis, tonsillar hyperplasia and adenoid hyperplasiaGorka Larrinaga
Department of Physiology, University of the Basque Country, Bilbao, Spain
Int J Pediatr Otorhinolaryngol 75:347-50. 2011..To analyse peptidase activities in the removed tonsils and adenoids from patients with chronic tonsillitis, tonsillar hyperplasia and adenoid hyperplasia... - Distribution of prolyl endopeptidase activities in rat and human brainJon Irazusta
Department of Physiology, Medical School, University of the Basque Country, Leioa, P O Box 699, 48, 080 Bilbao, Spain
Neurochem Int 40:337-45. 2002..The particulate form was enriched in the synaptosomal and the myelinic membranes. The high activity of prolyl endopeptidase in the human cortex suggests that prolyl endopeptidase could play a role in the functions of this brain area... - Effects of morphine administration and its withdrawal on rat brain aminopeptidase activitiesJon Irazusta
Department of Physiology, Faculty of Medicine, University of the Basque Country, P O Box 699, Vizcaya E 48080, Bilbao, Spain
Regul Pept 110:225-30. 2003..The results of the present report indicate that aminopeptidases may play an important role in the processes of tolerance and withdrawal associated with morphine administration...